Nemtabrutinib With Venetoclax and Obinutuzumab in Patients With Chronic Lymphocytic Leukemia

Part of paid clinical trials in Milwaukee, Wisconsin.

Sponsor
Medical College of Wisconsin
Study ID
NCT07690891
Phase
PHASE2
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Nemtabrutinib — DRUG
    45 mg daily for 15 28-day cycles.
  • Venetoclax — DRUG
    Cycle 4, Days 1-7: 20 mg; Cycle 4, Days 8-14: 50 mg; Cycle 4, Days 15-21: 100 mg; Cycle 4, Days 22-28: 200 mg; Cycle 5-15: 400 mg.
  • Obinutuzumab — DRUG
    Cycle 4, Day 1: 100 mg; Cycle 4, Day 2: 900 mg; Cycle 4, Day 8: 1000 mg; Cycle 4, Day 15: 1000 mg; Cycles 5-9, Day 1: 1000 mg.

Study Details

This is a single-arm, open-label Phase 2 study designed to evaluate the treatment outcomes of nemtabrutinib-venetoclax-obinutuzumab as a frontline management for chronic lymphocytic leukemia (CLL).

Key Dates

First listed
Jul 8, 2026
Start date
Oct 1, 2026
Status verified
Jul 2026
Primary completion
Dec 1, 2029
Completion
Sep 1, 2031

Study Design

Enrollment
30 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Nemtabrutinib with Venetoclax and Obinutuzumab
    * Nemtabrutinib will be administered orally. * Venetoclax will be administered orally * Obinutuzumab will be administered intravenously.

Primary Outcome Measure

Undetectable MRD [ Time Frame: 15 months ]

Central Contacts

  • Medical College of Wisconsin Cancer Center Clinical Trials Office
    866-680-0505
    [email protected]

Locations (1)

FacilityCityStateZIPSite coordinators
Froedtert & the Medical College of WisconsinMilwaukeeWisconsin53226
Guru Guru Murthy, MD
[email protected]
414-805-4600

Find similar trials in Milwaukee, WI

By condition
Leukemia (other)
By specialty
OncologyBlood cancer
By research site
Froedtert & the Medical College of Wisconsin· Milwaukee, WI

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