Evogliptin Evidence: Trial Results and Peer-Reviewed Publications

Hipa.ai Research · Source: PubMed & ClinicalTrials.gov / AACT · Last updated:

The clinical evidence base for Evogliptin comprises 11 peer-reviewed publications across 9 journals, 0 pivotal-trial primary-outcome rows reported to ClinicalTrials.gov, spanning indications including Diabetes Mellitus, Type 2. Most recent publication: Efficacy and safety of dapagliflozin add-on to evogliptin plus metformin therapy in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study., Diabetes Obes Metab, 2024.

Top peer-reviewed publications

Curated set of pivotal-trial result papers and recent publications in high-tier journals.

  1. Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extension.
    Moon JS, Park IR, Kim HJ, et al. · Diabetes Metab J · 2023
    PubMed: PMID 37750183 · NCT04170998
  2. Efficacy and safety of dapagliflozin add-on to evogliptin plus metformin therapy in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study.
    Jeong IK, Choi KM, Han KA, et al. · Diabetes Obes Metab · 2024
    PubMed: PMID 39223856 · NCT04356742 · Diabetes Mellitus, Type 2
  3. Efficacy and safety of evogliptin in the treatment of type 2 diabetes mellitus in a Brazilian population: a randomized bridging study.
    Cercato C, Felício JS, Russo LAT, et al. · Diabetol Metab Syndr · 2022
    PubMed: PMID 31890041 · NCT02689362 (EVOLUTION) · Diabetes Mellitus, Type 2
  4. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly.
    Otto CM, Lind BK, Kitzman DW, et al. · N Engl J Med · 1999
    PubMed: PMID 10403851 · NCT04521452
  5. Calcific aortic stenosis.
    Lindman BR, Clavel MA, Mathieu P, et al. · Nat Rev Dis Primers · 2018
    PubMed: PMID 27188578 · NCT04521452
  6. Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells.
    Choi B, Lee S, Kim SM, et al. · Circulation · 2017
    PubMed: PMID 28179397 · NCT04521452
  7. Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.
    Brandenburg VM, Reinartz S, Kaesler N, et al. · Circulation · 2019
    PubMed: PMID 28533322 · NCT04521452
  8. 2017 ESC/EACTS Guidelines for the management of valvular heart disease.
    Baumgartner H, Falk V, Bax JJ, et al. · Eur Heart J · 2019
    PubMed: PMID 28886619 · NCT04521452

Publications by year

1999–2024: 11 publications.

1999
2
2015
2
2017
1
2018
1
2019
2
2022
1
2023
1
2024
1

Publications by indication

Diabetes Mellitus, Type 2 (2)

  • Efficacy and safety of dapagliflozin add-on to evogliptin plus metformin therapy in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study.
    Diabetes Obes Metab · 2024 · PMID 39223856 · NCT04356742
  • Efficacy and safety of evogliptin in the treatment of type 2 diabetes mellitus in a Brazilian population: a randomized bridging study.
    Diabetol Metab Syndr · 2022 · PMID 31890041 · NCT02689362

Publications by journal

  • Circulation3 papers
  • Diabetes Metab J1 paper
  • Diabetes Obes Metab1 paper
  • Diabetol Metab Syndr1 paper
  • J Am Coll Cardiol1 paper
  • N Engl J Med1 paper
  • Nat Rev Dis Primers1 paper
  • Eur Heart J1 paper
  • Am J Cardiol1 paper

All Evogliptin publications (11)

2024 (1 paper)

  1. Efficacy and safety of dapagliflozin add-on to evogliptin plus metformin therapy in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study.
    Jeong IK, Choi KM, Han KA, et al. · Diabetes Obes Metab · 2024 · Derived
    PubMed: PMID 39223856 · NCT04356742 · Diabetes Mellitus, Type 2

2023 (1 paper)

  1. Efficacy and Safety of Evogliptin Add-on Therapy to Dapagliflozin/Metformin Combinations in Patients with Poorly Controlled Type 2 Diabetes Mellitus: A 24-Week Multicenter Randomized Placebo-Controlled Parallel-Design Phase-3 Trial with a 28-Week Extension.
    Moon JS, Park IR, Kim HJ, et al. · Diabetes Metab J · 2023 · Derived
    PubMed: PMID 37750183 · NCT04170998

2022 (1 paper)

  1. Efficacy and safety of evogliptin in the treatment of type 2 diabetes mellitus in a Brazilian population: a randomized bridging study.
    Cercato C, Felício JS, Russo LAT, et al. · Diabetol Metab Syndr · 2022 · Derived
    PubMed: PMID 31890041 · NCT02689362 (EVOLUTION) · Diabetes Mellitus, Type 2

2019 (2 papers)

  1. Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study.
    Brandenburg VM, Reinartz S, Kaesler N, et al. · Circulation · 2019 · Background
    PubMed: PMID 28533322 · NCT04521452
  2. 2017 ESC/EACTS Guidelines for the management of valvular heart disease.
    Baumgartner H, Falk V, Bax JJ, et al. · Eur Heart J · 2019 · Background
    PubMed: PMID 28886619 · NCT04521452

2018 (1 paper)

  1. Calcific aortic stenosis.
    Lindman BR, Clavel MA, Mathieu P, et al. · Nat Rev Dis Primers · 2018 · Background
    PubMed: PMID 27188578 · NCT04521452

2017 (1 paper)

  1. Dipeptidyl Peptidase-4 Induces Aortic Valve Calcification by Inhibiting Insulin-Like Growth Factor-1 Signaling in Valvular Interstitial Cells.
    Choi B, Lee S, Kim SM, et al. · Circulation · 2017 · Background
    PubMed: PMID 28179397 · NCT04521452

2015 (2 papers)

  1. Calcification in Aortic Stenosis: The Skeleton Key.
    Pawade TA, Newby DE, Dweck MR, et al. · J Am Coll Cardiol · 2015 · Background
    PubMed: PMID 26227196 · NCT04521452
  2. Population-wide trends in aortic stenosis incidence and outcomes.
    Bonow RO, Greenland P · Circulation · 2015 · Background
    PubMed: PMID 25691712 · NCT04521452

1999 (2 papers)

  1. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly.
    Otto CM, Lind BK, Kitzman DW, et al. · N Engl J Med · 1999 · Background
    PubMed: PMID 10403851 · NCT04521452
  2. Comparison of frequency of new coronary events in older subjects with and without valvular aortic sclerosis.
    Aronow WS, Ahn C, Shirani J, et al. · Am J Cardiol · 1999 · Background
    PubMed: PMID 10073870 · NCT04521452

Sources and methodology

  • Publications: ctgov.study_references (PubMed PMIDs auto-attached by ClinicalTrials.gov to each trial), reference types RESULT, DERIVED, and BACKGROUND.
  • Per-arm outcome values: ctgov.outcome_measurements joined to ctgov.design_outcomes where outcome_type = 'PRIMARY', restricted to phase PHASE3 and PHASE2/PHASE3.
  • Publication metadata (title, journal, year, authors): PubMed E-utilities efetch.fcgi
  • Data freshness: Thu, 14 May 2026 22:02:35 GMT.
This page summarizes published evidence for general reference and does not constitute medical advice. For clinical decisions, consult the linked primary publications and your healthcare provider. Data sourced from PubMed and the ClinicalTrials.gov / AACT database maintained by the Clinical Trials Transformation Initiative (CTTI).