Mezigdomide Clinical Trials (2026): 19 Studies for Multiple Myeloma & Recurrent Multiple Myeloma
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
19 Mezigdomide clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 11 indications (including Multiple Myeloma & Recurrent Multiple Myeloma) and 2,441 total planned enrollment. 2 Phase 3 Mezigdomide trials and 1 Phase 2 are listed. 12 Mezigdomide clinical trials are actively recruiting at 52 U.S. sites across 16 states. Most recent activity: NCT05519085 (Nov 2033).
Where to Participate: All Mezigdomide Trial Sites in the U.S. (52 sites across 16 states)
Every actively recruiting Mezigdomidetrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | University of Alabama at Birmingham | Birmingham35294 | NCT06988488 | Map |
| AL | University of Alabama at Birmingham | Birmingham35294-3300 | NCT06121843 | Map |
| AZ | Mayo Clinic in Arizona - Phoenix | Phoenix85054 | NCT06121843 | Map |
| CA | City of Hope Comprehensive Cancer Center | Duarte91010 | NCT06121843 | Map |
| CA | City of Hope Medical Center | Duarte91010 | NCT06048250 | Map |
| CA | UCSF Medical Center - Hematology and Blood and Marrow Transplant Clinic | San Francisco94143 | NCT05651932 | Map |
| CT | Yale New Haven Hospital-Smilow Cancer Center | New Haven06510 | NCT06988488 | Map |
| FL | Mayo Clinic Hospital - Florida | Jacksonville32224 | NCT05651932 | Map |
| FL | Mayo Clinic in Florida | Jacksonville32224 | NCT06121843 | Map |
| GA | Northside Hospital | Atlanta30342 | NCT06121843 | Map |
| GA | The Winship Cancer Institute of Emory University | Atlanta30322 | NCT05651932 | Map |
| MA | Beth Israel Deaconess Medical Center | Boston02215 | NCT06121843 | Map |
| MA | Dana Farber Cancer Institute | Boston02215 | NCT02343042 | Map |
| MA | Dana-Farber Cancer Institute | Boston02215 | NCT06121843 | Map |
| MA | Dana-Farber Cancer Institute | Boston02215 | NCT05651932 | Map |
| MA | Massachusetts General Hospital | Boston02114 | NCT07032714 | Map |
| MA | Massachusetts General Hospital | Boston02114 | NCT05651932 | Map |
| MN | Mayo Clinic - Transplant Center - Rochester | Rochester55905 | NCT05651932 | Map |
| MN | Mayo Clinic in Rochester, Minnesota | Rochester55905 | NCT06121843 | Map |
| NE | University Of Nebraska Medical Center | Omaha68198 | NCT06121843 | Map |
| NJ | Memorial Sloan Kettering at Basking Ridge (All Protocol Activities) | Basking Ridge07920 | NCT07356154 | Map |
| NJ | Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) | Basking Ridge07920 | NCT07105059 | Map |
| NJ | Hackensack University Medical Center | Hackensack07601 | NCT06988488 | Map |
| NJ | Hackensack University Medical Center | Hackensack07601 | NCT05651932 | Map |
| NJ | John Theurer Cancer Center at Hackensack University Medical Center | Hackensack07601-2191 | NCT06121843 | Map |
| NJ | Memorial Sloan Kettering Monmouth (All Protocol Activities) | Middletown07748 | NCT07356154 | Map |
| NJ | Memorial Sloan Kettering Monmouth (Limited Protocol Activities) | Middletown07748 | NCT07105059 | Map |
| NJ | Memorial Sloan Kettering Bergen (All Protocol Activities) | Montvale07645 | NCT07356154 | Map |
| NJ | Memorial Sloan Kettering Bergen (Limited Protocol Activities) | Montvale07645 | NCT07105059 | Map |
| NY | Roswell Park Cancer Institute | Buffalo14263 | NCT06121843 | Map |
| NY | Roswell Park Cancer Institute | Buffalo14263 | NCT06627751 | Map |
| NY | Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) | Commack11725 | NCT07105059 | Map |
| NY | Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities) | Commack11725 | NCT07356154 | Map |
| NY | Memorial Sloan Kettering Westchester (Limited Protocol Activities) | Harrison10604 | NCT07356154 | Map |
| NY | Memorial Sloan Kettering Westchester (Limited Protocol Activities) | Harrison10604 | NCT07105059 | Map |
| NY | Laura and Isaac Perlmutter Cancer Center | New York10016 | NCT06121843 | Map |
| NY | Memorial Sloan Kettering Cancer Center | New York10065 | NCT06121843 | Map |
| NY | Memorial Sloan Kettering Cancer Center (All Protocol Activities) | New York10065 | NCT07356154 | Map |
| NY | Memorial Sloan Kettering Cancer Center (All Protocol Activities) | New York10065 | NCT07105059 | Map |
| NY | Memorial Sloan-Kettering Cancer Center | New York10065 | NCT05651932 | Map |
| NY | Memorial Sloan Kettering Nassau (All Protocol Activities) | Rockville Centre11553 | NCT07356154 | Map |
| NY | Memorial Sloan Kettering Nassau (Limited Protocol Activities) | Uniondale11553 | NCT07105059 | Map |
| NC | Atrium Health, Levine Cancer Institute | Charlotte28204 | NCT05651932 | Map |
| NC | Duke Institute of Cancer/ Duke University | Durham27710 | NCT02343042 | Map |
| NC | Duke University Hospital | Durham27705 | NCT05651932 | Map |
| PA | University of Pennsylvania | Philadelphia19104 | NCT05651932 | Map |
| TN | Tennessee Oncology | Nashville37203 | NCT06121843 | Map |
| TN | Tennessee Oncology | Nashville37203 | NCT05651932 | Map |
| TX | University of Texas Southwestern Harold C. Simmons Comprehensive Cancer Center | Dallas75235 | NCT05651932 | Map |
| TX | University of Texas MD Anderson Cancer Center | Houston77030 | NCT06988488 | Map |
| TX | University of Texas MD Anderson Cancer Center | Houston77030 | NCT06121843 | Map |
| WA | Fred Hutch Cancer Center | Seattle98109 | NCT02343042 | Map |
Mezigdomide clinical trials at a glance: phase × recruitment status
| Phase | recruiting | active not recruiting | completed | terminated | withdrawn | not yet recruiting | available | Total |
|---|---|---|---|---|---|---|---|---|
| P1 | 5 | 1 | 2 | 1 | 1 | 10 | ||
| P1/P2 | 4 | 1 | 5 | |||||
| P2 | 1 | 1 | ||||||
| P3 | 1 | 1 | 2 | |||||
| N/A | 1 | 1 |
Recruiting Mezigdomide clinical trials (12)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT05519085 | SUCCESSOR-1A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) | P3 | Relapsed or Refractory Multiple Myeloma | 810 | Sep 2022 |
| NCT06627751 | Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease | P2 | Extramedullary Disease in Multiple Myeloma | 28 | May 2025 |
| NCT07356154 | A Study of Revumenib and Mezigdomide in People With Leukemia | P1/P2 | Leukemia | 52 | Jan 2026 |
| NCT07105059 | A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma | P1 | Multiple Myeloma | 18 | Aug 2025 |
| NCT06121843 | BMS-986393A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma | P1 | Multiple Myeloma | 187 | Feb 2024 |
| NCT07032714 | MAGENTAMezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma | P1 | Relapsed Refractory Multiple Myeloma (RRMM) | 25 | Dec 2025 |
| NCT05651932 | A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma | P1 | Multiple Myeloma | 165 | Feb 2023 |
| NCT07355335 | Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML | P1 | KMT2A-rearranged | 24 | Jul 2026 |
| NCT06645678 | MELT-MMMezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma | P1/P2 | Relapsed Refractory Multiple Myeloma (RRMM) | 75 | Nov 2024 |
| NCT06988488 | A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma | P1/P2 | Multiple Myeloma | 62 | Oct 2025 |
| NCT02343042 | STOMPSelinexor and Backbone Treatments of Multiple Myeloma Patients | P1/P2 | Multiple Myeloma | 300 | Oct 2015 |
| NCT06048250 | CC-92480Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma | P1 | Multiple Myeloma | 15 | Apr 2024 |
Mezigdomide clinical trials by indication
Multiple Myeloma (7)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07105059 | — | P1 | recruiting | A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma |
| NCT06121843 | BMS-986393 | P1 | recruiting | A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma |
| NCT05651932 | — | P1 | recruiting | A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma |
| NCT06988488 | — | P1/P2 | recruiting | A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma |
| NCT02343042 | STOMP | P1/P2 | recruiting | Selinexor and Backbone Treatments of Multiple Myeloma Patients |
| NCT06048250 | CC-92480 | P1 | recruiting | Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma |
| NCT06163898 | — | P1 | terminated | A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma |
Relapsed Refractory Multiple Myeloma (RRMM) (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07032714 | MAGENTA | P1 | recruiting | Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma |
| NCT06645678 | MELT-MM | P1/P2 | recruiting | Mezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma |
Relapsed or Refractory Multiple Myeloma (2)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05519085 | SUCCESSOR-1 | P3 | recruiting | A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) |
| NCT05552976 | SUCCESSOR-2 | P3 | active not recruiting | A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) |
KMT2A-rearranged (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07355335 | — | P1 | not yet recruiting | Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML |
Leukemia (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07356154 | — | P1/P2 | recruiting | A Study of Revumenib and Mezigdomide in People With Leukemia |
Extramedullary Disease in Multiple Myeloma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06627751 | — | P2 | recruiting | Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease |
Renal Impairment (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06318676 | — | P1 | completed | A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment |
Recurrent Multiple Myeloma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05981209 | — | P1 | active not recruiting | Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies |
Relapsed and Refractory Multiple Myeloma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06050512 | — | P1/P2 | withdrawn | Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma |
Hepatic Impairment (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05707390 | — | P1 | completed | A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment |
Other (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06994117 | — | N/A | available | Expanded Access for Mezigdomide |
Mezigdomide pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| SUCCESSOR-1 | NCT05519085 | P3 | recruiting | Relapsed or Refractory Multiple Myeloma | 810 | — |
| SUCCESSOR-2 | NCT05552976 | P3 | active not recruiting | Relapsed or Refractory Multiple Myeloma | 606 | — |
Terminated and withdrawn Mezigdomide trials (2)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT06050512withdrawnMezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma
- NCT06163898terminatedA Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma
All Mezigdomide trials (19)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT05519085 | SUCCESSOR-1 | A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) | P3 | recruiting | 810 | Celgene | Sep 2022 |
| NCT06627751 | Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease | P2 | recruiting | 28 | Roswell Park Cancer Institute | May 2025 | |
| NCT05552976 | SUCCESSOR-2 | A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) | P3 | active not recruiting | 606 | Bristol-Myers Squibb | Jan 2023 |
| NCT07356154 | A Study of Revumenib and Mezigdomide in People With Leukemia | P1/P2 | recruiting | 52 | Memorial Sloan Kettering Cancer Center | Jan 2026 | |
| NCT07105059 | A Study of Teclistamab and Mezigdomide in People With Multiple Myeloma | P1 | recruiting | 18 | Memorial Sloan Kettering Cancer Center | Aug 2025 | |
| NCT06121843 | BMS-986393 | A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma | P1 | recruiting | 187 | Juno Therapeutics, Inc., a Bristol-Myers Squibb Company | Feb 2024 |
| NCT07032714 | MAGENTA | Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma | P1 | recruiting | 25 | Massachusetts General Hospital | Dec 2025 |
| NCT05651932 | A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma | P1 | recruiting | 165 | K36 Therapeutics, Inc. | Feb 2023 | |
| NCT07355335 | Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML | P1 | not yet recruiting | 24 | Massachusetts General Hospital | Jul 2026 | |
| NCT06645678 | MELT-MM | Mezigdomide and Elranatamab for Relapsed and/or Refractory Multiple Myeloma | P1/P2 | recruiting | 75 | YOUNGIL KOH | Nov 2024 |
| NCT06988488 | A Study to Determine the Recommended Dose and Schedule, and Evaluate the Safety and Preliminary Efficacy of Mezigdomide in Combination With Elranatamab in Participants With Relapsed and/or Refractory Multiple Myeloma | P1/P2 | recruiting | 62 | Celgene | Oct 2025 | |
| NCT02343042 | STOMP | Selinexor and Backbone Treatments of Multiple Myeloma Patients | P1/P2 | recruiting | 300 | Karyopharm Therapeutics Inc | Oct 2015 |
| NCT05981209 | Elotuzumab, CC-92480, and Dexamethasone for the Treatment of Relapsed or Refractory Myeloma After CD38- and BCMA-Targeted Therapies | P1 | active not recruiting | 12 | Abdullah Khan | Dec 2023 | |
| NCT06050512 | Mezigdomide Plus Ixazomib and Dexamethasone for Relapsed and Refractory Multiple Myeloma | P1/P2 | withdrawn | 0 | Kathleen Dorritie | Oct 2023 | |
| NCT06048250 | CC-92480 | Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma | P1 | recruiting | 15 | City of Hope Medical Center | Apr 2024 |
| NCT06163898 | A Study to Evaluate Alnuctamab in Combination With Mezigdomide in Participants With Relapsed and/or Refractory Multiple Myeloma | P1 | terminated | 4 | Celgene | Feb 2024 | |
| NCT06994117 | Expanded Access for Mezigdomide | — | available | 0 | Bristol-Myers Squibb | — | |
| NCT06318676 | A Study to Evaluate the Drug Levels of Mezigdomide in Adult Participants With Renal Impairment | P1 | completed | 26 | Celgene | Mar 2024 | |
| NCT05707390 | A Study of Mezigdomide in Healthy Participants and Participants With Hepatic Impairment | P1 | completed | 32 | Bristol-Myers Squibb | Feb 2023 |
Mezigdomide clinical trials: frequently asked questions
- How many Mezigdomide clinical trials are there?
- 19 Mezigdomide clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 11 are actively recruiting participants. 2 are marked completed.
- Are Mezigdomide clinical trials recruiting in 2026?
- Yes — 11 Mezigdomide trials are actively recruiting in 2026, with 52 U.S. sites across 16 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Mezigdomide being studied for?
- Mezigdomide is being studied for Multiple Myeloma, Recurrent Multiple Myeloma, Relapsed or Refractory Multiple Myeloma, Relapsed Refractory Multiple Myeloma (RRMM), Refractory Multiple Myeloma and 16 more. The trials are grouped by indication on this page.
- What phase is Mezigdomide in?
- Mezigdomide clinical trials span 2 Phase 3, 1 Phase 2, 10 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Mezigdomide clinical trials?
- The lead sponsor across the most Mezigdomide trials is Celgene, with 11 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Mezigdomideas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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Related pages on Hipa.ai: