Nucresiran Clinical Trials (2026): 2 Studies for hATTR-PN & Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
2 Nucresiran clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 2 indications (including hATTR-PN & Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy) and 1,375 total planned enrollment. 2 Phase 3 Nucresiran trials are listed. 2 Nucresiran clinical trials are actively recruiting at 47 U.S. sites across 24 states. Most recent activity: NCT07052903 (Nov 2032).
Where to Participate: All Nucresiran Trial Sites in the U.S. (47 sites across 24 states)
Every actively recruiting Nucresirantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| CA | Clinical Trial Site | La Jolla92037 | NCT07052903 | Map |
| CA | Clinical Trial Site | Stanford94305 | NCT07052903 | Map |
| CO | Clinical Trial Site | Aurora80045 | NCT07223203 | Map |
| CT | Clinical Trial Site | Norwich06360 | NCT07052903 | Map |
| DC | Clinical Trial Site | Washington D.C.20010 | NCT07052903 | Map |
| FL | Clinical Trial Site | Brandon33511 | NCT07052903 | Map |
| FL | Clinical Trial Site | Miami33125 | NCT07052903 | Map |
| GA | Clinical Trial Site | Atlanta30309 | NCT07052903 | Map |
| GA | Clinical Trial Site | Gainesville30501 | NCT07052903 | Map |
| GA | Clinical Trial Site | Tucker30084 | NCT07052903 | Map |
| IL | Clinical Trial Site | Chicago60611 | NCT07223203 | Map |
| IL | Clinical Trial Site | Evanston60201 | NCT07052903 | Map |
| IN | Clinical Trial Site | Indianapolis46202 | NCT07052903 | Map |
| IN | Clinical Trial Site | Indianapolis46260 | NCT07052903 | Map |
| KS | Clinical Trial Site | Kansas City66160 | NCT07052903 | Map |
| MD | Clinical Trial Site | Baltimore21287 | NCT07052903 | Map |
| MD | Clinical Trial Site | Baltimore21287 | NCT07223203 | Map |
| MA | Clinical Trial Site | Boston02115 | NCT07052903 | Map |
| MA | Clinical Trial Site | Boston02118 | NCT07052903 | Map |
| MA | Clinical Trial Site | Boston02118 | NCT07223203 | Map |
| MI | Clinical Trial Site | Detroit48202 | NCT07052903 | Map |
| MN | Clinical Trial Site | Rochester55905 | NCT07052903 | Map |
| MN | Clinical Trial Site | Rochester55905 | NCT07223203 | Map |
| MO | Clinical Trial Site | St Louis63110 | NCT07052903 | Map |
| NY | Clinical Trial Site | Manhasset11030 | NCT07052903 | Map |
| NY | Clinical Trial Site | New York10029 | NCT07052903 | Map |
| NY | Clinical Trial Site | New York10032 | NCT07052903 | Map |
| NY | Clinical Trial Site | New York10065 | NCT07052903 | Map |
| NY | Clinical Trial Site | New York10032 | NCT07223203 | Map |
| NY | Clinical Trial Site | The Bronx10467 | NCT07052903 | Map |
| NC | Clinical Trial Site | Chapel Hill27514 | NCT07223203 | Map |
| NC | Clinical Trial Site | Charlotte28204 | NCT07052903 | Map |
| OH | Clinical Trial Site | Cleveland44195 | NCT07052903 | Map |
| OR | Clinical Trial Site | Portland97239 | NCT07052903 | Map |
| PA | Clinical Trial Site | Lancaster17602 | NCT07052903 | Map |
| PA | Clinical Trial Site | Philadelphia19104 | NCT07052903 | Map |
| SC | Clinical Trial Site | Charleston29425 | NCT07052903 | Map |
| TX | Clinical Trial Site | Dallas75246 | NCT07052903 | Map |
| TX | Clinical Trial Site | Dallas75246 | NCT07223203 | Map |
| TX | Clinical Trial Site | Houston77030 | NCT07052903 | Map |
| TX | Clinical Trial Site | Plano75024 | NCT07052903 | Map |
| UT | Clinical Trial Site | Salt Lake City84132 | NCT07052903 | Map |
| VA | Clinical Trial Site | Charlottesville22903 | NCT07052903 | Map |
| VA | Clinical Trial Site | Falls Church22042 | NCT07052903 | Map |
| VA | Clinical Trial Site | Norfolk23507 | NCT07052903 | Map |
| VA | Clinical Trial Site | Richmond23298 | NCT07052903 | Map |
| WA | Clinical Trial Site | Spokane99204 | NCT07052903 | Map |
Nucresiran clinical trials at a glance: phase × recruitment status
| Phase | recruiting | Total |
|---|---|---|
| P3 | 2 | 2 |
Recruiting Nucresiran clinical trials (2)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07052903 | TRITON-CMTRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy | P3 | Transthyretin Amyloidosis With Cardiomyopathy | 1,250 | Jul 2025 |
| NCT07223203 | TRITON-PNTRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy | P3 | Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | 125 | Dec 2025 |
Nucresiran clinical trials by indication
Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07223203 | TRITON-PN | P3 | recruiting | TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy |
Transthyretin Amyloidosis With Cardiomyopathy (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07052903 | TRITON-CM | P3 | recruiting | TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy |
Nucresiran pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| TRITON-CM | NCT07052903 | P3 | recruiting | Transthyretin Amyloidosis With Cardiomyopathy | 1,250 | — |
| TRITON-PN | NCT07223203 | P3 | recruiting | Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | 125 | — |
All Nucresiran trials (2)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07052903 | TRITON-CM | TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy | P3 | recruiting | 1,250 | Alnylam Pharmaceuticals | Jul 2025 |
| NCT07223203 | TRITON-PN | TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy | P3 | recruiting | 125 | Alnylam Pharmaceuticals | Dec 2025 |
Nucresiran clinical trials: frequently asked questions
- How many Nucresiran clinical trials are there?
- 2 Nucresiran clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants.
- Are Nucresiran clinical trials recruiting in 2026?
- Yes — 2 Nucresiran trials are actively recruiting in 2026, with 47 U.S. sites across 24 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Nucresiran being studied for?
- Nucresiran is being studied for hATTR-PN, Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, Transthyretin Amyloidosis With Cardiomyopathy. The trials are grouped by indication on this page.
- What phase is Nucresiran in?
- Nucresiran clinical trials span 2 Phase 3. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Nucresiran clinical trials?
- The lead sponsor across the most Nucresiran trials is Alnylam Pharmaceuticals. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Nucresiranas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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