Nucresiran Clinical Trials (2026): 2 Studies for hATTR-PN & Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

2 Nucresiran clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 2 indications (including hATTR-PN & Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy) and 1,375 total planned enrollment. 2 Phase 3 Nucresiran trials are listed. 2 Nucresiran clinical trials are actively recruiting at 47 U.S. sites across 24 states. Most recent activity: NCT07052903 (Nov 2032).

Where to Participate: All Nucresiran Trial Sites in the U.S. (47 sites across 24 states)

Every actively recruiting Nucresirantrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
CAClinical Trial SiteLa Jolla92037NCT07052903Map
CAClinical Trial SiteStanford94305NCT07052903Map
COClinical Trial SiteAurora80045NCT07223203Map
CTClinical Trial SiteNorwich06360NCT07052903Map
DCClinical Trial SiteWashington D.C.20010NCT07052903Map
FLClinical Trial SiteBrandon33511NCT07052903Map
FLClinical Trial SiteMiami33125NCT07052903Map
GAClinical Trial SiteAtlanta30309NCT07052903Map
GAClinical Trial SiteGainesville30501NCT07052903Map
GAClinical Trial SiteTucker30084NCT07052903Map
ILClinical Trial SiteChicago60611NCT07223203Map
ILClinical Trial SiteEvanston60201NCT07052903Map
INClinical Trial SiteIndianapolis46202NCT07052903Map
INClinical Trial SiteIndianapolis46260NCT07052903Map
KSClinical Trial SiteKansas City66160NCT07052903Map
MDClinical Trial SiteBaltimore21287NCT07052903Map
MDClinical Trial SiteBaltimore21287NCT07223203Map
MAClinical Trial SiteBoston02115NCT07052903Map
MAClinical Trial SiteBoston02118NCT07052903Map
MAClinical Trial SiteBoston02118NCT07223203Map
MIClinical Trial SiteDetroit48202NCT07052903Map
MNClinical Trial SiteRochester55905NCT07052903Map
MNClinical Trial SiteRochester55905NCT07223203Map
MOClinical Trial SiteSt Louis63110NCT07052903Map
NYClinical Trial SiteManhasset11030NCT07052903Map
NYClinical Trial SiteNew York10029NCT07052903Map
NYClinical Trial SiteNew York10032NCT07052903Map
NYClinical Trial SiteNew York10065NCT07052903Map
NYClinical Trial SiteNew York10032NCT07223203Map
NYClinical Trial SiteThe Bronx10467NCT07052903Map
NCClinical Trial SiteChapel Hill27514NCT07223203Map
NCClinical Trial SiteCharlotte28204NCT07052903Map
OHClinical Trial SiteCleveland44195NCT07052903Map
ORClinical Trial SitePortland97239NCT07052903Map
PAClinical Trial SiteLancaster17602NCT07052903Map
PAClinical Trial SitePhiladelphia19104NCT07052903Map
SCClinical Trial SiteCharleston29425NCT07052903Map
TXClinical Trial SiteDallas75246NCT07052903Map
TXClinical Trial SiteDallas75246NCT07223203Map
TXClinical Trial SiteHouston77030NCT07052903Map
TXClinical Trial SitePlano75024NCT07052903Map
UTClinical Trial SiteSalt Lake City84132NCT07052903Map
VAClinical Trial SiteCharlottesville22903NCT07052903Map
VAClinical Trial SiteFalls Church22042NCT07052903Map
VAClinical Trial SiteNorfolk23507NCT07052903Map
VAClinical Trial SiteRichmond23298NCT07052903Map
WAClinical Trial SiteSpokane99204NCT07052903Map

Nucresiran clinical trials at a glance: phase × recruitment status

PhaserecruitingTotal
P322

Recruiting Nucresiran clinical trials (2)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07052903TRITON-CMTRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3Transthyretin Amyloidosis With Cardiomyopathy1,250Jul 2025
NCT07223203TRITON-PNTRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyP3Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy125Dec 2025

Nucresiran clinical trials by indication

Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy (1)

NCTAcronymPhaseStatusTitle
NCT07223203TRITON-PNP3recruitingTRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy

Transthyretin Amyloidosis With Cardiomyopathy (1)

NCTAcronymPhaseStatusTitle
NCT07052903TRITON-CMP3recruitingTRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Nucresiran pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
TRITON-CMNCT07052903P3recruitingTransthyretin Amyloidosis With Cardiomyopathy1,250
TRITON-PNNCT07223203P3recruitingHereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy125

All Nucresiran trials (2)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07052903TRITON-CMTRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3recruiting1,250Alnylam PharmaceuticalsJul 2025
NCT07223203TRITON-PNTRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin Amyloidosis With PolyneuropathyP3recruiting125Alnylam PharmaceuticalsDec 2025

Nucresiran clinical trials: frequently asked questions

How many Nucresiran clinical trials are there?
2 Nucresiran clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants.
Are Nucresiran clinical trials recruiting in 2026?
Yes — 2 Nucresiran trials are actively recruiting in 2026, with 47 U.S. sites across 24 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Nucresiran being studied for?
Nucresiran is being studied for hATTR-PN, Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy, Transthyretin Amyloidosis With Cardiomyopathy. The trials are grouped by indication on this page.
What phase is Nucresiran in?
Nucresiran clinical trials span 2 Phase 3. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Nucresiran clinical trials?
The lead sponsor across the most Nucresiran trials is Alnylam Pharmaceuticals. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Nucresiranas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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