Palazestrant Clinical Trials (2026): 5 Studies for Metastatic Breast Cancer & Breast Cancer

Hipa.ai Research · Source: ClinicalTrials.gov / AACT

Synced daily from ClinicalTrials.gov via AACT. Last sync: .

5 Palazestrant clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 3 indications (including Metastatic Breast Cancer & Breast Cancer) and 1,940 total planned enrollment. 2 Phase 3 Palazestrant trials are listed. 2 Palazestrant clinical trials are actively recruiting at 68 U.S. sites across 29 states. Most recent activity: NCT07085767 (Jan 2032).

Where to Participate: All Palazestrant Trial Sites in the U.S. (68 sites across 29 states)

Every actively recruiting Palazestranttrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.

StateFacilityCityTrialMap
ARClinical Trial SiteHot Springs71913NCT07085767Map
CAClinical Trial SiteBeverly Hills90211NCT07085767Map
CAClinical Trial SiteLa Jolla92093NCT07085767Map
CAClinical Trial SiteLos Alamitos90720NCT07085767Map
CAClinical Trial SiteOakland94611NCT07085767Map
CAClinical Trial SiteRoseville95661NCT07085767Map
CAClinical Trial SiteSan Francisco94115NCT07085767Map
CAClinical Trial SiteSan Francisco94158NCT07085767Map
CAClinical Trial SiteSanta Barbara93105NCT07085767Map
CAClinical Trial SiteSanta Clara95051NCT07085767Map
CAClinical Trial SiteVallejo94589NCT07085767Map
CAClinical Trial SiteWalnut Creek94596NCT07085767Map
COClinical Trial SiteAurora80045NCT07085767Map
COClinical Trial SiteDenver80220NCT07085767Map
CTClinical Trial SiteNew Haven06511NCT07085767Map
FLFlorida Cancer SpecialistsSarasota34232NCT06784193Map
FLClinical Trial SiteTampa33612NCT07085767Map
GAClinical Trial SiteMarietta30060NCT07085767Map
HIClinical Trial SiteHonolulu96813NCT07085767Map
ILClinical Trial SitePeoria61615NCT07085767Map
ILClinical Trial SiteUrbana61801NCT07085767Map
LAUniversity Medical Center - New OrleansNew Orleans70112NCT06784193Map
MEClinical Trial SiteScarborough04074NCT07085767Map
MDClinical Trial SiteAnnapolis21401NCT07085767Map
MDClinical Trial SiteBaltimore21201NCT07085767Map
MDClinical Trial SiteBaltimore21205NCT07085767Map
MDClinical Trial SiteCatonsville21228NCT07085767Map
MADana-Farber Cancer InstituteBoston02215NCT06784193Map
MAClinical Trial SiteBurlington01805NCT07085767Map
MIClinical Trial SiteAnn Arbor48109NCT07085767Map
MISTART - MidwestGrand Rapids49546NCT06784193Map
MNClinical Trial SiteMinneapolis55404NCT07085767Map
MSClinical Trial SiteJackson39216NCT07085767Map
MOClinical Trial SiteKansas City64132NCT07085767Map
NHClinical Trial SiteLebanon03756NCT07085767Map
NMClinical Trial SiteSanta Fe87505NCT07085767Map
NYClinical Trial SiteNew York10029NCT07085767Map
NYClinical Trial SiteNew York10032NCT07085767Map
NCClinical Trial SiteCharlotte28204NCT07085767Map
NCClinical Trial SiteDurham27710NCT07085767Map
OHClinical Trial SiteCincinnati45245NCT07085767Map
OHClinical Trial SiteColumbus43212NCT07085767Map
OHClinical Trial SiteColumbus43219NCT07085767Map
ORClinical Trial SitePortland97239NCT07085767Map
PAClinical Trial SiteHorsham19044NCT07085767Map
PAClinical Trial SiteSayre18840NCT07085767Map
TNClinical Trial SiteBartlett38133NCT07085767Map
TNClinical Trial SiteKnoxville37909NCT07085767Map
TNClinical Trial SiteMount Juliet37122NCT07085767Map
TNClinical Trial SiteNashville37232NCT07085767Map
TNSCRI Oncology PartnersNashville37203NCT06784193Map
TNClinical Trial SiteTennessee City37203NCT07085767Map
TXClinical Trial SiteDallas75235NCT07085767Map
TXClinical Trial SiteDallas75390NCT07085767Map
TXClinical Trial SiteDenton76201NCT07085767Map
TXClinical Trial SiteEl Paso79902NCT07085767Map
TXClinical Trial SiteHouston77024NCT07085767Map
TXClinical Trial SiteSan Antonio78229NCT07085767Map
TXSTART - San AntonioSan Antonio78229NCT06784193Map
UTClinical Trial SiteSalt Lake City84106NCT07085767Map
UTSTART - Mountain RegionWest Valley City84119NCT06784193Map
VAClinical Trial SiteFort Belvoir22060NCT07085767Map
VAClinical Trial SiteMidlothian23114NCT07085767Map
VAClinical Trial SiteNorfolk23502NCT07085767Map
WAClinical Trial SiteOlympia98502NCT07085767Map
WAClinical Trial SiteSeattle98109NCT07085767Map
WAClinical Trial SiteVancouver98684NCT07085767Map
WIClinical Trial SiteMilwaukee52336NCT07085767Map

Palazestrant clinical trials at a glance: phase × recruitment status

Phaserecruitingactive not recruitingTotal
P1123
P3112

Recruiting Palazestrant clinical trials (2)

Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).

NCT IDTitlePhaseIndicationEnrollmentStarted
NCT07085767OPERA-02Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerP3Breast Cancer1,000Nov 2025
NCT06784193Phase 1 Study of OP-3136 in Advanced or Metastatic Solid TumorsP1Advanced or Metastatic ER+ HER2- Breast Cancer (mBC)180Dec 2024

Palazestrant clinical trials by indication

Breast Cancer (3)

NCTAcronymPhaseStatusTitle
NCT07085767OPERA-02P3recruitingPalazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer
NCT06016738OPERA-01P3active not recruitingOP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer
NCT05266105—P1active not recruitingA Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer Patients

Advanced or Metastatic ER+ HER2- Breast Cancer (mBC) (1)

NCTAcronymPhaseStatusTitle
NCT06784193—P1recruitingPhase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

Metastatic Breast Cancer (1)

NCTAcronymPhaseStatusTitle
NCT05508906—P1active not recruitingPhase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer

Palazestrant pivotal trial highlights (Phase 2/3/4)

Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.

AcronymNCTPhaseStatusIndicationEnrollmentPubMed
OPERA-02NCT07085767P3recruitingBreast Cancer1,000—
OPERA-01NCT06016738P3active not recruitingBreast Cancer510PMID 41461598

All Palazestrant trials (5)

Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.

NCT IDAcronymTitlePhaseStatusEnrollmentSponsorStarted
NCT07085767OPERA-02Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast CancerP3recruiting1,000Olema Pharmaceuticals, Inc.Nov 2025
NCT06016738OPERA-01OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast CancerP3active not recruiting510Olema Pharmaceuticals, Inc.Nov 2023
NCT05508906Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast CancerP1active not recruiting190Olema Pharmaceuticals, Inc.Aug 2022
NCT06784193Phase 1 Study of OP-3136 in Advanced or Metastatic Solid TumorsP1recruiting180Olema Pharmaceuticals, Inc.Dec 2024
NCT05266105A Phase 1 Study of Oral OP-1250 in Combination With Palbociclib in HR+/HER2- Breast Cancer PatientsP1active not recruiting60Olema Pharmaceuticals, Inc.Dec 2021

Palazestrant clinical trials: frequently asked questions

How many Palazestrant clinical trials are there?
5 Palazestrant clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants.
Are Palazestrant clinical trials recruiting in 2026?
Yes — 2 Palazestrant trials are actively recruiting in 2026, with 68 U.S. sites across 29 states. See the recruiting trials and the per-state site list further down this page.
What conditions is Palazestrant being studied for?
Palazestrant is being studied for Metastatic Breast Cancer, Breast Cancer, ER Positive Breast Cancer, HER2 Negative Breast Carcinoma, Locally Advanced Breast Cancer and 8 more. The trials are grouped by indication on this page.
What phase is Palazestrant in?
Palazestrant clinical trials span 2 Phase 3, 3 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
Who sponsors Palazestrant clinical trials?
The lead sponsor across the most Palazestrant trials is Olema Pharmaceuticals, Inc.. Each trial row links to the full study detail page including sponsor information.

Sources and methodology

Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Palazestrantas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.

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