Tapinarof Clinical Trials (2026): 19 Studies for Plaque Psoriasis & Atopic Dermatitis
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
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19 Tapinarof clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 7 indications (including Plaque Psoriasis & Atopic Dermatitis) and 4,927 total planned enrollment. 9 Phase 3 Tapinarof trials and 3 Phase 2, 4 Phase 4 are listed. 3 Tapinarof clinical trials are actively recruiting. Most recent activity: NCT07352566 (Jun 2030).
Tapinarof clinical trials at a glance: phase × recruitment status
| Phase | active not recruiting | enrolling by invitation | completed | not yet recruiting | Total |
|---|---|---|---|---|---|
| Early P1 | 1 | 1 | |||
| P1 | 1 | 1 | |||
| P2 | 1 | 2 | 3 | ||
| P2/P3 | 1 | 1 | |||
| P3 | 2 | 7 | 9 | ||
| P4 | 3 | 1 | 4 |
Recruiting Tapinarof clinical trials (3)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT07352566 | Utilization of a Microdevice for Psoriasis and Atopic Dermatitis | P4 | Psoriasis | 10 | Aug 2026 |
| NCT05981118 | Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) | P2/P3 | ICD10 Code L40.9 for Psoriasis | 40 | Jul 2024 |
| NCT06661213 | Tapinarof for Cutaneous Lupus Erythematosus | Early P1 | Cutaneous Lupus Erythematosus | 10 | Apr 2025 |
Tapinarof clinical trials by indication
Plaque Psoriasis (6)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05172726 | — | P3 | active not recruiting | Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects |
| NCT07546214 | — | P1 | completed | A Study Comparing Tapinarof Cream 1% and Vtama® Cream 1% in the Treatment of Plaque Psoriasis. |
| NCT04053387 | — | P3 | completed | Long Term Extension Study of Tapinarof for Plaque Psoriasis in Adults (3003) |
| NCT03983980 | — | P3 | completed | Tapinarof for the Treatment of Plaque Psoriasis in Adults (3002) |
| NCT03956355 | — | P3 | completed | Tapinarof for the Treatment of Plaque Psoriasis in Adults (3001) |
| NCT04042103 | — | P2 | completed | Maximal Use Study of Tapinarof Cream, 1% in Adults With Extensive Plaque Psoriasis |
Atopic Dermatitis (5)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07265479 | Adoring | P3 | active not recruiting | A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis |
| NCT05142774 | — | P3 | completed | Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis |
| NCT05014568 | — | P3 | completed | Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults |
| NCT05032859 | DMVT-505-3102 | P3 | completed | Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults (DMVT-505-3102) |
| NCT05186805 | — | P2 | completed | Maximal Use Study of Tapinarof Cream, 1% in Pediatric Subjects With Extensive Atopic Dermatitis |
Psoriasis (4)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07352566 | — | P4 | not yet recruiting | Utilization of a Microdevice for Psoriasis and Atopic Dermatitis |
| NCT06103695 | — | P4 | completed | Vtama in Psoriasis Patients Being Treated With Biologics. |
| NCT05789576 | — | P4 | completed | A Study to Investigate Efficacy and Safety of VTAMA® (Tapinarof) Cream, 1% in Plaque Psoriasis in the Head and Neck Region |
| NCT05680740 | — | P4 | completed | A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis |
Cutaneous Lupus Erythematosus (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06661213 | — | Early P1 | enrolling by invitation | Tapinarof for Cutaneous Lupus Erythematosus |
Plaque Type Psorisis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06742957 | — | P3 | completed | Study Comparing Tapinarof Cream 1% To VTAMA ® (Tapinarof Cream 1%) In the Treatment of Plaque Psoriasis |
Palmoplantar Keratoderma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06561321 | — | P2 | active not recruiting | Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma |
ICD10 Code L40.9 for Psoriasis (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05981118 | — | P2/P3 | enrolling by invitation | Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) |
Tapinarof pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| Adoring | NCT07265479 | P3 | active not recruiting | Atopic Dermatitis | 187 | — |
| DMVT-505-3102 | NCT05032859 | P3 | completed | Atopic Dermatitis | 406 | PMID 38777187 |
All Tapinarof trials (19)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT07352566 | Utilization of a Microdevice for Psoriasis and Atopic Dermatitis | P4 | not yet recruiting | 10 | University of California, San Francisco | Aug 2026 | |
| NCT06561321 | Study to Evaluate the Safety and Efficacy of Tapinarof in Adults With Palmoplantar Keratoderma | P2 | active not recruiting | 6 | Indiana University | Oct 2024 | |
| NCT05981118 | Comparison of Post-Inflammatory Pigment Alteration After Psoriasis Treatment (PIPA - Dermavant) | P2/P3 | enrolling by invitation | 40 | Wake Forest University Health Sciences | Jul 2024 | |
| NCT06661213 | Tapinarof for Cutaneous Lupus Erythematosus | Early P1 | enrolling by invitation | 10 | Northwestern University | Apr 2025 | |
| NCT07265479 | Adoring | A Study to Investigate Safety and Efficacy of Tapinarof Cream, 1% in Participants Ages 3 Months to < 24 Months With Atopic Dermatitis | P3 | active not recruiting | 187 | Organon and Co | Dec 2025 |
| NCT05172726 | Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects | P3 | active not recruiting | 58 | Organon and Co | Dec 2021 | |
| NCT07546214 | A Study Comparing Tapinarof Cream 1% and Vtama® Cream 1% in the Treatment of Plaque Psoriasis. | P1 | completed | 575 | Sun Pharmaceutical Industries, Inc. | Oct 2025 | |
| NCT06742957 | Study Comparing Tapinarof Cream 1% To VTAMA ® (Tapinarof Cream 1%) In the Treatment of Plaque Psoriasis | P3 | completed | 560 | Teva Pharmaceuticals USA | Dec 2024 | |
| NCT05142774 | Long Term Extension Study of Tapinarof Cream, 1% for Subjects With Atopic Dermatitis | P3 | completed | 728 | Organon and Co | Oct 2021 | |
| NCT06103695 | Vtama in Psoriasis Patients Being Treated With Biologics. | P4 | completed | 30 | Psoriasis Treatment Center of Central New Jersey | Feb 2023 | |
| NCT05789576 | A Study to Investigate Efficacy and Safety of VTAMA® (Tapinarof) Cream, 1% in Plaque Psoriasis in the Head and Neck Region | P4 | completed | 31 | Organon and Co | Mar 2023 | |
| NCT05680740 | A Study to Investigate Efficacy and Safety of VTAMA (Tapinarof) Cream, 1% in Intertriginous Plaque Psoriasis | P4 | completed | 34 | Organon and Co | Dec 2022 | |
| NCT05014568 | Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults | P3 | completed | 407 | Organon and Co | Sep 2021 | |
| NCT05032859 | DMVT-505-3102 | Tapinarof for the Treatment of Atopic Dermatitis in Children and Adults (DMVT-505-3102) | P3 | completed | 406 | Organon and Co | Sep 2021 |
| NCT05186805 | Maximal Use Study of Tapinarof Cream, 1% in Pediatric Subjects With Extensive Atopic Dermatitis | P2 | completed | 36 | Organon and Co | Nov 2021 | |
| NCT04053387 | Long Term Extension Study of Tapinarof for Plaque Psoriasis in Adults (3003) | P3 | completed | 763 | Organon and Co | Aug 2019 | |
| NCT03983980 | Tapinarof for the Treatment of Plaque Psoriasis in Adults (3002) | P3 | completed | 515 | Organon and Co | Jun 2019 | |
| NCT03956355 | Tapinarof for the Treatment of Plaque Psoriasis in Adults (3001) | P3 | completed | 510 | Organon and Co | May 2019 | |
| NCT04042103 | Maximal Use Study of Tapinarof Cream, 1% in Adults With Extensive Plaque Psoriasis | P2 | completed | 21 | Organon and Co | Jul 2019 |
Tapinarof clinical trials: frequently asked questions
- How many Tapinarof clinical trials are there?
- 19 Tapinarof clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 2 are actively recruiting participants. 13 are marked completed.
- Are Tapinarof clinical trials recruiting in 2026?
- Yes — 2 Tapinarof trials are actively recruiting in 2026. See the recruiting trials and the per-state site list further down this page.
- What conditions is Tapinarof being studied for?
- Tapinarof is being studied for Plaque Psoriasis, Atopic Dermatitis, Psoriasis, Plaque Type Psorisis, Palmoplantar Keratoderma and 2 more. The trials are grouped by indication on this page.
- What phase is Tapinarof in?
- Tapinarof clinical trials span 4 Phase 4, 9 Phase 3, 3 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Tapinarof clinical trials?
- The lead sponsor across the most Tapinarof trials is Organon and Co, with 7 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Tapinarofas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
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