Tebentafusp Clinical Trials (2026): 14 Studies for Metastatic Uveal Melanoma & Uveal Melanoma
Hipa.ai Research · Source: ClinicalTrials.gov / AACT
Synced daily from ClinicalTrials.gov via AACT. Last sync: .
14 Tebentafusp clinical trials are catalogued on Hipa.ai from the AACT mirror of ClinicalTrials.gov, spanning 10 indications (including Metastatic Uveal Melanoma & Uveal Melanoma) and 2,696 total planned enrollment. 2 Phase 3 Tebentafusp trials and 7 Phase 2 are listed. 10 Tebentafusp clinical trials are actively recruiting at 48 U.S. sites across 24 states. Most recent activity: NCT06246149 (Nov 2032).
Where to Participate: All Tebentafusp Trial Sites in the U.S. (48 sites across 24 states)
Every actively recruiting Tebentafusptrial site, sorted by state then city. Each row links to the trial detail page (eligibility, contacts, full study record). Sites no longer enrolling at the location level are excluded. ClinicalTrials.gov / AACT does not provide street-level addresses; the map link uses the facility's geocoded coordinates where available.
| State | Facility | City | Trial | Map |
|---|---|---|---|---|
| AL | University of Alabama | Birmingham35294 | NCT05785754 | Map |
| AZ | Mayo Clinic | Phoenix85054 | NCT05785754 | Map |
| AZ | Mayo Clinic Arizona | Phoenix85054 | NCT05549297 | Map |
| AZ | HonorHealth | Scottsdale85258 | NCT05785754 | Map |
| CA | University of Southern California - Norris Cancer Center | Los Angeles90033 | NCT06942442 | Map |
| CO | University of Colorado | Aurora80045 | NCT05785754 | Map |
| CO | University of Colorado Cancer Center | Aurora80045 | NCT06070012 | Map |
| CO | Sarah Cannon Research Institute Denver Healthone | Denver80218 | NCT05785754 | Map |
| CT | Yale Cancer Center | New Haven06519 | NCT05785754 | Map |
| DC | Georgetown University Medical Center | Washington D.C.20007 | NCT06070012 | Map |
| FL | Mayo Clinic | Jacksonville32224 | NCT05785754 | Map |
| FL | Mayo Clinic Florida | Jacksonville32224 | NCT05549297 | Map |
| FL | University of Miami | Miami33136 | NCT05785754 | Map |
| FL | University of Miami | Miami33136 | NCT06627244 | Map |
| FL | Orlando Health Cancer Institute | Orlando32806 | NCT05549297 | Map |
| FL | Moffitt Cancer Center | Tampa33612 | NCT07276386 | Map |
| GA | Winship Cancer Institute of Emory University | Atlanta30322 | NCT05549297 | Map |
| KS | University of Kansas Cancer Center - Westwood | Westwood66205 | NCT05549297 | Map |
| KY | St Elizabeth Healthcare (St Elizabeth Medical | Edgewood41017 | NCT05549297 | Map |
| KY | St Elizabeth Healthcare (St Elizabeth Medical Center) | Edgewood41017 | NCT05549297 | Map |
| MD | John Hopkins Sidney Kimmel Comprehensive Cancer Center | Baltimore21231 | NCT05785754 | Map |
| MA | Beth Israel Deaconess Medical Center (BIDMC) | Boston02215 | NCT05549297 | Map |
| MA | Dana Farber Cancer Institute | Boston02215 | NCT05549297 | Map |
| MA | Massachusetts General Hospital | Boston02114 | NCT05549297 | Map |
| MN | University of Minnesota Medical Center | Minneapolis55455 | NCT05549297 | Map |
| MN | Mayo Clinic | Rochester55905 | NCT05785754 | Map |
| MN | Mayo Clinic Minnesota | Rochester55905 | NCT05549297 | Map |
| MO | Washington University School of Medicine | St Louis63110 | NCT05549297 | Map |
| NJ | Rutgers Cancer Institute of New Jersey | New Brunswick08901 | NCT05549297 | Map |
| NY | Northwell Health -Center for Advanced Medicine | Lake Success11042 | NCT06246149 | Map |
| NY | Northwell Health Cancer Institute - Zuckerberg Cancer Center | Lake Success11042 | NCT05549297 | Map |
| NY | Memorial Sloan Kettering Cancer Center | New York10065 | NCT06942442 | Map |
| NY | Memorial Sloan Kettering Cancer Center | New York10068 | NCT05549297 | Map |
| NY | MonteFiore | The Bronx10461 | NCT05785754 | Map |
| OH | Ohio State University | Columbus43210 | NCT05785754 | Map |
| OH | The Ohio State University Comprehensive Cancer Center | Columbus43210 | NCT05549297 | Map |
| OK | OU Health Stephenson Cancer Center | Oklahoma City73104 | NCT05549297 | Map |
| PA | Sidney Kimmel Cancer Center at Thomas Jefferson University | Philadelphia19107 | NCT06414590 | Map |
| PA | Thomas Jefferson University | Philadelphia19107 | NCT06626516 | Map |
| PA | Thomas Jefferson University Medical Oncology Clinic | Philadelphia19107 | NCT05549297 | Map |
| PA | UPMC Hillman Cancer Center | Pittsburgh15232 | NCT06070012 | Map |
| PA | UPMC Hillman Cancer Center | Pittsburgh15232 | NCT05549297 | Map |
| SC | Gibbs Cancer Center and Research Institute | Spartanburg29303 | NCT05549297 | Map |
| TN | University of Tennessee Medical Center | Knoxville37920 | NCT05549297 | Map |
| TN | SCRI Oncology Partners | Nashville37203 | NCT05785754 | Map |
| TX | Houston Methodist Hospital/Houston Methodist Cancer Center | Houston77030 | NCT05549297 | Map |
| UT | University of Utah Huntsman Cancer Institute | Salt Lake City84112 | NCT05549297 | Map |
| WA | Fred Hutchinson Cancer Center | Seattle98109 | NCT05549297 | Map |
Tebentafusp clinical trials at a glance: phase × recruitment status
| Phase | recruiting | active not recruiting | withdrawn | available | Total |
|---|---|---|---|---|---|
| P1 | 1 | 1 | |||
| P1/P2 | 1 | 1 | 1 | 3 | |
| P2 | 6 | 1 | 7 | ||
| P3 | 2 | 2 | |||
| N/A | 1 | 1 |
Recruiting Tebentafusp clinical trials (10)
Studies currently enrolling participants. Click any NCT ID to view the trial detail page (eligibility, sites, contacts).
| NCT ID | Title | Phase | Indication | Enrollment | Started |
|---|---|---|---|---|---|
| NCT06246149 | ATOMAdjuvant Tebentafusp in High Risk Ocular Melanoma | P3 | Uveal Melanoma | 290 | Nov 2024 |
| NCT06626516 | Tebentafusp-tebn With LDT in Metastatic UM | P1/P2 | Metastatic Uveal Melanoma | 109 | Oct 2025 |
| NCT06414590 | Neoadjuvant Tebentafusp for Uveal Melanoma | P2 | Locally Advanced Unresectable Uveal Melanoma | 19 | Sep 2025 |
| NCT06627244 | Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma | P2 | Metastatic Uveal Melanoma | 30 | Feb 2025 |
| NCT07276386 | Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma | P2 | Metastatic Uveal Melanoma | 18 | Dec 2025 |
| NCT06942442 | A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma | P2 | HLA-A*0201 Positive Cells Present | 47 | Oct 2025 |
| NCT06070012 | Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma | P2 | Uveal Melanoma | 44 | Aug 2025 |
| NCT05549297 | TEBE-AMTebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM) | P3 | Advanced Melanoma | 540 | Dec 2022 |
| NCT07057596 | NEO-TBNeoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma | P2 | Mestastatic Uveal Melanoma | 19 | Jul 2025 |
| NCT05785754 | DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors | P1 | Advanced or Metastatic Solid Tumors | 320 | Jun 2023 |
Tebentafusp clinical trials by indication
Metastatic Uveal Melanoma (3)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06626516 | — | P1/P2 | recruiting | Tebentafusp-tebn With LDT in Metastatic UM |
| NCT06627244 | — | P2 | recruiting | Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma |
| NCT07276386 | — | P2 | recruiting | Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma |
Uveal Melanoma (3)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06246149 | ATOM | P3 | recruiting | Adjuvant Tebentafusp in High Risk Ocular Melanoma |
| NCT06070012 | — | P2 | recruiting | Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma |
| NCT04960891 | Non Applicable | N/A | available | A Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafusp |
HLA-A*0201 Positive Cells Present (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06942442 | — | P2 | recruiting | A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma |
Locally Advanced Unresectable Uveal Melanoma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT06414590 | — | P2 | recruiting | Neoadjuvant Tebentafusp for Uveal Melanoma |
Mestastatic Uveal Melanoma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT07057596 | NEO-TB | P2 | recruiting | Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma |
Advanced or Metastatic Solid Tumors (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05785754 | — | P1 | recruiting | DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors |
Advanced Melanoma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05549297 | TEBE-AM | P3 | recruiting | Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM) |
Melanoma (Skin) (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT05315258 | TebeMRD | P2 | active not recruiting | Tebentafusp in Molecular Relapsed Disease (MRD) Melanoma |
Select Advanced Solid Tumors (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT04262466 | — | P1/P2 | active not recruiting | Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors |
Malignant Melanoma (1)
| NCT | Acronym | Phase | Status | Title |
|---|---|---|---|---|
| NCT02535078 | — | P1/P2 | withdrawn | Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma |
Tebentafusp pivotal trial highlights (Phase 2/3/4)
Phase-2/3/4 studies with named acronyms — the registration-grade trials most cited in label discussions and Wikipedia.
| Acronym | NCT | Phase | Status | Indication | Enrollment | PubMed |
|---|---|---|---|---|---|---|
| ATOM | NCT06246149 | P3 | recruiting | Uveal Melanoma | 290 | — |
| TEBE-AM | NCT05549297 | P3 | recruiting | Advanced Melanoma | 540 | — |
| NEO-TB | NCT07057596 | P2 | recruiting | Mestastatic Uveal Melanoma | 19 | — |
| TebeMRD | NCT05315258 | P2 | active not recruiting | Melanoma (Skin) | 850 | — |
Terminated and withdrawn Tebentafusp trials (1)
Studies that ended before completion. Reasons are filed in each trial's ClinicalTrials.gov entry.
- NCT02535078withdrawnPhase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma
All Tebentafusp trials (14)
Sorted by most recent activity (completion → start → posted date). Each row links to the trial detail page on Hipa.ai.
| NCT ID | Acronym | Title | Phase | Status | Enrollment | Sponsor | Started |
|---|---|---|---|---|---|---|---|
| NCT06246149 | ATOM | Adjuvant Tebentafusp in High Risk Ocular Melanoma | P3 | recruiting | 290 | European Organisation for Research and Treatment of Cancer - EORTC | Nov 2024 |
| NCT06626516 | Tebentafusp-tebn With LDT in Metastatic UM | P1/P2 | recruiting | 109 | Thomas Jefferson University | Oct 2025 | |
| NCT06414590 | Neoadjuvant Tebentafusp for Uveal Melanoma | P2 | recruiting | 19 | Thomas Jefferson University | Sep 2025 | |
| NCT06627244 | Study of Tebentafusp and Radioembolization in the Treatment of Metastatic Uveal Melanoma | P2 | recruiting | 30 | University of Miami | Feb 2025 | |
| NCT07276386 | Phase 2 Combination of Melphalan/HDS Via PHP + Tebentafusp in Treating Metastatic Uveal Melanoma | P2 | recruiting | 18 | H. Lee Moffitt Cancer Center and Research Institute | Dec 2025 | |
| NCT06942442 | A Phase II Trial of Tebentafusp in HLA-A*02:01 Positive Patients With Advanced Clear Cell Sarcoma | P2 | recruiting | 47 | Sarcoma Alliance for Research through Collaboration | Oct 2025 | |
| NCT06070012 | Tebentafusp in HLA-A*0201 Positive Previously Untreated Metastatic Uveal Melanoma | P2 | recruiting | 44 | Diwakar Davar | Aug 2025 | |
| NCT05549297 | TEBE-AM | Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM) | P3 | recruiting | 540 | Immunocore Ltd | Dec 2022 |
| NCT07057596 | NEO-TB | Neoadjuvant Tebentafusp in Patients With Metastatic Uveal Melanoma | P2 | recruiting | 19 | Grupo Español Multidisciplinar de Melanoma | Jul 2025 |
| NCT04262466 | Safety and Efficacy of IMC-F106C as a Single Agent and in Combination With Checkpoint Inhibitors | P1/P2 | active not recruiting | 410 | Immunocore Ltd | Feb 2020 | |
| NCT05315258 | TebeMRD | Tebentafusp in Molecular Relapsed Disease (MRD) Melanoma | P2 | active not recruiting | 850 | University of Oxford | Jul 2022 |
| NCT05785754 | DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors | P1 | recruiting | 320 | DynamiCure Biotechnology | Jun 2023 | |
| NCT02535078 | Phase 1b/2 Study of the Combination of IMCgp100 With Durvalumab and/or Tremelimumab in Advanced Cutaneous Melanoma | P1/P2 | withdrawn | 0 | Immunocore Ltd | Nov 2015 | |
| NCT04960891 | Non Applicable | A Cohort IND Expanded Access Program for Supporting Patient Access to Tebentafusp | — | available | 0 | Immunocore Ltd | — |
Tebentafusp clinical trials: frequently asked questions
- How many Tebentafusp clinical trials are there?
- 14 Tebentafusp clinical trials are catalogued on Hipa.ai, sourced from the AACT mirror of ClinicalTrials.gov. 10 are actively recruiting participants.
- Are Tebentafusp clinical trials recruiting in 2026?
- Yes — 10 Tebentafusp trials are actively recruiting in 2026, with 48 U.S. sites across 24 states. See the recruiting trials and the per-state site list further down this page.
- What conditions is Tebentafusp being studied for?
- Tebentafusp is being studied for Metastatic Uveal Melanoma, Uveal Melanoma, Clear Cell Sarcoma (CCS), HLA-A*0201 Positive Cells Present, Locally Advanced Unresectable Uveal Melanoma and 8 more. The trials are grouped by indication on this page.
- What phase is Tebentafusp in?
- Tebentafusp clinical trials span 2 Phase 3, 7 Phase 2, 1 Phase 1. The phase × status matrix at the top of this page breaks down counts by phase and recruitment status.
- Who sponsors Tebentafusp clinical trials?
- The lead sponsor across the most Tebentafusp trials is Immunocore Ltd, with 9 additional lead sponsors listed in the data. Each trial row links to the full study detail page including sponsor information.
Sources and methodology
Trial inventory derived from the AACT mirror of ClinicalTrials.gov. Trials are filtered to those naming Tebentafuspas an intervention. Phase, status, enrollment, sponsor, and dates are taken from the source `studies` table; primary indication is the first listed condition. Acronyms are extracted from each trial's brief title where present. PubMed links are populated for trials whose published primary outcomes have been indexed in our evidence cache.
Last refreshed .
Related pages on Hipa.ai: