City of Hope Chicago

Clinical research site in Zion, Illinois · 2520 ELISHA AVE, ZION, IL 60099-2676 · (847) 746-4358 · Website

Part of City of Hope

As of July 2026, 21 paid clinical trials are recruiting at City of Hope Chicago in Zion, Illinois. Active studies at this site cover conditions such as Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma and Advanced Rectal Adenocarcinoma. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Recruiting clinical trials at City of Hope Chicago (21)

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

for Carcinoma, Renal Cell

109 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07227415·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

34 locations incl. Goodyear

Sponsor: Amgen

Sex: Male·Age: 18+

Code: NCT07213674·Phase 3·Recruiting·Listed Oct 2025

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A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

129 locations incl. Daphne

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06667076·Phase 2·Recruiting·Listed Oct 2024

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MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

for Multiple Myeloma

95 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06152575·Phase 3·Recruiting·Listed Nov 2023

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A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

50 locations incl. Anchorage

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06793215·Phase 3·Recruiting·Listed Jan 2025

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LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

for Metastatic Non-small Cell Lung Cancer

37 locations incl. Birmingham

Sponsor: NovoCure GmbH

Sex: All·Age: 18+

Code: NCT06216301·Phase 3·Recruiting·Listed Jan 2024

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Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

for Breast Cancer

49 locations incl. Mobile

Sponsor: Greenwich LifeSciences, Inc.

Sex: All·Age: 18 - 100

Code: NCT05232916·Phase 3·Recruiting·Listed Feb 2022

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A Study to Select a Dose Regimen (Part A) and to Investigate Overall Survival (Part B) With Nanvuranlat Compared With Physician's Best Choice in Participants Aged 18 Years or Older With Biliary Tract Cancer

for Advanced Biliary Tract Cancer

18 locations incl. Duarte

Sponsor: J-Pharma Co., Ltd.

Sex: All·Age: 18+

Code: NCT07265674·Phase 3·Recruiting·Listed Dec 2025

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A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

for Breast Cancer

20 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT07100106·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

for Breast Cancer, Metastatic

21 locations incl. Tucson

Sponsor: ALX Oncology Inc.

Sex: All·Age: 18+

Code: NCT07007559·Phase 2·Recruiting·Listed Jun 2025

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Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

for Hematologic Malignancies

10 locations incl. Birmingham

Sponsor: Sellas Life Sciences Group

Sex: All·Age: 12+

Code: NCT04588922·Phase 1, Phase 2·Recruiting·Listed Oct 2020

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Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

for Locally Advanced Solid Tumor

14 locations incl. Palo Alto

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732831·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma

for Metastatic Pancreatic Ductal Adenocarcinoma

4 locations incl. Zion

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07490301·Phase 2, Phase 3·Recruiting·Listed Mar 2026

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AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors

for Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)

5 locations incl. Irvine

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07403721·Phase 1·Recruiting·Listed Feb 2026

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A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

for Metastatic Hepatocellular Carcinoma

7 locations incl. Goodyear

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06427941·Phase 1·Recruiting·Listed May 2024

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A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma

for Lymphoma

4 locations incl. Goodyear

Sponsor: VIVUS LLC

Sex: All·Age: 18+

Code: NCT06915246·Phase 2·Recruiting·Listed Apr 2025

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Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

for Advanced Colon Adenocarcinoma

11 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07595874·Phase 2·Recruiting·Listed May 2026

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Epcoritamab, Rituximab, Gemcitabine and Oxaliplatin (R-GemOx) as Salvage Therapy Before Autologous Stem Cell Transplant for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07365306·Phase 2·Recruiting·Listed Jan 2026

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

13 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

11 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting·Listed Nov 2025

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Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients

for Resectable Colorectal Carcinoma

13 locations incl. Goodyear

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07125729·Recruiting·Listed Aug 2025

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More research sites in Zion

Midwestern Regional Medical Center (10 trials)
City of Hope at Chicago (6 trials)
City Of Hope - Chicago (3 trials)
City of Hope® Cancer Center Chicago (2 trials)
Midwestern Regional Medical Center dba City of Hope Chicago (2 trials)
COH Chicago (1 trial)
Cancer Treatment Centers of America (CTCA) (1 trial)
City of Hope - Cancer Center Chicago (1 trial)
City of Hope - Chicago Cancer Center (1 trial)
City of Hope Chicago Cancer Center (1 trial)

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Paid clinical trials in Zion, IL · Illinois clinical trials