Prisma Health Upstate

Clinical research site in Greenville, South Carolina · 200 PATEWOOD DR, BUILDING A, GREENVILLE, SC 29615-3593 · (864) 454-2604 · Website

As of September 2026, 44 paid clinical trials are recruiting at Prisma Health Upstate in Greenville, South Carolina. Active studies at this site cover conditions such as End Stage Renal Disease, Intracranial Aneurysm and AML. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

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Recruiting clinical trials at Prisma Health Upstate (44)

CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis

for Transthyretin Amyloid Cardiomyopathy (ATTR CM)

61 locations incl. Phoenix

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07207811·Phase 3·Recruiting·Listed Oct 2025

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Assessment of CCM in HF With Higher Ejection Fraction

for Heart Failure

76 locations incl. Birmingham

Sponsor: Impulse Dynamics

Sex: All·Age: 18+

Code: NCT05064709·Recruiting·Listed Oct 2021

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A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

for RSV Infection

80 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 0+·Accepts healthy volunteers

Code: NCT06866405·Phase 3·Recruiting·Listed Mar 2025

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A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

for Obstructive Hypertrophic Cardiomyopathy

48 locations incl. Anchorage

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT05489705·Recruiting·Listed Aug 2022

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A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

for Diffuse Large B-Cell Lymphoma

47 locations incl. Mobile

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06717347·Phase 3·Recruiting·Listed Dec 2024

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Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC

for Locally Advanced Pancreatic Cancer

15 locations incl. Sacramento

Sponsor: RenovoRx

Sex: All·Age: 18+

Code: NCT03257033·Phase 3·Recruiting·Listed Aug 2017

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Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for AML

36 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06001788·Phase 1·Recruiting·Listed Aug 2023

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A Study to Evaluate Axatilimab and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

for Chronic Graft-versus-host-disease

36 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 12+

Code: NCT06585774·Phase 3·Recruiting·Listed Sep 2024

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

45 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting·Listed Jul 2023

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

33 locations incl. Scottsdale

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting·Listed Aug 2023

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

56 locations incl. Little Rock

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting·Listed Jan 2024

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SAVE-FistulaS: the SelfWrap-Assisted ArterioVEnous Fistulas Study

for Chronic Kidney Diseases

28 locations incl. Bullhead City

Sponsor: VenoStent

Sex: All·Age: 18+

Code: NCT06001827·Recruiting·Listed Aug 2023

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Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

for Spinal Muscular Atrophy (SMA)

42 locations incl. Phoenix

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: All ages

Code: NCT04174157·Recruiting·Listed Nov 2019

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MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions

for In-Stent Restenosis

28 locations incl. Birmingham

Sponsor: Concept Medical Inc.

Sex: All·Age: 18 - 110

Code: NCT05908331·Recruiting·Listed Jun 2023

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Continuous Dual Aspiration Technique With Zoom System for Stroke

for Ischemic Stroke

17 locations incl. Huntsville

Sponsor: Imperative Care, Inc.

Sex: All·Age: 18+

Code: NCT07491952·Recruiting·Listed Mar 2026

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Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

for Glioblastoma (GBM)

28 locations incl. Birmingham

Sponsor: Black Diamond Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07326566·Phase 2·Recruiting·Listed Jan 2026

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A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD

for Sickle Cell Disease

35 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 12+

Code: NCT05431088·Phase 2, Phase 3·Recruiting·Listed Jun 2022

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Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

21 locations incl. Birmingham

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting·Listed Oct 2024

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The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

for Sickle Cell Disease

16 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 10 - 65

Code: NCT06975865·Phase 3·Recruiting·Listed May 2025

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A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

for Systemic Lupus Erythematosus (With and Without Nephritis)

14 locations incl. Phoenix

Sponsor: Allogene Therapeutics

Sex: All·Age: 18 - 74

Code: NCT07085104·Phase 1·Recruiting·Listed Jul 2025

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The Artisse™ Intrasaccular Device is Indicated for the Treatment of Wide-neck Bifurcating Intracranial Aneurysms (IAs).

for Intracranial Aneurysm

24 locations incl. Los Angeles

Sponsor: Medtronic Neurovascular Clinical Affairs

Sex: All·Age: 18 - 75

Code: NCT02998229·Recruiting·Listed Dec 2016

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The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

18 locations incl. Burbank

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting·Listed Jul 2020

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A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

for End Stage Renal Disease (ESRD)

20 locations incl. Phoenix

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18 - 90

Code: NCT04671771·Recruiting·Listed Dec 2020

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Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

for Diabetes

20 locations incl. Dothan

Sponsor: Sonavex, Inc.

Sex: All·Age: 18 - 84

Code: NCT06190717·Recruiting·Listed Jan 2024

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Serranator POINT FORCE Registry

for Peripheral Artery Disease (PAD)

18 locations incl. Scottsdale

Sponsor: Cagent Vascular LLC

Sex: All·Age: 18+

Code: NCT06687590·Recruiting·Listed Nov 2024

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A Phase 1/2 Study of KK2430 in Participants With Hematologic Neoplasms

for Hematologic Neoplasms

1 location in Greenville

Sponsor: Kyowa Kirin Co., Ltd.

Sex: All·Age: 18+

Code: NCT07629726·Phase 1, Phase 2·Recruiting·Listed Jun 2026

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GORE® ENFORM Biomaterial Product Study

for Hernia, Ventral

7 locations incl. San Diego

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT04718168·Recruiting·Listed Jan 2021

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Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

for Amputation

6 locations incl. Pittsfield

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT06908538·Recruiting·Listed Apr 2025

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NV PSR INSPIRE-A Pipeline™ Vantage Post Approval Study

for Intracranial Aneurysm

8 locations incl. Jacksonville

Sponsor: Medtronic Neurovascular Clinical Affairs

Sex: All·Age: 22+

Code: NCT06604884·Recruiting·Listed Sep 2024

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An Engineered Sirpα Fused to Anti-Pd-L1 And Tgf-β Fusion Protein (HCB301) in Subjects With Selected Advanced Tumors

for Advanced Solid Tumor

1 location in Greenville

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT06487624·Phase 1·Recruiting·Listed Jul 2024

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Early Feasibility Study (EFS) Evaluating Percutaneous Repair of the Atrial Septum With a Novel PFO Occluder: The PROTEA-PFO Study

for PFO

5 locations incl. Los Angeles

Sponsor: Recross Cardio, Inc.

Sex: All·Age: 18 - 65

Code: NCT07172464·Recruiting·Listed Sep 2025

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X-ray Psoralen Activated Cancer Therapy in Head and Neck, Breast, Sarcoma and Melanoma

for Advanced Solid Tumor Cancer

4 locations incl. Washington D.C.

Sponsor: Immunolight, LLC

Sex: All·Age: 18+

Code: NCT04389281·Phase 1·Recruiting·Listed May 2020

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CraniSeal Post Approval Study

for Leak, Cerebrospinal Fluid

7 locations incl. Jacksonville

Sponsor: Pramand LLC

Sex: All·Age: 18+

Code: NCT06406790·Phase 4·Recruiting·Listed May 2024

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A Safety and Efficacy Study of HCB101, Fc-fusion Protein Targeting SIRPα-CD47 Pathway, in Solid or Hematological Tumors

for Advanced Solid Tumor

4 locations incl. Port Saint Lucie

Sponsor: FBD Biologics Limited

Sex: All·Age: 18+

Code: NCT05892718·Phase 1·Recruiting·Listed Jun 2023

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Pounce™ Thrombectomy System Retrospective Registry

for Peripheral Arterial Disease

7 locations incl. Peoria

Sponsor: SurModics, Inc.

Sex: All·Age: 18+

Code: NCT05868161·Recruiting·Listed May 2023

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Building Retention and Initiation Through Delivery of Peer-Guided Evidence-Based Practices

for Opioid Use Disorder

1 location in Greenville

Sponsor: Prisma Health-Upstate

Sex: All·Age: 18+

Code: NCT07541417·Recruiting·Listed Apr 2026

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MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

for Femoral Neck Fractures

20 locations incl. Irvine

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT07244211·Recruiting·Listed Nov 2025

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Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy

for Open tíbia Fracture

27 locations incl. Chandler

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05615844·Phase 3·Recruiting·Listed Nov 2022

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Primary Subtalar Arthrodesis for Calcaneal Fractures

for Calcaneus Fracture

17 locations incl. Orange

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06249126·Recruiting·Listed Feb 2024

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Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

for Opioid Use Disorder

9 locations incl. Jacksonville

Sponsor: T. John Winhusen, PhD

Sex: All·Age: 18+

Code: NCT06651177·Phase 2·Recruiting·Listed Oct 2024

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Paid clinical trials in Greenville, SC · South Carolina clinical trials