University of California, Irvine

Clinical research site in Irvine, California · C380 MEDICAL SCIENCE I, IRVINE, CA 92697-4069 · (949) 824-5818 · Website

Part of University of California Irvine

As of July 2026, 51 paid clinical trials are recruiting at University of California, Irvine in Irvine, California. Active studies at this site cover conditions such as Alopecia Areata, Alzheimer Disease and Amyotrophic Lateral Sclerosis. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Recruiting clinical trials at University of California, Irvine (51)

Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

for Non-small Cell Lung Cancer

28 locations incl. Fresno

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07195695·Phase 3·Recruiting·Listed Sep 2025

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A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy

for Age-related Macular Degeneration (AMD)

140 locations incl. Chandler

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 50 - 85

Code: NCT06541704·Phase 3·Recruiting·Listed Aug 2024

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A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Pediatric Participants With Nonsegmental Vitiligo

for NonSegmental Vitiligo

69 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 2 - 11

Code: NCT06548360·Phase 3·Recruiting·Listed Aug 2024

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A Phase 2 Study and Open-Label Extension of NEU-411 in Companion Diagnostic-Positive Participants With Early Parkinson's Disease

for Parkinson Disease

45 locations incl. Sun City

Sponsor: Neuron23 Inc.

Sex: All·Age: 40 - 80

Code: NCT06680830·Phase 2·Recruiting·Listed Nov 2024

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Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

for Tricuspid Regurgitation

46 locations incl. Irvine

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04097145·Recruiting·Listed Sep 2019

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A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)

for Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

41 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 12+

Code: NCT06338995·Phase 3·Recruiting·Listed Apr 2024

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Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

for Relapsing Multiple Sclerosis

40 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 40 - 70

Code: NCT06846281·Phase 3·Recruiting·Listed Feb 2025

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Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

for AAA - Abdominal Aortic Aneurysm

56 locations incl. Little Rock

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT06218875·Recruiting·Listed Jan 2024

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Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

for Acute Decompensated Heart Failure

37 locations incl. Irvine

Sponsor: Reprieve Cardiovascular, Inc

Sex: All·Age: 22+

Code: NCT06898515·Phase 3·Recruiting·Listed Mar 2025

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

34 locations incl. Birmingham

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting·Listed Sep 2022

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

33 locations incl. Scottsdale

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting·Listed Sep 2022

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A Study Exploring Changes in a Variety of Biomarkers Following Dosing With MT1988 in Participants at Clinical High Risk for Psychosis

for Clinical High Risk for Psychosis (CHR)

15 locations incl. Irvine

Sponsor: Monument Therapeutics Limited

Sex: All·Age: 17 - 30

Code: NCT07226895·Phase 1, Phase 2·Recruiting·Listed Nov 2025

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A Study to Test Whether Spesolimab Helps People With a Skin Condition Called Pyoderma Gangrenosum

for Pyoderma Gangrenosum

21 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06624670·Phase 3·Recruiting·Listed Oct 2024

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Onyx™ Liquid Embolic IDE Clinical Study

for Peripheral Arterial Hemorrhage

18 locations incl. Phoenix

Sponsor: Medtronic Endovascular

Sex: All·Age: 22+

Code: NCT06742801·Recruiting·Listed Dec 2024

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A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

for Multiple Sclerosis

14 locations incl. Irvine

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18 - 60

Code: NCT06220201·Phase 1·Recruiting·Listed Jan 2024

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Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)

for Pulmonary Embolism

13 locations incl. Birmingham

Sponsor: Innova Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06041594·Recruiting·Listed Sep 2023

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A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

11 locations incl. Little Rock

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting·Listed Jun 2024

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A Phase 1 Study of FT819 in B-cell Mediated Autoimmune Disease

for Antineutrophilic Cytoplasmic Antibody (ANCA)- Associated Vasculitis (AAV)

16 locations incl. Beverly Hills

Sponsor: Fate Therapeutics

Sex: All·Age: 12 - 70

Code: NCT06308978·Phase 1·Recruiting·Listed Mar 2024

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Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss

for Non Small Cell Lung Cancer

15 locations incl. Scottsdale

Sponsor: Tango Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06810544·Phase 1, Phase 2·Recruiting·Listed Feb 2025

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting·Listed Aug 2024

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A Global Prospective Observational Registry of Patients With Pompe Disease

for Pompe Disease

15 locations incl. Little Rock

Sponsor: Amicus Therapeutics

Sex: All·Age: All ages

Code: NCT06121011·Recruiting·Listed Nov 2023

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A Real World Study of eCoin for Urgency Urinary Incontinence: Post Approval Evaluation (RECIPE)

for Overactive Bladder

19 locations incl. Homewood

Sponsor: Valencia Technologies Corporation

Sex: All·Age: 18+

Code: NCT05685433·Recruiting·Listed Jan 2023

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Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients With Relapsed or Refractory Acute Myeloid Leukemia

for Leukemia, Myeloid, Acute

10 locations incl. Birmingham

Sponsor: Aptose Biosciences Inc.

Sex: All·Age: 18+

Code: NCT03850574·Phase 1, Phase 2·Recruiting·Listed Feb 2019

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A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease

for Late-onset Pompe Disease

3 locations incl. Irvine

Sponsor: Denali Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT07354724·Phase 1·Recruiting·Listed Jan 2026

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A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL

for CTCL

6 locations incl. Duarte

Sponsor: Prescient Therapeutics, Ltd.

Sex: All·Age: 18+

Code: NCT06854653·Phase 2·Recruiting·Listed Mar 2025

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A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)

for Limb Girdle Muscular Dystrophy

6 locations incl. Irvine

Sponsor: AskBio Inc

Sex: All·Age: 18 - 65

Code: NCT05230459·Phase 1, Phase 2·Recruiting·Listed Feb 2022

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Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

for NSCLC

2 locations incl. Irvine

Sponsor: CJ Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT05877430·Phase 1, Phase 2·Recruiting·Listed May 2023

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Padeliporfin VTP Treatment for Unresectable Pancreatic Adenocarcinoma

for Locally Advanced Unresectable Pancreatic Adenocarcinoma

2 locations incl. Duarte

Sponsor: Impact Biotech Ltd

Sex: All·Age: 18+

Code: NCT05919238·Phase 1·Recruiting·Listed Jun 2023

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Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

for Huntington Disease

1 location in Irvine

Sponsor: Leslie Thompson

Sex: All·Age: 18 - 65

Code: NCT07451613·Phase 1, Phase 2·Recruiting·Listed Mar 2026

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MAPT Protocol: Fixation Versus Arthroplasty Surgical Treatments for Early Recovery After HIP Fracture (FASTER-HIP)

for Femoral Neck Fractures

13 locations incl. Irvine

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT07244211·Recruiting·Listed Nov 2025

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Clinical Procedures to Support Research in ALS

for Amyotrophic Lateral Sclerosis

10 locations incl. Irvine

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT03489278·Recruiting·Listed Apr 2018

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Regeneron AA Multicenter (Dupilumab)

for Alopecia Areata

3 locations incl. Irvine

Sponsor: Emma Guttman

Sex: All·Age: 18+

Code: NCT05551793·Phase 2·Recruiting·Listed Sep 2022

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Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

for Intracerebral Hemorrhage

17 locations incl. Irvine

Sponsor: Zeenat Qureshi Stroke Institute

Sex: All·Age: 18 - 100

Code: NCT06402968·Recruiting·Listed May 2024

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Telerehabilitation In The Home After Stroke

for Stroke

27 locations incl. Downey

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting·Listed Nov 2024

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Positive Affect Treatment for Adolescents With Early Life Adversity

for Depression

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 12 - 16·Accepts healthy volunteers

Code: NCT06273137·Recruiting·Listed Feb 2024

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Neural Bases of Vocal Sensorimotor Impairment in Aphasia

for Aphasia

3 locations incl. Irvine

Sponsor: The University of Texas at Dallas

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT04742894·Recruiting·Listed Feb 2021

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My Life and My Experiences Project

for Stress and Memory in Adolescence

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT06821178·Recruiting·Listed Feb 2025

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An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasm

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT05123365·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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Dupilumab in the Treatment of Pediatric Alopecia Areata

for Alopecia Areata

5 locations incl. Irvine

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 6 - 17

Code: NCT05866562·Phase 2·Recruiting·Listed May 2023

Apply to this trial

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Paid clinical trials in Irvine, CA · California clinical trials