As of September 2026, 388 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Irvine offers studies at sites including City of Hope at Irvine Lennar for conditions such as Breast Cancer, Multiple Myeloma, Endometrial Cancer, Alzheimer Disease. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Researchers run research studies in Irvine, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| City of Hope at Irvine Lennar | Anatomic Stage IV Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 63 |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Stage IV Colorectal Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Metastatic Malignant Solid Neoplasm | 60 |
| University of California, Irvine | Alopecia Areata, Alzheimer Disease, Amyotrophic Lateral Sclerosis | 35 |
| University of California Irvine | Lupus Nephritis, Acute Decompensated Heart Failure, Age-related Macular Degeneration (AMD) | 20 |
| Kaiser Permanente-Irvine | Breast Cancer, Chronic Lymphocytic Leukemia, Ovarian Carcinoma | 19 |
| City of Hope - Orange County Lennar Foundation Cancer Center | Breast Cancer, Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer, Metastatic Breast Cancer | 12 |
| City of Hope Orange County Lennar Foundation Cancer Center | Breast Neoplasms, Multiple Myeloma, Carcinoma, Non-Small-Cell Lung | 11 |
| Irvine Clinical Research | Alzheimer Disease, Amyloid, Plaque, Amyloid | 10 |
| City of Hope | Advanced Hodgkin Lymphoma, Cancer, Cardiovascular Events | 8 |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Hepatocellular Carcinoma, Advanced Hepatocellular Carcinoma, Cachexia | 6 |
| Beckman Laser Institute and Medical Clinic | Abnormal Vascular Flow, Dermatologic Diseases, Gingivitis | 4 |
| Hoag Memorial Hospital Presbyterian | Prostate Cancer, B7H3, Castration Resistant Metastatic Prostate Cancer | 4 |
| Irvine Center for Clinical Research | Alzheimer's Disease, Alzheimers Disease | 4 |
| City of Hope - Lennar | Anemia, KRAS G12C-mutated Solid Tumors, Lung Cancer, KRAS, NRAS, HRAS-mutated NSCLC | 3 |
| City of Hope - Lennar Foundation Cancer Center | Breast Cancer, Ductal Carcinoma in Situ, Multiple Myeloma | 3 |
| Hoag Hospital Irvine | Breast Cancer, Breast Cancer Metastatic, Breast Neoplasm | 3 |
| Hoag Memorial Hospital | Esophageal Cancer, Gastric Cancer (GC), Gastroesophageal Junction | 3 |
| Susan Samueli Integrative Health Institute | Fibromyalgia, Hypertension, Mild to Moderate Hypertension | 3 |
| UC Irvine | Advanced Adenocarcinoma, Diabetes Mellitus Type 2, Neutropenia | 3 |
| UCI Health - Irvine | Advanced Hepatocellular Carcinoma, Cachexia, Carcinoma, Hepatocellular | 3 |
| Univ of California, Irvine- Gavin Herbert Eye Institute | Amblyopia | 3 |
| University of California | Depression, Anxiety, Heart Diseases, Hypertension | 3 |
| University of California - Irvine Medical Center | Huntington's Disease, Non-muscle Invasive Bladder Cancer, Non-muscle Invasive Bladder Cancer With Carcinoma in Situ | 3 |
| University of California at Irvine | Cerebroside Lipidosis Syndrome, Fabry Disease, Gaucher Disease | 3 |
| City of Hope Lennar Foundation Cancer Center | Carcinoma, Small Cell Lung, Lung Neoplasms, Small Cell Cancer Of The Lung | 3 |
Recruiting trials in Irvine grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 388 recruiting clinical trials in Irvine, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Irvine compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Irvine include Breast Cancer (10), Multiple Myeloma (9), Endometrial Cancer (8), Alzheimer Disease (6), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Irvine on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Irvine include City of Hope at Irvine Lennar, UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, University of California, Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Irvine are Cancer & tumors (201), Neurology & pain (24), Diabetes & metabolic (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.