UPMC Shadyside Hospital

Clinical research site in Pittsburgh, Pennsylvania · 200 LOTHROP ST, PITTSBURGH, PA 15213-2536 · (412) 432-5500

As of September 2026, 48 paid clinical trials are recruiting at UPMC Shadyside Hospital in Pittsburgh, Pennsylvania. Active studies at this site cover conditions such as Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Carcinoma and Stage II Lip and Oral Cavity Cancer AJCC v8. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 1, 2026.

New trial at UPMC Shadyside Hospital? We'll email you when one opens.

Recruiting clinical trials at UPMC Shadyside Hospital (48)

A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised

for COVID-19 Infection

66 locations incl. Canoga Park

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07013474·Phase 3·Recruiting·Listed Jun 2025

Apply to this trial

A Study to Understand How the Study Medicine (PF-06823859) Works in People With Active Idiopathic Inflammatory Myopathies [Dermatomyositis (DM) and Polymyositis (PM)]

for Myositis

38 locations incl. Glendale

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT05895786·Phase 3·Recruiting·Listed Jun 2023

Apply to this trial

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

for Type 1 Diabetes Mellitus With Hypoglycemia

37 locations incl. Birmingham

Sponsor: Zucara Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT05762107·Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

for Aortic Stenosis, Calcific

50 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 65+

Code: NCT04889872·Recruiting·Listed May 2021

Apply to this trial

DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM)

for Glioblastoma (GBM)

17 locations incl. Duarte

Sponsor: Diakonos Oncology Corporation

Sex: All·Age: 18+

Code: NCT06805305·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke

for Acute Ischemic Stroke

14 locations incl. Tucson

Sponsor: Pharmazz, Inc.

Sex: All·Age: 18 - 80

Code: NCT05691244·Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults

for Lumbar Spine Stenosis

3 locations in Pittsburgh

Sponsor: OpalGenix, Inc

Sex: All·Age: 18 - 99

Code: NCT05452694·Recruiting·Listed Jul 2022

Apply to this trial

Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

for Thoracic Surgery

4 locations in Pittsburgh

Sponsor: OpalGenix, Inc

Sex: All·Age: 18 - 99

Code: NCT05525923·Recruiting·Listed Sep 2022

Apply to this trial

Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients

for Mild Cognitive Impairment (MCI)

1 location in Pittsburgh

Sponsor: Pravat Mandal

Sex: All·Age: 55 - 80

Code: NCT07583251·Phase 1·Recruiting·Listed May 2026

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

623 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

1100 locations incl. Anchorage

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer

for Astrocytoma, IDH-Mutant, Grade 3

97 locations incl. Duarte

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 12+

Code: NCT07215910·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

for Stage III Colon Cancer

915 locations incl. Fairhope

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021

Apply to this trial

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

463 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016

Apply to this trial

Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

for Intracranial Meningioma

446 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT02523014·Phase 2·Recruiting·Listed Aug 2015

Apply to this trial

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for Bladder Adenocarcinoma

222 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03866382·Phase 2·Recruiting·Listed Mar 2019

Apply to this trial

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

107 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07195734·Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

for Adenocarcinoma of the Colon

327 locations incl. Goodyear

Sponsor: NRG Oncology

Sex: All·Age: 45 - 70

Code: NCT05080673·Recruiting·Listed Oct 2021

Apply to this trial

Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

270 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020

Apply to this trial

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

278 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020

Apply to this trial

E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

374 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

Apply to this trial

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for Metastatic Renal Cell Carcinoma

280 locations incl. Kingman

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022

Apply to this trial

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

146 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06532279·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

257 locations incl. Tucson

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial

for Non-Muscle Invasive Bladder Urothelial Carcinoma

131 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06770582·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

for Recurrent Head and Neck Squamous Cell Carcinoma

129 locations incl. Little Rock

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 79

Code: NCT04671667·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

for Buccal Mucosa Squamous Cell Carcinoma

87 locations incl. Gilbert

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04333537·Phase 2, Phase 3·Recruiting·Listed Apr 2020

Apply to this trial

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

399 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023

Apply to this trial

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

71 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials

for Stroke

40 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05338697·Recruiting·Listed Apr 2022

Apply to this trial

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

for Head and Neck Squamous Cell Carcinoma

169 locations incl. Gilbert

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT06992427·Phase 3·Recruiting·Listed May 2025

Apply to this trial

Anticoagulation in ICH Survivors for Stroke Prevention and Recovery

for Intracerebral Hemorrhage

142 locations incl. Birmingham

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT03907046·Phase 3·Recruiting·Listed Apr 2019

Apply to this trial

Monitoring Patients With Repetitive Head Impact With Gamma-glutamylcysteine Supplementation

for Repetitive Head Impacts

1 location in Pittsburgh

Sponsor: Pravat Mandal

Sex: All·Age: 30 - 70

Code: NCT07050173·Phase 1·Recruiting·Listed Jul 2025

Apply to this trial

Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest

for Cardiac Arrest

1 location in Pittsburgh

Sponsor: Byron Drumheller

Sex: All·Age: 18+

Code: NCT06511999·Recruiting·Listed Jul 2024

Apply to this trial

Arrhythmia Detection After MI

for Acute Myocardial Infarction

1 location in Pittsburgh

Sponsor: Samir Saba

Sex: All·Age: 18+

Code: NCT05073419·Recruiting·Listed Oct 2021

Apply to this trial

Impact of Suture Type on Pigment Disturbances in Patients of Skin of Color

for Scar

3 locations in Pittsburgh

Sponsor: Melissa Pugliano-Mauro

Sex: All·Age: 18+

Code: NCT05408117·Recruiting·Listed Jun 2022

Apply to this trial

Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT)

for Status Epilepticus

52 locations incl. Tucson

Sponsor: University of Virginia

Sex: All·Age: 1+

Code: NCT06907173·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

for Metastatic Lung Small Cell Carcinoma

148 locations incl. Anaheim

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT04804644·Phase 3·Recruiting·Listed Mar 2021

Apply to this trial

Enrichment of Glutathione Using Gamma-glutamylcysteine Supplementation in Parkinson's Disease Patients.

for Parkinsons Disease (PD)

1 location in Pittsburgh

Sponsor: Pravat Mandal

Sex: All·Age: 50 - 80

Code: NCT07064005·Phase 1·Recruiting·Listed Jul 2025

Apply to this trial

Green Light for Post-Operative Wellness

for Surgery

1 location in Pittsburgh

Sponsor: Rebecca E Kotcher, MD

Sex: All·Age: 18+

Code: NCT07218289·Recruiting·Listed Oct 2025

Apply to this trial

Showing the 40 most relevant of 48 recruiting trials at this site. Browse all with filters →

Get new-trial alerts for UPMC Shadyside Hospital

We'll email you whenever a new clinical trial starts recruiting at this research site in Pittsburgh, PA. Unsubscribe anytime.

More research sites in Pittsburgh

University of Pittsburgh (158 trials)
UPMC Hillman Cancer Center (147 trials)
University of Pittsburgh Medical Center (130 trials)
Allegheny General Hospital (62 trials)
Children's Hospital of Pittsburgh of UPMC (59 trials)
UPMC Children's Hospital of Pittsburgh (52 trials)
Allegheny Health Network (32 trials)
UPMC-Passavant Hospital (32 trials)
UPMC-Saint Clair Hospital Cancer Center (27 trials)
UPMC-Saint Margaret (25 trials)

Is this your research site?

This page is built from public ClinicalTrials.gov records. If you work here, we can correct it, send you the patients who apply, and build you a free website from your real studies — verify it with your work email, or read what we do for research sites.

Explore more

Paid clinical trials in Pittsburgh, PA · Pennsylvania clinical trials