A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancerfor Ovarian Carcinoma539 locations incl. BirminghamSponsor: NRG OncologySex: Female·Age: 35 - 50Code: NCT04251052·RecruitingApply to this trial
Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)for Recurrent Lung Non-Small Cell CarcinomaDrug: Cemiplimab386 locations incl. DaphneSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT06616584·Phase 2, Phase 3·RecruitingApply to this trial
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)for Acute Myeloid Leukemia335 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05564390·Phase 2·RecruitingApply to this trial
Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trialfor Metastatic Clear Cell Renal Cell Carcinoma387 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT04510597·Phase 3·RecruitingApply to this trial
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumabfor Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8Drug: Nivolumab390 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 5 - 60Code: NCT05675410·Phase 3·RecruitingApply to this trial
Testing the Addition of an Antiangiogenic Drug (Bevacizumab) to Chemotherapy (Carboplatin and Paclitaxel) Combined With Immunotherapy (Pembrolizumab) for pMMR, TP53 Mutated Endometrial Cancerfor Advanced Endometrial CarcinomaDrug: Bevacizumab222 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT07198074·Phase 3·RecruitingApply to this trial
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trialfor Advanced Esophageal AdenocarcinomaDrug: Nivolumab372 locations incl. Little RockSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06203600·Phase 2, Phase 3·RecruitingApply to this trial
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Studyfor Clinical Stage III Cutaneous Melanoma AJCC v8Drug: Cabozantinib223 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT05136196·Phase 2·RecruitingApply to this trial
Reaching Rural Cancer Survivors Who Smoke Using Text-Based Programfor Cigarette Smoking-Related Carcinoma222 locations incl. KingmanSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05008848·Phase 3·RecruitingApply to this trial
Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancerfor Oropharyngeal p16INK4a-Negative Squamous Cell CarcinomaDrug: Atezolizumab338 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT01810913·Phase 2, Phase 3·RecruitingApply to this trial
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancerfor Breast Cancer451 locations incl. FairbanksSponsor: Canadian Cancer Trials GroupSex: Female·Age: 35+Code: NCT03488693·Phase 3·RecruitingApply to this trial
Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancerfor Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8153 locations incl. GilbertSponsor: NRG OncologySex: All·Age: 18+Code: NCT06532279·Phase 2·RecruitingApply to this trial
Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia211 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554406·Phase 2·RecruitingApply to this trial
Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)for Myelodysplastic Syndrome138 locations incl. BerkeleySponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06577441·Phase 2·RecruitingApply to this trial
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax221 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06317649·Phase 2·RecruitingApply to this trial
Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancerfor Renal Pelvis and Ureter Urothelial CarcinomaDrug: Durvalumab258 locations incl. KingmanSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT04628767·Phase 2, Phase 3·RecruitingApply to this trial
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancerfor Hematopoietic and Lymphatic System Neoplasm190 locations incl. BirminghamSponsor: Children's Oncology GroupSex: Female·Age: Up to 39Code: NCT06513962·Phase 3·RecruitingApply to this trial
Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trialfor Recurrent Endometrial CarcinomaDrug: Selumetinib293 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05554328·Phase 2·RecruitingApply to this trial
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)for Acute Myeloid LeukemiaDrug: Venetoclax167 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 59Code: NCT05554393·Phase 2·RecruitingApply to this trial
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Studyfor Metastatic Colorectal Adenocarcinoma184 locations incl. KingmanSponsor: Alliance for Clinical Trials in OncologySex: All·Age: 18+Code: NCT05673148·Phase 3·RecruitingApply to this trial
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)for Acute Myeloid Leukemia129 locations incl. TucsonSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06672146·Phase 2·RecruitingApply to this trial
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brainfor Anatomic Stage IV Breast Cancer AJCC v8262 locations incl. TucsonSponsor: NRG OncologySex: All·Age: 18+Code: NCT06500455·Phase 3·RecruitingApply to this trial
Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistulafor Pancreatic Carcinoma118 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT06807437·Phase 3·RecruitingApply to this trial
Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancerfor Prostate Adenocarcinoma402 locations incl. BirminghamSponsor: NRG OncologySex: Male·Age: 18+Code: NCT05946213·Phase 3·RecruitingApply to this trial
Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancersfor Metastatic Salivary Gland Carcinoma152 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT05408845·Phase 2·RecruitingApply to this trial
Testing Immunotherapy With or Without Stereotactic Body Radiation Therapy in Patients With Advanced Liver Cancer, HELIO-RT Trialfor Advanced Hepatocellular Carcinoma138 locations incl. BerkeleySponsor: NRG OncologySex: All·Age: 18+Code: NCT07166406·Phase 3·RecruitingApply to this trial
Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphomafor Diffuse Large B-Cell Lymphoma87 locations incl. TucsonSponsor: SWOG Cancer Research NetworkSex: All·Age: 18+Code: NCT05633615·Phase 2·RecruitingApply to this trial
Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomasfor Metastatic Dedifferentiated Liposarcoma245 locations incl. PhoenixSponsor: National Cancer Institute (NCI)Sex: All·Age: 18+Code: NCT06422806·Phase 3·RecruitingApply to this trial
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgeryfor Grade 2 Meningioma198 locations incl. BirminghamSponsor: NRG OncologySex: All·Age: 18+Code: NCT03180268·Phase 3·RecruitingApply to this trial
Project: Every Child for Younger Patients With Cancerfor Adrenal Gland Pheochromocytoma245 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 25Code: NCT02402244·RecruitingApply to this trial
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinomafor Endometrial AdenocarcinomaDrug: Ipilimumab137 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: Female·Age: 18+Code: NCT05112601·Phase 2·RecruitingApply to this trial
Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinomafor Recurrent Head and Neck Squamous Cell Carcinoma178 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 18 - 79Code: NCT04671667·Phase 2·RecruitingApply to this trial
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)for Recurrent T Acute Lymphoblastic Leukemia163 locations incl. BirminghamSponsor: SWOG Cancer Research NetworkSex: All·Age: 12+Code: NCT04315324·Phase 1, Phase 2·RecruitingApply to this trial
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutationsfor Acute Myeloid Leukemia185 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 21Code: NCT04293562·Phase 3·RecruitingApply to this trial
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLyfor B Acute Lymphoblastic Leukemia203 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: 365 Days - 25Code: NCT03959085·Phase 3·RecruitingApply to this trial
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)for B Acute Lymphoblastic Leukemia139 locations incl. BirminghamSponsor: National Cancer Institute (NCI)Sex: All·Age: 366 Days - 46Code: NCT06124157·Phase 2·RecruitingApply to this trial
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcomafor Embryonal Rhabdomyosarcoma165 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 21Code: NCT05304585·Phase 3·RecruitingApply to this trial
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Studyfor Acute Lymphoblastic Leukemia164 locations incl. BirminghamSponsor: PedAL BCU, LLCSex: All·Age: Up to 22Code: NCT04726241·Phase 1, Phase 2·RecruitingApply to this trial
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWTfor Anaplastic Kidney Wilms Tumor177 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: Up to 30Code: NCT04322318·Phase 2·RecruitingApply to this trial
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)for Ganglioneuroblastoma152 locations incl. BirminghamSponsor: Children's Oncology GroupSex: All·Age: 365 Days - 30Code: NCT03126916·Phase 3·RecruitingApply to this trial