Clinical Trials at National Institutes of Health Clinical Center

As of June 2026, 660 paid clinical trials are recruiting at National Institutes of Health Clinical Center in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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660 clinical trials at National Institutes of Health Clinical Center

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Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)

for NOMID

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: Up to 99·Accepts healthy volunteers

Code: NCT02974595·Recruiting

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Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

for Malaria

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT02639299·Recruiting

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Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

for Metabolic Disease

2 locations incl. Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02890342·Recruiting

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Study of Direct Brain Recording and Stimulation for Memory Enhancement

for Epilepsy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 65

Code: NCT04095026·Enrolling By Invitation

Effects of External Ear Stimulation on Pain Perception and Mood

for Pain in Healthy Participants

1 location in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT02821741·Recruiting

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Effect of Corticosteroids on Inflammation at the Edge of Acute Multiple Sclerosis Plaques

for Multiple Sclerosis

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 120

Code: NCT02784210·Phase 2·Recruiting

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Clinical and Molecular Studies in Families With Inherited Eye Disease

for Inherited Eye Disease

3 locations incl. La Jolla

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 4 - 120

Code: NCT02771236·Recruiting

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Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT02821806·Recruiting

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Natural History, Pathogenesis, and Outcome of Ocular Disorders

for Eye Disease

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 1 Month - 100

Code: NCT02821767·Recruiting

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Clinical and Scientific Assessment of Pain and Painful Disorders

for Normal Physiology

1 location in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 12 - 120·Accepts healthy volunteers

Code: NCT02707029·Recruiting

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Evaluation of Children With Endocrine and Metabolic-Related Conditions

for Adrenal Insufficiency

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 3 Months - 100

Code: NCT02769975·Recruiting

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Natural History of Spinocerebellar Ataxia Type 7 (SCA7)

for Spinocerebellar Ataxia

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 12 - 100

Code: NCT02741440·Recruiting

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Evaluation of Adults With Endocrine and Metabolic-Related Conditions

for Endocrine Diseases

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT02830308·Recruiting

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Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction

for Normal Physiology

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT02535702·Recruiting

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Natural History of Craniofacial Anomalies and Developmental Growth Variants

for Prognathism

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 2 - 100·Accepts healthy volunteers

Code: NCT02639312·Recruiting

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Biospecimen Procurement for Center for Immuno-Oncology Immunotherapy Protocols

for Multiple Myeloma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT02682667·Recruiting

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Pathological Basis of MRI Signal Changes in Multiple Sclerosis

for Multiple Sclerosis

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT02659956·Recruiting

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Rod and Cone Mediated Function in Retinal Disease

for Retinal Degeneration

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 5 - 100·Accepts healthy volunteers

Code: NCT02617966·Recruiting

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Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism

for Brown Adipose Tissue (BAT) Physiology

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT02692885·Recruiting

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Tumor Related Epilepsy

for Epilepsy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 8 - 99

Code: NCT02639325·Recruiting

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Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

for Normal Physiology

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 34·Accepts healthy volunteers

Code: NCT02629107·Recruiting

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Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT02594202·Recruiting

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A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

for Melanoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 72

Code: NCT02621021·Phase 2·Recruiting

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Neurobiology of Suicide

for Healthy Volunteers

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT02543983·Phase 2·Recruiting

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Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

for Primary T-cell Immunodeficiency Disorders

2 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 4 - 75·Accepts healthy volunteers

Code: NCT02579967·Phase 2·Recruiting

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Psychological Treatments for Youth With Severe Irritability.

for Irritability

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 8 - 17

Code: NCT02531893·Recruiting

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Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

for Neurofibromatosis 1

6 locations incl. Washington D.C.

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT02544022·Recruiting

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Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

for Bladder Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT02379429·Recruiting

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Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell Studies

for Lyphoma, B-Cell

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT02473757·Enrolling By Invitation

Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

for Undiagnosed Diseases

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02543996·Recruiting

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Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network

for Genetic Disease

33 locations incl. Birmingham

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02450851·Recruiting

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Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease

for Rheumatic Disease

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 18 - 90

Code: NCT02504879·Recruiting

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Natural History and Genetics of Food Allergy and Related Conditions

for Food Allergy

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 Day - 99·Accepts healthy volunteers

Code: NCT02504853·Recruiting

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Natural History of Noncirrhotic Portal Hypertension

for Cystic Fibrosis

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 12 - 100

Code: NCT02417740·Recruiting

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Long-term Observation of Hemagglutinin and Neuraminidase Inhibition Antibody Titers After Influenza Challenge

for Post Influenza

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT02511002·Enrolling By Invitation

Genome Transplant Dynamics

for Thoracic Organ Transplantation

6 locations incl. Washington D.C.

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 14 - 80

Code: NCT02423070·Recruiting

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Genetics of Inherited Eye Disease

for Genetic Eye Disease

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 1 - 120·Accepts healthy volunteers

Code: NCT02471287·Recruiting

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Studies of Dermatologic Diseases Biospecimen Acquisition Protocol

for Dermatologic Conditions

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT02471352·Recruiting

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Effects of Bronchial Segmental Endotoxin Instillation in Humans

for Acute Lung Inflammation

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT02392442·Phase 2·Enrolling By Invitation

Neural and Psychological Mechanisms of Pain Perception

for Pain

1 location in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT02446262·Recruiting

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