Clinical Trials at National Institutes of Health Clinical Center

As of July 2026, 593 paid clinical trials are recruiting at National Institutes of Health Clinical Center, located at 10 CENTER DR, BLDG. 10 ROOM 2-5940, BETHESDA, MD 20892-0001, phone (301) 496-6353 in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 21, 2026.

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599 clinical trials at National Institutes of Health Clinical Center

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Natural History of Treated Neurocysticercosis and Long-Term Outcomes

for Cysticercosis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 99·Accepts healthy volunteers

Code: NCT00001205·Recruiting·Listed Nov 1999

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Adaptive Optics Retinal Imaging

for Eye Diseases

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 12 - 120·Accepts healthy volunteers

Code: NCT02317328·Recruiting·Listed Dec 2014

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Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

for Alcohol Use Disorder

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 65

Code: NCT06269627·Phase 4·Recruiting·Listed Feb 2024

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Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity

for Mitochondrial Disease

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 2 Months - 115·Accepts healthy volunteers

Code: NCT04419870·Recruiting·Listed Jun 2020

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A First-in-Human Phase I Trial With Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors, Carcinomas and Malignant Peripheral Nerve Sheath Tumors

for Neuroendocrine Carcinomas

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06041516·Phase 1·Recruiting·Listed Sep 2023

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Natural History of Pregnancy and Pregnancy Outcomes in Metreleptin-Treated vs Untreated Subjects With Lipodystrophy

for Lipodystrophy

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 6 Months - 98

Code: NCT05419037·Recruiting·Listed Jun 2022

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National Eye Institute Biorepository for Retinal Diseases

for Age-Related Macular Degeneration

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 2 - 120·Accepts healthy volunteers

Code: NCT01496625·Recruiting·Listed Dec 2011

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Care of the Prostate Cancer Patient and Prospective Procurement of Prostate Cancer Tissue

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT02594202·Recruiting·Listed Nov 2015

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Recruitment and Characterization of Healthy Research Volunteers for NIMH Intramural Studies

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70

Code: NCT03304665·Recruiting·Listed Oct 2017

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Studies on Tumors of the Thyroid

for Hurthle Cell Thyroid Cancer

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 6 Months - 98

Code: NCT00001160·Recruiting·Listed Nov 1999

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Sample Collection From Healthy Volunteers for Assay Optimization

for Healthy Volunteers

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 80·Accepts healthy volunteers

Code: NCT03538600·Recruiting·Listed May 2018

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A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

for Locally Advanced Alveolar Soft Part Sarcoma

Drug: Atezolizumab

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06066138·Phase 1·Recruiting·Listed Oct 2023

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Feasibility of Adipose Tissue Triglyceride (TG) Labelling in Familial Partial Lipodystrophy (FPLD)

for Lipodystrophy

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 65

Code: NCT05996536·Recruiting·Listed Aug 2023

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Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 85

Code: NCT03986034·Phase 2·Recruiting·Listed Jun 2019

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Admission and Management of Occupational or Other Exposures to Biodefense/Bioterrorism Agents or to Epidemic/Emerging Infectious Diseases

for Occupational Accidents

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 99·Accepts healthy volunteers

Code: NCT01200953·Recruiting·Listed Sep 2010

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Study of the Disease Process of Lymphangioleiomyomatosis

for Lung Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 16 - 100

Code: NCT00001465·Recruiting·Listed Nov 1999

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Natural History Study of Patients With Neurofibromatosis Type 2

for Neurofibromatosis

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 8 - 75

Code: NCT00598351·Recruiting·Listed Jan 2008

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Defining the Natural History of Squamous Cell Carcinoma in Fanconi Anemia

for Fanconi Anemia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 8 - 90

Code: NCT05687149·Recruiting·Listed Jan 2023

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[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers

for Sinonasal Neuroendocrine Carcinoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06479811·Phase 1·Recruiting·Listed Jun 2024

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Study of the ITK Inhibitor Soquelitinib to Reduce Lymphoproliferation and Improve Cytopenias in Autoimmune Lymphoproliferative Syndrome (ALPS)-FAS Patients

for Autoimmune Lymphoproliferative Syndrome

Drug: Soquelitinib

Sites in Bethesda +2 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 16 - 120

Code: NCT06730126·Phase 2·Recruiting·Listed Dec 2024

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Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

for Malignant Solid Tumors

Sites in Bethesda +2 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 4 Weeks+·Accepts healthy volunteers

Code: NCT03739827·Recruiting·Listed Nov 2018

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Environmental Risk Factors for the Anti-synthetase Syndrome

for Myositis

Sites in Bethesda +1 more location

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 2 - 100·Accepts healthy volunteers

Code: NCT01276470·Recruiting·Listed Jan 2011

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Screening for LID Clinical Studies Unit Healthy Volunteer Protocols

for Zika

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT01386424·Recruiting·Listed Jul 2011

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Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy People for the Expansion of T Cells for Adoptive Cell Therapy

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT02821806·Recruiting·Listed Jul 2016

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Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults

for Cardiovascular Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT03372733·Phase 2·Recruiting·Listed Dec 2017

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Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

for Hematologic Neoplasms

Sites in Bethesda +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 85·Accepts healthy volunteers

Code: NCT04959175·Phase 1, Phase 2·Recruiting·Listed Jul 2021

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The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell Transplantation

for Peripheral Blood Stem Cell Transplantation

Sites in Bethesda +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120·Accepts healthy volunteers

Code: NCT05436418·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis

for Takayasu's Arteritis

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 3+·Accepts healthy volunteers

Code: NCT02257866·Recruiting·Listed Oct 2014

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Role of Genetic Factors in the Development of Lung Disease

for Cystic Fibrosis

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 90·Accepts healthy volunteers

Code: NCT00001532·Recruiting·Listed Nov 1999

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Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 110

Code: NCT05724121·Recruiting·Listed Feb 2023

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Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)

for Waldenstrom Macroglobulinemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 110

Code: NCT00923507·Recruiting·Listed Jun 2009

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Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

for Gastric Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 6+

Code: NCT04557969·Recruiting·Listed Sep 2020

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National Ophthalmic Genotyping and Phenotyping Network (eyeGENE (Registered Trademark)), Stage 3 - Expansion of DNA and Data Repositories for Rare Inherited Ophthalmic Diseases

for Inherited Ophthalmic Diseases

2 locations in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 1 Day - 120

Code: NCT06491615·Recruiting·Listed Jul 2024

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Pilot Study to Investigate Magnetic Resonance (MR) Image Guided Focal Therapy in Prostate Cancer

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT04808427·Recruiting·Listed Mar 2021

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A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

for Neurofibromatosis Type 1

Sites in Bethesda +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 120

Code: NCT06507748·Recruiting·Listed Jul 2024

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Natural History, Pathogenesis and Outcome of Melorheostosis A Rare Osteosclerotic Disease

for Rheumatic Disease

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 18 - 90

Code: NCT02504879·Recruiting·Listed Jul 2015

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Cardamom and Topical Roseomonas in Atopic Dermatitis

for Atopic Dermatitis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 2 - 100

Code: NCT06096857·Phase 2·Recruiting·Listed Oct 2023

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Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer

for Squamous Cell Carcinoma of the Head and Neck

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06223568·Phase 2·Recruiting·Listed Jan 2024

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A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

for Melanoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 72

Code: NCT02621021·Phase 2·Recruiting·Listed Dec 2015

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Human Movement Database

for Movement Disorder

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 1 Month - 99·Accepts healthy volunteers

Code: NCT00001252·Recruiting·Listed Nov 1999

Apply to this trial