Clinical Trials at National Institutes of Health Clinical Center

As of July 2026, 593 paid clinical trials are recruiting at National Institutes of Health Clinical Center, located at 10 CENTER DR, BLDG. 10 ROOM 2-5940, BETHESDA, MD 20892-0001, phone (301) 496-6353 in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

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Healthy volunteers only

599 clinical trials at National Institutes of Health Clinical Center

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Influence of Brain Oscillation-Dependent TMS on Motor Function

for Healthy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT03288220·Recruiting·Listed Sep 2017

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Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population

for Herpes Zoster

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05580458·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

for Neurological Regression

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Day - 100

Code: NCT00029965·Recruiting·Listed Jan 2002

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Men at High Genetic Risk for Prostate Cancer

for Prostatic Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 30 - 75

Code: NCT03805919·Recruiting·Listed Jan 2019

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Noninvasive Pre-surgical Evaluation of Patients With Focal Epilepsy and Establishment of a Normative Imaging Database

for Epilepsy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 8 - 120·Accepts healthy volunteers

Code: NCT02107989·Recruiting·Listed Apr 2014

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Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments

for Obesity

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: Female·Age: 21 - 75·Accepts healthy volunteers

Code: NCT03288207·Recruiting·Listed Sep 2017

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Natural History of Sickle Cell Disease

for Pain Crisis

Sites in Bethesda +1 more location

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 90

Code: NCT00081523·Recruiting·Listed Apr 2004

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Viral Load in Blood and Lymph Tissues in People Living With HIV

for HIV

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT00001316·Recruiting·Listed Nov 1999

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Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis

for Coccidioidomycosis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 2 - 100

Code: NCT02190266·Recruiting·Listed Jul 2014

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The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

for Systemic Lupus Erythematosus

1 location in Bethesda

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Sex: All·Age: 18 - 80

Code: NCT05440422·Phase 2·Recruiting·Listed Jun 2022

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Early Metabolic Effects of Antiretroviral Drugs in Healthy volUnteers: a Phase 2 Randomized Study

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT05652478·Phase 2·Recruiting·Listed Dec 2022

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Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

for Mortality in Sickle Cell

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT05213572·Recruiting·Listed Jan 2022

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Prospective Monitoring of Subjects With Biochemically Recurrent Prostate Cancer Using 18FDCFPyL

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05588128·Recruiting·Listed Oct 2022

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Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

for Human Immunodeficiency Virus

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03300830·Recruiting·Listed Oct 2017

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Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

for CAD

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03331380·Recruiting·Listed Nov 2017

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Natural History of Bronchiectasis

for Bronchiectasis

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 5 - 100·Accepts healthy volunteers

Code: NCT00943514·Recruiting·Listed Jul 2009

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A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

for fMRI

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 7 - 35·Accepts healthy volunteers

Code: NCT01434368·Recruiting·Listed Sep 2011

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Natural History, Physiology, Microbiome and Biochemistry Studies of Propionic Acidemia

for Metabolic Disease

Sites in Bethesda +1 more location

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02890342·Recruiting·Listed Sep 2016

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Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)

for Metastatic Colorectal Cancer

Drug: Retifanlimab

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06149481·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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Ultra-Low Field (ULF) Point-of-Care (POC) MRI System for Brain Morphology and Pathology

for Nervous System Diseases (C10 Unique ID D009422)

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 3 - 99

Code: NCT06203626·Recruiting·Listed Jan 2024

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Natural History Study of Patients With Excess Androgen

for Congenital Adrenal Hyperplasia (CAH)

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 99

Code: NCT00250159·Recruiting·Listed Nov 2005

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PET Imaging of Phosphodiesterase-4B (PDE4B) in Alcohol Use Disorder

for Alcohol Use Disorder

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70

Code: NCT06795581·Phase 1·Recruiting·Listed Jan 2025

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Specimen Collections From Participants With HIV Infection, KSHV Infection, Viral-Related Pre-malignant Lesions and Cancer

for HIV

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT00006518·Recruiting·Listed Nov 2000

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Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

for Metabolic Disease

Sites in Bethesda +1 more location

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 1 - 100·Accepts healthy volunteers

Code: NCT01143454·Recruiting·Listed Jun 2010

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Hereditary Leiomyomatosis Renal Cell Cancer - Study of the Genetic Cause and the Predisposition to Renal Cancer

for Renal Tumor Histology

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2+·Accepts healthy volunteers

Code: NCT00050752·Recruiting·Listed Dec 2002

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Collection and Analysis of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers

for Healthy Volunteers

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 8 - 99·Accepts healthy volunteers

Code: NCT00442195·Recruiting·Listed Mar 2007

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Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency

for Inherited Bone Marrow Failure Syndrome

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT06090669·Phase 1·Recruiting·Listed Oct 2023

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Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption

for HIV

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 100

Code: NCT05419024·Phase 2·Recruiting·Listed Jun 2022

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Phenotype/Genotype Correlations in Movement Disorders

for Movement Disorder

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 2 - 100

Code: NCT00018889·Recruiting·Listed Jul 2001

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Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)

for Undiagnosed Diseases

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 1 Month - 100·Accepts healthy volunteers

Code: NCT02543996·Recruiting·Listed Sep 2015

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Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer

for Colorectal Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2+

Code: NCT01915225·Recruiting·Listed Aug 2013

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A Natural History Study of Children and Adults With Olfactory Neuroblastoma

for Olfactory Neuroblastoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 3 - 120

Code: NCT04755205·Recruiting·Listed Feb 2021

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Predicting Future Errors During Skill Performance

for Healthy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT06707207·Recruiting·Listed Nov 2024

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Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression

for Suicide

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70

Code: NCT06511908·Phase 2·Recruiting·Listed Jul 2024

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Adult and Juvenile Myositis

for Dermatomyositis

Sites in Bethesda +1 more location

Sponsor: National Institute of Environmental Health Sciences (NIEHS)

Sex: All·Age: 2 - 100·Accepts healthy volunteers

Code: NCT00017914·Recruiting·Listed Jun 2001

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Cerebral Palsy and the Study of Brain Activity During Motor Tasks

for Cerebral Palsy

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 5 - 100·Accepts healthy volunteers

Code: NCT01829724·Recruiting·Listed Apr 2013

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Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

for Non-Alcoholic Steatohepatitis

Drug: Semaglutide

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03884075·Phase 2·Recruiting·Listed Mar 2019

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A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome

for Immunodeficiency

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 75

Code: NCT05027945·Phase 2·Recruiting·Listed Aug 2021

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Evaluation of Patients With Immune Function Abnormalities

for Chronic Granulomatous Disease (CGD)

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT00128973·Recruiting·Listed Aug 2005

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Neurobiology of Suicide

for Healthy Volunteers

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT02543983·Phase 2·Recruiting·Listed Sep 2015

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