Clinical Trials at National Institutes of Health Clinical Center

As of July 2026, 593 paid clinical trials are recruiting at National Institutes of Health Clinical Center, located at 10 CENTER DR, BLDG. 10 ROOM 2-5940, BETHESDA, MD 20892-0001, phone (301) 496-6353 in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 21, 2026.

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599 clinical trials at National Institutes of Health Clinical Center

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A Natural History Study of Bone and Mineral Disorders

for Tumor Induced Osteomalcia

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 1 Day - 100

Code: NCT00024804·Recruiting·Listed Oct 2001

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Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

for Human Papillomavirus

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 100·Accepts healthy volunteers

Code: NCT05026138·Recruiting·Listed Aug 2021

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Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy

for Somatostatin Receptor Positive

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT06427798·Phase 1, Phase 2·Recruiting·Listed May 2024

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Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement

for Kohlmeier-Degos Disease

Drug: Baricitinib

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 99

Code: NCT06923072·Phase 2·Recruiting·Listed Apr 2025

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The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise

for EBV

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 2 - 100

Code: NCT01011712·Recruiting·Listed Nov 2009

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Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics

for Familial Mediterranean Fever (FMF)

Sites in Bethesda +1 more location

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 2 Months - 115·Accepts healthy volunteers

Code: NCT00001373·Recruiting·Listed Nov 1999

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Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms

for Endocrine Tumors

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 4+

Code: NCT01005654·Recruiting·Listed Nov 2009

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Metagenomics Next-generation Sequencing Approach to Detect Microbial DNA/RNA Overtime in Individuals Undergoing Hematopoietic Stem Cell Transplant

for Hematopoietic Stem Cell Transplantation

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 3 - 100

Code: NCT06904053·Recruiting·Listed Apr 2025

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Clinical and Genetic Studies in Familial Non-medullary Thyroid Cancer

for Non-Medullary Thyroid Cancer

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 7 - 90

Code: NCT01109420·Recruiting·Listed Apr 2010

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Magnetic Resonance Imaging (MRI) to Evaluate Activity of Multiple Sclerosis (MS)

for Multiple Sclerosis

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00001248·Recruiting·Listed Nov 1999

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Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

for Epilepsy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 60

Code: NCT02531880·Phase 1·Recruiting·Listed Aug 2015

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Fungal Infection Susceptibility

for Cryptococcal Infection

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT00001352·Recruiting·Listed Nov 1999

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Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

for Myelodysplastic Syndromes

Drug: Pacritinib

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120

Code: NCT06303193·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Clonal Evolution in Follicular Lymphoma

for Follicular Lymphoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03190928·Recruiting·Listed Jun 2017

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Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study

for Obesity

Sites in Bethesda +1 more location

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 12 - 25·Accepts healthy volunteers

Code: NCT06730113·Recruiting·Listed Dec 2024

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Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

for Non-Small Cell Lung Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT02146170·Recruiting·Listed May 2014

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Thinking and Memory Problems in People With HIV

for HIV Positive

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 110·Accepts healthy volunteers

Code: NCT01875588·Recruiting·Listed Jun 2013

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Natural History, Pathogenesis, and Outcome of Ocular Disorders

for Eye Disease

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 1 Month - 100

Code: NCT02821767·Recruiting·Listed Jul 2016

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Study of the Esophageal String Test (EST) for the Diagnosis of Helicobacter Pylori

for Helicobacter Pylori

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 99

Code: NCT06871579·Recruiting·Listed Mar 2025

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Diagnosing and Treating Low Blood Sugar Levels

for Hypoglycemia

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 120

Code: NCT00001276·Recruiting·Listed Nov 1999

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Clinical and Basic Investigations Into Hermansky-Pudlak Syndrome

for Hermansky-Pudlak Syndrome (HPS)

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Month - 115

Code: NCT00001456·Recruiting·Listed Nov 1999

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Diabetes and Heart Disease Risk in Blacks

for Cardiovascular Diseases

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT00001853·Recruiting·Listed Nov 1999

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Physical and Behavioral Traits of Overweight and Obese Adults

for Obesity

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT00428987·Recruiting·Listed Jan 2007

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Hematopoietic Stem Cell Mobilization in Idiopathic CD4 Lymphocytopenia Patients and Healthy Controls for the Study of T Cell Maturation and Trafficking in Murine Models

for Idiopathic CD4-Positive

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT02015013·Phase 2·Recruiting·Listed Dec 2013

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VRC 900: Evaluation of Tissue-Specific Immune Responses in Adults 18 Years of Age and Older

for Immunity, Mucosal

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT01132859·Recruiting·Listed May 2010

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Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

for Severe Aplastic Anemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 75

Code: NCT03173937·Phase 1, Phase 2·Recruiting·Listed Jun 2017

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Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer

for Endocrine Tumors

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 72

Code: NCT03412877·Phase 2·Recruiting·Listed Jan 2018

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Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

for Severe Aplastic Anemia (SAA)

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 75

Code: NCT03520647·Phase 2·Recruiting·Listed May 2018

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PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

for Parkinson's Disease

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04396873·Phase 1·Recruiting·Listed May 2020

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PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

for Depression

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT04582916·Phase 1·Recruiting·Listed Oct 2020

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[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET

for Depression

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT05703685·Phase 1·Recruiting·Listed Jan 2023

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Immune System Related Kidney Disease

for Kidney Disease

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 10 - 99

Code: NCT00001979·Recruiting·Listed Jan 2000

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The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

for Polycystic Ovary Syndrome

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 40

Code: NCT03049462·Phase 1·Recruiting·Listed Feb 2017

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Collection of Blood, Bone Marrow, Skin, Saliva, and Stool Samples From Healthy Volunteers Used for Comparative Analysis of Myeloid Malignancies

for Myelodysplastic Syndromes

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT05588154·Recruiting·Listed Oct 2022

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Imaging Techniques in MRI

for Cardiac Risk Factors

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT01130545·Recruiting·Listed May 2010

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Characterization of Diseases With Salivary Gland Involvement

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 4 - 100·Accepts healthy volunteers

Code: NCT02327884·Recruiting·Listed Dec 2014

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Studies of the Pathogenesis of HIV Infection in Human Peripheral Blood Cells and/or Body Fluids in People Living With and Without HIV

for HIV

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 120·Accepts healthy volunteers

Code: NCT00001281·Recruiting·Listed Nov 1999

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Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death

for Primary Immune Deficiency

Sites in Bethesda +1 more location

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 Month - 100

Code: NCT00246857·Recruiting·Listed Oct 2005

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A Natural History Study of Metabolic Sizing in Health and Disease

for Metabolic Disorders

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 2 - 99·Accepts healthy volunteers

Code: NCT05398783·Recruiting·Listed Jun 2022

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Multiparametric Magnetic Resonance Imaging of the Prostate to Assess Disease Progression and Genomics in Patients Undergoing Active Surveillance for Prostate Cancer

for Prostate Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT04692675·Recruiting·Listed Jan 2021

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