Clinical Trials at National Institutes of Health Clinical Center

As of June 2026, 660 paid clinical trials are recruiting at National Institutes of Health Clinical Center in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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660 clinical trials at National Institutes of Health Clinical Center

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Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

for Metastatic Melanoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT05155033·Phase 2·Recruiting

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Comprehensive Molecular and Clinical Evaluation of Pediatric and Adult MDS

for Myelodysplastic Syndromes

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 Day - 120·Accepts healthy volunteers

Code: NCT05350748·Recruiting

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Respiratory Virus Sampling and Repository

for Influenza

2 locations incl. Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3+

Code: NCT05266222·Recruiting

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Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis

for Chronic Granulomatous Disease-associated Colitis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 10 - 60

Code: NCT05333471·Phase 1, Phase 2·Recruiting

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NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

for Chronic Granulomatous Disease

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: Male·Age: 18 - 75

Code: NCT05189925·Phase 1·Recruiting

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Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy

for Acute Ovarian Failure

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: Female·Age: 4 - 35

Code: NCT05440617·Recruiting

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Cooperative Assessment of Late Effects for SCD Curative Therapies

for Sickle Cell Disease

5 locations incl. Washington D.C.

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 4 - 65

Code: NCT05153967·Recruiting

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Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

for Chronic Granulomatous Disease

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 4 - 65

Code: NCT05463133·Phase 1, Phase 2·Recruiting

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Controls and Healthy Vasculature Initiative

for Vascular And Immunologic Diseases

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT05403151·Recruiting

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Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

for Hereditary Leiomyomatosis and Renal Cell Carcinoma

Drug: Atezolizumab

13 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT04981509·Phase 2·Recruiting

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A Natural History Study of Children and Adults With Olfactory Neuroblastoma

for Olfactory Neuroblastoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 3 - 120

Code: NCT04755205·Recruiting

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Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease

for Sickle Cell Disease

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 18 - 120

Code: NCT05170412·Recruiting

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Phase I Study of Anti-CD22 Chimeric Receptor T Cells in Patients With Relapsed/Refractory Hairy Cell Leukemia and Variant

for Hairy Cell Leukemia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04815356·Phase 1·Recruiting

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Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

for Hematologic Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120·Accepts healthy volunteers

Code: NCT05327023·Phase 1, Phase 2·Recruiting

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Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array

for Normal Physiology

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04950309·Recruiting

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Mechanisms Underlying Individual Variations of Taste and Smell in Obesity

for Obesity

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04714892·Recruiting

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Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies

for Costello Syndrome

2 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 Month - 99·Accepts healthy volunteers

Code: NCT04888936·Recruiting

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Tissue Procurement and Natural History Study of Neuroendocrine Neoplasms (NENs) Including Adrenocortical Carcinoma (ACC)

for Neuroendocrine Tumors

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT05237934·Recruiting

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Stargardt-like Macular Dystrophy (STDG3) Secondary to Mutations in ELOVL4

for Stargardt-Like Macular Dystrophy

1 location in Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 10 - 100

Code: NCT04591483·Recruiting

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Natural History Study of CADASIL

for Cardiovascular Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05072483·Recruiting

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Investigational Use of Neuromuscular Ultrasound

for Muscular Dystrophy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 110·Accepts healthy volunteers

Code: NCT05237973·Recruiting

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PT-112 in Subjects With Thymoma and Thymic Carcinoma

for Thymic Epithelial Tumor

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT05104736·Phase 2·Recruiting

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Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

for Mortality in Sickle Cell

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT05213572·Recruiting

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Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers

for Cholangiocarcinoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04645160·Phase 1, Phase 2·Recruiting

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Human Immune Response to Ixodes Scapularis Tick Bites

for Tick-borne Diseases

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT05036707·Phase 1, Phase 2·Recruiting

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Study of Skeletal Disorders

for Skeletal Disorders

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 2 Months - 100·Accepts healthy volunteers

Code: NCT05031507·Recruiting

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Tissue Acquisition and Genomics Analysis of Breast Cancer and Other Gynecologic Malignancies

for Breast Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03762733·Enrolling By Invitation

Evaluation of Patients With Gastrointestinal Disease

for Lower GI Disease

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 120

Code: NCT05041374·Recruiting

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Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health

for Post-Coronavirus Disease 19

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 100

Code: NCT04573062·Recruiting

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Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV

for Viral Associated Malignancies

Drug: Nivolumab

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99

Code: NCT04902443·Phase 1·Recruiting

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GPC3 Targeted CAR-T Cell Therapy in Advanced GPC3 Expressing Solid Tumor Malignancies

for Hepatocellular Carcinoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT05003895·Phase 1·Recruiting

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Natural History Study of Parathyroid Disorders

for Parathyroid Cancer

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 6 Months - 100

Code: NCT04969926·Recruiting

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Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

for Neurofibromatosis 1

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT04750928·Phase 1, Phase 2·Recruiting

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Natural History of KSHV-Associated Multicentric Castleman s Disease

for Multicentric Castleman s Disease

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04968288·Recruiting

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Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

for Human Papillomavirus

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 100·Accepts healthy volunteers

Code: NCT05026138·Recruiting

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Electrophysiologic Sleep Phenotyping and Sleep-Dependent Neuro-maturation in Clinical and Healthy Pediatric Populations

for Healthy Children

5 locations incl. Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 6 Months - 8·Accepts healthy volunteers

Code: NCT04639830·Recruiting

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The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

for Metastic Thyroid Cancer

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 98

Code: NCT04927416·Phase 2·Recruiting

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Clinical, Molecular and Imaging Biomarkers in Spinal and Bulbar Muscular Atrophy (SBMA)

for Spinal and Bulbar Muscular Atrophy

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: Male·Age: 18 - 120·Accepts healthy volunteers

Code: NCT04944940·Recruiting

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Natural History of Acquired and Inherited Bone Marrow Failure Syndromes

for Severe Aplastic Anemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 99

Code: NCT05012111·Recruiting

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Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women

for Cardiovascular (CV) Risk

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: Female·Age: 19 - 45·Accepts healthy volunteers

Code: NCT04014348·Recruiting

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