Clinical Trials at National Institutes of Health Clinical Center

As of June 2026, 660 paid clinical trials are recruiting at National Institutes of Health Clinical Center in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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660 clinical trials at National Institutes of Health Clinical Center

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Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers

for Alcohol Associated Liver Disease

Drug: Alirocumab

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT04781322·Phase 1·Recruiting

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Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

for Peritoneal Mesothelioma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04847063·Phase 1·Recruiting

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Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases

for COVID-19

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05078905·Recruiting

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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers

for Cardiovascular Disease

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04216342·Phase 1·Recruiting

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Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma

for Kaposi Sarcoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99

Code: NCT04941274·Phase 1, Phase 2·Recruiting

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Teriflunomide in HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis

for HAM/TSP

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 120

Code: NCT04799288·Phase 1, Phase 2·Recruiting

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Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies

for Hematologic Neoplasms

2 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 85·Accepts healthy volunteers

Code: NCT04959175·Phase 1, Phase 2·Recruiting

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Precision-Based Genomics in Prostate Cancer

for Prostate Cancer

11 locations incl. La Jolla

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT04706663·Recruiting

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Gonadal Tissue Freezing for Fertility Preservation in Individuals at Risk for Ovarian Dysfunction, Premature Ovarian Insufficiency and Clinically Indicated Gonadectomy

for Turner Syndrome

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 2 - 35

Code: NCT04948658·Recruiting

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Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

for Influenza

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 120

Code: NCT04794829·Recruiting

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PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease

for Parkinson's Disease

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04396873·Phase 1·Recruiting

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Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets

for Meniere's Disease

1 location in Bethesda

Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD)

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04806282·Recruiting

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Long-term Observation of Participants With Mood Disorders

for Depression

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04877977·Recruiting

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Addictions Neuroclinical Assessment (ANA)

for Normal Physiology

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04946851·Enrolling By Invitation

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

for Primary Immunodeficiency

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04864886·Recruiting

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PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)

for Depression

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT04582916·Phase 1·Recruiting

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Biochemical and Phenotypical Aspects of Smith-Lemli-Opitz Syndrome and Related Disorders of Cholesterol Metabolism

for Smith Lemli Opitz Syndrome

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT05047354·Recruiting

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Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

for Autism Spectrum Disorder

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 11 - 25·Accepts healthy volunteers

Code: NCT04798274·Recruiting

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A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

16 locations incl. Duarte

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT04830137·Phase 1·Recruiting

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Androgen Receptor, Implications for Health and Wellbeing: Natural History Study of Individuals With Androgen Insensitivity

for Androgen Insensitivity Syndrome

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 - 99·Accepts healthy volunteers

Code: NCT04708431·Recruiting

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Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

for Anatomic Stage III Breast Cancer AJCC v8

4 locations incl. Gainesville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04550494·Phase 2·Recruiting

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Data Collection Study of Pediatric and Adolescent Gynecology Conditions

for Disorders of Sex Development (DSD)

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT04717349·Recruiting

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Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

for Familial Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 30 - 120·Accepts healthy volunteers

Code: NCT04431024·Recruiting

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The Beneficial Effects of Naps on Motor Learning

for Stroke

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04312126·Recruiting

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Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease

for Diet

1 location in Bethesda

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 18 - 99·Accepts healthy volunteers

Code: NCT04305431·Recruiting

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A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

for Cancer Of Prostate

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18 - 110

Code: NCT04633252·Phase 1, Phase 2·Recruiting

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Natural History of Autosomal Dominant Hearing Loss

for Hearing Loss

1 location in Bethesda

Sponsor: National Institute on Deafness and Other Communication Disorders (NIDCD)

Sex: All·Age: 3 - 99·Accepts healthy volunteers

Code: NCT04501081·Recruiting

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Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant

for Hairy Cell Leukemia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04322383·Phase 2·Recruiting

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Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

for Gastric Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 6+

Code: NCT04557969·Recruiting

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Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing

for Amyotrophic Lateral Sclerosis Type 4

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 5 - 120·Accepts healthy volunteers

Code: NCT04394871·Recruiting

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Oral Metformin for Treatment of ABCA4 Retinopathy

for ABCA4 Retinopathy

2 locations incl. Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 12 - 100

Code: NCT04545736·Phase 1, Phase 2·Recruiting

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Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

for Hairy Cell Leukemia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04324112·Phase 2·Recruiting

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Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors

for Advanced Solid Tumors

2 locations incl. Fairway

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120

Code: NCT04222413·Phase 1·Recruiting

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Acute Infection in Mitochondrial Disease: Metabolism, Infection and Immunity

for Mitochondrial Disease

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 2 Months - 115·Accepts healthy volunteers

Code: NCT04419870·Recruiting

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Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular Degeneration

for Dry Age-Related Macular Degeneration

2 locations incl. Baltimore

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 55 - 95

Code: NCT04339764·Phase 1, Phase 2·Recruiting

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Allogeneic Hematopoietic Stem Cell Transplant for Patients With Inborn Errors of Immunity

for Lymphoproliferative Disorders

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 4 - 69

Code: NCT04339777·Phase 2·Recruiting

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En-bloc Transurethral Resection of Bladder Tumor (En-bloc TURBT) Specimens Using a Redesigned Surgical Resectoscope Device

for Bladder Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04235764·Recruiting

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Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel

for Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04449549·Phase 2·Recruiting

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Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

for Urothelial Cancer

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04235777·Phase 1·Recruiting

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PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

for Kaposi Sarcoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 99

Code: NCT04303117·Phase 1, Phase 2·Recruiting

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