Clinical Trials at National Institutes of Health Clinical Center

As of June 2026, 660 paid clinical trials are recruiting at National Institutes of Health Clinical Center in Bethesda, Maryland. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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660 clinical trials at National Institutes of Health Clinical Center

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Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

for Wide Spectrum of Diseases

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 120·Accepts healthy volunteers

Code: NCT04450927·Enrolling By Invitation

Natural History and Management of Von Hippel-Lindau (VHL) Associated Pancreatic Neuroendocrine Tumors

for VHL Pancreatic Neuroendocrine Tumors

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT04074135·Phase 2·Recruiting

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Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies

for Cervical Intraepithelial Neoplasia

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04266093·Enrolling By Invitation

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

for Severe Aplastic Anemia

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 3 - 99

Code: NCT04304820·Phase 2·Recruiting

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Belimumab With Rituximab for Primary Membranous Nephropathy

for Membranous Nephropathy

Drug: Rituximab

20 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT03949855·Phase 2·Recruiting

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CHIP/CCUS Natural History Protocol

for Clonal Hematopoiesis of Indeterminate Potential

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 99

Code: NCT04102423·Recruiting

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Reverse Phenotyping Core

for Harboring of Unexpected Genetic Variant

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 4 - 120

Code: NCT03632239·Enrolling By Invitation

Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression

for Depression

1 location in Bethesda

Sponsor: National Institute of Mental Health (NIMH)

Sex: All·Age: 18 - 70

Code: NCT03973268·Phase 1·Recruiting

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Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)

for Idiopathic CD4 Lymphopenia

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT04097561·Phase 1·Recruiting

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IDENTIFY Study: Natural History of Maternal Neoplasia

for Maternal Neoplasia

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: Female·Age: 18 - 100

Code: NCT04049604·Recruiting

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Paradoxical Tuberculosis Reactions in Patients Without HIV Infection

for Tuberculosis

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 99

Code: NCT04052022·Recruiting

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Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

for Myeloid Chimerism

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 2 - 80·Accepts healthy volunteers

Code: NCT04008368·Phase 1, Phase 2·Recruiting

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Pediatric cGVHD Symptom Scale

for Graft vs Host Disease

15 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 99·Accepts healthy volunteers

Code: NCT04044365·Recruiting

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Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

for Alpha and Beta Thalassemia

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT03937817·Recruiting

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Patient-Centered Assessment of Symptoms and Outcomes

for Fatigue

1 location in Bethesda

Sponsor: National Center for Complementary and Integrative Health (NCCIH)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03952624·Recruiting

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A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis

for Lysosomal Diseases

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 6 Months - 12

Code: NCT03952637·Phase 1, Phase 2·Recruiting

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Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

for Non-Hodgkin's Lymphoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04002947·Phase 2·Recruiting

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The Use of 124-I-PET/CT Whole Body and Lesional Dosimetry in Differentiated Thyroid Cancer

for Thyroid Cancer

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 90

Code: NCT03841617·Phase 2·Recruiting

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Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

for Non-Alcoholic Steatohepatitis

Drug: Semaglutide

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03884075·Phase 2·Recruiting

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Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

for Primary Immunodeficiency

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 1 Day - 99

Code: NCT03610802·Recruiting

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Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

for Autoimmune Disease

Drug: Nivolumab

51 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03816345·Phase 1·Recruiting

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Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 85

Code: NCT03986034·Phase 2·Recruiting

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Nicotinic Receptor Genetic Variation and Alcohol Reward

for Alcohol Drinking

1 location in Bethesda

Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Sex: All·Age: 21 - 60·Accepts healthy volunteers

Code: NCT03294460·Phase 1·Recruiting

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Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

for Bladder Adenocarcinoma

Drug: Cabozantinib

578 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03866382·Phase 2·Recruiting

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Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery

for Pituitary Neoplasm

1 location in Bethesda

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Sex: All·Age: 18 - 85

Code: NCT03678389·Recruiting

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Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in People With Elevated Total Serum IgE Levels and Atopic Dermatitis

for Milk and/or Peanut Allergy

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 21

Code: NCT03835767·Phase 2·Recruiting

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Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

for Peripheral T-cell Lymphomas

2 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 - 120·Accepts healthy volunteers

Code: NCT03922724·Phase 2·Recruiting

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Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers

for Healthy Volunteer

1 location in Bethesda

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT03878121·Phase 1·Recruiting

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Children and Adults With Chordoma

for Chordoma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2+

Code: NCT03910465·Recruiting

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Longitudinal Studies of Patient With FPDMM

for Inherited Hematological Diseases

1 location in Bethesda

Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All·Age: 1 Day - 100·Accepts healthy volunteers

Code: NCT03854318·Recruiting

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Men at High Genetic Risk for Prostate Cancer

for Prostatic Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 30 - 75

Code: NCT03805919·Recruiting

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Study of Endocrine-Related Conditions and Physiology

for Endocrine Disease

1 location in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 90

Code: NCT03867448·Recruiting

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Perception, Sensation, Cognition and Action in Humans

for Normal Physiology

2 locations incl. Bethesda

Sponsor: National Eye Institute (NEI)

Sex: All·Age: 13 - 65·Accepts healthy volunteers

Code: NCT03407066·Recruiting

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Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

for Mesothelioma

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2+

Code: NCT03830229·Recruiting

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Long-Term Follow-Up of Survivors of Pediatric Cushing Disease

for Cushing Disease

1 location in Bethesda

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Sex: All·Age: 2 - 90·Accepts healthy volunteers

Code: NCT03831958·Recruiting

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Haplo-identical Transplantation for Severe Aplastic Anemia, Hypo-plastic MDS and PNH Using Peripheral Blood Stem Cells and Post-transplant Cyclophosphamide for GVHD Prophylaxis

for Severe Aplastic Anemia (SAA)

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 4 - 75

Code: NCT03520647·Phase 2·Recruiting

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Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

for Malignant Solid Tumors

3 locations incl. Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 4 Weeks+·Accepts healthy volunteers

Code: NCT03739827·Recruiting

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Chronic Graft-versus-Host Disease in the Oral Cavity of Patients Following Allogeneic Hematopoietic Stem Cell Transplant and Including Healthy Controls

for Graft Versus Host Disease

1 location in Bethesda

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03602599·Recruiting

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5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors

for Neoplasms

1 location in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT03366116·Phase 1·Recruiting

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Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

for Sickle Cell

1 location in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03685721·Recruiting

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