Breast oncology Clinical Trials in Boston, MA

As of July 2026, 101 paid clinical trials are recruiting for Breast oncology in Boston, Massachusetts. Breast oncology research tests new hormone therapies, HER2-targeted agents, PARP inhibitors, antibody-drug conjugates, and immunotherapy combinations across early-stage and metastatic disease. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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103 clinical trials for Breast oncology

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Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors

for Biliary Tract Cancer

Sites in Boston +5 more locations

Sponsor: ModeX Therapeutics, An OPKO Health Company

Sex: All·Age: 18+

Code: NCT06239194·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

for Breast Neoplasms

Sites in Boston +4 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06686394·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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IKS014 in Advanced Solid Tumors That Express HER2

for Breast Cancer

Sites in Boston +3 more locations

Sponsor: Iksuda Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT05872295·Phase 1·Recruiting·Listed May 2023

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Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

for Breast Cancer

Sites in Boston +1 more location

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT05950945·Phase 3·Recruiting·Listed Jul 2023

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A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

for Non Small Cell Lung Cancer

Sites in Boston +7 more locations

Sponsor: Compass Therapeutics

Sex: All·Age: 18+

Code: NCT06150664·Phase 1·Recruiting·Listed Nov 2023

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FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT05304962·Phase 1·Recruiting·Listed Mar 2022

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This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors

for Non Small Cell Lung Cancer

Sites in Boston +2 more locations

Sponsor: Zumutor Biologics Inc.

Sex: All·Age: 18+

Code: NCT06451497·Phase 1·Recruiting·Listed Jun 2024

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

Sites in Boston +5 more locations

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

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Phase 1 Study of OP-3136 in Advanced or Metastatic Solid Tumors

for Advanced or Metastatic ER+ HER2- Breast Cancer (mBC)

Sites in Boston +6 more locations

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06784193·Phase 1·Recruiting·Listed Jan 2025

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Comprehensive Outcomes for After Cancer Health

for Ovarian Cancer

Sites in Boston +3 more locations

Sponsor: Pack Health

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05349227·Recruiting·Listed Apr 2022

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Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Boston, Winchester +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

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PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

for Estrogen-receptor-positive Breast Cancer

1 location in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07222215·Phase 2·Recruiting·Listed Oct 2025

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E-Mindfulness Approaches for Living After Breast Cancer

for Breast Cancer

Sites in Boston, Stoneham +355 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 50

Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024

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The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study

for Metastatic Breast Cancer

Sites in Boston, Weymouth +71 more locations

Sponsor: American Society of Clinical Oncology

Sex: All·Age: 65+

Code: NCT06377852·Phase 3·Recruiting·Listed Apr 2024

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ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

for Metastatic Breast Cancer

1 location in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07198724·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

Sites in Boston, Stoneham +635 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting·Listed Jun 2023

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Distance-Based Exercise to Preserve Function and Prevent Disability

for Localized Malignant Solid Neoplasm

Sites in Boston +17 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884·Recruiting·Listed Jul 2025

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Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for Anatomic Stage III Breast Cancer AJCC v8

Drug: Pidnarulex

Sites in Boston +1 more location

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07137416·Phase 1·Recruiting·Listed Aug 2025

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Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

for Locoregional Recurrence

Drug: Ribociclib

Sites in Boston +18 more locations

Sponsor: Oana Danciu

Sex: All·Age: 18+

Code: NCT05467891·Phase 2·Recruiting·Listed Jul 2022

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Sacituzumab Govitecan In TNBC

for Invasive Breast Cancer

Sites in Boston, Newton & Danvers

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04230109·Phase 2·Recruiting·Listed Jan 2020

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Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer

for Impaired Cognition

Sites in Boston & Salem

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 60+·Accepts healthy volunteers

Code: NCT02290834·Recruiting·Listed Nov 2014

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

Sites in Boston +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting·Listed Dec 2023

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Scalp Cooling in MBC

for Metastatic Breast Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04986579·Phase 2·Recruiting·Listed Aug 2021

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Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

for Anatomic Stage III Breast Cancer AJCC v8

Sites in Boston +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12+

Code: NCT05372640·Phase 1·Recruiting·Listed May 2022

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Individualizing Approaches to Surveillance Mammography in Older Breast Cancer Survivors - The I-MAMMO Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 80+·Accepts healthy volunteers

Code: NCT07123649·Phase 2·Recruiting·Listed Aug 2025

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ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

Sites in Boston, Brighton +45 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting·Listed May 2021

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Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for Brain Cancer

2 locations in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04899908·Phase 2·Recruiting·Listed May 2021

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Efficacy of Trastuzumab Deruxtecan in Metastatic Breast Cancer With Different HER2 Expression Patterns

for Metastatic Breast Cancer

Sites in Boston +1 more location

Sponsor: Sun Yat-sen University

Sex: Female·Age: 18 - 80

Code: NCT06551220·Recruiting·Listed Aug 2024

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Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

Sites in Boston, Foxborough +13 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting·Listed Jul 2020

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Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT03990896·Phase 2·Recruiting·Listed Jun 2019

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Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Boston +5 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 70+

Code: NCT04305834·Phase 2·Recruiting·Listed Mar 2020

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Atezolizumab + Sacituzumab Govitecan to Prevent Recurrence in TNBC (ASPRIA)

for Breast Cancer

Drug: Atezolizumab

Sites in Boston +3 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04434040·Phase 2·Recruiting·Listed Jun 2020

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VS-6766+Abema+Fulv in Met HR+/HER- BC

for Breast Cancer

2 locations in Boston

Sponsor: Adrienne G. Waks

Sex: All·Age: 18+

Code: NCT05608252·Phase 1, Phase 2·Recruiting·Listed Nov 2022

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Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

for Breast Cancer

Sites in Boston +6 more locations

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT04841148·Phase 2·Recruiting·Listed Apr 2021

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Exercise in Metastatic Breast Cancer: EMBody

for Breast Cancer

Sites in Boston +1 more location

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT05468034·Recruiting·Listed Jul 2022

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SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers

for Breast Cancer

Sites in Boston, Weymouth +9 more locations

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06896474·Recruiting·Listed Mar 2025

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TeleHealth Resistance Exercise Intervention to Preserve Dose Intensity and Vitality in Elder Breast Cancer Patients

for Breast Cancer

Sites in Boston +2 more locations

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 65+

Code: NCT05535192·Recruiting·Listed Sep 2022

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Video Education With Result Dependent dIsclosure

for Genetic Testing

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT05225428·Recruiting·Listed Feb 2022

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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Hypertension Receiving Bevacizumab for Breast Cancer

for Breast Carcinoma

Drug: Bevacizumab

1 location in Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT02610413·Recruiting·Listed Nov 2015

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Whole Exome Sequencing in Finding Causative Variants in Germline DNA Samples From Patients With Congestive Heart Failure Receiving Therapy for Breast Cancer

for Breast Carcinoma

1 location in Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT02610426·Recruiting·Listed Nov 2015

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Conditions in Breast oncology (Boston, MA)

Breast cancer· 79 Metastatic breast cancer· 31 Triple-negative breast cancer· 18 HER2-negative breast cancer· 9 HER2-positive breast cancer· 8