Paid Clinical Trials in Boston, MA

As of August 2026, 2,873 paid clinical trials are recruiting in Boston, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 13, 2026.

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2,484 clinical trials

Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study

for Chronic Obstructive Pulmonary Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT01177618·Recruiting·Listed Aug 2010

Apply to this trial

National Pregnancy Registry for Psychiatric Medications

for Pregnant Women

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT01246765·Recruiting·Listed Nov 2010

Apply to this trial

Gastric Emptying of Water and Sports Drink in Labor

for Pregnancy

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: Female·Age: 18 - 50

Code: NCT04229043·Recruiting·Listed Jan 2020

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LIFT: Life Improvement Trial

for ME/CFS

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06366724·Phase 2·Recruiting·Listed Apr 2024

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Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System

for Barrett's Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 14 - 85·Accepts healthy volunteers

Code: NCT02947971·Recruiting·Listed Oct 2016

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Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03830801·Recruiting·Listed Feb 2019

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Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

for Cardiovascular Diseases

Sites in Boston +1 more location

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06244199·Recruiting·Listed Feb 2024

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IS-free Treg HaploHCT

for Stem Cell Transplant Complications

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 75

Code: NCT04678401·Phase 1·Recruiting·Listed Dec 2020

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Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients

for Chronic Lung Disease

Sites in Boston +5 more locations

Sponsor: University of Michigan Rogel Cancer Center

Sex: All·Age: 36 Months+

Code: NCT05866302·Recruiting·Listed May 2023

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Strength After Breast Cancer

for Breast Cancer

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: Female·Age: 18+

Code: NCT06052488·Recruiting·Listed Sep 2023

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BMT-CARE: Psychosocial Intervention for Transplant Caregivers

for Bone Marrow Transplant Complications

Sites in Boston +2 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06472089·Recruiting·Listed Jun 2024

Apply to this trial

Right-Size Clinic Visits Using Memora Platform for PROMIS

for Orthopedic Disorders

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT04441567·Recruiting·Listed Jun 2020

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Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706

for HIV Infections

Sites in Boston +3 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06665646·Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

The COMPASSION Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06507930·Recruiting·Listed Jul 2024

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The Cancer of the Pancreas Screening-5 CAPS5)Study

for Pancreas Cancer

Sites in Boston +8 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT02000089·Phase 3·Recruiting·Listed Dec 2013

Apply to this trial

A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

for Skin Cancer

2 locations in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06664151·EARLY_Phase 1·Recruiting·Listed Oct 2024

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Spray Cryotherapy for the Management of Benign Central Airway Stenosis (Cryo-BAS)

for Stenosis of Trachea

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: All ages

Code: NCT06761170·Phase 2·Recruiting·Listed Jan 2025

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Hydrogen's Feasibility and Safety as a Therapy in ECPR

for Cardiac Arrest

Sites in Boston +3 more locations

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT05574296·Phase 1·Recruiting·Listed Oct 2022

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T1D Pregnancy & Me

for Diabetes Mellitus, Type 1

Sites in Boston +9 more locations

Sponsor: Jaeb Center for Health Research

Sex: Female·Age: 18+

Code: NCT06959316·Recruiting·Listed May 2025

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Mechanisms Underlying Efficacy of Prolonged Exposure

for Post Traumatic Stress Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05788302·Recruiting·Listed Mar 2023

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SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention)

for Gastrointestinal Cancer

Sites in Boston, Brighton & Methuen

Sponsor: Nadine McCleary, MD, MPH

Sex: All·Age: 18+

Code: NCT05375643·Recruiting·Listed May 2022

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A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

for Recurrent Mycosis Fungoides

Sites in Boston +9 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07003100·Recruiting·Listed Jun 2025

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Angelman Syndrome Natural History Study

for Angelman Syndrome

Sites in Boston +7 more locations

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT04507997·Recruiting·Listed Aug 2020

Apply to this trial

Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort

for Huntington's Disease

Sites in Boston +51 more locations

Sponsor: CHDI Foundation, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT01574053·Recruiting·Listed Apr 2012

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Enhanced Local Intensified Radiation Therapy in Elderly Glioblastoma: A Phase 2 Hybrid Randomized Trial

for Glioblastoma (GBM)

Sites in Boston, Milford & South Weymouth

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06835803·Phase 2·Recruiting·Listed Feb 2025

Apply to this trial

Prevalence and Impact of Obstructive Sleep Apnea in Multiple Sclerosis

for Multiple Sclerosis

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT04603196·Recruiting·Listed Oct 2020

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Clinical Trial to Evaluate the Safety and Immunogenicity of a Priming Regimen of 426c.Mod.Core-C4b Followed by HxB2.WT.Core-C4b Boosts, Both Adjuvanted With 3M-052 AF + Alum, in Adult Participants Without HIV and in Overall Good Health

for HIV

Sites in Boston +4 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06796686·Phase 1·Recruiting·Listed Jan 2025

Apply to this trial

ECA-enhanced Document Explanation RCT

for Healthy

2 locations in Boston

Sponsor: Northeastern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06435819·Recruiting·Listed May 2024

Apply to this trial

Clarifying the Optimal Application of SLT Therapy Trial

for Glaucoma and Ocular Hypertension

Sites in Boston, Reading +25 more locations

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT04967989·Phase 3·Recruiting·Listed Jul 2021

Apply to this trial

Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

for Major Depressive Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05523817·Recruiting·Listed Aug 2022

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Eating to Adjust the Timing System

for Dietary Intervention

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05800990·Recruiting·Listed Apr 2023

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Semaglutide for Helping Opioid Recovery

for Opioid Use Disorder

Drug: Semaglutide

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06639464·Phase 2·Recruiting·Listed Oct 2024

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Computerized Decision Support for Identification and Management of Familial Hypercholesterolemia

for Familial Hypercholesterolaemia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: All ages

Code: NCT06743659·Recruiting·Listed Dec 2024

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Pilot Study to Identify the Mediators and Inflammatory Cell Surface Receptors Involved in Allergic Airway Inflammation

for Asthma

1 location in Boston

Sponsor: Benjamin Medoff

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT00595491·Phase 1·Recruiting·Listed Jan 2008

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Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

for Gout

Sites in Boston +6 more locations

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT04875702·Phase 4·Recruiting·Listed May 2021

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Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia

for Avoidant/Restrictive Food Intake Disorder

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05587127·Recruiting·Listed Oct 2022

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I Can Move With Purpose Now! A Pilot Lifestyle Intervention Study in Myeloproliferative Neoplasm Patients

for Myeloproliferative Disorders

3 locations in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05842603·Recruiting·Listed May 2023

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Maintenance Niraparib Plus Ipilimumab in Patients With Metastatic Pancreatic Adenocarcinoma Whose Disease Has Not Progressed on Platinum-Based Chemotherapy

for Pancreatic Adenocarcinoma Metastatic

Drug: Ipilimumab

Sites in Boston +1 more location

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT06747845·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Improving Spatial Perception and Speech Understanding in Multitalker Mixtures

for Hearing Loss

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05260307·Recruiting·Listed Mar 2022

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Feasibility Tests for Various Prism Configurations for Visual Field Loss

for Hemianopia, Homonymous

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 7 - 80

Code: NCT04424979·Recruiting·Listed Jun 2020

Apply to this trial