Paid Clinical Trials in California

California has 6,384 paid clinical trials enrolling now across cities including Los Angeles, San Francisco and San Diego. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in California include Stanford Medicine, UCLA Health and UCSF, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 30, 2026.

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5,295 clinical trials

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FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

for Metastatic Head and Neck Squamous Cell Carcinoma

Sites in Los Angeles, San Francisco +48 more locations

Sponsor: Bicara Therapeutics

Sex: All·Age: 18+

Code: NCT06788990·Phase 2, Phase 3·Recruiting·Listed Jan 2025

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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

for Viral Lung Infection and Acute Respiratory Failure

Sites in Newport Beach, Torrance +33 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05624450·Phase 3·Recruiting·Listed Nov 2022

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A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

for Lupus Erythematosus, Systemic

Sites in San Francisco, Stanford +11 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 70

Code: NCT06897930·Phase 1, Phase 2·Recruiting·Listed Mar 2025

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

Sites in San Diego, Santa Monica +51 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting·Listed Aug 2024

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A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

for Breast Cancer

Sites in San Francisco, Stanford +10 more locations

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT05307705·Phase 1·Recruiting·Listed Apr 2022

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

for Breast Cancer

Drug: Durvalumab

Sites in Sacramento, Glendale +34 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023

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A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

for B-cell Malignancies

Sites in La Jolla +8 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06542250·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

for Endometrial Cancer

Drug: Rilvegostomig

Sites in La Jolla, Duarte +43 more locations

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT06989112·Phase 3·Recruiting·Listed May 2025

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A Phase 1 Study of BHV-1530 in Advanced Solid Tumors

for Solid Tumor

Sites in Newport Beach +15 more locations

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18+

Code: NCT06874335·Phase 1·Recruiting·Listed Mar 2025

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Observational Study Protocol: LIVER-R

for Hepatobiliary Cancers

Sites in Los Angeles, Walnut Creek +22 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06252753·Recruiting·Listed Feb 2024

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Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT

for Ovarian Cancer

1 location in Orange

Sponsor: University of California, Irvine

Sex: Female·Age: 18+

Code: NCT04520139·Phase 1, Phase 2·Recruiting·Listed Aug 2020

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Fludarabine and Cyclophosphamide With or Without Rituximab Before CD19 Chimeric Antigen Receptor T Cells for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma

Drug: Rituximab

1 location in Sacramento

Sponsor: University of California, Davis

Sex: All·Age: 18+

Code: NCT05052528·Phase 1·Recruiting·Listed Sep 2021

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An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

for Systemic Lupus Erythematosus

Sites in Los Angeles +19 more locations

Sponsor: AstraZeneca

Sex: All·Age: 5 - 17

Code: NCT05835310·Phase 3·Recruiting·Listed Apr 2023

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A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

for Metastatic Colorectal Cancer

Sites in Los Angeles +10 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06792695·Phase 2·Recruiting·Listed Jan 2025

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A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

for Breast Cancer

Sites in Santa Monica, Santa Rosa +8 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05123482·Phase 1, Phase 2·Recruiting·Listed Nov 2021

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A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma

for Asthma

Sites in Bakersfield, Mission Viejo +16 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 12 - 17

Code: NCT05757102·Phase 3·Recruiting·Listed Mar 2023

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

Sites in Beverly Hills, Anaheim +47 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting·Listed Apr 2024

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in San Francisco, Walnut Creek +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06692738·Phase 3·Recruiting·Listed Nov 2024

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A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)

for Staphylococcus Aureus

Sites in Los Angeles, Glendale +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT06749457·Phase 1, Phase 2·Recruiting·Listed Dec 2024

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A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC

for Non-squamous Non-small Cell Lung Cancer

Drug: Rilvegostomig

Sites in San Francisco, San Diego +59 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06627647·Phase 3·Recruiting·Listed Oct 2024

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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma

for Asthma

Sites in San Diego, Orange +88 more locations

Sponsor: AstraZeneca

Sex: All·Age: 12 - 17

Code: NCT06307665·Phase 3·Recruiting·Listed Mar 2024

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Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

for Arthritis, Psoriatic

Sites in San Diego, La Jolla +36 more locations

Sponsor: MoonLake Immunotherapeutics AG

Sex: All·Age: 18+

Code: NCT06641089·Phase 3·Recruiting·Listed Oct 2024

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A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

for Non-small Cell Lung Cancer

Sites in Duarte, Santa Monica +12 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT05877599·Phase 1·Recruiting·Listed May 2023

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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

for Multiple Myeloma

Sites in Duarte, Irvine +6 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06106945·Phase 1, Phase 2·Recruiting·Listed Oct 2023

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A Study of AZD3470, a PRMT5 Inhibitor, Given as Monotherapy and in Combination in Patients With MTAP Deficient Advanced/Metastatic Solid Tumors

for Advanced Solid Tumors That Are MTAP Deficient

Sites in San Francisco +6 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06130553·Phase 1, Phase 2·Recruiting·Listed Nov 2023

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A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease

for Graves' Disease

Drug: IMVT-1402

Sites in Los Angeles, San Francisco +56 more locations

Sponsor: Immunovant Sciences GmbH

Sex: All·Age: 18 - 75

Code: NCT06727604·Phase 2·Recruiting·Listed Dec 2024

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A Study of Mocertatug Rezetecan in Combination With Anti-cancer Therapies for Advanced Solid Tumors (BEHOLD-2)

for Tumours, Gynecological

Sites in La Jolla +4 more locations

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06796907·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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A Phase 2 Study of CRD-4730 in CPVT

for Catecholaminergic Polymorphic Ventricular Tachycardia

Sites in San Francisco +4 more locations

Sponsor: Cardurion Pharmaceuticals, Inc.

Sex: All·Age: 18 - 99

Code: NCT06658899·Phase 2·Recruiting·Listed Oct 2024

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

Sites in San Francisco, Palo Alto +59 more locations

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting·Listed Jul 2024

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

Sites in Los Angeles, San Francisco +29 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting·Listed Jun 2024

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A Trial to Evaluate the Efficacy and Safety of Tralokinumab in Combination With Topical Corticosteroids in Children and Infants With Moderate-to-severe Atopic Dermatitis

for Atopic Dermatitis

Sites in San Diego, Palo Alto +12 more locations

Sponsor: LEO Pharma

Sex: All·Age: 6 Months - 11

Code: NCT06311682·Phase 3·Recruiting·Listed Mar 2024

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Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies

for Advanced Solid Malignancies

Sites in Los Angeles, San Francisco +6 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT05417594·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

for Clear Cell Renal Cell Carcinoma

Sites in San Diego, Santa Monica +18 more locations

Sponsor: Arcus Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05536141·Phase 1·Recruiting·Listed Sep 2022

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Study of Acalabrutinib and Rituximab in Untreated Elderly and/or Frail Patients With DLBCL

for Diffuse Large B-Cell Lymphoma

Drug: Rituximab

Sites in Orange +2 more locations

Sponsor: AstraZeneca

Sex: All·Age: 65 - 99

Code: NCT05952024·Phase 2·Recruiting·Listed Jul 2023

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Newport Beach, Torrance +61 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06883305·Phase 3·Recruiting·Listed Mar 2025

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Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

Sites in Los Angeles, Newport Beach +37 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting·Listed Apr 2024

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Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

for Locally Advanced (Inoperable) or Metastatic Breast Cancer

Sites in Los Angeles, San Francisco +30 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT04862663·Phase 3·Recruiting·Listed Apr 2021

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A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

for Chronic Obstructive Pulmonary Disease (COPD)

Sites in Los Angeles, San Diego +60 more locations

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06878261·Phase 3·Recruiting·Listed Mar 2025

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Dose-Ranging Safety, Tolerability, and Efficacy Study of AZD2373 in Participants With APOL1-Mediated Kidney Disease

for APOL1-Mediated Kidney Disease

Sites in Los Angeles, Beverly Hills +76 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 65

Code: NCT06824987·Phase 2·Recruiting·Listed Feb 2025

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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

for Heart Failure and Impaired Kidney Function

Drug: Dapagliflozin

Sites in Los Angeles, San Francisco +111 more locations

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06307652·Phase 3·Recruiting·Listed Mar 2024

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