Clinical Trials at Cleveland Clinic

As of July 2026, 345 paid clinical trials are recruiting at Cleveland Clinic, located at Cleveland Clinic Mellen Center, 1950 E 89th St U Bldg, Cleveland, OH 44195, phone (216) 444-8600 in Cleveland, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

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345 clinical trials at Cleveland Clinic

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HA35 Acute Alcohol Study

for Healthy Controls

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT05025865·EARLY_Phase 1·Recruiting

Apply to this trial

HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

for Cirrhosis, Liver

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 21 - 65

Code: NCT05166499·Recruiting

Apply to this trial

Robotic Versus Open Ventral Hernia Repair

for Ventral Hernia

4 locations incl. Gainesville

Sponsor: Lucas Beffa

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05472987·Recruiting

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Mesh Removal Versus No Mesh Removal for Chronic Groin Pain After Inguinal Hernia Repair

for Chronic Groin Pain

1 location in Cleveland

Sponsor: David Krpata

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05484635·Recruiting

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Uterine Manipulation During Minimally Invasive Surgery for Early Stage Endometrial Cancer

for ENDOMETRIAL CANCER

5 locations incl. Cleveland

Sponsor: Anthony Costales, MD

Sex: Female·Age: 18 - 90

Code: NCT04586959·Recruiting

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B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair

for Thoracic Aortic Aneurysm

1 location in Cleveland

Sponsor: Eric Roselli, M. D.

Sex: All·Age: 18+

Code: NCT04747626·Recruiting

Apply to this trial

Intracardiac Echocardiography Guided Watchman Device Implant

for Atrial Fibrillation

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06007872·Recruiting

Apply to this trial

Early Diagnosis of Pancreatic Cancer Duodenal Fluid-Based Biomarker Exploratory Study

for Pancreatic Cancers

2 locations incl. Aurora

Sponsor: Do Hyun Park

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT07030348·Recruiting

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Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

for Heart Failure and Reduced Ejection Fraction

5 locations incl. Minneapolis

Sponsor: Minneapolis Heart Institute Foundation

Sex: All·Age: 18+

Code: NCT07131631·Recruiting

Apply to this trial

A Cardiac Disease Quality of Life Study

for Hypertrophic Obstructive Cardiomyopathy

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18 - 70

Code: NCT04080492·Recruiting

Apply to this trial

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease

for Parkinson Disease

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07110376·Recruiting

Apply to this trial

Preventing Injured Knees From osteoArthritis: Severity Outcomes

for Osteoarthritis, Knee

9 locations incl. Atlanta

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45

Code: NCT06096259·Phase 2·Recruiting

Apply to this trial

Early Versus Late Adjunctive Vasopressin in Septic Shock

for Sepsis

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT06709573·Phase 4·Recruiting

Apply to this trial

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

for Barrett's Esophagus

10 locations incl. Baltimore

Sponsor: Case Western Reserve University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00288119·Recruiting

Apply to this trial

Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery

for Pituitary Tumor

2 locations incl. Phoenix

Sponsor: Lori Wood

Sex: All·Age: 19 - 85

Code: NCT05659524·Recruiting

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A Study of Sacituzumab Govitecan (IMMU-132) in Patients With Recurrent or Persistent Cervical Cancer

for Cervical Cancer

2 locations incl. New Haven

Sponsor: Yale University

Sex: Female·Age: 18+

Code: NCT05838521·Phase 2·Recruiting

Apply to this trial

The PIVATAL Study -Study of Ventricular Arrhythmia (VTA) Ablation in Left Ventricular Assist Device (LVAD) Patients

for Arrythmia

19 locations incl. Phoenix

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT05034432·Phase 4·Recruiting

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Preoperative Pelvic Floor Physical Therapy to Minimize Stress Urinary Incontinence After Holmium Laser Enucleation of the Prostate

for Benign Prostatic Hyperplasia With Outflow Obstruction

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: Male·Age: 18+

Code: NCT06179654·Recruiting

Apply to this trial

Vertebral Artery Origin Treatment Via Endovascular Techniques Registry (VOTER)

for Vertebral Artery Stenosis

10 locations incl. Jacksonville

Sponsor: St. Louis University

Sex: All·Age: 18 - 90

Code: NCT03999983·Recruiting

Apply to this trial

Safety and Durability of Sirolimus for Treatment of LAM

for Lymphangioleiomyomatosis

20 locations incl. Stanford

Sponsor: University of Cincinnati

Sex: Female·Age: 18+

Code: NCT02432560·Recruiting

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Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

for Heart Failure

1 location in Cleveland

Sponsor: NHS Greater Glasgow and Clyde

Sex: All·Age: 40+

Code: NCT05919342·Recruiting

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Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study

for Stage D Heart Failure

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT04191681·Phase 4·Recruiting

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Ultrasound-Guided Versus Standard Margin Selection in Ileocecal Resection of Terminal Ileal CD

for Crohn's Disease (CD)

1 location in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07680283·Recruiting·Listed Jul 2, 2026

Apply to this trial

EXACT Study: A Blinded Study in Patients With Alport Syndrome to Evaluate Exaluren Efficacy and Safety

for Alport Syndrome, X-Linked

8 locations incl. Los Angeles

Sponsor: Eloxx Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07523581·Phase 2·Recruiting

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A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

for Lymphoma, Non-Hodgkin

23 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07101328·Phase 1·Recruiting

Apply to this trial