Oncology Clinical Trials in Columbus, OH

As of June 2026, 323 paid clinical trials are recruiting for Oncology in Columbus, Ohio. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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323 clinical trials for Oncology

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Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for Solid Tumor, Adult

16 locations incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT04981119·Recruiting

Apply to this trial

Intralesional Influenza Vaccine for the Treatment of Stage I-IV Melanoma

for Clinical Stage I Cutaneous Melanoma AJCC v8

1 location in Columbus

Sponsor: Carlo Contreras

Sex: All·Age: 18 - 99

Code: NCT04697576·Phase 1·Recruiting

Apply to this trial

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

for Richter Syndrome

Drug: Polatuzumab Vedotin

4 locations incl. New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT04679012·Phase 2·Recruiting

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Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors

for Malignant Solid Neoplasm

843 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04871542·Recruiting

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Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

for Advanced Solid Tumor

6 locations incl. Santa Monica

Sponsor: Senhwa Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04890613·Phase 1·Recruiting

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Donor-Derived Ex-Vivo Expanded Natural Killer Cell Infusions in Children and Young Adults With High Risk Acute Myeloid Leukemia Receiving Myeloablative HLA-Haploidentical Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

13 locations incl. Phoenix

Sponsor: Michael Pulsipher

Sex: All·Age: 0 - 25

Code: NCT04836390·Phase 2·Enrolling By Invitation

Study of Oral Administration of LP-168 in Patients With Relapsed or Refractory B-cell Malignancies.

for CLL/SLL

4 locations incl. Durham

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 18+

Code: NCT04775745·Phase 1·Recruiting

Apply to this trial

ATEMPT 2.0: Adjuvant T-DM1 vs TH

for Breast Cancer

53 locations incl. San Francisco

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04893109·Phase 2·Recruiting

Apply to this trial

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

for HNSCC

4 locations incl. Baltimore

Sponsor: University Hospital Freiburg

Sex: All·Age: 65+

Code: NCT05337631·Recruiting

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Study of Carboplatin and Mirvetuximab Soravtansine in First-Line Treatment of Patients Receiving Neoadjuvant Chemotherapy With Advanced-Stage Ovarian, Fallopian Tube or Primary Peritoneal Cancer

for Ovarian Cancer

9 locations incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: Female·Age: 18+

Code: NCT04606914·Phase 2·Recruiting

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CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)

for Lymphoma, Non-Hodgkin

31 locations incl. Birmingham

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT04637763·Phase 1·Recruiting

Apply to this trial

An Internet-based Program to Help Cancer Survivors Manage Pain

for Cancer

149 locations incl. Fort Smith

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT04462302·Recruiting

Apply to this trial

Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Tremelimumab

30 locations incl. Orange

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03606967·Phase 2·Recruiting

Apply to this trial

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting

Apply to this trial

Evaluation of a Mixed Meal Test for Diagnosis and Characterization and Type 3c Diabetes Mellitus Secondary to Pancreatic Cancer and Chronic Pancreatitis (DETECT)

for Pancreatic Cancer

10 locations incl. Los Angeles

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 30 - 84

Code: NCT03460769·Recruiting

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

387 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting

Apply to this trial

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

621 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting

Apply to this trial

A Study of AZD0486 in Subjects With B-Cell Non-Hodgkin Lymphoma

for B-cell Non Hodgkin Lymphoma

10 locations incl. Tampa

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT04594642·Phase 1·Recruiting

Apply to this trial

DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE)

for Breast Cancer

19 locations incl. Tucson

Sponsor: Criterium, Inc.

Sex: All·Age: All ages

Code: NCT04567420·Phase 2·Recruiting

Apply to this trial

Vyxeos for Re-induction Treatment of Acute Myeloid Leukemia Patients With Persistent Disease After Induction

for Blasts More Than 5 Percent of Bone Marrow Nucleated Cells

2 locations incl. Sacramento

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18 - 75

Code: NCT04049539·Phase 1, Phase 2·Recruiting

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Acral Lentiginous Melanoma

Drug: Ipilimumab

331 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting

Apply to this trial

A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

for Advanced Solid Tumors

Drug: Cemiplimab

21 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04626635·Phase 1, Phase 2·Recruiting

Apply to this trial

A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

13 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting

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A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

38 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT04302025·Phase 2·Recruiting

Apply to this trial

Study of TL-895 in Subjects With Myelofibrosis or Indolent Systemic Mastocytosis

for Myelofibrosis

6 locations incl. Aurora

Sponsor: Telios Pharma, Inc.

Sex: All·Age: 18+

Code: NCT04655118·Phase 2·Recruiting

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Disposable Perfusion Phantom for Accurate DCE (Dynamic Contrast Enhanced)-MRI Measurement of Pancreatic Cancer Therapy Response

for Pancreatic Cancer

2 locations incl. Columbus

Sponsor: Ohio State University

Sex: All·Age: 19+

Code: NCT04588025·Recruiting

Apply to this trial

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

Drug: Apalutamide

342 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting

Apply to this trial

Pancreatic Cancer Early Detection Consortium

for Pancreas Cancer

45 locations incl. Phoenix

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04970056·Recruiting

Apply to this trial

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

539 locations incl. Birmingham

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting

Apply to this trial

A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies

for Myelodysplastic Syndrome

49 locations incl. Birmingham

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT04227847·Phase 1·Recruiting

Apply to this trial

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

185 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting

Apply to this trial

Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

for Breast Cancer

15 locations incl. Stamford

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04468061·Phase 2·Recruiting

Apply to this trial

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

for Cancer

41 locations incl. Tucson

Sponsor: Tizona Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04485013·Phase 1·Recruiting

Apply to this trial

CYTO Reductive Surgery in Kidney Cancer Plus Immunotherapy and Targeted Kinase Inhibition

for Kidney Cancer

4 locations incl. New Brunswick

Sponsor: Mark Stein

Sex: All·Age: 18+

Code: NCT04322955·Phase 2·Recruiting

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

1150 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting

Apply to this trial

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

for Myelodysplastic Syndromes

Drug: Venetoclax

24 locations incl. Los Angeles

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04256317·Phase 2, Phase 3·Recruiting

Apply to this trial

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

for Melanoma

Drug: Cemiplimab

23 locations incl. Phoenix

Sponsor: Vyriad, Inc.

Sex: All·Age: 18+

Code: NCT04291105·Phase 2·Recruiting

Apply to this trial

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

for Prostate Adenocarcinoma

Drug: Apalutamide

345 locations incl. Phoenix

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT04134260·Phase 3·Recruiting

Apply to this trial

Expanded/Activated Gamma Delta T-cell Infusion Following Hematopoietic Stem Cell Transplantation and Post-transplant Cyclophosphamide

for Acute Myeloid Leukemia

2 locations incl. Westwood

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 65

Code: NCT03533816·Phase 1·Recruiting

Apply to this trial

A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer

for Neoplasms

30 locations incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 1 - 39

Code: NCT05999994·Phase 2·Recruiting

Apply to this trial

Conditions in Oncology (Columbus, OH)

Non-small cell lung cancer (NSCLC)· 47 Solid tumor· 45 Breast cancer· 36 Acute myeloid leukemia (AML)· 25 Cancer (any)· 22 Ovarian cancer· 20 Chronic lymphocytic leukemia (CLL)· 17 Endometrial cancer· 16 Multiple myeloma· 15 Melanoma· 14 Colorectal cancer· 13 Prostate cancer· 13 Myelodysplastic syndromes (MDS)· 13 Non-Hodgkin lymphoma· 12 Hematologic malignancy· 12 Metastatic breast cancer· 11 Pancreatic cancer· 10 Glioma· 10 Leukemia (other)· 10 Follicular lymphoma· 10 Small lymphocytic lymphoma· 10 Head and neck cancer· 10 Lung cancer· 9 Diffuse large B-cell lymphoma (DLBCL)· 9 Mantle cell lymphoma· 9 Bladder cancer· 8 Glioblastoma· 8 Triple-negative breast cancer· 7 Gastric cancer· 7 Kidney cancer· 7 Neuroblastoma· 7 Metastatic prostate cancer· 6 Fallopian tube cancer· 6 Myelofibrosis· 6 Gastroesophageal junction cancer· 5 Biliary tract cancer· 5 Acute lymphoblastic leukemia· 5 Mesothelioma· 5 HER2-positive breast cancer· 4 Chronic myelomonocytic leukemia· 4 Marginal zone lymphoma· 4 Sarcoma· 4 HER2-negative breast cancer· 3 Esophageal cancer· 3 Liver cancer· 3 Hodgkin lymphoma· 3 Soft tissue sarcoma· 3 Small cell lung cancer· 2 Colon cancer· 2 Rectal cancer· 2 Cervical cancer· 2 Uterine cancer· 2 Brain cancer· 2 Brain metastases· 2 Myeloproliferative neoplasm· 2 Burkitt lymphoma· 2 Osteosarcoma· 2 Neuroendocrine tumors· 2 Skin cancer· 1 Ewing sarcoma· 1