Clinical Trials at University of Texas Southwestern Medical Center

As of July 2026, 163 paid clinical trials are recruiting at University of Texas Southwestern Medical Center, located at 5323 HARRY HINES BLVD, DALLAS, TX 75390, phone (214) 648-7833 in Dallas, Texas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

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164 clinical trials at University of Texas Southwestern Medical Center

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A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

for mCRPC (Metastatic Castration-resistant Prostate Cancer)

Sites in Dallas, Houston +16 more locations

Sponsor: Pathos AI, Inc.

Sex: Male·Age: 18+

Code: NCT06785636·Phase 1, Phase 2·Recruiting·Listed Jan 2025

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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

for Solid Tumor, Adult

Sites in Dallas, Houston +17 more locations

Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

Sex: All·Age: 18+

Code: NCT06625775·Phase 1·Recruiting·Listed Oct 2024

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A Study of TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

for Coagulation Disorder

Sites in Dallas +12 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT05156983·Phase 3·Recruiting·Listed Dec 2021

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A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

for Metastatic Castration-Resistant Prostate Cancer

Sites in Dallas, Houston +18 more locations

Sponsor: Kyntra Bio

Sex: Male·Age: 18+

Code: NCT06842498·Phase 2·Recruiting·Listed Feb 2025

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A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy

for Spinal Muscular Atrophy

Drug: Apitegromab

Sites in Dallas, Flower Mound +12 more locations

Sponsor: Scholar Rock, Inc.

Sex: All·Age: Up to 2

Code: NCT07047144·Phase 2·Recruiting·Listed Jul 2025

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A Study to Investigate Efficacy and Safety of Pegtibatinase Compared With Placebo in Participants ≥12 to ≤65 Years of Age With Classical Homocystinuria (HCU) Due to Cystathionine Beta Synthase Deficiency Receiving Standard of Care Treatment

for Homocystinuria

Sites in Dallas +12 more locations

Sponsor: Travere Therapeutics, Inc.

Sex: All·Age: 12 - 65

Code: NCT06247085·Phase 3·Recruiting·Listed Feb 2024

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Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

for Glioblastoma

Sites in Dallas +9 more locations

Sponsor: CarThera

Sex: All·Age: 18+

Code: NCT05902169·Phase 3·Recruiting·Listed Jun 2023

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A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

for Myelodysplastic Syndromes

Drug: Venetoclax

Sites in Dallas, Houston +20 more locations

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT04256317·Phase 2, Phase 3·Recruiting·Listed Feb 2020

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A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)

for Phenylketonuria (PKU)

Sites in Dallas +11 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT05813678·Recruiting·Listed Apr 2023

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Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

for Kidney Disease, End-Stage

Sites in Dallas, Houston +12 more locations

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT04634916·Recruiting·Listed Nov 2020

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Adoptive Cell Therapy Long-term Follow-up (LTFU) Study

for Neoplasms

Sites in Dallas, Houston +10 more locations

Sponsor: USWM CT, LLC

Sex: All·Age: All ages

Code: NCT03391778·Phase 1·Recruiting·Listed Jan 2018

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A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma

for Renal Cell Carcinoma

Sites in Dallas, Lubbock +18 more locations

Sponsor: HiberCell, Inc.

Sex: All·Age: 18+

Code: NCT06234605·Phase 1·Recruiting·Listed Jan 2024

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Study of Denikitug (GS-1811) Given Alone or With Zimberelimab in Adults With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Dallas, Houston +7 more locations

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT05007782·Phase 1·Recruiting·Listed Aug 2021

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A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

for Heart

Sites in Dallas, Tomball +19 more locations

Sponsor: Vasa Therapeutics

Sex: All·Age: 50+

Code: NCT07219511·Phase 1·Recruiting·Listed Oct 2025

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A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer

for Non-muscle-invasive Bladder Cancer

Sites in Dallas, Fort Worth +17 more locations

Sponsor: SURGE Therapeutics

Sex: All·Age: 18+

Code: NCT05710848·Phase 1, Phase 2·Recruiting·Listed Feb 2023

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First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

for PIK3CA Mutation

Sites in Dallas, Houston +21 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05216432·Phase 1·Recruiting·Listed Jan 2022

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CRISPR-Edited Allogeneic Anti-BCMA CAR-T Cell Therapy in Patients With Relapsed/Refractory Multiple Myeloma

for Relapsed/Refractory Multiple Myeloma

Sites in Dallas +15 more locations

Sponsor: Caribou Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05722418·Phase 1·Recruiting·Listed Feb 2023

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XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

for Heart Transplant

Sites in Dallas +13 more locations

Sponsor: XVIVO Perfusion

Sex: All·Age: 18+

Code: NCT06895070·Recruiting·Listed Mar 2025

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Study to Evaluate ARINA-1 in the Prevention of Bronchiolitis Obliterans Progression in Participants With Bilateral Lung Transplant

for Pre-Bronchiolitis Obliterans Syndrome

Sites in Dallas, Houston +16 more locations

Sponsor: Renovion, Inc.

Sex: All·Age: 18 - 75

Code: NCT05654922·Phase 3·Recruiting·Listed Dec 2022

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Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis

for Idiopathic Pulmonary Fibrosis (IPF)

Sites in Dallas, McKinney +10 more locations

Sponsor: InSilico Medicine Hong Kong Limited

Sex: All·Age: 40+

Code: NCT05975983·Phase 2·Recruiting·Listed Aug 2023

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Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia

for Achondroplasia

Drug: Vosoritide

Sites in Dallas, Houston +7 more locations

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: 2 - 17

Code: NCT07441876·Phase 2, Phase 3·Recruiting·Listed Mar 2026

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[18F]FPyQCP PET Imaging of Fibroblast Activation Protein in Selected Oncology Indications

for Colorectal Cancer

1 location in Dallas

Sponsor: Blue Earth Diagnostics

Sex: All·Age: 18 - 80

Code: NCT07432633·Phase 1, Phase 2·Recruiting·Listed Feb 2026

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Study of the Kinesin Oral Molecular Degrader BBI-940 in Subjects With Advanced or Metastatic Breast Cancer

for Breast Cancer

Sites in Dallas, Austin +6 more locations

Sponsor: Boundless Bio, Inc.

Sex: All·Age: 18+

Code: NCT07408089·Phase 1·Recruiting·Listed Feb 2026

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Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for Non Small Cell Lung Cancer (NSCLC)

Sites in Dallas +1 more location

Sponsor: Integro Theranostics

Sex: All·Age: 18+

Code: NCT07276789·Phase 2·Recruiting·Listed Dec 2025

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Radiation Free Study

for Aortic Aneurysm

Sites in Dallas +4 more locations

Sponsor: Philips Clinical & Medical Affairs Global

Sex: All·Age: 18+

Code: NCT06549348·Recruiting·Listed Aug 2024

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A Study to Investigate Multiple Sclerosis Relapse Prevention With mRNA-1195 Compared With Placebo in Participants Aged 18 to ≤55 Years

for Multiple Sclerosis

Sites in Dallas, Plano +4 more locations

Sponsor: ModernaTX, Inc.

Sex: All·Age: 18 - 55

Code: NCT06735248·Phase 2·Recruiting·Listed Dec 2024

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PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma

Sites in Dallas, Houston +4 more locations

Sponsor: PanTher Therapeutics

Sex: All·Age: 18+

Code: NCT06673017·Phase 1·Recruiting·Listed Nov 2024

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A Long-Term Study of JNT-517 in Participants With Phenylketonuria

for Phenylketonuria (PKU)

Sites in Dallas, Houston +6 more locations

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 4+

Code: NCT06628128·Phase 3·Recruiting·Listed Oct 2024

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Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

for Acquired Antithrombin Deficiency

Sites in Dallas +8 more locations

Sponsor: Octapharma

Sex: All·Age: 18 - 85

Code: NCT06096116·Phase 3·Recruiting·Listed Oct 2023

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Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.

for Hereditary Spastic Paraplegia Type 50

1 location in Dallas

Sponsor: Elpida Therapeutics SPC

Sex: All·Age: 4 Months - 72 Months

Code: NCT06692712·Phase 3·Recruiting·Listed Nov 2024

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ARTIDIS Nanomechanical Generated Measurements for Early Breast Lesions

for Breast Cancer

Sites in Dallas & Houston

Sponsor: ARTIDIS AG

Sex: All·Age: 18+

Code: NCT06085833·Recruiting·Listed Oct 2023

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A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications

for Movement Disorders

Sites in Dallas +3 more locations

Sponsor: InSightec

Sex: All·Age: 30 - 99

Code: NCT05539196·Recruiting·Listed Sep 2022

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Study of Inebilizumab in Pediatric Subjects With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

Drug: Inebilizumab

Sites in Dallas +3 more locations

Sponsor: Amgen

Sex: All·Age: 2 - 17

Code: NCT05549258·Phase 2·Recruiting·Listed Sep 2022

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A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Dallas, Houston +5 more locations

Sponsor: LigaChem Biosciences, Inc.

Sex: All·Age: 18+

Code: NCT05941507·Phase 1, Phase 2·Recruiting·Listed Jul 2023

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APVO436 Phase 1b/2 Study in Patients With Newly Diagnosed AML

for Acute Myeloid Leukemia (AML)

Sites in Dallas, Houston +5 more locations

Sponsor: Aptevo Therapeutics

Sex: All·Age: 18+

Code: NCT06634394·Phase 1·Recruiting·Listed Oct 2024

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A Study of AC676 for the Treatment of Relapsed/Refractory B-Cell Malignancies

for Relapsed/Refractory B-cell Malignancies

Sites in Dallas +7 more locations

Sponsor: Accutar Biotechnology Inc

Sex: All·Age: 18+

Code: NCT05780034·Phase 1·Recruiting·Listed Mar 2023

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Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Reduced Ejection Fraction

for Congestive Heart Failure

Sites in Dallas +4 more locations

Sponsor: Sardocor Corp.

Sex: All·Age: 18 - 80

Code: NCT04703842·Phase 1, Phase 2·Recruiting·Listed Jan 2021

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Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction

for Heart Failure, Diastolic

Sites in Dallas +1 more location

Sponsor: Sardocor Corp.

Sex: All·Age: 50+

Code: NCT06061549·Phase 1·Recruiting·Listed Sep 2023

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Imaging Acetadote Metabolism in Glioblastoma

for Glioblastoma

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT07387666·EARLY_Phase 1·Recruiting·Listed Feb 2026

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IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion

for Mild Autonomous Cortisol Secretion (MACS)

Drug: Semaglutide

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT07361874·Recruiting·Listed Jan 2026

Apply to this trial