Clinical Trials at Karmanos Cancer Institute

As of July 2026, 86 paid clinical trials are recruiting at Karmanos Cancer Institute, located at Karmanos Cancer Institute, 4100 John R St, Detroit, MI 48201, phone (800) 527-6266 in Detroit, Michigan. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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87 clinical trials at Karmanos Cancer Institute

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

Sites in Detroit +18 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting·Listed Oct 2021

Apply to this trial

A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases

for Muscular Diseases

Sites in Detroit +12 more locations

Sponsor: Arcellx, Inc.

Sex: All·Age: 18+

Code: NCT06626919·Phase 1·Recruiting·Listed Oct 2024

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A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation (ALLOHA-2)

for AML

Sites in Detroit +20 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05473910·Phase 1·Recruiting·Listed Jul 2022

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Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

Sites in Detroit +14 more locations

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting·Listed Aug 2023

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A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Detroit +12 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06859762·Phase 1·Recruiting·Listed Mar 2025

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Study of SGR-3515 In Participants With Advanced Solid Tumors.

for Advanced Solid Tumor

Sites in Detroit, Ann Arbor +11 more locations

Sponsor: Schrödinger, Inc.

Sex: All·Age: 18+

Code: NCT06463340·Phase 1·Recruiting·Listed Jun 2024

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A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Detroit +17 more locations

Sponsor: Marengo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05592626·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

Sites in Detroit +19 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021

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A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

Sites in Detroit +11 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting·Listed Oct 2020

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FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Detroit +13 more locations

Sponsor: Fate Therapeutics

Sex: All·Age: 18+

Code: NCT06241456·Phase 1·Recruiting·Listed Feb 2024

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Chiauranib for Advanced Solid Malignant Tumors and Relapsed/Refractory SCLC.

for Small Cell Lung Cancer

Sites in Detroit +10 more locations

Sponsor: Chipscreen Biosciences, Ltd.

Sex: All·Age: 18+

Code: NCT05271292·Phase 1, Phase 2·Recruiting·Listed Mar 2022

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A First-in-Human Study of MEN2501 in Participants With Platinum-Resistant Ovarian Cancer

for Platinum-resistant Ovarian Cancer

Sites in Detroit +6 more locations

Sponsor: Stemline Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT07226427·Phase 1·Recruiting·Listed Nov 2025

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First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, in Patients With Advanced or Metastatic Solid Tumors, Including Ovarian Cancer

for Advanced Solid Tumors

Sites in Detroit +5 more locations

Sponsor: Accent Therapeutics

Sex: All·Age: 18+

Code: NCT06799065·Phase 1·Recruiting·Listed Jan 2025

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A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

for Relapsed/Refractory Systemic Light Chain Amyloidosis

Drug: Linvoseltamab

Sites in Detroit +7 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06292780·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases

for Solid Tumor Malignancies

Sites in Detroit +5 more locations

Sponsor: A2A Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06136884·Phase 1·Recruiting·Listed Nov 2023

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PTM-101 in Pancreatic Ductal Adenocarcinoma (PDAC)

for Pancreatic Ductal Adenocarcinoma

Sites in Detroit +5 more locations

Sponsor: PanTher Therapeutics

Sex: All·Age: 18+

Code: NCT06673017·Phase 1·Recruiting·Listed Nov 2024

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Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

for Advanced Solid Tumors

Sites in Detroit +2 more locations

Sponsor: Acrotech Biopharma Inc.

Sex: All·Age: 18+

Code: NCT07036133·Phase 1·Recruiting·Listed Jun 2025

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Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations

for Metastatic Hepatocellular Carcinoma

Sites in Detroit +8 more locations

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06915753·Phase 1·Recruiting·Listed Apr 2025

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A Study to Evaluate the Safety and Efficacy of OPB-101 in Platinum-resistant Ovarian Cancer

for Ovarian Cancer Recurrent

Sites in Detroit +3 more locations

Sponsor: Outpace Bio, Inc.

Sex: Female·Age: 18+

Code: NCT07030907·Phase 1·Recruiting·Listed Jun 2025

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Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

Sites in Detroit +1 more location

Sponsor: Hanmi Pharmaceutical Company Limited

Sex: All·Age: 18+

Code: NCT06724016·Phase 1·Recruiting·Listed Dec 2024

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A Study to Assess the Efficacy of WSD0922-FU in Patients With C797S+ Advanced Non-small Cell Lung Cancer

for Non Small Cell Lung Cancer

Sites in Detroit +7 more locations

Sponsor: Wayshine Biopharm, Inc.

Sex: All·Age: 18+

Code: NCT06868485·Phase 2·Recruiting·Listed Mar 2025

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Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.

for Advanced Adenocarcinoma

Sites in Detroit +8 more locations

Sponsor: BioAtla, Inc.

Sex: All·Age: 18+

Code: NCT05808634·Phase 1·Recruiting·Listed Apr 2023

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BP1001-A in Patients With Advanced or Recurrent Solid Tumors

for Solid Tumor, Adult

Sites in Detroit +3 more locations

Sponsor: Bio-Path Holdings, Inc.

Sex: All·Age: 18+

Code: NCT04196257·Phase 1·Recruiting·Listed Dec 2019

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A Beta-only IL-2 ImmunoTherapY Study

for Advanced Solid Tumor

Sites in Detroit +4 more locations

Sponsor: Medicenna Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05086692·Phase 1, Phase 2·Recruiting·Listed Oct 2021

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Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors

for Female Breast Cancer

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 20 - 79

Code: NCT07436078·Recruiting·Listed Feb 2026

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Detroit, Ann Arbor +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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A Study of the TheraBionic P1 Device in Breast Cancer

for Breast Cancer Stage I

Sites in Detroit, Farmington Hills +6 more locations

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: Female·Age: 22+

Code: NCT07218432·Recruiting·Listed Oct 2025

Apply to this trial

Horizon Two: HR NDMM (MMRC-100)

for High Risk Newly Diagnosed Multiple Myeloma

Sites in Detroit +6 more locations

Sponsor: Multiple Myeloma Research Consortium

Sex: All·Age: 18+

Code: NCT07053436·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Detroit +34 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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Asciminib as Initial Therapy for Patients With Chronic Myeloid Leukemia in Chronic Phase

for Chronic Myeloid Leukemia, Chronic Phase

Sites in Detroit +7 more locations

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18+

Code: NCT05143840·Phase 2·Recruiting·Listed Dec 2021

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DapagliFLOzin in Renal AL Amyloidosis (FLORAL)

for Renal AL Amyloidosis

Drug: Dapagliflozin

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT06420167·Phase 2·Recruiting·Listed May 2024

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Dietary Reporting In The Amyloidoses

for Amyloidosis

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT05738005·Recruiting·Listed Feb 2023

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Iberdomide and Daratumumab as Maintenance Therapy After an Autologous Stem Cell Transplant for Multiple Myeloma

for Multiple Myeloma

Drug: Daratumumab

Sites in Detroit & Lansing

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT06107738·Phase 2·Recruiting·Listed Oct 2023

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TheraBionic P1 Device in Subjects With Advanced Hepatocellular Carcinoma

for Hepatocellular Carcinoma Recurrent

Sites in Detroit, Lapeer +4 more locations

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 22+

Code: NCT07118202·Recruiting·Listed Aug 2025

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Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

for Castration-Resistant Prostate Carcinoma

Drug: Ruxolitinib

Sites in Detroit, Ann Arbor +1 more location

Sponsor: University of Michigan Rogel Cancer Center

Sex: Male·Age: 18+

Code: NCT06616155·Phase 1, Phase 2·Recruiting·Listed Sep 2024

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A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

for AML (Acute Myelogenous Leukemia)

Sites in Detroit +12 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: 18 - 66

Code: NCT06859424·Phase 2·Recruiting·Listed Mar 2025

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Clinical Trial of Upfront Haploidentical or Unrelated Donor BMT to Restore Normal Hematopoiesis in Aplastic Anemia

for Severe Aplastic Anemia

Sites in Detroit +24 more locations

Sponsor: Medical College of Wisconsin

Sex: All·Age: 3 - 75

Code: NCT06517641·Phase 2·Recruiting·Listed Jul 2024

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First-in-human Study of Interferon-y PET Imaging to Assess Response to Immunotherapy

for Non Small Cell Lung Cancer

1 location in Detroit

Sponsor: Nerissa T. Viola

Sex: All·Age: 18+

Code: NCT06439914·Phase 1·Recruiting·Listed Jun 2024

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Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer

for Metastatic Colorectal Adenocarcinoma

Sites in Detroit, Macomb +7 more locations

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 22+

Code: NCT07130903·Phase 2·Recruiting·Listed Aug 2025

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F-Tryptophan PET/CT in Human Cancers

for Intracranial Glioma

1 location in Detroit

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 18+

Code: NCT05556473·Phase 1·Recruiting·Listed Sep 2022

Apply to this trial