Oncology Clinical Trials in Duarte, CA

As of July 2026, 263 paid clinical trials are recruiting for Oncology in Duarte, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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267 clinical trials for Oncology

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Evaluation of the Safety and Efficacy of Abenacianine (VGT-309) to Identify Cancer in Subjects Undergoing Surgery for Cancer in the Lung

for Lung Cancer

Sites in Duarte, Newport Beach +6 more locations

Sponsor: Vergent Bioscience, Inc.

Sex: All·Age: 18+

Code: NCT07499674·Phase 3·Recruiting·Listed Mar 2026

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Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

for Small Cell Lung Cancer

Sites in Duarte, Irvine +2 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07476287·Phase 2·Recruiting·Listed Mar 2026

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Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

for Solid Tumor

Drug: Givastomig

Sites in Duarte +2 more locations

Sponsor: I-Mab Biopharma US Limited

Sex: All·Age: 18+

Code: NCT07432295·Phase 2·Recruiting·Listed Feb 2026

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A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

for Multiple Myeloma

Sites in Duarte, Irvine +3 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07409246·Phase 1·Recruiting·Listed Feb 2026

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A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

for Colorectal Cancer

Sites in Duarte, Los Angeles +6 more locations

Sponsor: Cartography Biosciences

Sex: All·Age: 18+

Code: NCT07321106·Phase 1·Recruiting·Listed Jan 2026

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A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

for Advanced Breast Cancer

Sites in Duarte +8 more locations

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07318805·Phase 1·Recruiting·Listed Jan 2026

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A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis

for Secondary AML

Sites in Duarte & San Diego

Sponsor: Aspera Biomedicines, Inc.

Sex: All·Age: 18+

Code: NCT07250646·Phase 1·Recruiting·Listed Nov 2025

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A Study to Evaluate INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

for Solid Tumors

Sites in Duarte, La Jolla +6 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT07195916·Phase 1·Recruiting·Listed Sep 2025

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A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Drug: Osimertinib

Sites in Duarte, Irvine +13 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07155187·Phase 2, Phase 3·Recruiting·Listed Sep 2025

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A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for Advanced Solid Tumors

Sites in Duarte, Newport Beach +4 more locations

Sponsor: SEED Therapeutics, Inc.

Sex: All·Age: 16+

Code: NCT07197554·Phase 1·Recruiting·Listed Sep 2025

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A Study of BG-C477 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Duarte +8 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT06596473·Phase 1·Recruiting·Listed Sep 2024

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First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

Sites in Duarte, Huntington Beach +7 more locations

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for Urothelial Carcinoma Bladder

Sites in Duarte, Irvine +10 more locations

Sponsor: Aktis Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07020117·Phase 1·Recruiting·Listed Jun 2025

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GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC

for Hepatocellular Carcinoma

Sites in Duarte +4 more locations

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT04864054·Phase 1, Phase 2·Recruiting·Listed Apr 2021

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A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Duarte, Irvine +6 more locations

Sponsor: Vividion Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06004245·Phase 1·Recruiting·Listed Aug 2023

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A First-in-human Study to Learn About the Safety of BAY 3547926 and How Well it Works in Participants With Advanced Liver Cancer

for Hepatocellular Carcinoma

Sites in Duarte +1 more location

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06764316·Phase 1·Recruiting·Listed Jan 2025

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LYL273 for Patients With Relapsed or Refractory mCRC

for Colorectal Cancer

Sites in Duarte, San Francisco +2 more locations

Sponsor: Lyell Immunopharma, Inc.

Sex: All·Age: 18+

Code: NCT05319314·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Duarte, Los Angeles +7 more locations

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT05981703·Phase 1·Recruiting·Listed Aug 2023

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Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

for Prostate Cancer

Sites in Duarte, Irvine +1 more location

Sponsor: Varian, a Siemens Healthineers Company

Sex: Male·Age: 18+

Code: NCT05804318·Recruiting·Listed Apr 2023

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO7673396 in Participants With Advanced Solid Tumors Harboring Rat Sarcoma Viral Oncogene Homolog (RAS) Mutation(s)

for Neoplasms

Sites in Duarte +5 more locations

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06884618·Phase 1·Recruiting·Listed Mar 2025

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Study With [225Ac]Ac-FL-020 in mCRPC Participants

for Metastatic Castration-resistant Prostate Cancer

Sites in Duarte, Irvine +3 more locations

Sponsor: Full-Life Technologies UK Limited

Sex: Male·Age: 18+

Code: NCT06492122·Phase 1·Recruiting·Listed Jul 2024

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Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for B-cell Acute Lymphoblastic Leukemia

Sites in Duarte, Los Angeles +7 more locations

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 13 - 90

Code: NCT06533579·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Sites in Duarte +6 more locations

Sponsor: Debiopharm International SA

Sex: All·Age: 18+

Code: NCT06969430·Phase 1, Phase 2·Recruiting·Listed May 2025

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A Study of Carmustine With and Without Ethanol in Subjects With Lymphoma

for Lymphoma

Sites in Duarte +3 more locations

Sponsor: VIVUS LLC

Sex: All·Age: 18+

Code: NCT06915246·Phase 2·Recruiting·Listed Apr 2025

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A Study to Evaluate the Adverse Events, Efficacy, and Optimal Dose of Intravenous (IV) ABBV-400 in Combination With IV Fluorouracil, Leucovorin, and Budigalimab in Adult Participants With Locally Advanced Unresectable or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma

for Locally Advanced Unresectable or Metastatic Gastric Adenocarcinoma

Sites in Duarte, Santa Monica +6 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06628310·Phase 2·Recruiting·Listed Oct 2024

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Safety and Immunogenicity of Innocell Autologous Cellular Immunotherapy for Recurrent Epithelial Ovarian Cancer

for Ovarian Cancer

1 location in Duarte

Sponsor: PhotonPharma, Inc.

Sex: Female·Age: 18+

Code: NCT06366490·Phase 1·Recruiting·Listed Apr 2024

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A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

for Myelofibrosis

Drug: Selinexor

Sites in Duarte +6 more locations

Sponsor: Karyopharm Therapeutics Inc

Sex: All·Age: 18+

Code: NCT05980806·Phase 2·Recruiting·Listed Aug 2023

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BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)

for Advanced Malignancies

Sites in Duarte +2 more locations

Sponsor: BioInvent International AB

Sex: All·Age: 18+

Code: NCT04752826·Phase 1, Phase 2·Recruiting·Listed Feb 2021

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A Study of KK2269 in Adult Participants With Solid Tumors

for Advanced Solid Tumor

Sites in Duarte, Newport Beach +5 more locations

Sponsor: Kyowa Kirin Co., Ltd.

Sex: All·Age: 18+

Code: NCT06266299·Phase 1·Recruiting·Listed Feb 2024

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

Sites in Duarte, La Jolla +4 more locations

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

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A Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Participants With Myelofibrosis

for Myelofibrosis

Drug: Ruxolitinib

Sites in Duarte, Irvine +4 more locations

Sponsor: Geron Corporation

Sex: All·Age: 18+

Code: NCT05371964·Phase 1·Recruiting·Listed May 2022

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

for Myelodysplastic Syndromes

Sites in Duarte +2 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT04419649·Phase 2·Recruiting·Listed Jun 2020

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Safety and Preliminary Efficacy of MT-601 in Patients With Relapsed/Refractory Lymphoma

for Non-Hodgkin Lymphoma, Adult

Sites in Duarte +6 more locations

Sponsor: Marker Therapeutics, Inc.

Sex: All·Age: 18 - 100

Code: NCT05798897·Phase 1·Recruiting·Listed Apr 2023

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A Long Term Follow-up Study of TScan TCR-T Products

for AML

Sites in Duarte +1 more location

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18 - 110

Code: NCT06976736·Recruiting·Listed May 2025

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A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

Sites in Duarte +2 more locations

Sponsor: GluBio Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06146257·Phase 1·Recruiting·Listed Nov 2023

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A Study of ADRX-0405 in Subjects With Select Advanced Solid Tumors

for Solid Tumors

Sites in Duarte, Santa Monica +6 more locations

Sponsor: Adcentrx Therapeutics

Sex: All·Age: 18+

Code: NCT06710379·Phase 1·Recruiting·Listed Nov 2024

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CBM588 Capsules in Combination With Nivolumab and Ipilimumab for the Treatment of Advanced Stage Kidney Cancer

for Advanced Clear Cell Renal Cell Carcinoma

Drug: Ipilimumab

1 location in Duarte

Sponsor: Osel, Inc.

Sex: All·Age: 18+

Code: NCT06399419·Phase 1·Recruiting·Listed May 2024

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A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

for Acute Leukemia

Sites in Duarte +8 more locations

Sponsor: Ossium Health, Inc.

Sex: All·Age: 18 - 75

Code: NCT05589896·Phase 1, Phase 2·Recruiting·Listed Oct 2022

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Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System

for Cancer

Sites in Duarte, Palo Alto +3 more locations

Sponsor: RefleXion Medical

Sex: All·Age: All ages

Code: NCT05406167·Recruiting·Listed Jun 2022

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64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

for Metastatic Sarcoma

Sites in Duarte, Orange +3 more locations

Sponsor: Lantheus Medical Imaging

Sex: All·Age: 15+

Code: NCT06298916·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Conditions in Oncology (Duarte, CA)

Solid tumor· 45 Acute myeloid leukemia (AML)· 30 Non-small cell lung cancer (NSCLC)· 27 Myelodysplastic syndromes (MDS)· 25 Hematologic malignancy· 23 Breast cancer· 22 Prostate cancer· 19 Colorectal cancer· 17 Pancreatic cancer· 15 Ovarian cancer· 15 Esophageal cancer· 14 Non-Hodgkin lymphoma· 14 Cancer (any)· 14 Metastatic breast cancer· 13 Multiple myeloma· 13 Gastric cancer· 12 Acute lymphoblastic leukemia· 11 Head and neck cancer· 11 Endometrial cancer· 10 Leukemia (other)· 10 Diffuse large B-cell lymphoma (DLBCL)· 10 Bladder cancer· 9 Myelofibrosis· 9 Lung cancer· 8 Gastroesophageal junction cancer· 7 Kidney cancer· 7 Chronic lymphocytic leukemia (CLL)· 7 Hodgkin lymphoma· 7 Mantle cell lymphoma· 7 Melanoma· 7 Liver cancer· 6 Biliary tract cancer· 6 Cervical cancer· 6 Triple-negative breast cancer· 5 Myeloproliferative neoplasm· 5 Small lymphocytic lymphoma· 5 Metastatic prostate cancer· 4 Follicular lymphoma· 4 Marginal zone lymphoma· 4 Sarcoma· 4 Metastatic colorectal cancer· 3 Colon cancer· 3 Fallopian tube cancer· 3 Glioblastoma· 3 Neuroendocrine tumors· 3 Small cell lung cancer· 2 Chronic myelomonocytic leukemia· 2 Thyroid cancer· 2 Osteosarcoma· 2 Ewing sarcoma· 2 HER2-positive breast cancer· 1 HER2-negative breast cancer· 1 Brain cancer· 1 Brain metastases· 1 Burkitt lymphoma· 1 Neuroblastoma· 1