Oncology Clinical Trials in Duarte, CA

As of July 2026, 263 paid clinical trials are recruiting for Oncology in Duarte, California. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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267 clinical trials for Oncology

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This is a Study to Evaluate the Safety and Tolerability of ABL503, and to Determine the Maximum Tolerated Dose (MTD) and Recommended Phase 2 Dose (RP2D) of ABL503 in Subjects with Any Progressive Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Duarte, Los Angeles +3 more locations

Sponsor: ABL Bio, Inc.

Sex: All·Age: 18+

Code: NCT04762641·Phase 1·Recruiting·Listed Feb 2021

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Study of REM-422 in Patients With AML or Higher Risk MDS

for Myelodysplastic Syndromes

Sites in Duarte +4 more locations

Sponsor: Remix Therapeutics

Sex: All·Age: 18+

Code: NCT06297941·Phase 1·Recruiting·Listed Mar 2024

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A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

for Advanced Cancer

Sites in Duarte +2 more locations

Sponsor: Proviva Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06190886·Phase 1·Recruiting·Listed Jan 2024

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Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

for Hematologic Malignancy

Sites in Duarte +4 more locations

Sponsor: Tr1X, Inc.

Sex: All·Age: 18+

Code: NCT06462365·Phase 1·Recruiting·Listed Jun 2024

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Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer

for Colorectal Neoplasms

Sites in Duarte, La Jolla +4 more locations

Sponsor: Surgimab

Sex: All·Age: 18+

Code: NCT03659448·Phase 3·Recruiting·Listed Sep 2018

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A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Sites in Duarte +2 more locations

Sponsor: Edgewood Oncology Inc.

Sex: All·Age: 18+

Code: NCT04243785·Phase 1·Recruiting·Listed Jan 2020

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Autologous huMNC2-CAR44 or huMNC2-CAR22 T Cells for Breast Cancer Targeting Cleaved Form of MUC1 (MUC1*)

for Metastatic Breast Cancer

1 location in Duarte

Sponsor: Minerva Biotechnologies Corporation

Sex: All·Age: 18+

Code: NCT04020575·Phase 1·Recruiting·Listed Jul 2019

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Alternative Splicing Based Prediction of Chemotherapy Response in Gastric Cancer

for Gastric Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07587229·Recruiting·Listed May 2026

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A Study of Revumenib and Mezigdomide in People With Leukemia

for Leukemia

Drug: Mezigdomide

Sites in Duarte +9 more locations

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 12+

Code: NCT07356154·Phase 1, Phase 2·Recruiting·Listed Jan 2026

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An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer

for Colon Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07255729·Recruiting·Listed Dec 2025

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Detection of Minimal Residual Disease Using Exosomal miRNA Distant Metastasis Markers

for Gastric Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07243015·Recruiting·Listed Nov 2025

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

Sites in Duarte, South Pasadena +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT07226115·Recruiting·Listed Nov 2025

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A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer

for Hepatocellular Carcinoma (HCC)

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07224750·Recruiting·Listed Nov 2025

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Liquid Biopsy for Early Detection of Colorectal Cancer Using Circular RNA

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07224789·Recruiting·Listed Nov 2025

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

Sites in Duarte, Baldwin Park +306 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020

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Oral Cryotherapy to Decrease Taste Changes in Prostate Cancer Patients Receiving Taxane Chemotherapy

for Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT07218718·Recruiting·Listed Oct 2025

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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

Drug: Apalutamide

Sites in Duarte, South Pasadena +276 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020

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L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance

for Hematopoietic and Lymphatic System Neoplasm

Sites in Duarte, Huntington Beach & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07220447·EARLY_Phase 1·Recruiting·Listed Oct 2025

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Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Duarte, South Pasadena +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

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Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Duarte, Downey +186 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

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Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

for Non-small Cell Lung Cancer

Sites in Duarte, Irvine +69 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06686771·Phase 3·Recruiting·Listed Nov 2024

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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Duarte, Glendale +111 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

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A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Duarte, Downey +169 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Duarte, Downey +151 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

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Molecular Genetics Studies of Cancer Patients and Their Relatives

for Malignant Neoplasm

Sites in Duarte, Fullerton +33 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04185935·Recruiting·Listed Dec 2019

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A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant

for Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07020533·Phase 1·Recruiting·Listed Jun 2025

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Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for Metastatic Malignant Solid Neoplasm

Sites in Duarte, Los Angeles +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687110·Phase 1·Recruiting·Listed Jan 2023

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Childhood Cancer Survivor Study

for Cancer

Sites in Duarte, Orange +25 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01120353·Recruiting·Listed May 2010

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Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

for Advanced Malignant Solid Neoplasm

Sites in Duarte, Irvine +21 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05327010·Phase 2·Recruiting·Listed Apr 2022

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Duarte, Downey +231 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

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A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

Sites in Duarte, West Covina +9 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting·Listed Nov 2025

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A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

for Ovarian Carcinoma

Sites in Duarte, Pasadena +471 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 35 - 50

Code: NCT04251052·Recruiting·Listed Jan 2020

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Biomarker-Guided Ruxolitinib for the Prevention of Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation

for Hematopoietic and Lymphatic System Neoplasm

Drug: Ruxolitinib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07025538·Phase 1·Recruiting·Listed Jun 2025

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Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

for Chronic Lymphocytic Leukemia

Drug: Epcoritamab

Sites in Duarte, Long Beach +5 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07218510·Phase 2·Recruiting·Listed Oct 2025

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in Duarte, South Pasadena +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

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I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

for Breast Neoplasms

Sites in Duarte, Los Angeles +31 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: All·Age: 18+

Code: NCT01042379·Phase 2·Recruiting·Listed Jan 2010

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Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT06996119·Phase 1·Recruiting·Listed May 2025

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Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte, Riverside & La Jolla

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT06763328·Phase 3·Recruiting·Listed Jan 2025

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in Duarte, Irvine +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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Conditions in Oncology (Duarte, CA)

Solid tumor· 45 Acute myeloid leukemia (AML)· 30 Non-small cell lung cancer (NSCLC)· 27 Myelodysplastic syndromes (MDS)· 25 Hematologic malignancy· 23 Breast cancer· 22 Prostate cancer· 19 Colorectal cancer· 17 Pancreatic cancer· 15 Ovarian cancer· 15 Esophageal cancer· 14 Non-Hodgkin lymphoma· 14 Cancer (any)· 14 Metastatic breast cancer· 13 Multiple myeloma· 13 Gastric cancer· 12 Acute lymphoblastic leukemia· 11 Head and neck cancer· 11 Endometrial cancer· 10 Leukemia (other)· 10 Diffuse large B-cell lymphoma (DLBCL)· 10 Bladder cancer· 9 Myelofibrosis· 9 Lung cancer· 8 Gastroesophageal junction cancer· 7 Kidney cancer· 7 Chronic lymphocytic leukemia (CLL)· 7 Hodgkin lymphoma· 7 Mantle cell lymphoma· 7 Melanoma· 7 Liver cancer· 6 Biliary tract cancer· 6 Cervical cancer· 6 Triple-negative breast cancer· 5 Myeloproliferative neoplasm· 5 Small lymphocytic lymphoma· 5 Metastatic prostate cancer· 4 Follicular lymphoma· 4 Marginal zone lymphoma· 4 Sarcoma· 4 Metastatic colorectal cancer· 3 Colon cancer· 3 Fallopian tube cancer· 3 Glioblastoma· 3 Neuroendocrine tumors· 3 Small cell lung cancer· 2 Chronic myelomonocytic leukemia· 2 Thyroid cancer· 2 Osteosarcoma· 2 Ewing sarcoma· 2 HER2-positive breast cancer· 1 HER2-negative breast cancer· 1 Brain cancer· 1 Brain metastases· 1 Burkitt lymphoma· 1 Neuroblastoma· 1