Clinical Trials at City of Hope Comprehensive Cancer Center

As of August 2026, 82 paid clinical trials are recruiting at City of Hope Comprehensive Cancer Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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83 clinical trials at City of Hope Comprehensive Cancer Center

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Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

for Astrocytoma, IDH-Mutant, Grade 2

Sites in Duarte, Orange +32 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06860594·Phase 1·Recruiting·Listed Mar 2025

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Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

Sites in Duarte, Irvine +38 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06287775·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

for Metastatic Malignant Solid Neoplasm

Sites in Duarte, Los Angeles +16 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687110·Phase 1·Recruiting·Listed Jan 2023

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A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma

for Cardiovascular Disorder

Sites in Duarte, Madera +33 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 7+

Code: NCT05705531·Recruiting·Listed Jan 2023

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Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

for Lung Adenocarcinoma

Sites in Duarte, South Pasadena +28 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05198830·Phase 2·Recruiting·Listed Jan 2022

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Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

for Locally Advanced Pancreatic Adenocarcinoma

Drug: Peposertib

Sites in Duarte, Orange +26 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04172532·Phase 1, Phase 2·Recruiting·Listed Nov 2019

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Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients

for Resectable Colorectal Carcinoma

Sites in Duarte, South Pasadena +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07125729·Recruiting·Listed Aug 2025

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

Sites in Duarte, La Jolla +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting·Listed Jun 2022

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Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

for Recurrent Hairy Cell Leukemia

Drug: Venetoclax

Sites in Duarte, Irvine +17 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311227·Phase 2·Recruiting·Listed Mar 2024

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Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

for Metastatic Urothelial Carcinoma

Sites in Duarte, Orange +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06439836·Phase 1·Recruiting·Listed Jun 2024

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in Duarte, Baldwin Park +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

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Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

for Recurrent Mantle Cell Lymphoma

Drug: Glofitamab

Sites in Duarte +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07003295·Phase 2·Recruiting·Listed Jun 2025

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

Sites in Duarte, Orange +95 more locations

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting·Listed Jul 2019

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

Drug: Mirdametinib

Sites in Duarte, Irvine +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting·Listed Jul 2025

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SPECT-CT Guided ELEctive Contralateral Neck Treatment for Patients With Lateralized Oropharyngeal Cancer

for Oropharyngeal Cancer

Sites in Duarte, Corona +21 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT05451004·Phase 3·Recruiting·Listed Jul 2022

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Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

for AIDS-Related Diffuse Large B-cell Lymphoma

Sites in Duarte +6 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05077527·Phase 1·Recruiting·Listed Oct 2021

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Comparing the Effectiveness of the Immunotherapy Agents Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma, NORM Trial

for Nodular Lymphocyte Predominant B-Cell Lymphoma

Drug: Mosunetuzumab

Sites in Duarte +32 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05886036·Phase 2·Recruiting·Listed Jun 2023

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Remdesivir for the Treatment of Upper Respiratory Tract Infection Due to RSV in Immunocompromised Individuals

for Hematopoietic and Lymphatic System Neoplasm

Sites in Duarte +2 more locations

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT06817889·Phase 2·Recruiting·Listed Feb 2025

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Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte, Pasadena +5 more locations

Sponsor: Jonsson Comprehensive Cancer Center

Sex: Female·Age: All ages

Code: NCT05595499·Phase 2·Recruiting·Listed Oct 2022

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Testing the Safety and Effectiveness of Radiation-based Treatment (Lutetium Lu 177 Dotatate) for Metastatic Prostate Cancer That Has Neuroendocrine Cells

for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation

Sites in Duarte, Los Angeles +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Male·Age: 18+

Code: NCT05691465·Phase 2·Recruiting·Listed Jan 2023

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Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in Duarte, Irvine +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

for Breast Atypical Hyperplasia

Sites in Duarte +3 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 35+

Code: NCT05941520·Phase 2·Recruiting·Listed Jul 2023

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Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

Sites in Duarte, Palo Alto +20 more locations

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting·Listed May 2023

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in Duarte, South Pasadena +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

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Testing the Combination of Anti-cancer Drugs Mosunetuzumab, Polatuzumab Vedotin, and Lenalidomide for the Treatment of Relapsed/Refractory Diffuse Large B-Cell Lymphoma

for Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Drug: Polatuzumab Vedotin

Sites in Duarte, Sacramento +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06015880·Phase 1·Recruiting·Listed Aug 2023

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

Sites in Duarte, Orange +114 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting·Listed Sep 2023

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte, Baldwin Park +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma

for Recurrent B-Cell Non-Hodgkin Lymphoma

Drug: Nivolumab

Sites in Duarte, Sacramento +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05272384·Phase 1·Recruiting·Listed Mar 2022

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Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

for Prostate Adenocarcinoma

Sites in Duarte, Burbank +130 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT05806515·Phase 2·Recruiting·Listed Apr 2023

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Duarte, Downey +74 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

for Cardiotoxicity

Sites in Duarte, South Pasadena +142 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03418961·Phase 3·Recruiting·Listed Feb 2018

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The da Vinci Single Port Robotic System for Use in Abdominal and Pelvic Surgical Procedures

for Disease or Disorder

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672368·Phase 2·Recruiting·Listed Jan 2023

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MAGIC Ruxolitinib for aGVHD

for Acute Graft-versus-host Disease

Drug: Ruxolitinib

Sites in Duarte +13 more locations

Sponsor: John Levine

Sex: All·Age: 18+

Code: NCT06936566·Phase 2·Recruiting·Listed Apr 2025

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

Sites in Duarte, Pasadena +338 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting·Listed Aug 2020

Apply to this trial

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

Sites in Duarte, Los Angeles +292 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting·Listed Sep 2018

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Study Adding Drugs to Usual Treatment for Large B-Cell Lymphoma That Returned or Did Not Respond to Treatment

for Grade 3b Follicular Lymphoma

Sites in Duarte, South Pasadena +97 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05890352·Phase 2·Recruiting·Listed Jun 2023

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Effects of Dexrazoxane Hydrochloride on Biomarkers Associated With Cardiomyopathy and Heart Failure After Cancer Treatment

for Hodgkin Lymphoma in Remission

Sites in Duarte, San Diego +54 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT01790152·Recruiting·Listed Feb 2013

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Modified Immune Cells (CD19 CAR T Cells) and Acalabrutinib for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

for Recurrent Mantle Cell Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT04484012·Phase 2·Recruiting·Listed Jul 2020

Apply to this trial

Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

for Metastatic Pancreatic Adenocarcinoma

Sites in Duarte, Arcadia +20 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06524973·Recruiting·Listed Jul 2024

Apply to this trial

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

Sites in Duarte, Orange +112 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting·Listed Mar 2020

Apply to this trial