Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Testing the Addition of Paclitaxel Administered Into the Abdominal Cavity Combined With Chemotherapy for Patients With Gastric Cancer Spread to the Abdominal Cavity

for Gastric Adenocarcinoma

55 locations incl. Irvine

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT07001748·Phase 2, Phase 3·Recruiting

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Point of Care Lung Ultrasound Examination in Patients With Shortness of Breath

for Lung Disease

3 locations incl. New Haven

Sponsor: GE Healthcare

Sex: All·Age: 22+

Code: NCT07046234·Enrolling By Invitation

The Impact of a Podcast-based Body Image Intervention Among Millennial Women

for Body Image

1 location in Chicago

Sponsor: University of the West of England

Sex: Female·Age: 29 - 44·Accepts healthy volunteers

Code: NCT07113678·Recruiting

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Transcutaneous Electrical Stimulation for Stroke Patients

for Upper Limb Hemiparesis Following Stroke

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT06950593·Recruiting

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A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

for Small-cell Lung Cancer

Drug: Durvalumab

44 locations incl. Casa Grande

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07005128·Phase 3·Recruiting

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COPD Resources, Education, and Activity Designed for You Study

for COPD

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40+

Code: NCT07125053·Recruiting

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Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

for Acute Myeloid Leukemia

22 locations incl. New Haven

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06484062·Phase 1·Recruiting

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Cemiplimab for the Treatment of Incurable Metastatic or Unresectable NUT Carcinoma

for Metastatic NUT Carcinoma

Drug: Cemiplimab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07050186·Phase 2·Recruiting

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FIBERGRAFT Aeridyan Posterolateral Fusion Study

for Degenerative Spine Disease

8 locations incl. Sacramento

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 18+

Code: NCT07059065·Recruiting

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Aging and Task-specific Training to Reduce Falls

for Fall Prevention

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 60 - 90·Accepts healthy volunteers

Code: NCT07094659·Phase 1, Phase 2·Recruiting

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Brain-Computer Interface Visualization Training to Optimize Muscle Activation Following Orthopaedic Surgery

for Anterior Cruciate Ligament Reconstruction

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07020312·Phase 2·Recruiting

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A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

for Epileptic Encephalopathy

6 locations incl. San Diego

Sponsor: Praxis Precision Medicines

Sex: All·Age: 1 Day - 18

Code: NCT07019922·Phase 3·Recruiting

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Abbott Cephea Mitral Valve Disease Registry

for Mitral Regurgitation

22 locations incl. Phoenix

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT07069673·Recruiting

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The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

for Sickle Cell Disease

14 locations incl. Birmingham

Sponsor: Sanofi

Sex: All·Age: 10 - 65

Code: NCT06975865·Phase 3·Recruiting

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A Study to Test the Safety and Tolerability of SBO-154 in Patients With Advanced Solid Tumors.

for Advanced Solid Tumors

5 locations incl. Scottsdale

Sponsor: Sun Pharma Advanced Research Company Limited

Sex: All·Age: 18+

Code: NCT07042100·Phase 1·Recruiting

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Long-Term Outcomes of Early Communication Intervention for Deaf/Hard of Hearing Toddlers

for Hearing Loss, Bilateral

1 location in Evanston

Sponsor: Northwestern University

Sex: All·Age: 5 - 8

Code: NCT07205484·Phase 2·Enrolling By Invitation

A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

6 locations incl. Duarte

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting

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Real-world Experience on Using Nemolizumab in the Treatment of Moderate-to- Severe Prurigo Nodularis in Adults

for Prurigo Nodularis

Drug: Nemolizumab

39 locations incl. Birmingham

Sponsor: Galderma R&D

Sex: All·Age: 18+

Code: NCT06988618·Recruiting

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A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes

for Diabetes Mellitus, Type 1

109 locations incl. Cullman

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07076199·Phase 3·Recruiting

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Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design

for Alcohol Drinking

2 locations incl. Champaign

Sponsor: University of Illinois at Urbana-Champaign

Sex: All·Age: 21 - 30·Accepts healthy volunteers

Code: NCT07125534·Recruiting

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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)

for Bipolar Disorder

28 locations incl. Tucson

Sponsor: Xenon Pharmaceuticals Inc.

Sex: All·Age: 18 - 74

Code: NCT07172516·Phase 3·Recruiting

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A Study to Assess Efficacy and Safety of Baxdrostat in Participants With Primary Aldosteronism

for Primary Hyperaldosteronism

Drug: Baxdrostat

21 locations incl. Los Angeles

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT07007793·Phase 3·Recruiting

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A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

for Prostate Cancer

Drug: Saruparib

42 locations incl. Phoenix

Sponsor: AstraZeneca

Sex: Male·Age: 18+

Code: NCT06952803·Phase 3·Recruiting

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Effects of Dihydroberberine (DHB) on GLP-1, Glycemic Control, Appetite, and Mood in Adults With Pre-Diabetes

for Prediabetes

1 location in Addison

Sponsor: Nanjing Nutrabuilding Bio-tech Co., Ltd.

Sex: All·Age: 35 - 65

Code: NCT07210684·Recruiting

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FiberLocker® System Augmentation of Rotator Cuff Repairs

for Rotator Cuff Tear

4 locations incl. Chicago

Sponsor: ZuriMED Technologies Inc.

Sex: All·Age: 30 - 70

Code: NCT06918041·Recruiting

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A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

for Breast Cancer

102 locations incl. Chandler

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07062965·Phase 3·Recruiting

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The Effect Cranberry-Based Products on the Female Microbiome

for Vaginal Microbiome

1 location in Chicago

Sponsor: Ocean Spray Cranberries, Inc.

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07109713·Recruiting

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Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Adolescents With Severe Alopecia Areata

for Alopecia Areata

54 locations incl. Birmingham

Sponsor: Sun Pharmaceutical Industries, Inc.

Sex: All·Age: 12 - 17

Code: NCT07133308·Phase 3·Recruiting

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Improving Mobility After Revascularization in Peripheral Artery Disease

for Peripheral Artery Disease

7 locations incl. Tucson

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06686121·Phase 3·Recruiting

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Faricimab + PRP vs. Vitrectomy + Endolaser for Treatment of PDR

for Proliferative Diabetic Retinopathy (PDR)

28 locations incl. Huntington Beach

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT06790784·Phase 3·Recruiting

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The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial

for Liver Diseases

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06871111·Phase 1·Recruiting

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A Study of Dotinurad Versus Allopurinol in Tophaceous Gout

for Tophaceous Gout

Drug: Dotinurad

86 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089888·Phase 3·Recruiting

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Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting

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Biomarkers for Cognitive Decline in Intracerebral Hemorrhage

for Primary Intracerebral Hemorrhage

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 80

Code: NCT06836141·Recruiting

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A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy)

for Dry Age-related Macular Degeneration

5 locations incl. Beverly Hills

Sponsor: Regenerative Patch Technologies, LLC

Sex: All·Age: 55 - 90

Code: NCT06557460·Phase 2·Recruiting

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Efficacy of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

for Persistent Corneal Epithelial Defect

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06919081·Phase 2·Recruiting

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Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

for Endometrial Cancer

68 locations incl. Tucson

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07044336·Phase 3·Recruiting

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A Study of Dotinurad Versus Allopurinol in Participants With Gout

for Gout

Drug: Dotinurad

80 locations incl. Birmingham

Sponsor: Crystalys Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07089875·Phase 3·Recruiting

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Combination iSTAT/Alinity and IR Oculography for Head CT Necessity and Recovery Prediction After mTBI

for Blood

1 location in North Chicago

Sponsor: Captain James A. Lovell Federal Health Care Center

Sex: All·Age: 18 - 85

Code: NCT07094230·Not Yet Recruiting

Standardized Application of Feeding Evaluations Using SMART Tool

for Infant and Young Child Feeding

14 locations incl. Barrington

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: Up to 1

Code: NCT07136610·Recruiting

Apply to this trial