Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,519 clinical trials

Get a weekly email when new trials open in Chicago, IL.

Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer

for Non Small Cell Lung Cancer

Sites in Elk Grove Village +8 more locations

Sponsor: N-Power Medicine

Sex: All·Age: 18+

Code: NCT07028489·Recruiting·Listed Jun 2025

Apply to this trial

Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding

for Acute Gastrointestinal Bleeding

Sites in Chicago +5 more locations

Sponsor: Medtronic - MITG

Sex: All·Age: 22+

Code: NCT06188585·Recruiting·Listed Jan 2024

Apply to this trial

An Outpatient Study of the Efficacy of ARS-2 in Patients With Chronic Spontaneous Urticaria

for Urticaria Chronic

Sites in Glenview +1 more location

Sponsor: ARS Pharmaceuticals, Inc.

Sex: All·Age: 18 - 65

Code: NCT06927999·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

A Study to Assess the Adverse Events and How Oral Emraclidine Moves Through the Body of Healthy Elderly Adult Participants

for Healthy Volunteer

Sites in Grayslake +3 more locations

Sponsor: AbbVie

Sex: All·Age: 65 - 85·Accepts healthy volunteers

Code: NCT07219030·Phase 1·Recruiting·Listed Oct 2025

Apply to this trial

A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4

for Congenital Myasthenic Syndrome

Sites in Chicago, O'Fallon +4 more locations

Sponsor: argenx

Sex: All·Age: 2+

Code: NCT06078553·Recruiting·Listed Oct 2023

Apply to this trial

A Study to Compare the Efficacy and Safety of TachoSil and Surgicel Original as an Adjunct to Control Mild to Moderate Soft Tissue Bleeding During Surgery

for Hemorrhage

Sites in Chicago +8 more locations

Sponsor: Corza Medical GmbH

Sex: All·Age: 1 Month+

Code: NCT06664775·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

for Knee Osteoarthritis

Sites in Chicago +7 more locations

Sponsor: Doron Therapeutics Inc.

Sex: All·Age: 40 - 80

Code: NCT07219771·Phase 3·Recruiting·Listed Oct 2025

Apply to this trial

A Multi Center Study Testing a New Implant for Adults With Severe Emphysema

for Emphysema or COPD

Sites in Chicago +2 more locations

Sponsor: Pulmair Medical, Inc.

Sex: All·Age: 22+

Code: NCT07119229·Recruiting·Listed Aug 2025

Apply to this trial

Comparing the Safety and Efficacy of ASI-02 to Agitated Saline for Suspected Right-to-left Shunt

for Right-To-Left Shunt

Sites in Chicago +6 more locations

Sponsor: Agitated Solutions, Inc.

Sex: All·Age: 18+

Code: NCT06938347·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Personal BP - CAI Study

for Blood Pressure

1 location in Evanston

Sponsor: Becton, Dickinson and Company

Sex: All·Age: 45+

Code: NCT06492746·Recruiting·Listed Jul 2024

Apply to this trial

REMASTer: REcurrent Brain Metastases After SRS Trial

for Brain Metastases

Sites in Chicago +7 more locations

Sponsor: Monteris Medical

Sex: All·Age: 18+

Code: NCT05124912·Recruiting·Listed Nov 2021

Apply to this trial

A Study of Pembrolizumab (MK-3475) in Pediatric Participants With an Advanced Solid Tumor or Lymphoma (MK-3475-051/KEYNOTE-051)

for Melanoma

Sites in Chicago +6 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 17

Code: NCT02332668·Phase 1, Phase 2·Recruiting·Listed Jan 2015

Apply to this trial

Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks

for Migraine

Drug: Ubrogepant

Sites in Naperville +2 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07310290·Recruiting·Listed Dec 2025

Apply to this trial

Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead ECG

for Hypertension, Pulmonary

Sites in Springfield, O'Fallon +2 more locations

Sponsor: Eko Devices, Inc.

Sex: All·Age: 18+

Code: NCT07087613·Recruiting·Listed Jul 2025

Apply to this trial

A Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SR604 in Two Participants Groups (Part A: Healthy Participants, and Part B: Participants With Hemophilia A or Hemophilia B or Factor VII Deficiency)

for Healthy Participants

Sites in Chicago +7 more locations

Sponsor: Equilibra Bioscience LLC

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06349473·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

Study of Single Doses of SBT777101 in Subjects With Rheumatoid Arthritis

for Rheumatoid Arthritis

Sites in Chicago +8 more locations

Sponsor: Sonoma Biotherapeutics, Inc.

Sex: All·Age: 18 - 70

Code: NCT06201416·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Safety and Effectiveness of eGERD Device to Reduce Gastroesophageal Reflux Disease (GERD) Symptoms

for GERD (Gastroesophageal Reflux Disease)

1 location in Chicago

Sponsor: Gerd Care Medical Ltd

Sex: All·Age: 22 - 75

Code: NCT06613438·Recruiting·Listed Sep 2024

Apply to this trial

FiberLocker® System Augmentation of Rotator Cuff Repairs

for Rotator Cuff Tear

Sites in Chicago +3 more locations

Sponsor: ZuriMED Technologies Inc.

Sex: All·Age: 30 - 70

Code: NCT06918041·Recruiting·Listed Apr 2025

Apply to this trial

A Phase 1 Study to Evaluate the Safety and Pharmacokinetics of ABBV-243 in Healthy Adults.

for Healthy Volunteers

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07306754·Phase 1·Recruiting·Listed Dec 2025

Apply to this trial

Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis

for Aortic Stenosis

1 location in Chicago

Sponsor: Dermed Diagnostics, Inc.

Sex: All·Age: 18+

Code: NCT07230964·Recruiting·Listed Nov 2025

Apply to this trial

Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer

for Ovarian Cancer

Sites in Peoria +4 more locations

Sponsor: Nerviano Medical Sciences

Sex: Female·Age: 18+

Code: NCT06930755·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial

Use of CereGate Therapy for Freezing of Gait in PD

for Parkinson Disease

Sites in Chicago +6 more locations

Sponsor: CereGate Inc.

Sex: All·Age: 21 - 80

Code: NCT05292794·Recruiting·Listed Mar 2022

Apply to this trial

Collection of Samples From the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance

for Colorectal Cancer

1 location in Lake Barrington

Sponsor: Universal Diagnostics

Sex: All·Age: 45 - 84·Accepts healthy volunteers

Code: NCT07310446·Recruiting·Listed Dec 2025

Apply to this trial

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

for Cervical Squamous Cell Carcinoma

Sites in Chicago +8 more locations

Sponsor: Alentis Therapeutics AG

Sex: All·Age: 18+

Code: NCT07169734·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

CT-95 in Advanced Cancers Associated With Mesothelin Expression

for Mesothelin-Expressing Tumors

Sites in Chicago +8 more locations

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06756035·Phase 1·Recruiting·Listed Jan 2025

Apply to this trial

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

for Hematologic Malignancy

Drug: Pelabresib

Sites in Chicago +5 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06401356·Phase 3·Recruiting·Listed May 2024

Apply to this trial

A Study to Evaluate the Safety and Tolerability, Pharmacokinetics, and Antiviral Activity of Maribavir for the Treatment of Cytomegalovirus (CMV) Infection in Children and Adolescents Who Have Received a Hematopoietic Stem Cell Transplant (HSCT) or a Solid Organ Transplant (SOT)

for Cytomegalovirus (CMV)

Sites in Chicago +7 more locations

Sponsor: Takeda

Sex: All·Age: Up to 17

Code: NCT05319353·Phase 3·Recruiting·Listed Apr 2022

Apply to this trial

Transdermal Compress IDE Study

for Prosthesis and Implants

Sites in Chicago +8 more locations

Sponsor: Balmoral Medical company

Sex: All·Age: 18 - 60

Code: NCT06134167·Recruiting·Listed Nov 2023

Apply to this trial

A Study Investigating the Effectiveness and Safety of Garadacimab for Treating Patients With Hereditary Angioedema (HAE)

for Hereditary Angioedemas

Sites in Saint Charles +4 more locations

Sponsor: CSL Behring

Sex: All·Age: 12+

Code: NCT07001280·Recruiting·Listed Jun 2025

Apply to this trial

A Study Assessing KB407 for the Treatment of Cystic Fibrosis

for Cystic Fibrosis

Sites in Northfield +5 more locations

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05504837·Phase 1·Recruiting·Listed Aug 2022

Apply to this trial

A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer

for HR+/HER2-negative Breast Cancer

Sites in Chicago +8 more locations

Sponsor: Totus Medicines

Sex: Female·Age: 18+

Code: NCT05683418·Phase 1·Recruiting·Listed Jan 2023

Apply to this trial

Ultra-High Frequency - Electrocardiogram (UHF-ECG) for the Diagnosis of Ventricular Electrical Dyssynchrony (VED)

for Bradycardia

Sites in Chicago +6 more locations

Sponsor: VDI Technologies

Sex: All·Age: 18+

Code: NCT06641362·Recruiting·Listed Oct 2024

Apply to this trial

A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI)

for Complicated Intra-abdominal Infections (cIAI)

Sites in Chicago +4 more locations

Sponsor: Tetraphase Pharmaceuticals, Inc

Sex: All·Age: 8 - 17

Code: NCT06794541·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

for Non Hodgkin Lymphoma

Sites in Chicago +7 more locations

Sponsor: Newave Pharmaceutical Inc

Sex: All·Age: 13+

Code: NCT04771572·Phase 1·Recruiting·Listed Feb 2021

Apply to this trial

Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy

for Allergic Reactions

Sites in Glenview +5 more locations

Sponsor: ARS Pharmaceuticals, Inc.

Sex: All·Age: 4+

Code: NCT06834165·Phase 4·Recruiting·Listed Feb 2025

Apply to this trial

Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery

for Congenital Antithrombin Deficiency

Sites in Peoria +4 more locations

Sponsor: Octapharma

Sex: All·Age: 12 - 80

Code: NCT04918173·Phase 3·Recruiting·Listed Jun 2021

Apply to this trial

A Study of CTX-712 in Relapsed/Refractory Acute Myeloid Leukemia and Higher Risk Myelodysplastic Syndromes

for Acute Myeloid Leukemia

Sites in Chicago +7 more locations

Sponsor: Chordia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05732103·Phase 1, Phase 2·Recruiting·Listed Feb 2023

Apply to this trial

Study to Evaluate VT3989 in Patients With Metastatic Solid Tumors

for Solid Tumor, Adult

Sites in Chicago +8 more locations

Sponsor: Vivace Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT04665206·Phase 1, Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

REgulatory T Cell Therapy to Achieve Immunosuppression REduction

for Kidney Transplantation

Sites in Chicago +2 more locations

Sponsor: Singulera Therapeutics Inc.

Sex: All·Age: 18 - 65

Code: NCT06552169·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Contour Neurovascular System™ ContiNued Access Investigational Device EXempTion (IDE) Trial (NEXT Trial)

for Cerebral Aneurysms

Sites in Park Ridge +8 more locations

Sponsor: Cerus Endovascular, Inc.

Sex: All·Age: 18 - 75

Code: NCT06693011·Recruiting·Listed Nov 2024

Apply to this trial