Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,971 clinical trials

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Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

for Breast Atypical Hyperplasia

4 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 35+

Code: NCT05941520·Phase 2·Recruiting

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Communication Bridge 3 Study

for Primary Progressive Aphasia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 100

Code: NCT06191198·Phase 2·Recruiting

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A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma

for Multiple Myeloma

50 locations incl. Gilbert

Sponsor: Kite, A Gilead Company

Sex: All·Age: 18+

Code: NCT06413498·Phase 3·Recruiting

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Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease

for Chronic Kidney Diseases

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 12 - 25

Code: NCT06430684·EARLY_Phase 1·Recruiting

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Effect of Neural Constraints on Movement in Stroke

for Stroke

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06666673·EARLY_Phase 1·Recruiting

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Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

for High Grade Glioma

Drug: Ribociclib

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05843253·Phase 2·Recruiting

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Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for Refractory Differentiated Thyroid Gland Carcinoma

301 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT06475989·Phase 3·Recruiting

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A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

for Chronic Inflammatory Demyelinating Polyneuropathy

Drug: riliprubart

31 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290141·Phase 3·Recruiting

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Telephone Support in Advanced Gastrointestinal Cancer

for Gastrointestinal Neoplasm Malignant

4 locations incl. Chicago

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT06532877·Recruiting

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EMAGINE 2.0 - Electromagnetic Field Ischemic Stroke - Novel Subacute Treatment

for Ischemic Stroke

14 locations incl. Downey

Sponsor: BrainQ Technologies Ltd.

Sex: All·Age: 22 - 80

Code: NCT06386874·Recruiting

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A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

for Acute HIV Infection

32 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05719441·Phase 2·Recruiting

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Treating Pulmonary Embolism With Laguna Thrombectomy System (TRUST)

for Pulmonary Embolism

10 locations incl. Irvine

Sponsor: Innova Vascular, Inc.

Sex: All·Age: 18 - 85

Code: NCT06041594·Recruiting

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Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)

for Necrotizing Enterocolitis

8 locations incl. Little Rock

Sponsor: Noveome Biotherapeutics, formerly Stemnion

Sex: All·Age: 2 Weeks - 8 Weeks

Code: NCT06315738·Phase 1, Phase 2·Recruiting

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A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis

for Atopic Dermatitis

Drug: Upadacitinib

30 locations incl. Little Rock

Sponsor: AbbVie

Sex: All·Age: 2 - 11

Code: NCT06461897·Phase 3·Recruiting

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Movement Amplification Gait Training to Enhance Walking Balance Post-Stroke

for Chronic Hemiparetic Stroke

2 locations incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT06400186·Recruiting

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Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

for Metastatic Pancreatic Neuroendocrine Tumor

9 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687123·Phase 1·Recruiting

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A Study to Evaluate Solrikitug in Participants With COPD (ZION)

for COPD

101 locations incl. Birmingham

Sponsor: Uniquity One (UNI)

Sex: All·Age: 40 - 75

Code: NCT06496620·Phase 2·Recruiting

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SMP-3124LP in Adults With Advanced Solid Tumors

for Solid Tumor

8 locations incl. Los Angeles

Sponsor: Sumitomo Pharma America, Inc.

Sex: All·Age: 18+

Code: NCT06526819·Phase 1, Phase 2·Recruiting

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EFS of the DUO System for Tricuspid Regurgitation

for Tricuspid Regurgitation

12 locations incl. Phoenix

Sponsor: CroiValve Limited

Sex: All·Age: 18+

Code: NCT05913908·Recruiting

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An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

for Hematologic Malignancy

Drug: Pelabresib

6 locations incl. Los Angeles

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06401356·Phase 3·Recruiting

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SuperSaturated Oxygen Comprehensive Observational Registry

for STEMI - ST Elevation Myocardial Infarction

25 locations incl. Fountain Valley

Sponsor: TherOx

Sex: All·Age: 18 - 80

Code: NCT06438315·Recruiting

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J-RISE: Relevant Implementation Strategies to Eliminate the Social and Structural Barriers to HIV Services Among Justice-involved Black Men Who Have Sex With Men and Other Key Populations

for HIV

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06477588·Recruiting

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Using Dupilumab to Improve Circadian Function, Sleep and Pruritus in Children With Moderate/Severe Atopic Dermatitis

for Atopic Dermatitis

Drug: Dupilumab

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 6 - 17

Code: NCT05042258·Phase 4·Recruiting

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Comparison of Two Sedation Regimens for Awake Fiberoptic Intubation

for Awake Fiberoptic Intubation

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT05736198·Recruiting

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ENhancing Exercise With LIGHT to Improve Functioning in PAD

for Peripheral Artery Disease

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06399900·Recruiting

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Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

for Biliary Tract Cancer

Drug: Rilvegostomig

48 locations incl. Scottsdale

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT06467357·Phase 3·Recruiting

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Comprehensive Geriatric Assessment (Tests) for Bladder Cancer Participants Undergoing Radical Cystectomy

for Bladder Cancer

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 65+

Code: NCT06427824·Recruiting

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

266 locations incl. Daphne

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting

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Real-component vs All-cement Articulating Spacers for Periprosthetic Knee Infection

for Prosthetic-joint Infection

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06293352·Recruiting

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A Study to Evaluate the Safety, Tolerability of INCB160058 in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

13 locations incl. Birmingham

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06313593·Phase 1·Recruiting

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Upadacitinib

12 locations incl. Oakland

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT06332534·Phase 3·Recruiting

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MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors

for Hypertension

1 location in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 60

Code: NCT06555952·Recruiting

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A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

for Untreated Follicular Lymphoma

Drug: Rituximab

51 locations incl. Huntsville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06549595·Phase 3·Recruiting

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Study of XB010 in Subjects With Solid Tumors

for Locally Advanced or Metastatic Solid Tumors

15 locations incl. Irvine

Sponsor: Exelixis

Sex: All·Age: 18+

Code: NCT06545331·Phase 1·Recruiting

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Brain Function Monitoring During Surgery

for Surgery

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 45

Code: NCT06619730·Recruiting

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A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

32 locations incl. Tucson

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06428019·Phase 3·Recruiting

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NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

for Atrial Fibrillation

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 40+

Code: NCT06511505·Not Yet Recruiting

Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting

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Segmentectomy After Induction Therapy (SAINT)

for Segmentectomy

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 89

Code: NCT06496659·Recruiting

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A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

Apply to this trial