Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Esomeprazole and Radiation Induced Esophagitis

for Radiation Esophagitis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT06120803·Phase 2·Recruiting·Listed Nov 2023

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Hip Arthroscopy Postoperative Opioid Demands

for Opioid Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04094701·Recruiting·Listed Sep 2019

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Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

Sites in Chicago +10 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting·Listed Apr 2025

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Deep Functional Phenotyping of the ALA Lung Health Cohort

for Lung Diseases

Sites in Chicago +11 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 25 - 35·Accepts healthy volunteers

Code: NCT06177717·Recruiting·Listed Dec 2023

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Peoria, Springfield +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

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NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

Sites in Chicago +12 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting·Listed Jun 2024

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DRonabinol Treatment of OSA

for Obstructive Sleep Apnea

1 location in Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: Up to 65

Code: NCT06477952·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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Evaluating Wearable Smart Sensors for Continuous Measurement of Vital Signs in ICU Patients

for Prematurity

2 locations in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: Up to 18·Accepts healthy volunteers

Code: NCT04723654·Recruiting·Listed Jan 2021

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Sites in Chicago, Peoria +239 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18 Minutes+

Code: NCT06031688·Phase 2·Recruiting·Listed Sep 2023

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Resuscitative TEE Collaborative Registry

for Cardiac Arrest

1 location in Chicago

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT04972526·Recruiting·Listed Jul 2021

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Combination Therapy for the Treatment of Diffuse Midline Gliomas

for Diffuse Intrinsic Pontine Glioma

Sites in Chicago +18 more locations

Sponsor: University of California, San Francisco

Sex: All·Age: 2 - 39

Code: NCT05009992·Phase 2·Recruiting·Listed Aug 2021

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Our Voices Matter: Intervention for Depression in Youth

for Depressive Symptoms

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 15 - 20·Accepts healthy volunteers

Code: NCT07216326·Recruiting·Listed Oct 2025

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

Sites in Zion +12 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Chicago +35 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Prospective Research Rare Kidney Stones (ProRKS)

for Hyperoxaluria

Sites in Chicago +7 more locations

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT02780297·Recruiting·Listed May 2016

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Postextubation Use of Noninvasive Respiratory Support in Severely Obese Patients

for Obesity, Morbid

Sites in Chicago, Winfield +2 more locations

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT05918575·Recruiting·Listed Jun 2023

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Electrophysiological Representations of Odor in the Human Brain Study 1

for Odor Intensity Ratings

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 12 - 65

Code: NCT06769464·Recruiting·Listed Jan 2025

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Comparative Effectiveness of Palliative Surgery Versus Additional Anti-Seizure Medications for Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome

Sites in Chicago +3 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: Up to 26

Code: NCT05374824·Recruiting·Listed May 2022

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Cardiac Power Output in Cardiogenic Shock Patients

for Heart Failure

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT05700617·EARLY_Phase 1·Recruiting·Listed Jan 2023

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MPN PROGRESSion Registry: Observational Study Tracking Symptoms, Treatments, and Disease Progression in People With Myeloproliferative Neoplasms (MPNs)

for Polycythemia Vera

Sites in Chicago +1 more location

Sponsor: MPN Research Foundation

Sex: All·Age: 18+

Code: NCT07362225·Recruiting·Listed Jan 2026

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Enhancing Rehabilitation Participation in Patients With SCI/D Using Motivational Interviewing

for Spinal Cord Injuries (SCI)

Sites in Chicago +2 more locations

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18+

Code: NCT07364773·Recruiting·Listed Jan 2026

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Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

for Multiple Myeloma

Drug: Teclistamab

Sites in Chicago +40 more locations

Sponsor: European Myeloma Network B.V.

Sex: All·Age: 18+

Code: NCT05243797·Phase 3·Recruiting·Listed Feb 2022

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Role of Adiposomes in Endothelial Dysfunction

for Obesity

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 50

Code: NCT05199454·Recruiting·Listed Jan 2022

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Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy

for Radiation Retinopathy

Sites in Chicago +26 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18+

Code: NCT05844982·Phase 3·Recruiting·Listed May 2023

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Platform Clinical Study for Conquering Scleroderma

for Interstitial Lung Disease Due to Systemic Disease

Sites in Chicago +23 more locations

Sponsor: Scleroderma Research Foundation, Inc.

Sex: All·Age: 18+

Code: NCT06195072·Phase 2·Recruiting·Listed Jan 2024

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End Diagnostic Overshadowing

for Disabilities Multiple

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 3 - 89·Accepts healthy volunteers

Code: NCT06608758·Recruiting·Listed Sep 2024

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Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

for Hiv

Sites in Chicago +17 more locations

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT06263426·Recruiting·Listed Feb 2024

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Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma

for AIDS-Related Diffuse Large B-cell Lymphoma

Sites in Chicago +6 more locations

Sponsor: AIDS Malignancy Consortium

Sex: All·Age: 18+

Code: NCT05077527·Phase 1·Recruiting·Listed Oct 2021

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(2R,6R)-Hydroxynorketamine for the Treatment of Neuropathic Pain

for Pain, Neuropathic

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 75

Code: NCT05864053·Phase 1, Phase 2·Recruiting·Listed May 2023

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for Adipocytic Neoplasm

Drug: Selinexor

Sites in Chicago +6 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06239272·Phase 1, Phase 2·Recruiting·Listed Feb 2024

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The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation

for Kidney Transplant Symptoms

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06206486·Recruiting·Listed Jan 2024

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Telephone Support in Advanced Gastrointestinal Cancer

for Gastrointestinal Neoplasm Malignant

Sites in Chicago +3 more locations

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT06532877·Recruiting·Listed Aug 2024

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Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study

for Malignant Digestive System Neoplasm

Sites in Urbana +57 more locations

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07215624·Recruiting·Listed Oct 2025

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Study of NALIRIFOX in Advanced Unresectable Small Bowel Tumors

for Small Bowel Adenocarcinoma

Sites in Chicago +6 more locations

Sponsor: Tiago Biachi de Castria

Sex: All·Age: 18+

Code: NCT06835387·Phase 2·Recruiting·Listed Feb 2025

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Childhood Cancer Survivor Study

for Cancer

Sites in Chicago +26 more locations

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01120353·Recruiting·Listed May 2010

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Tissue Destruction and Healing in Celiac Disease

for Celiac Disease

Sites in Chicago +2 more locations

Sponsor: University of Chicago

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT05680012·Recruiting·Listed Jan 2023

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Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

for Lung Non-Small Cell Carcinoma

Sites in Chicago, Peoria +241 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06116682·Phase 2·Recruiting·Listed Nov 2023

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Medical Management With Endovascular Thrombectomy Versus Medical Management Alone in Patients Presenting Beyond 24 Hours of Last Known Well

for Acute Ischemic Stroke

Sites in Chicago +5 more locations

Sponsor: Amrou Sarraj

Sex: All·Age: 18 - 85

Code: NCT07115940·Recruiting·Listed Aug 2025

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Response to Exercise and Nitric Oxide in PAD

for Peripheral Artery Disease

2 locations in Chicago

Sponsor: Northwestern University

Sex: All·Age: 50+

Code: NCT06657976·Phase 2·Recruiting·Listed Oct 2024

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Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

Sites in Chicago +9 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting·Listed Dec 2023

Apply to this trial