Paid Clinical Trials in Illinois

Illinois has 2,956 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 16, 2026.

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2,956 clinical trials

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GI-05: The Impact of Olanzapine Among Patients Receiving Neoadjuvant Chemotherapy for Gastric Cancer

for Gastric Adenocarcinoma

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07581405·Phase 2·Not Yet Recruiting

Defining the Ablative Dose for Y-90 TARE

for HCC - Hepatocellular Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT07586046·Phase 2·Not Yet Recruiting

BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder

for Early-stage Breast Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18+

Code: NCT07596212·Phase 1, Phase 2·Not Yet Recruiting

A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).

for Alzheimer Disease

Drug: Donanemab

52 locations incl. Phoenix

Sponsor: Eli Lilly and Company

Sex: All·Age: 55+

Code: NCT07602582·Phase 3·Not Yet Recruiting

Multi-Site Trial of Tirzepatide for Smoking Cessation

for Smoking Cessation

Drug: Tirzepatide

4 locations incl. Los Angeles

Sponsor: University of Southern California

Sex: All·Age: 21 - 65

Code: NCT07602699·Phase 2·Recruiting

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Co-Designing and Evaluating Additional Mothers and Babies Program Content for Expectant and New Parents of Children With Down Syndrome

for Depression

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07469176·Not Yet Recruiting

Treatment of Antibody-Mediated Rejection (ABMR) With CarBel

for Kidney Transplant Rejection

10 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 75

Code: NCT06918990·Phase 1·Recruiting

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A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.

for Pneumococcal Disease

58 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 42 Days - 211 Days·Accepts healthy volunteers

Code: NCT07629440·Phase 3·Recruiting

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Resilience-Building for Advance Care Planning

for Advanced Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 80

Code: NCT07428278·Recruiting

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tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy

for Cerebral Palsy

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 4 - 17

Code: NCT07433023·Phase 2·Recruiting

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Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy

for Cerebral Palsy

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 8 - 17

Code: NCT07434492·Phase 2·Recruiting

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A Phase 2b Study of the Effects of Camoteskimab in Adults With Moderate-to-Severe Atopic Dermatitis

for Atopic Dermatitis

33 locations incl. Birmingham

Sponsor: Apollo Therapeutics Ltd

Sex: All·Age: 18 - 65

Code: NCT07599813·Phase 2·Recruiting

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A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration

for Neovascular Age-related Macular Degeneration

Drug: Aflibercept

18 locations incl. Long Beach

Sponsor: Amgen

Sex: All·Age: 50+

Code: NCT07614776·Phase 3·Recruiting

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A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer

for ER-Positive HER2-Negative Breast Cancer

Drug: Camizestrant

12 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07647328·Phase 3·Not Yet Recruiting

A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndrome

24 locations incl. Gilbert

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT07422480·Phase 3·Recruiting

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A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight

for Obesity

Drug: Semaglutide

99 locations incl. Birmingham

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07564414·Phase 3·Recruiting

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BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

for HR+/HER2- Breast Cancer

5 locations incl. Anchorage

Sponsor: BeOne Medicines

Sex: All·Age: 18+

Code: NCT07492641·Phase 3·Recruiting

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Assessing Two Coenzyme Q10 Products in Men and Women

for CoQ10 Blood Levels

1 location in Addison

Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Sex: All·Age: 21 - 65·Accepts healthy volunteers

Code: NCT07530250·Recruiting

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Evaluation of Gixam's Efficacy Predicting the Presence of Advanced and Non-advanced Colorectal Neoplasia in a FIT Negative Population

for CRC Screening

5 locations incl. Orlando

Sponsor: Jubaan Ltd.

Sex: All·Age: 45 - 84

Code: NCT07623902·Recruiting

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Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

for Major Depressive Disorder

25 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT06705478·Phase 2·Recruiting

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Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

for Small Cell Lung Cancer

4 locations incl. Duarte

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07476287·Phase 2·Recruiting

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A Study of VIRTUGUIDE System and DePuy Synthes Lapidus Implant in Participants Undergoing Lapidus Procedure

for Hallux Valgus

8 locations incl. Morrison

Sponsor: DePuy Synthes Products, Inc.

Sex: All·Age: 22+

Code: NCT07567092·Not Yet Recruiting

AtraUmatic Laparoscopic HerNia Repair Clinical Investigation to Evaluate the Safety and Performance of The ECLIPSIUM System for Mesh Fixation IDE

for Hernia

12 locations incl. Loma Linda

Sponsor: Tissium

Sex: All·Age: 22+

Code: NCT07277946·Recruiting

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Symbiotic-GI-16: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Gastroesophageal Cancer

for Untreated Advanced or Metastatic Gastric, Gastroesophageal Junction , or Esophageal Adenocarcinoma

Drug: PF-08634404

61 locations incl. Los Angeles

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07392892·Phase 2, Phase 3·Recruiting

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Early Signals of the Transition From Immune Quiescence to Activation in the Liver Allograft Microenvironment and in the Circulation

for Liver Transplant

10 locations incl. San Francisco

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 3 - 13

Code: NCT07549503·Phase 2·Recruiting

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Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer

for Ovarian Cancer

5 locations incl. Peoria

Sponsor: Nerviano Medical Sciences

Sex: Female·Age: 18+

Code: NCT06930755·Phase 1·Recruiting

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Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

for Locally Advanced Pancreatic Adenocarcinoma

274 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06998940·Phase 3·Recruiting

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A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

for Myasthenia Gravis, Generalized

11 locations incl. Boca Raton

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT07501702·Phase 2·Recruiting

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Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System

for Type 2 Diabetes Mellitus

12 locations incl. Los Angeles

Sponsor: Insulet Corporation

Sex: All·Age: 14 - 75

Code: NCT07579702·Recruiting

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Sarilumab Efficacy and Safety in Adults With Early Polymyalgia Rheumatica

for Polymyalgia Rheumatica

9 locations incl. Denver

Sponsor: Sanofi

Sex: All·Age: 50+

Code: NCT07286214·Phase 4·Recruiting

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Study to Assess Adverse Events and How Oral Emraclidine Moves Through the Body of Adult Healthy Volunteers

for Healthy Volunteers

1 location in Grayslake

Sponsor: AbbVie

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07587008·Phase 1·Recruiting

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An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)

for Cardiovascular Disease and Lipoprotein(a)

Drug: Pelacarsen

115 locations incl. Andalusia

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT07517263·Phase 3·Recruiting

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Enfortumab Vedotin in Combination With Pembrolizumab vs. Concurrent Chemoradiotherapy (cCRT) in People With Muscle Invasive Bladder Cancer (EV-309)

for Urothelial Cancer

9 locations incl. Santa Barbara

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT07566156·Phase 3·Recruiting

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Assess the Effects of Replacing Foods High in Refined Carbohydrates With Avocado on Biomarkers of Inflammation.

for Overweight (BMI > 25)

2 locations incl. Chicago

Sponsor: Midwest Center for Metabolic and Cardiovascular Research

Sex: All·Age: 21 - 74·Accepts healthy volunteers

Code: NCT07566325·Not Yet Recruiting

A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

for Obesity

Drug: NNC0487-0111

202 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT07567001·Phase 3·Not Yet Recruiting

Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

for Obesity or Overweight

39 locations incl. Pelham

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07575399·Phase 3·Recruiting

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A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)

for Overweight

48 locations incl. Chandler

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07575932·Phase 2·Recruiting

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A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

for Major Depressive Disorder

27 locations incl. Gilbert

Sponsor: Definium Therapeutics US, Inc.

Sex: All·Age: 18 - 74

Code: NCT07592689·Phase 3·Recruiting

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Dasatinib for HIV-1 Reservoir Reduction

for HIV Infections

3 locations incl. Chicago

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT07342491·Phase 1·Recruiting

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A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

for Solid Tumors

Drug: Adagrasib

17 locations incl. Phoenix

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT07415031·Phase 2·Recruiting

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