Paid Clinical Trials in Illinois

Illinois has 2,847 paid clinical trials enrolling now across cities including Chicago, Peoria and Evanston. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 14, 2026.

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2,519 clinical trials

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Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection

for Liver Transplant Surgery

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06698146·Recruiting·Listed Nov 2024

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Using Text Messages to Improve Oral Chemotherapy for Adolescents and Adults With Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 15+

Code: NCT06446661·Recruiting·Listed Jun 2024

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Mastery Learning in Communication Skills

for Communication Research

1 location in Chicago

Sponsor: Heather Ballard

Sex: All·Age: 20 - 60·Accepts healthy volunteers

Code: NCT05979090·Recruiting·Listed Aug 2023

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ROAM OA: Functional and Patient Reported Outcomes Wearing a Knee Brace for Unicompartmental OA

for Knee Osteoarthritis

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 40 - 85

Code: NCT07224958·Recruiting·Listed Nov 2025

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PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort

for Parkinson Disease

Sites in Chicago +29 more locations

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT04477785·Recruiting·Listed Jul 2020

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Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

for Colorectal Cancer Stage II

Sites in Peoria, Springfield +373 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07018869·Phase 3·Recruiting·Listed Jun 2025

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Does Ethyl Chloride Spray Work?

for Injection Fear

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06651788·Recruiting·Listed Oct 2024

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Non-invasive VNS for Parkinson's Gait

for Parkinson's Disease

1 location in Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 50 - 88

Code: NCT06562569·Recruiting·Listed Aug 2024

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Medrol Dosepak for Outpatient Total Knee Arthroplasty

for Total Knee Arthroplasty

1 location in Oak Brook

Sponsor: Rush University Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05097976·Phase 4·Recruiting·Listed Oct 2021

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Oxygenation in Vascular Lesions of the Colon

for Vascular Lesion

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT06230731·Recruiting·Listed Jan 2024

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Kidney Stone Inflammation

for Kidney Stone

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06436235·Recruiting·Listed May 2024

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Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

for Sickle Cell Disease

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 16 - 60

Code: NCT03121001·Phase 2·Recruiting·Listed Apr 2017

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Alternative Therapies for Improving Physical Function in Individuals With Stroke

for Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT03869138·Recruiting·Listed Mar 2019

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Dual Task Perturbation Training for OAwMCI

for Mild Cognitive Impairment

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT04938349·Recruiting·Listed Jun 2021

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Analysis of Human ALS Tissues and Registry of ALS Patients

for Amyotrophic Lateral Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT05067179·Recruiting·Listed Oct 2021

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Home-based FES Training in People With Chronic Stroke

for Chronic Stroke

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT05849532·Recruiting·Listed May 2023

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The Grief Navigation Trial: A Comparison of Two Interventions to Support Parents After Their Child's Unexpected or Traumatic Death

for Bereavement

Sites in Chicago, Peoria +5 more locations

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06136260·Recruiting·Listed Nov 2023

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Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites

for Nicotine Use Disorder

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 26

Code: NCT06837220·Recruiting·Listed Feb 2025

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Proton-Spatially Fractionated Radiotherapy and Standard Radiation Therapy for the Treatment of Newly Diagnosed Retroperitoneal Soft Tissue Sarcoma

for Retroperitoneal Sarcoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06327477·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

for Breast Atypical Hyperplasia

Sites in Chicago +3 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 35+

Code: NCT05941520·Phase 2·Recruiting·Listed Jul 2023

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The REACTplusNMES Trial: A Double-blinded RCT

for Stroke, Ischemic

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT06127602·Recruiting·Listed Nov 2023

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Abemaciclib Dose Escalation to Maintain Intensity (ADE-MI)

for Breast Cancer

Sites in Chicago +2 more locations

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT06169371·Phase 4·Recruiting·Listed Dec 2023

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Achieving Routine Intervention and Screening for Emotional Health

for Type 2 Diabetes Mellitus (T2DM)

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT06887049·Recruiting·Listed Mar 2025

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Functional Balance Intervention in Multiple Sclerosis

for Multiple Sclerosis

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90

Code: NCT06341023·Recruiting·Listed Apr 2024

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Reactive Balance Training for Fall Prevention

for Healthy Young

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT04205279·Recruiting·Listed Dec 2019

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Promoting Recovery Outcomes Through Precise Early Locomotor Interventions in Persons With Spinal Cord Injury

for Spinal Cord Injuries

Sites in Chicago +1 more location

Sponsor: Milap Sandhu

Sex: All·Age: 16 - 75

Code: NCT06176833·Recruiting·Listed Dec 2023

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Epcoritamab and Lenalidomide in Treating Patients With Refractory or Relapsed Immunodeficiency-Related Large B-Cell Lymphoma

for Recurrent B-Cell Non-Hodgkin Lymphoma

Drug: Epcoritamab

1 location in Chicago

Sponsor: Reem Karmali

Sex: All·Age: 18+

Code: NCT06723457·Phase 2·Recruiting·Listed Dec 2024

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Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

for Spontaneous Breathing Trial in ICU

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18+

Code: NCT07005505·Recruiting·Listed Jun 2025

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Biliary Atresia Study in Infants and Children

for Biliary Atresia

Sites in Chicago +8 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: 6 Months - 20

Code: NCT00345553·Recruiting·Listed Jun 2006

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Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

Sites in Chicago +21 more locations

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting·Listed May 2023

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Better Lifestyle Counseling for African American Women During Pregnancy

for Overweight or Obesity

2 locations in Chicago

Sponsor: University of Illinois at Chicago

Sex: Female·Age: 18 - 40

Code: NCT05234125·Recruiting·Listed Feb 2022

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CApivasertib, Venetoclax And Low-intensity chemotheRapY for Adults With ALL/LBL

for Leukemia

Drug: Venetoclax

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07294677·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorithms

for Malocclusion

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 12 - 70·Accepts healthy volunteers

Code: NCT05573308·Recruiting·Listed Oct 2022

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Accelerometer Measured Early Recovery After Prolapse Surgery

for Pelvic Organ Prolapse

Sites in Chicago +6 more locations

Sponsor: NICHD Pelvic Floor Disorders Network

Sex: Female·Age: 18 - 99

Code: NCT07218016·Recruiting·Listed Oct 2025

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International Registry for Men With Advanced Prostate Cancer (IRONMAN)

for Prostate Cancer

Sites in Chicago, Warrenville +33 more locations

Sponsor: Prostate Cancer Clinical Trials Consortium

Sex: Male·Age: 21+

Code: NCT03151629·Recruiting·Listed May 2017

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in Peoria, Urbana +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

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An Investigational Scan (rhPSMA-7.3 PET/CT) for Detecting Biochemically Recurrent Prostate Cancer, ENLIGHTEN Trial

for Biochemically Recurrent Prostate Carcinoma

1 location in Chicago

Sponsor: Northwestern University

Sex: Male·Age: All ages

Code: NCT06813898·EARLY_Phase 1·Recruiting·Listed Feb 2025

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Neural Prediction to Enhance Language

for Bilateral Sensorineural Hearing Loss

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 0 Months - 5

Code: NCT05962359·Recruiting·Listed Jul 2023

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Oral Health Intervention for Caregivers of Children Presenting for Dental Surgery

for Early Childhood Caries

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: Up to 7

Code: NCT07220850·Recruiting·Listed Oct 2025

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Advancing Transplantation Outcomes in Children

for Kidney Transplant

Sites in Chicago +19 more locations

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 13 - 20

Code: NCT06055608·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial