Paid Clinical Trials in Irvine, CA

As of August 2026, 362 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 10, 2026.

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340 clinical trials

Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

Sites in Irvine, Orange +10 more locations

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting·Listed Nov 2020

Apply to this trial

Clinical Procedures to Support Research in ALS

for Amyotrophic Lateral Sclerosis

Sites in Irvine, Palo Alto +8 more locations

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT03489278·Recruiting·Listed Apr 2018

Apply to this trial

Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

for Intracerebral Hemorrhage

Sites in Irvine, Lancaster +18 more locations

Sponsor: Zeenat Qureshi Stroke Institute

Sex: All·Age: 18 - 100

Code: NCT06402968·Recruiting·Listed May 2024

Apply to this trial

ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Irvine, Los Angeles +34 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

Apply to this trial

Ivonescimab for the Treatment of Thymic Cancer

for Thymus Carcinoma

Drug: Ivonescimab

Sites in Irvine, Los Angeles +3 more locations

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06980077·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

for Advanced Malignant Solid Neoplasm

Sites in Irvine, Duarte +25 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06311214·Phase 2·Recruiting·Listed Mar 2024

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An Acupuncture Study for People At High Risk for Sepsis

for Sepsis

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT06344819·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

Regeneron AA Multicenter (Dupilumab)

for Alopecia Areata

Drug: Dupilumab

Sites in Irvine +2 more locations

Sponsor: Emma Guttman

Sex: All·Age: 18+

Code: NCT05551793·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in Irvine, Corona +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

Apply to this trial

An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

for Ovary Cancer

Sites in Irvine +5 more locations

Sponsor: University of Colorado, Denver

Sex: Female·Age: 18 - 100

Code: NCT05887609·Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

for Advanced Hodgkin Lymphoma

Sites in Irvine, Palo Alto +4 more locations

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06745076·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Telerehabilitation In The Home After Stroke

for Stroke

Sites in Irvine, Pomona +25 more locations

Sponsor: University of California, Los Angeles

Sex: All·Age: 18 - 80

Code: NCT06682429·Recruiting·Listed Nov 2024

Apply to this trial

Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors

for Hematopoietic and Lymphatic System Neoplasm

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06500377·Recruiting·Listed Jul 2024

Apply to this trial

Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

for Opioid Use Disorder

Sites in Irvine, El Centro +2 more locations

Sponsor: University of California, Davis

Sex: All·Age: 14+

Code: NCT07024498·Recruiting·Listed Jun 2025

Apply to this trial

Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery

for Clear Cell Renal Cell Carcinoma

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07037004·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

The Effects of Core Shamanism in Fibromyalgia

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: Female·Age: 18 - 75

Code: NCT06579261·Recruiting·Listed Aug 2024

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Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 80

Code: NCT06571110·Recruiting·Listed Aug 2024

Apply to this trial

Acoustic and Electrical Stimulation for the Treatment of Tinnitus

for Tinnitus

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03511807·Recruiting·Listed Apr 2018

Apply to this trial

Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

Drug: Nivolumab

Sites in Irvine +5 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

A Multicenter Prospective Observational Cohort Study Evaluating the Impact of Cancer-Directed Treatment and Medication Use, Including Cannabis Use, in Multiple Myeloma Patients

for Multiple Myeloma

Sites in Irvine, Newport Beach +9 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07225738·Recruiting·Listed Nov 2025

Apply to this trial

Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

Sites in Irvine, Orange +114 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting·Listed Sep 2023

Apply to this trial

Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

for Chronic Lymphocytic Leukemia

Drug: Epcoritamab

Sites in Irvine, Long Beach +5 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07218510·Phase 2·Recruiting·Listed Oct 2025

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Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

for Metastatic Pancreatic Neuroendocrine Tumor

Sites in Irvine, Orange +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05687123·Phase 1·Recruiting·Listed Jan 2023

Apply to this trial

Positive Affect Treatment for Adolescents With Early Life Adversity

for Depression

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 12 - 16·Accepts healthy volunteers

Code: NCT06273137·Recruiting·Listed Feb 2024

Apply to this trial

ExCrossV Multi Site Trial for Vascularized High Risk Keratoplasty

for Corneal Transplant Failure

Sites in Irvine, Los Angeles +10 more locations

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18+

Code: NCT06753916·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Tarlatamab in Advanced Delta-like 3 (DLL3)-Expressing Tumors Including Neuroendocrine Neoplasms

for DLL3-expressing Tumors

Drug: Tarlatamab

Sites in Irvine, Los Angeles +3 more locations

Sponsor: Jonsson Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06788938·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Irvine, Newport Beach +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

Apply to this trial

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Irvine, Newport Beach +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

Apply to this trial

Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Irvine, Long Beach +4 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 70+

Code: NCT04305834·Phase 2·Recruiting·Listed Mar 2020

Apply to this trial

Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Irvine, Laguna Hills +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

for Acneiform Eruption Due to Chemical

Sites in Irvine, Orange +7 more locations

Sponsor: Hoth Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05639933·Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

for Prostate Adenocarcinoma

Sites in Irvine, Duarte +130 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT05806515·Phase 2·Recruiting·Listed Apr 2023

Apply to this trial

My Life and My Experiences Project

for Stress and Memory in Adolescence

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 12 - 18·Accepts healthy volunteers

Code: NCT06821178·Recruiting·Listed Feb 2025

Apply to this trial

Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target

for Dermatologic Diseases

2 locations in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT00842283·Recruiting·Listed Feb 2009

Apply to this trial

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

for Adverse Childhood Experiences

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 11 - 14·Accepts healthy volunteers

Code: NCT06821035·Recruiting·Listed Feb 2025

Apply to this trial

Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

Sites in Irvine, Fullerton +71 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting·Listed Apr 2024

Apply to this trial

A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

Sites in Irvine, Fullerton +66 more locations

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting·Listed May 2020

Apply to this trial

Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06249282·Phase 1·Recruiting·Listed Feb 2024

Apply to this trial

An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasm

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT05123365·Phase 1, Phase 2·Recruiting·Listed Nov 2021

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Irvine, Upland +14 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

Apply to this trial