Paid Clinical Trials in Irvine, CA

As of September 2026, 388 paid clinical trials are recruiting in Irvine, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.

Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: September 24, 2026.

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355 clinical trials

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Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for Advanced Malignant Solid Neoplasm

Sites in Irvine, Orange +13 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05691491·Phase 1, Phase 2·Recruiting·Listed Jan 2023

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Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

for Recurrent Chronic Lymphocytic Leukemia

Drug: Mirdametinib

Sites in Irvine, Duarte +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061951·Phase 2·Recruiting·Listed Jul 2025

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Telehealth Self-Management Coaching Sessions to Improve Quality of Life in Pancreatic Cancer Survivors and Their Family Care Givers

for Metastatic Pancreatic Adenocarcinoma

Sites in Irvine, Newport Beach +20 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06524973·Recruiting·Listed Jul 2024

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Personalized Reduction of Chemotherapy Intensity Through ctDNA Evaluation for the Treatment of Patients With Advanced Hodgkin Lymphoma

for Advanced Hodgkin Lymphoma

Sites in Irvine, Palo Alto +4 more locations

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06745076·Phase 2·Recruiting·Listed Dec 2024

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Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients

for Resectable Colorectal Carcinoma

Sites in Irvine, Newport Beach +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07125729·Recruiting·Listed Aug 2025

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Pilot Study on In-vivo Non-invasive Skin Imaging Using Multiphoton Microscopy

for Skin Lesion

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT01771718·Recruiting·Listed Jan 2013

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Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

for Lung Non-Small Cell Carcinoma

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05830058·Phase 2·Recruiting·Listed Apr 2023

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DCIS: RECAST Trial Ductal Carcinoma In Situ: Re-Evaluating Conditions for Active Surveillance Suitability as Treatment

for Ductal Carcinoma in Situ

Sites in Irvine, Duarte +23 more locations

Sponsor: QuantumLeap Healthcare Collaborative

Sex: Female·Age: 18+

Code: NCT06075953·Phase 2·Recruiting·Listed Oct 2023

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

Sites in Irvine, Orange +101 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting·Listed Jan 2024

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De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

for Stage I Breast Cancer

Sites in Irvine, Orange +705 more locations

Sponsor: NRG Oncology

Sex: All·Age: 50 - 70

Code: NCT04852887·Phase 3·Recruiting·Listed Apr 2021

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Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer

for Metastatic Microsatellite Stable Colorectal Carcinoma

Sites in Irvine, Orange +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06654037·Phase 1·Recruiting·Listed Oct 2024

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Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene

for Burkitt Lymphoma

Drug: Pidnarulex

Sites in Irvine, Orange +6 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07069699·Phase 1, Phase 2·Recruiting·Listed Jul 2025

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Neoadjuvant Nivolumab + Relatlimab (Opdualag) Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma

for Basal Cell Carcinoma

Drug: Relatlimab

Sites in Irvine, La Jolla & San Francisco

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT06624475·Phase 2·Recruiting·Listed Oct 2024

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Neural Bases of Vocal Sensorimotor Impairment in Aphasia

for Aphasia

Sites in Irvine +2 more locations

Sponsor: The University of Texas at Dallas

Sex: All·Age: 21 - 75·Accepts healthy volunteers

Code: NCT04742894·Recruiting·Listed Feb 2021

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Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

for Recurrent Lung Non-Small Cell Carcinoma

Drug: Cemiplimab

Sites in Irvine, Anaheim +379 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06616584·Phase 2, Phase 3·Recruiting·Listed Sep 2024

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Using Nicotine to Reverse Age-related Auditory Processing Deficits

for Auditory Perceptual Impairment

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT04971954·Recruiting·Listed Jul 2021

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Irvine, Anaheim +584 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting·Listed Oct 2018

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

Sites in Irvine, Los Angeles +34 more locations

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting·Listed Aug 2024

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Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer

for Advanced Clear Cell Renal Cell Carcinoma

Drug: Ipilimumab

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07128680·Phase 1·Recruiting·Listed Aug 2025

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Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

for Intracerebral Hemorrhage

Sites in Irvine, Lancaster +18 more locations

Sponsor: Zeenat Qureshi Stroke Institute

Sex: All·Age: 18 - 100

Code: NCT06402968·Recruiting·Listed May 2024

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An Acupuncture Study for People At High Risk for Sepsis

for Sepsis

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT06344819·Phase 2·Recruiting·Listed Apr 2024

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Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-line Treatment in Stage IIIB-IV Non-small Cell Lung Cancer, IMMUNO-BIOMAP Trial

for Lung Non-Small Cell Carcinoma

Sites in Irvine, Newport Beach +11 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07288034·Phase 2·Recruiting·Listed Dec 2025

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Clinical Procedures to Support Research in ALS

for Amyotrophic Lateral Sclerosis

Sites in Irvine, Palo Alto +8 more locations

Sponsor: University of Miami

Sex: All·Age: 18+

Code: NCT03489278·Recruiting·Listed Apr 2018

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An Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib

for Ovary Cancer

Sites in Irvine +5 more locations

Sponsor: University of Colorado, Denver

Sex: Female·Age: 18 - 100

Code: NCT05887609·Phase 2·Recruiting·Listed Jun 2023

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Mapping Ibogaine Neural Dynamics in Opioid Use Disorder

for Opioid Use Disorder (OUD)

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 21 - 70

Code: NCT07226570·Recruiting·Listed Nov 2025

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Regeneron AA Multicenter (Dupilumab)

for Alopecia Areata

Drug: Dupilumab

Sites in Irvine +2 more locations

Sponsor: Emma Guttman

Sex: All·Age: 18+

Code: NCT05551793·Phase 2·Recruiting·Listed Sep 2022

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

Sites in Irvine, Corona +36 more locations

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting·Listed Jun 2018

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The Effects of Core Shamanism in Fibromyalgia

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: Female·Age: 18 - 75

Code: NCT06579261·Recruiting·Listed Aug 2024

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L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance

for Hematopoietic and Lymphatic System Neoplasm

Sites in Irvine, Huntington Beach & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07220447·EARLY_Phase 1·Recruiting·Listed Oct 2025

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Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Irvine, Newport Beach +913 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05929768·Phase 3·Recruiting·Listed Jul 2023

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Coordinating Outpatient bupreNorphiNe for Emergency Care and Continuing Treatment

for Opioid Use Disorder

Sites in Irvine, El Centro +2 more locations

Sponsor: University of California, Davis

Sex: All·Age: 14+

Code: NCT07024498·Recruiting·Listed Jun 2025

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Analgesic Response to Opioids in Patients With Fibromyalgia After Conventional Acupuncture Versus Sham Acupuncture

for Fibromyalgia

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18 - 80

Code: NCT06571110·Recruiting·Listed Aug 2024

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Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery

for Clear Cell Renal Cell Carcinoma

Sites in Irvine & Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07037004·Phase 2·Recruiting·Listed Jun 2025

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Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for Metastatic Malignant Neoplasm in the Liver

Sites in Irvine, Newport Beach +378 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05040360·Phase 2·Recruiting·Listed Sep 2021

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Acoustic and Electrical Stimulation for the Treatment of Tinnitus

for Tinnitus

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03511807·Recruiting·Listed Apr 2018

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Phase 2 Study of Combination Tivozanib and Nivolumab in Advanced Non-Clear Cell Renal Cell Carcinoma

for Renal Cell Carcinoma

Drug: Nivolumab

Sites in Irvine +5 more locations

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06053658·Phase 2·Recruiting·Listed Sep 2023

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

Sites in Irvine, Orange +114 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting·Listed Sep 2023

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Positive Affect Treatment for Adolescents With Early Life Adversity

for Depression

1 location in Irvine

Sponsor: University of California, Irvine

Sex: All·Age: 12 - 16·Accepts healthy volunteers

Code: NCT06273137·Recruiting·Listed Feb 2024

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for Diffuse Large B-Cell Lymphoma

Sites in Irvine, Laguna Hills +81 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT05633615·Phase 2·Recruiting·Listed Dec 2022

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Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

for Prostate Adenocarcinoma

Sites in Irvine, Duarte +130 more locations

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT05806515·Phase 2·Recruiting·Listed Apr 2023

Apply to this trial