Clinical Trials at Mayo Clinic in Florida

As of July 2026, 161 paid clinical trials are recruiting at Mayo Clinic in Florida, located at 4500 SAN PABLO RD S, JACKSONVILLE, FL 32224-1865, phone (904) 953-2000 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 13, 2026.

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161 clinical trials at Mayo Clinic in Florida

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BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

for Clinical Stage III Cutaneous Melanoma AJCC v8

Drug: Cabozantinib

223 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05136196·Phase 2·Recruiting

Apply to this trial

Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung

for Advanced Extrapulmonary Neuroendocrine Carcinoma

Drug: Atezolizumab

255 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05058651·Phase 2, Phase 3·Recruiting

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Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

211 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554406·Phase 2·Recruiting

Apply to this trial

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

for Renal Pelvis and Ureter Urothelial Carcinoma

Drug: Durvalumab

258 locations incl. Kingman

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04628767·Phase 2, Phase 3·Recruiting

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Testing the Use of the Combination of Selumetinib and Olaparib or Selumetinib Alone Targeted Treatment for RAS Pathway Mutant Recurrent or Persistent Ovarian and Endometrial Cancers, A ComboMATCH Treatment Trial

for Recurrent Endometrial Carcinoma

Drug: Selumetinib

293 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT05554328·Phase 2·Recruiting

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Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

for Muscle Invasive Bladder Urothelial Carcinoma

146 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07061964·Phase 2·Recruiting

Apply to this trial

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

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Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

for Lymphoplasmacytic Lymphoma

Drug: Venetoclax

135 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04840602·Phase 2·Recruiting

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

54 locations incl. Birmingham

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

109 locations incl. Birmingham

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting

Apply to this trial

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for Cutaneous Melanoma, Stage II

130 locations incl. Mobile

Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All·Age: 18+

Code: NCT03860883·Recruiting

Apply to this trial

Testing the Addition of Immunotherapy Before Surgery for Patients With Sarcomatoid Mesothelioma

for Pleural Biphasic Mesothelioma

132 locations incl. Anchorage

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT05647265·Phase 2·Recruiting

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Testing the Addition of an Anti-Cancer Drug, Gemcitabine, to Usual Treatment (BCG Alone) in People Whose Non-Muscle Invasive Bladder Cancer (NMIBC) Came Back After Prior BCG Therapy

for Recurrent Non-Muscle Invasive Bladder Carcinoma

58 locations incl. Birmingham

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07000084·Phase 3·Recruiting

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Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

for Metastatic Digestive System Neuroendocrine Tumor G1

33 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05773274·Phase 2·Recruiting

Apply to this trial

Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

73 locations incl. Tucson

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting

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Testing Teclistamab (TECVAYLI) in Combination With Iberdomide for Relapsed or Refractory Multiple Myeloma

for Recurrent Multiple Myeloma

Drug: Teclistamab

14 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06465316·Phase 1·Recruiting

Apply to this trial

A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

for Cancer

3 locations incl. Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05655494·Recruiting

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Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

for Recurrent Glioblastoma, IDH-Wildtype

Drug: Selinexor

36 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05432804·Phase 1, Phase 2·Recruiting

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Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

for Colorectal Carcinoma

9 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05410977·Recruiting

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Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer

for Recurrent Ovarian High Grade Serous Adenocarcinoma

27 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18+

Code: NCT04633239·Phase 1·Recruiting

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TRPC6 Characterization to Predict and Prevent Chemotherapy Related Cardiomyopathy and Heart Failure With Breast Cancer

for Breast Carcinoma

2 locations incl. Gainesville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05507879·Recruiting

Apply to this trial

Smart Symptom Tracking ALEX Application for Tracking and Monitoring Gastrointestinal Health, Smart Horizons Pilot Trial

for Colorectal Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 44·Accepts healthy volunteers

Code: NCT07618273·Recruiting·Listed Jun 1, 2026

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A Study Of Exercise In Patients With Spontaneous Coronary Artery Dissection And Fibromuscular Dysplasia

for Fibromuscular Dysplasia

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 21 - 65

Code: NCT07526766·Recruiting

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The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

for Obesity

Drug: Tirzepatide

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 46 - 60·Accepts healthy volunteers

Code: NCT07218445·Phase 4·Recruiting

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Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

for Lung Transplant

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06770023·Phase 1·Recruiting

Apply to this trial

Ex Vivo Expansion (ACT-X)

for Solid Tumor

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07137312·Recruiting

Apply to this trial

BMS-986340 in Combination With Nivolumab, Gemcitabine and Nab-paclitaxel for the Treatment of Metastatic and Recurrent Pancreatic Adenocarcinoma

for Metastatic Pancreatic Adenocarcinoma

Drug: Nivolumab

3 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07226856·Phase 2·Recruiting

Apply to this trial

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2·Recruiting

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Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE)

for Gastric Antral Vascular Ectasia

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07169799·Recruiting

Apply to this trial

A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

for Chronic Dizziness

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07420803·Recruiting

Apply to this trial

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

for Metastatic Malignant Solid Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06911008·Phase 1·Recruiting

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Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

for Community-acquired Pneumonia

5 locations incl. Scottsdale

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07164131·Phase 4·Recruiting

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Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

for Human Papillomavirus-Negative Neck Squamous Cell Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06997094·Phase 1·Recruiting

Apply to this trial

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

for Adjustment Disorder

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07221409·Recruiting

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A Digital Treatment Platform for the Delivery of Home-Based Sequential Therapy in Patients With Glioma

for Glioma

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07074756·Recruiting

Apply to this trial

Augmented Reality Real-Time Guidance for MRI-Guided Interventions

for Liver

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07120906·Recruiting

Apply to this trial

Continuous Glucose Monitoring for the Management of Hyperglycemia in Patients With Glioblastoma

for Glioblastoma, IDH-Wildtype

3 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07091864·Recruiting

Apply to this trial

Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk

for Breast Carcinoma

2 locations incl. Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07207564·Recruiting

Apply to this trial

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

for Biochemically Recurrent Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT07073794·Phase 2·Recruiting

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A Study of Live Tumor Fragments of Surgical Resections

for Cancer

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07000864·Recruiting

Apply to this trial