Clinical Trials at Mayo Clinic in Florida

As of August 2026, 142 paid clinical trials are recruiting at Mayo Clinic in Florida, located at 4500 SAN PABLO RD S, JACKSONVILLE, FL 32224-1865, phone (904) 953-2000 in Jacksonville, Florida. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: August 27, 2026.

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144 clinical trials at Mayo Clinic in Florida

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Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

for Hematopoietic and Lymphatic System Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06640010·Recruiting·Listed Oct 2024

Apply to this trial

Radiation Therapy With RapidPlan Knowledge-based Planning vs Human-Driven Planning for Treatment of Prostate Cancer

for Prostate Carcinoma

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT06625034·Phase 3·Recruiting·Listed Oct 2024

Apply to this trial

Immune Response to Anti-HER2 Therapies in Patients With HER2-Positive Stage I-IV Breast Cancer

for Breast Adenocarcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT04517838·Recruiting·Listed Aug 2020

Apply to this trial

Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding

for Endometrial Carcinoma

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 55+

Code: NCT06365905·Recruiting·Listed Apr 2024

Apply to this trial

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

for Advanced Esophageal Squamous Cell Carcinoma

Drug: Nivolumab

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06265285·Phase 2·Recruiting·Listed Feb 2024

Apply to this trial

Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients

for Localized Prostate Carcinoma

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT05045066·EARLY_Phase 1·Recruiting·Listed Sep 2021

Apply to this trial

Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis

for Metastatic Penile Squamous Cell Carcinoma

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT06104618·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

Virtual Reality Intervention to Improve Psychological Symptom Burden for Cancer Patients Undergoing Treatment

for Adjustment Disorder

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT07221409·Recruiting·Listed Oct 2025

Apply to this trial

Diaphragmatic Breathing for the Treatment of Bloating and Distension

for Bloating

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06596759·Recruiting·Listed Sep 2024

Apply to this trial

Continuous Glucose Monitor for Mayo Clinic Advanced Care at Home Patients

for Diabetes Mellitus

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05880810·Recruiting·Listed May 2023

Apply to this trial

Postoperative Outcomes and Patient Satisfaction With Mayo Clinic Florida Care Hotel After Mastectomy and Tissue Expander Placement

for Breast Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06783179·Recruiting·Listed Jan 2025

Apply to this trial

Assessment of a Minimally Invasive Collection Device for Molecular Analysis of Esophageal Samples

for Barrett Esophagus

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 90

Code: NCT06071845·Recruiting·Listed Oct 2023

Apply to this trial

DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Breast Cancer Patients

for HER2-negative Breast Cancer

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06388122·Recruiting·Listed Apr 2024

Apply to this trial

A Study of Live Tumor Fragments of Surgical Resections

for Cancer

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07000864·Recruiting·Listed Jun 2025

Apply to this trial

Fasting Mimicking Diet for Reducing Immune Related Adverse Events for Cancer Patients on Immune Checkpoint Inhibitors, FMD-ICI Trial

for Advanced Malignant Solid Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06438588·Recruiting·Listed Jun 2024

Apply to this trial

Enhancing Skin Appearance and Quality of Life in Breast Cancer Survivors on Aromatase Inhibitor Therapy

for Anatomic Stage 0 Breast Cancer AJCC v8

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT06401889·Recruiting·Listed May 2024

Apply to this trial

Radioembolization With Tremelimumab and Durvalumab for Locally Advanced Unresectable or Oligo-Metastatic Intrahepatic Cholangiocarcinoma

for Locally Advanced Intrahepatic Cholangiocarcinoma

Drug: Tremelimumab

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06058663·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

for Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05541016·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

Integrating Molecular Pathology, Radiology, and Genetics to Improve Breast Cancer Risk

for Breast Carcinoma

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: Female·Age: 18 - 100·Accepts healthy volunteers

Code: NCT07207564·Recruiting·Listed Oct 2025

Apply to this trial

Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE)

for Gastric Antral Vascular Ectasia

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07169799·Recruiting·Listed Sep 2025

Apply to this trial

Reduced Dose Radiotherapy for the Treatment of Indolent Non-Hodgkin Lymphoma

for Indolent B-Cell Non-Hodgkin Lymphoma

Sites in Jacksonville +6 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06386315·Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

for Advanced Anal Carcinoma

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05969860·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

for Metastatic Malignant Neoplasm in the Brain

Sites in Jacksonville +6 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05222620·Phase 2·Recruiting·Listed Feb 2022

Apply to this trial

A Collaborative Intervention for Improving Cancer Pain Management in Cancer Survivors

for Hematopoietic and Lymphoid System Neoplasm

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06198010·Recruiting·Listed Jan 2024

Apply to this trial

Evaluating In Home Cancer Therapy Versus In Clinic Cancer Therapy in Black Men With Locally Advanced, Biochemically Recurrent and Metastatic Prostate Cancer

for Biochemically Recurrent Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Male·Age: 18+

Code: NCT07073794·Phase 2·Recruiting·Listed Jul 2025

Apply to this trial

A Multilevel Approach to Connecting Underrepresented Populations to Clinical Trials

for Cancer

Sites in Jacksonville, Gainesville & Miami

Sponsor: University of Florida

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT05655494·Recruiting·Listed Dec 2022

Apply to this trial

Stroke Thrombectomy and Aneurysm Registry

for Stroke

Sites in Jacksonville, Gainesville +52 more locations

Sponsor: Medical University of South Carolina

Sex: All·Age: 1 - 120

Code: NCT04994756·Recruiting·Listed Aug 2021

Apply to this trial

INTERogating Cancer for Etiology, Prevention and Therapy Navigation

for Cancer

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06008392·Recruiting·Listed Aug 2023

Apply to this trial

Accuracy of 18F-rhPSMA-7.3 PET/ MRI for Prediction of Lymph Node Metastasis in Localized High-Risk Prostate Cancer

for Localized Prostate Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: Male·Age: 30 - 85

Code: NCT06389786·Recruiting·Listed Apr 2024

Apply to this trial

Multi-Cancer Detection Observational Cohort Study

for Cancer

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 21+·Accepts healthy volunteers

Code: NCT06962995·Recruiting·Listed May 2025

Apply to this trial

Cancer Genetic Testing in Ethnic Populations

for Breast Carcinoma

Sites in Jacksonville +1 more location

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04475640·Recruiting·Listed Jul 2020

Apply to this trial

Vaccine Therapy Plus Pembrolizumab in Treating Advanced Ovarian, Fallopian Tube, or Primary Peritoneal Cavity Cancer

for Fallopian Tube Carcinosarcoma

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: Female·Age: 18+

Code: NCT05920798·Phase 1, Phase 2·Recruiting·Listed Jun 2023

Apply to this trial

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05746325·Recruiting·Listed Feb 2023

Apply to this trial

Allogenic Adipose-Derived Mesenchymal Stem Cells for the Treatment of Recurrent Glioblastoma or Recurrent Astrocytoma in Patients Undergoing Craniotomy

for Recurrent Glioblastoma, IDH-Wildtype

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT05789394·Phase 1·Recruiting·Listed Mar 2023

Apply to this trial

Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06279572·Recruiting·Listed Feb 2024

Apply to this trial

In-home Intravesical Chemotherapy for the Treatment of Bladder Cancer, INVITE Trial

for Non-Muscle Invasive Bladder Carcinoma

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06704191·Phase 1, Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

Identification and Differentiation of Thyroid Nodules by Acoustic Imaging and Viscoelastic Parameters

for Thyroid Gland Carcinoma

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 8+·Accepts healthy volunteers

Code: NCT06207188·Recruiting·Listed Jan 2024

Apply to this trial

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

for Metastatic Malignant Solid Neoplasm

1 location in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06911008·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial

Home-based Pulmonary Rehabilitation and Health Coaching in Patients With Fibrotic Interstitial Lung Disease

for Lung Fibrosis

Sites in Jacksonville +3 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT06751069·Recruiting·Listed Dec 2024

Apply to this trial

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

for Bone Sarcoma

Sites in Jacksonville +2 more locations

Sponsor: Mayo Clinic

Sex: All·Age: 15+

Code: NCT05033288·Recruiting·Listed Sep 2021

Apply to this trial