Clinical Trials at Arkansas Children's Hospital

As of July 2026, 89 paid clinical trials are recruiting at Arkansas Children's Hospital, located at 1 CHILDRENS WAY, SLOT 664, LITTLE ROCK, AR 72202-3500, phone (501) 364-2526 in Little Rock, Arkansas. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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91 clinical trials at Arkansas Children's Hospital

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Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Little Rock +152 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

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A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

Sites in Little Rock +116 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019

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Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

for Recurrent B Acute Lymphoblastic Leukemia

Sites in Little Rock +134 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 21

Code: NCT02981628·Phase 2·Recruiting·Listed Dec 2016

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

Sites in Little Rock +74 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting·Listed Oct 2023

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A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Little Rock +100 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

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Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

Sites in Little Rock +111 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting·Listed Mar 2024

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A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

Sites in Little Rock +107 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting·Listed Oct 2021

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Ensuring Access to Optimal Therapy in CF: The ENACT Study

for Cystic Fibrosis (CF)

Sites in Little Rock +2 more locations

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 3+

Code: NCT07148739·Phase 4·Recruiting·Listed Aug 2025

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Prevention of Bleeding in Patients With Moderate and Severe Hemophilia A Playing Sports: A Comparison Between Factor VIII and Emicizumab Prophylaxis

for Hemophilia A

Sites in Little Rock +9 more locations

Sponsor: Wayne State University

Sex: All·Age: 6 - 19

Code: NCT05022459·Recruiting·Listed Aug 2021

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Naxitamab Added to Induction for Newly Diagnosed High-Risk Neuroblastoma

for Neuroblastoma

Sites in Little Rock +18 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 12 Months - 21

Code: NCT05489887·Phase 2·Recruiting·Listed Aug 2022

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PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

for Bronchopulmonary Dysplasia (BPD)

Sites in Little Rock +4 more locations

Sponsor: Duke University

Sex: All·Age: 7 Days - 28 Days

Code: NCT07101640·Phase 1, Phase 2·Recruiting·Listed Aug 2025

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Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Little Rock +232 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

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Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for Atypical Teratoid/Rhabdoid Tumor

Sites in Little Rock +11 more locations

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 26

Code: NCT06465199·Phase 1, Phase 2·Recruiting·Listed Jun 2024

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TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II

for Lymphoblastic Leukemia

Sites in Little Rock +16 more locations

Sponsor: Tanja Andrea Gruber

Sex: All·Age: Up to 1

Code: NCT05848687·Phase 1, Phase 2·Recruiting·Listed May 2023

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Venetoclax in Children With Relapsed Acute Myeloid Leukemia (AML)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Little Rock +44 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: 29 Days - 21

Code: NCT05183035·Phase 3·Recruiting·Listed Jan 2022

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

Sites in Little Rock +170 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting·Listed Mar 2020

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Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Little Rock +210 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

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Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

for Acute Myeloid Leukemia

Sites in Little Rock +27 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 25

Code: NCT07022678·Phase 3·Recruiting·Listed Jun 2025

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Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children

for Hemorrhagic Shock

Sites in Little Rock +22 more locations

Sponsor: Philip Spinella

Sex: All·Age: Up to 17

Code: NCT06070350·Phase 3·Recruiting·Listed Oct 2023

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A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

Sites in Little Rock +145 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting·Listed May 2024

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A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

Sites in Little Rock +133 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting·Listed Dec 2020

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The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

for Extubation Failure

Sites in Little Rock +15 more locations

Sponsor: University of Pennsylvania

Sex: All·Age: 0 Days - 9 Weeks

Code: NCT05446272·Recruiting·Listed Jul 2022

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Catheter-Related Early Thromboprophylaxis With Enoxaparin Studies

for Deep Venous Thrombosis

Sites in Little Rock +19 more locations

Sponsor: Yale University

Sex: All·Age: Up to 17

Code: NCT04924322·Phase 2, Phase 3·Recruiting·Listed Jun 2021

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Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma

for Pleuropulmonary Blastoma

Sites in Little Rock +75 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT06647953·Phase 3·Recruiting·Listed Oct 2024

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Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

for Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection

Sites in Little Rock +21 more locations

Sponsor: University of Calgary

Sex: All·Age: 9 Months - 21

Code: NCT05219110·Recruiting·Listed Feb 2022

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Pediatric Precision Laboratory Advanced Neuroblastoma Therapy

for Neuroblastoma

Sites in Little Rock +19 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 22

Code: NCT02559778·Phase 2·Recruiting·Listed Sep 2015

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Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

for Embryonal Rhabdomyosarcoma

Sites in Little Rock +162 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022

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DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

for Medulloblastoma

Sites in Little Rock +22 more locations

Sponsor: Giselle Sholler

Sex: All·Age: Up to 21

Code: NCT04696029·Phase 2·Recruiting·Listed Jan 2021

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Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

for Acute Myeloid Leukemia

Sites in Little Rock +8 more locations

Sponsor: Norman J. Lacayo

Sex: All·Age: Up to 21

Code: NCT05101551·Phase 1·Recruiting·Listed Nov 2021

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Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer

for Hematopoietic and Lymphatic System Neoplasm

Sites in Little Rock, Fort Smith +178 more locations

Sponsor: Children's Oncology Group

Sex: Female·Age: Up to 39

Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024

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Comparison of Uncomplicated Candidemia Therapy Duration in Children

for Invasive Candidiasis

Sites in Little Rock +20 more locations

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days+

Code: NCT05763251·Recruiting·Listed Mar 2023

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Tipifarnib and Naxitamab for Relapsed/Refractory Neuroblastoma

for Neuroblastoma

Sites in Little Rock +11 more locations

Sponsor: Giselle Sholler

Sex: All·Age: 1 - 21

Code: NCT06540963·Phase 2·Recruiting·Listed Aug 2024

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

Sites in Little Rock +144 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017

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Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

for Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)

Sites in Little Rock +31 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 Day - 17

Code: NCT05267821·Phase 2, Phase 3·Recruiting·Listed Mar 2022

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A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

for Hematopoietic and Lymphatic System Neoplasm

Sites in Little Rock +75 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 15 - 20

Code: NCT06410209·Phase 2·Recruiting·Listed May 2024

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A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue

for Pediatric Sarcoma, Refractory

Sites in Little Rock +21 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 2 - 40

Code: NCT05634369·Phase 1, Phase 2·Recruiting·Listed Dec 2022

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Improving Safety and Quality of Tracheal Intubation Practice in Pediatric ICUs

for Failed or Difficult Intubation, Sequela

Sites in Little Rock +50 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT02493478·Recruiting·Listed Jul 2015

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Optimizing Pain Treatment in Children On Mechanical Ventilation

for Mechanical Ventilation

Sites in Little Rock +14 more locations

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 2 Months - 17

Code: NCT06994442·Phase 3·Recruiting·Listed May 2025

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

Sites in Little Rock +16 more locations

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting·Listed Jan 2021

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Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

Sites in Little Rock +113 more locations

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting·Listed Mar 2020

Apply to this trial