Oncology Clinical Trials in Louisville, KY

As of July 2026, 115 paid clinical trials are recruiting for Oncology in Louisville, Kentucky. Oncology trials evaluate immunotherapies, targeted therapies, antibody-drug conjugates, and combination regimens across solid tumors and blood cancers — from early-phase first-in-human studies to phase 3 registration trials. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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115 clinical trials for Oncology

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A Window of Opportunity Trial to Learn if Linvoseltamab is Safe and Well Tolerated, and How Well it Works in Adult Participants With Recently Diagnosed Multiple Myeloma Who Have Not Already Received Treatment

for Multiple Myeloma

Drug: Linvoseltamab

Sites in Louisville +12 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05828511·Phase 1, Phase 2·Recruiting·Listed Apr 2023

Apply to this trial

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult Participants With Advanced Prostate Cancer

for Metastatic Castration-resistant Prostate Cancer

Sites in Louisville +12 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT05125016·Phase 1, Phase 2·Recruiting·Listed Nov 2021

Apply to this trial

Safety, Pharmacokinetics, and Efficacy of AI-081, a Bispecific Antibody for PD-1 And VEGF in Advanced Solid Tumors

for Advanced Solid Tumor

Drug: AI-081

Sites in Louisville +18 more locations

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06635785·Phase 1, Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

Phase 1/2 Study of Linvoseltamab in Adult Patients With Relapsed or Refractory Multiple Myeloma

for Multiple Myeloma

Drug: Linvoseltamab

Sites in Louisville +6 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT03761108·Phase 1, Phase 2·Recruiting·Listed Dec 2018

Apply to this trial

A Study of ASP1002 in Adults for Treatment of Solid Tumors

for Advanced Solid Tumors

Sites in Louisville +11 more locations

Sponsor: Astellas Pharma Global Development, Inc.

Sex: All·Age: 18+

Code: NCT05719558·Phase 1·Recruiting·Listed Feb 2023

Apply to this trial

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for Non Small Cell Lung Cancer

Sites in Louisville +23 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT05983432·Phase 1·Recruiting·Listed Aug 2023

Apply to this trial

A Clinical Study of YL205 in Patients With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Louisville +10 more locations

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT06459973·Phase 1, Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

for Advanced Cancer

Sites in Louisville +11 more locations

Sponsor: Riboscience, LLC.

Sex: All·Age: 18+

Code: NCT05270213·Phase 1·Recruiting·Listed Mar 2022

Apply to this trial

A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Drug: Livmoniplimab

Sites in Louisville +11 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06109272·Phase 2, Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Endometrial Cancer.

for Endometrial Cancer

Drug: Lifileucel

Sites in Louisville +11 more locations

Sponsor: Iovance Biotherapeutics, Inc.

Sex: Female·Age: 18 - 70

Code: NCT06481592·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

for Pulmonary Nodule, Solitary

Sites in Louisville, Lexington +20 more locations

Sponsor: Veracyte, Inc.

Sex: All·Age: 29 - 85

Code: NCT06426628·Recruiting·Listed May 2024

Apply to this trial

Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar

for Colorectal Cancer

Sites in Louisville +5 more locations

Sponsor: Exero Medical Ltd.

Sex: All·Age: 21+

Code: NCT07337590·Recruiting·Listed Jan 2026

Apply to this trial

A Study of BI 3810944 in Patients With Advanced Cancer

for Solid Tumours

Sites in Louisville +3 more locations

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07224425·Phase 1·Recruiting·Listed Nov 2025

Apply to this trial

EXoPERT EMERALD Clinical Study

for Breast Cancer

Sites in Louisville, Lexington +7 more locations

Sponsor: EXoPERT

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT07186296·Recruiting·Listed Sep 2025

Apply to this trial

A Study of ZW251 in Participants With Advanced Solid Tumors

for Hepatocellular Carcinoma

Sites in Louisville +7 more locations

Sponsor: Zymeworks BC Inc.

Sex: All·Age: 18+

Code: NCT07164313·Phase 1·Recruiting·Listed Sep 2025

Apply to this trial

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

for Tumor Skin

Sites in Louisville +7 more locations

Sponsor: Obsidian Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06060613·Phase 1, Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

for Cervical Squamous Cell Carcinoma

Sites in Louisville +8 more locations

Sponsor: Alentis Therapeutics AG

Sex: All·Age: 18+

Code: NCT07169734·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

for Squamous Non-small-cell Lung Cancer

Sites in Louisville +7 more locations

Sponsor: Alentis Therapeutics AG

Sex: All·Age: 18+

Code: NCT06747585·Phase 1, Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Louisville +7 more locations

Sponsor: Vividion Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06004245·Phase 1·Recruiting·Listed Aug 2023

Apply to this trial

Safety, Pharmacokinetics (PK), and Efficacy of ONC 841 in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Louisville +7 more locations

Sponsor: OncoC4, Inc.

Sex: All·Age: 18+

Code: NCT06352359·Phase 1·Recruiting·Listed Apr 2024

Apply to this trial

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Sites in Louisville, Lexington +3 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT05142189·Phase 1·Recruiting·Listed Dec 2021

Apply to this trial

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Louisville +6 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT06750185·Phase 1·Recruiting·Listed Dec 2024

Apply to this trial

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

for Non-Small Cell Lung Cancer

Sites in Louisville +6 more locations

Sponsor: Avistone Biotechnology Co., Ltd.

Sex: All·Age: 18+

Code: NCT06046495·Phase 1·Recruiting·Listed Sep 2023

Apply to this trial

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

for Renal Cell Cancer

Sites in Louisville +2 more locations

Sponsor: Portage Biotech

Sex: All·Age: 18+

Code: NCT04969315·Phase 1, Phase 2·Recruiting·Listed Jul 2021

Apply to this trial

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

for Chronic Lymphocytic Leukemia

Drug: Sonrotoclax

Sites in Louisville +151 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 65+

Code: NCT07321652·Phase 3·Recruiting·Listed Jan 2026

Apply to this trial

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

for Breast Cancer

Sites in Louisville, Bardstown +1103 more locations

Sponsor: NRG Oncology

Sex: Female·Age: 18 - 60

Code: NCT05879926·Phase 3·Recruiting·Listed May 2023

Apply to this trial

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

Sites in Louisville, Bardstown +464 more locations

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016

Apply to this trial

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

for Lung Non-Small Cell Carcinoma

Sites in Louisville, Elizabethtown +638 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020

Apply to this trial

Testing Continuous Versus Intermittent Treatment With the Study Drug Zanubrutinib for Older Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Sites in Louisville +226 more locations

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 60+

Code: NCT05976763·Phase 3·Recruiting·Listed Aug 2023

Apply to this trial

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for Acute Myeloid Leukemia

Sites in Louisville, Lexington +326 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Louisville, Lexington +221 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06317649·Phase 2·Recruiting·Listed Mar 2024

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Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for Myelodysplastic Syndrome

Sites in Louisville +139 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06577441·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for Prostate Adenocarcinoma

Sites in Louisville, Elizabethtown +397 more locations

Sponsor: NRG Oncology

Sex: Male·Age: 18+

Code: NCT05946213·Phase 3·Recruiting·Listed Jul 2023

Apply to this trial

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Louisville, Elizabethtown +255 more locations

Sponsor: NRG Oncology

Sex: All·Age: 18+

Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024

Apply to this trial

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Sites in Louisville, Lexington +207 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554406·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Louisville, Lexington +186 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

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Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

Sites in Louisville, Lexington +162 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554393·Phase 2·Recruiting·Listed Sep 2022

Apply to this trial

A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

for Hematologic Malignancies

Sites in Louisville +112 more locations

Sponsor: Center for International Blood and Marrow Transplant Research

Sex: All·Age: All ages

Code: NCT01351545·Recruiting·Listed May 2011

Apply to this trial

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Louisville, Lexington +169 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

Apply to this trial

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Sites in Louisville +126 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06672146·Phase 2·Recruiting·Listed Nov 2024

Apply to this trial

Conditions in Oncology (Louisville, KY)

Non-small cell lung cancer (NSCLC)· 15 Solid tumor· 15 Acute myeloid leukemia (AML)· 11 Breast cancer· 8 Head and neck cancer· 8 Pancreatic cancer· 7 Ovarian cancer· 7 Myelodysplastic syndromes (MDS)· 6 Diffuse large B-cell lymphoma (DLBCL)· 6 Hematologic malignancy· 6 Multiple myeloma· 5 Melanoma· 5 Lung cancer· 4 Colorectal cancer· 4 Endometrial cancer· 4 Non-Hodgkin lymphoma· 4 Neuroblastoma· 4 Cancer (any)· 4 Metastatic breast cancer· 3 Triple-negative breast cancer· 3 Liver cancer· 3 Biliary tract cancer· 3 Metastatic prostate cancer· 3 Gastric cancer· 2 Esophageal cancer· 2 Gastroesophageal junction cancer· 2 Prostate cancer· 2 Cervical cancer· 2 Fallopian tube cancer· 2 Chronic lymphocytic leukemia (CLL)· 2 Leukemia (other)· 2 Osteosarcoma· 2 Small cell lung cancer· 1 Colon cancer· 1 Bladder cancer· 1 Kidney cancer· 1 Brain cancer· 1 Brain metastases· 1 Acute lymphoblastic leukemia· 1 Myelofibrosis· 1 Myeloproliferative neoplasm· 1 Hodgkin lymphoma· 1 Mantle cell lymphoma· 1 Small lymphocytic lymphoma· 1 Ewing sarcoma· 1 Rhabdomyosarcoma· 1 Pediatric cancer· 1