Paid Clinical Trials in Louisville, KY
As of September 2026, 484 paid clinical trials are recruiting in Louisville, Kentucky. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Louisville offers studies at sites including University of Louisville for conditions such as Heart Failure, Obesity, Acute Myeloid Leukemia, Overweight. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Louisville
Trials by drug in Louisville
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Newly added in Louisville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Modified P200TE Data Collection
Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF)
446 clinical trials
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
A Study of Dotinurad Versus Allopurinol in Participants With Gout
A Study of Dotinurad Versus Allopurinol in Tophaceous Gout
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
A Clinical Study of Molnupiravir to Prevent Severe Illness From Coronavirus Disease 2019 (COVID-19) in People Who Are High Risk (MK-4482-023)
A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Top Research Study Locations in Louisville
Researchers run research studies in Louisville, KY at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Louisville | Gastroparesis, Gastroparesis Nondiabetic, AAA - Abdominal Aortic Aneurysm | 63 |
| Norton Cancer Institute | Multiple Myeloma, Advanced Solid Tumors, Metastatic Castration-resistant Prostate Cancer | 35 |
| UofL Health Medical Center Northeast | Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm, Acute Myeloid Leukemia Post Cytotoxic Therapy | 34 |
| Norton Children's Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 30 |
| The James Graham Brown Cancer Center at University of Louisville | Anatomic Stage II Breast Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Lung Cancer Screening | 27 |
| Baptist Health Louisville | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 20 |
| University of Louisville Hospital | Acute Decompensated Heart Failure, Alcohol Use Disorder, Alcohol-associated Liver Disease | 14 |
| Norton Healthcare | Atrial Arrhythmia, Atrial Fibrillation, Postoperative, Atrial Tachycardia | 9 |
| Gastroenterology Health Partners | Irritable Bowel Syndrome, Obesity or Overweight, Ulcerative Colitis | 7 |
| University of Louisville Health | Brain Injuries, Diffuse Large B Cell Lymphoma (DLBCL), Diffuse Large B Cell Lymphoma Refractory | 6 |
| Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine | Neuroblastoma, Ewing Sarcoma, Liposarcoma | 5 |
| Norton Women's and Children's Hospital | Cervical Cancer, Fallopian Tube Neoplasms, Multiple Myeloma | 5 |
| Robley Rex VA Medical Center | Burn Pit Exposure, Environmental Exposures, Forever Chemicals | 5 |
| Monroe Biomedical Research | Obesity, Overweight, Obesity & Overweight | 4 |
| Monroe Biomedical Research - Louisville | Overweight, Obesity, Obesity, Abdominal | 4 |
| Norton Audubon Hospital | Colorectal Neoplasms, Lumbar Spinal Stenosis, Non-Small Cell Lung Cancer Metastatic | 4 |
| Norton Brownsboro Hospital | Colorectal Neoplasms, Lumbar Spinal Stenosis, Non-Small Cell Lung Cancer Metastatic | 4 |
| Norton Cancer Institute - Downtown | Breast Cancer, Cervical Cancer, Colorectal Neoplasms | 4 |
| Norton Hospital | Cardiovascular Diseases, Cervical Cancer, Colorectal Neoplasms | 4 |
| UofL Health Brown Cancer Center | Breast Cancer, Leukemia, Myeloid, Acute, Locally Advanced or Metastatic Castration-resistant Prostate Cancer | 4 |
| University Of Louisville Brown Cancer Center | Immune Thrombocytopenic Purpura (ITP), Advanced Melanoma, Large B-cell Lymphoma | 4 |
| Frazier Rehabilitation and Neuroscience Institute | Spinal Cord Injuries, Autonomic Dysreflexia, Breathing Exercises | 3 |
| James Graham Brown Cancer Center | Infusion Reactions, Metastatic Breast Cancer, Non Small Cell Lung Cancer | 3 |
| Norton Brownsboro Hospital and Medical Campus | Intracranial Meningioma, NF2 Gene Mutation, Ovarian Carcinoma | 3 |
| Norton Cancer Institute, Downtown | Colorectal Neoplasms, Extensive-stage Small Cell Lung Cancer (ES-SCLC), Non-Small Cell Lung Cancer Metastatic | 3 |
Active & Upcoming Studies in Louisville (2026)
Recruiting trials in Louisville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (167 active studies)
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
- Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia · Phase 3 · Children's Oncology Group
Cardiovascular (42 active studies)
- Integrating Values Based Communication in Heart Failure Management · Abigail Latimer
- A Phase 3 Trial of Inhaled Mosliciguat in PH-ILD (PHrontier) · Phase 3 · Pulmovant, Inc.
Diabetes & metabolic (32 active studies)
- A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity · Phase 3 · Eli Lilly and Company
- Efficacy, Safety, and Pharmacokinetics of Tirzepatide (LY3298176) Once Weekly Versus Placebo in Pediatric Participants 6 to Less Than 12 Years of Age Who Have Obesity (ADVANCE-SURMOUNT-KIDS) · Phase 3 · Eli Lilly and Company
Neurology & pain (14 active studies)
- Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis · University of Louisville
- Study to Evaluate the Effectiveness and Safety of Ozanimod Compared to Fingolimod in Children and Adolescents With Relapsing Remitting Multiple Sclerosis · Phase 3 · Bristol-Myers Squibb
Eye & vision (5 active studies)
- Long-term Effects of Acoltremon vs. Control in Dry Eye Disease · The Eye Care Institute
- Modified P200TE Data Collection · Optos, PLC
Vaccines (4 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID · University of Louisville
Pediatric (4 active studies)
- CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes · ClinQure, Inc.
- Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome · HELP for NOWS Consortium
HIV / STI (3 active studies)
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
- Long-Acting Injectable HIV PrEP PROs · Anupama Raghuram MD
Mental health & behavior (2 active studies)
- Testing STAR and TextSTAR: A Randomized Controlled Trial · University of Wisconsin, Madison
- Harm Reduction for Smokers With Mental Illness · Dartmouth-Hitchcock Medical Center
Common conditions studied in Louisville
- Heart Failure (12 active studies)
- Obesity (12 active studies)
- Acute Myeloid Leukemia (10 active studies)
- Overweight (10 active studies)
- Breast Cancer (7 active studies)
- Gastroparesis (7 active studies)
Leading research sponsors in Louisville
- University of Louisville
- AstraZeneca
- National Cancer Institute (NCI)
- Children's Oncology Group
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Louisville?
There are approximately 484 recruiting clinical trials in Louisville, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Louisville pay participants?
Most recruiting trials in Louisville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Louisville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Louisville?
The most common conditions under active study in Louisville include Heart Failure (12), Obesity (12), Acute Myeloid Leukemia (10), Overweight (10), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Louisville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Louisville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Louisville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Louisville?
Recruiting research sites in Louisville include University of Louisville, Norton Cancer Institute, UofL Health Medical Center Northeast, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Louisville right now?
The largest active categories in Louisville are Cancer & tumors (167), Cardiovascular (42), Diabetes & metabolic (32). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.