Paid Clinical Trials in Louisville, KY
As of August 2026, 496 paid clinical trials are recruiting in Louisville, Kentucky. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Louisville offers studies at sites including University of Louisville for conditions such as Heart Failure, Acute Myeloid Leukemia, Obesity, Head and Neck Squamous Cell Carcinoma. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Louisville
Trials by drug in Louisville
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Newly added in Louisville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Kentucky - Quality Improvement Implementation Lung Cancer Screening (QUILS™) Health Services Research Intervention
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight
A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study
A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer
462 clinical trials
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemia
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Study to Evaluate the Safety and Efficacy of Larsucosterol in Participants With Alcohol-associated Hepatitis (AH)
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)
A Study Evaluating BFB759 in Moderate to Severe Hidradenitis Suppurativa
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)
A Study of Dotinurad Versus Allopurinol in Participants With Gout
A Study of Dotinurad Versus Allopurinol in Tophaceous Gout
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
Ocular Assessments in Patients Treated With Tivdak® in Recurrent or Metastatic Cervical Cancer
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
Top Research Study Locations in Louisville
Researchers run research studies in Louisville, KY at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Louisville | Gastroparesis, Gastroparesis Nondiabetic, AAA - Abdominal Aortic Aneurysm | 65 |
| The James Graham Brown Cancer Center at University of Louisville | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 37 |
| Norton Cancer Institute | Multiple Myeloma, Ovarian Cancer, Advanced Solid Tumors | 35 |
| UofL Health Medical Center Northeast | Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm | 34 |
| Norton Children's Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 32 |
| Baptist Health Louisville | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 21 |
| University of Louisville Hospital | Acute Decompensated Heart Failure, Alcohol Use Disorder, Alcohol-associated Liver Disease | 13 |
| Norton Healthcare | Atrial Arrhythmia, Atrial Fibrillation, Postoperative, Atrial Tachycardia | 9 |
| Gastroenterology Health Partners | Irritable Bowel Syndrome, Obesity or Overweight, Ulcerative Colitis | 7 |
| Robley Rex VA Medical Center | Burn Pit Exposure, Diabetes Mellitus, Type 1, Environmental Exposures | 6 |
| University of Louisville Health | Brain Injuries, Diffuse Large B Cell Lymphoma (DLBCL), Diffuse Large B Cell Lymphoma Refractory | 6 |
| Norton Children's Research Institute/Affiliated with University of Louisville School of Medicine | Neuroblastoma, Ewing Sarcoma, Liposarcoma | 5 |
| Norton Hospital | Pulmonary Hypertension, Cardiovascular Diseases, Cervical Cancer | 5 |
| Norton Women's and Children's Hospital | Cervical Cancer, Fallopian Tube Neoplasms, Multiple Myeloma | 5 |
| Monroe Biomedical Research | Obesity, Overweight, Atherosclerotic Cardiovascular Disease | 4 |
| Monroe Biomedical Research - Louisville | Obesity, Overweight, Osteoarthritis | 4 |
| Norton Audubon Hospital | Colorectal Neoplasms, Lumbar Spinal Stenosis, Non-Small Cell Lung Cancer Metastatic | 4 |
| Norton Brownsboro Hospital | Colorectal Neoplasms, Lumbar Spinal Stenosis, Non-Small Cell Lung Cancer Metastatic | 4 |
| Norton Brownsboro Hospital and Medical Campus | Anatomic Stage IV Breast Cancer AJCC v8, Intracranial Meningioma, Metastatic Breast Carcinoma | 4 |
| Norton Cancer Institute - Downtown | Breast Cancer, Cervical Cancer, Colorectal Neoplasms | 4 |
| Norton Cancer Institute, Downtown | Colorectal Neoplasms, Extensive-stage Small Cell Lung Cancer (ES-SCLC), Metastatic Urothelial Cancer | 4 |
| Norton Pulmonary Specialists | Interstitial Lung Disease, Pulmonary Hypertension, Idiopathic Pulmonary Fibrosis | 4 |
| UofL Health Brown Cancer Center | Breast Cancer, Leukemia, Myeloid, Acute, Locally Advanced or Metastatic Castration-resistant Prostate Cancer | 4 |
| University Of Louisville Brown Cancer Center | Immune Thrombocytopenic Purpura (ITP), Advanced Melanoma, Large B-cell Lymphoma | 4 |
| Frazier Rehabilitation and Neuroscience Institute | Spinal Cord Injuries, Autonomic Dysreflexia, Breathing Exercises | 3 |
Active & Upcoming Studies in Louisville (2026)
Recruiting trials in Louisville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (179 active studies)
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
- A Study of ARC-02 in B-cell NHL · Phase 1 · Taiho Oncology, Inc.
Cardiovascular (43 active studies)
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity · Phase 3 · Novo Nordisk A/S
Diabetes & metabolic (33 active studies)
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- A Study to Test Whether BI 3034701 Helps People to Lose Weight Who Live With Obesity or Overweight · Phase 2 · Boehringer Ingelheim
Neurology & pain (18 active studies)
- Gastric Electrical Stimulation for Abdominal Pain in Patients With Gastroparesis · University of Louisville
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Eye & vision (5 active studies)
- Long-term Effects of Acoltremon vs. Control in Dry Eye Disease · The Eye Care Institute
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
Pediatric (5 active studies)
- CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes · ClinQure, Inc.
- Target Trial Emulation for Pharmacologic Treatment of Neonatal Opioid Withdrawal Syndrome · HELP for NOWS Consortium
Vaccines (4 active studies)
- Osteopathic Manipulative Therapy Effects on Post-Acute Sequelae of COVID-19 (PASC) or Long COVID · University of Louisville
- A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe Disease · Phase 3 · Pfizer
HIV / STI (3 active studies)
- A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study) · Phase 2 · ViiV Healthcare
- Long-Acting Injectable HIV PrEP PROs · Anupama Raghuram MD
Mental health & behavior (2 active studies)
- Testing STAR and TextSTAR: A Randomized Controlled Trial · University of Wisconsin, Madison
- Harm Reduction for Smokers With Mental Illness · Dartmouth-Hitchcock Medical Center
Common conditions studied in Louisville
- Heart Failure (12 active studies)
- Acute Myeloid Leukemia (11 active studies)
- Obesity (11 active studies)
- Head and Neck Squamous Cell Carcinoma (8 active studies)
- Overweight (8 active studies)
- Breast Cancer (7 active studies)
Leading research sponsors in Louisville
- University of Louisville
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Louisville?
There are approximately 496 recruiting clinical trials in Louisville, Kentucky listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Louisville pay participants?
Most recruiting trials in Louisville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Louisville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Louisville?
The most common conditions under active study in Louisville include Heart Failure (12), Acute Myeloid Leukemia (11), Obesity (11), Head and Neck Squamous Cell Carcinoma (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Louisville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Louisville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Louisville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Louisville?
Recruiting research sites in Louisville include University of Louisville, The James Graham Brown Cancer Center at University of Louisville, Norton Cancer Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Louisville right now?
The largest active categories in Louisville are Cancer & tumors (179), Cardiovascular (43), Diabetes & metabolic (33). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.