Paid Clinical Trials in Massachusetts

Massachusetts has 3,446 paid clinical trials enrolling now across cities including Boston, Worcester and Burlington. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 31, 2026.

Filter results

Filter results

State

City

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

2,953 clinical trials

A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1

for Unresectable Head and Neck Squamous Cell Carcinoma

Sites in Boston +13 more locations

Sponsor: BioNTech SE

Sex: All·Age: 18+

Code: NCT04534205·Phase 2, Phase 3·Recruiting·Listed Sep 2020

Apply to this trial

Non-Invasive Preeclampsia Screening and Biobank

for Preeclampsia (PE)

Sites in Boston +19 more locations

Sponsor: Sequenom, Inc.

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06643741·Recruiting·Listed Oct 2024

Apply to this trial

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

for Advanced Solid Tumor

Sites in Boston +14 more locations

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06997029·Phase 1·Recruiting·Listed May 2025

Apply to this trial

Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

Sites in Boston +16 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting·Listed Mar 2024

Apply to this trial

A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension

for Uncontrolled Hypertension

Sites in Boston +21 more locations

Sponsor: Retension Pharmaceuticals. Inc.

Sex: All·Age: 18 - 70

Code: NCT07142356·Phase 2·Recruiting·Listed Aug 2025

Apply to this trial

A Study Observing Everyday Effectiveness and Safety of the Drug Elafibranor in Participants With Primary Biliary Cholangitis Who Are Receiving Ongoing Treatment

for Primary Biliary Cholangitis

Drug: Elafibranor

Sites in Boston +18 more locations

Sponsor: Ipsen

Sex: All·Age: All ages

Code: NCT06447168·Recruiting·Listed Jun 2024

Apply to this trial

A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

for Multiple Myeloma

Sites in Boston +14 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06121843·Phase 1·Recruiting·Listed Nov 2023

Apply to this trial

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

for Solid Tumor Cancer

Sites in Boston +10 more locations

Sponsor: Avenzo Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07193511·Phase 1, Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

Study of COYA 302 for the Treatment of ALS

for Amyotrophic Lateral Sclerosis (ALS)

Sites in Boston +20 more locations

Sponsor: Coya Therapeutics

Sex: All·Age: 18 - 80

Code: NCT07161999·Phase 2·Recruiting·Listed Sep 2025

Apply to this trial

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

for Angelman Syndrome

Sites in Boston +17 more locations

Sponsor: Ionis Pharmaceuticals, Inc.

Sex: All·Age: 2 - 50

Code: NCT06914609·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors

for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Drug: Cemiplimab

Sites in Boston +22 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT03972657·Phase 1, Phase 2·Recruiting·Listed Jun 2019

Apply to this trial

A Study of Patritumab Deruxtecan in Pediatric Participants With Relapsed or Refractory Solid Tumors (MK-9999-01C/LIGHTBEAM-U01)

for Malignant Neoplasm

Sites in Boston +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 Month - 17

Code: NCT06941272·Phase 1, Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

An Open-label Study of JSB462 (Luxdegalutamide) in Combination With Abiraterone in Adult Male Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

for Metastatic Hormone-sensitive Prostate Cancer

Drug: JSB462

Sites in Boston +20 more locations

Sponsor: Novartis Pharmaceuticals

Sex: Male·Age: 18+

Code: NCT06991556·Phase 2·Recruiting·Listed May 2025

Apply to this trial

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

for Locally Advanced or Metastatic Solid Tumors

Sites in Boston +8 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT05581004·Phase 1·Recruiting·Listed Oct 2022

Apply to this trial

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

for Carcinoma, Non-Small-Cell Lung

Sites in Boston +17 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18+

Code: NCT06667908·Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

for Squamous Cell Carcinoma of Head and Neck

Drug: Amivantamab

Sites in Boston +13 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT06385080·Phase 1, Phase 2·Recruiting·Listed Apr 2024

Apply to this trial

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

for Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer

Sites in Boston +8 more locations

Sponsor: Hoffmann-La Roche

Sex: Female·Age: 18+

Code: NCT04802759·Phase 1, Phase 2·Recruiting·Listed Mar 2021

Apply to this trial

4D-710 in Adult Patients With Cystic Fibrosis

for Cystic Fibrosis Lung

Sites in Boston +17 more locations

Sponsor: 4D Molecular Therapeutics

Sex: All·Age: 18+

Code: NCT05248230·Phase 2·Recruiting·Listed Feb 2022

Apply to this trial

A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

for Lymphoma

Sites in Boston +13 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT07015242·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

A Follow-up Study of Mezagitamab in Adults With Chronic Primary Immune Thrombocytopenia

for Immune Thrombocytopenic Purpura (ITP)

Sites in Boston, Worcester +14 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06948318·Phase 3·Recruiting·Listed Apr 2025

Apply to this trial

Assessment of Support With Impella® Best Practices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

for AMI Cardiogenic Shock

Sites in Boston +17 more locations

Sponsor: Abiomed Inc.

Sex: All·Age: 18+

Code: NCT06964685·Recruiting·Listed May 2025

Apply to this trial

A Study to Investigate Airway Inflammation With Dupilumab Subcutaneously in Participants Aged ≥40 to ≤85 Years With Chronic Obstructive Pulmonary Disease.

for Chronic Obstructive Pulmonary Disease

Drug: Dupilumab

Sites in Boston +9 more locations

Sponsor: Sanofi

Sex: All·Age: 40 - 85

Code: NCT07053423·Phase 4·Recruiting·Listed Jul 2025

Apply to this trial

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

for MTAP-deleted Solid Tumors

Sites in Boston +16 more locations

Sponsor: Bayer

Sex: All·Age: 18+

Code: NCT06914128·Phase 1, Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

ARC-IM System to Manage Symptomatic Blood Pressure Instability Secondary to Chronic Spinal Cord Injury

for Spinal Cord Injuries

Sites in Cambridge +11 more locations

Sponsor: ONWARD Medical, Inc.

Sex: All·Age: 18 - 75

Code: NCT07147296·Recruiting·Listed Aug 2025

Apply to this trial

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

for Systemic Lupus Erythematosus

Drug: Inebilizumab

Sites in Boston +11 more locations

Sponsor: Amgen

Sex: All·Age: 18 - 75

Code: NCT06570798·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

for Solid Tumor

Sites in Boston +10 more locations

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06619587·Phase 1·Recruiting·Listed Oct 2024

Apply to this trial

A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)

for PIK3CA-Related Overgrowth Spectrum (PROS)

Sites in Boston +19 more locations

Sponsor: Relay Therapeutics, Inc.

Sex: All·Age: 2+

Code: NCT06789913·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Patiromer for Treatment of Hyperkalaemia in Children Under 12 Years of Age

for Hyperkalemia

Drug: patiromer

Sites in Boston +10 more locations

Sponsor: Vifor Pharma, Inc.

Sex: All·Age: 0 - 11

Code: NCT05766839·Phase 2·Recruiting·Listed Mar 2023

Apply to this trial

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

Sites in Boston +16 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2·Recruiting·Listed May 2024

Apply to this trial

A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

for Relapsed or Refractory Multiple Myeloma (RRMM)

Sites in Boston +19 more locations

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06615479·Phase 3·Recruiting·Listed Sep 2024

Apply to this trial

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

for Solid Tumors

Sites in Boston +10 more locations

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT05836324·Phase 1·Recruiting·Listed May 2023

Apply to this trial

A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

for Diffuse Large B-cell Lymphoma (DLBCL)

Drug: Odronextamab

Sites in Boston +17 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091865·Phase 3·Recruiting·Listed Oct 2023

Apply to this trial

A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)

for Healthy Volunteers, Pulmonary Arterial Hypertension

Sites in Boston, Burlington +18 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06649110·Phase 1, Phase 2·Recruiting·Listed Oct 2024

Apply to this trial

Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

Sites in Boston +23 more locations

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting·Listed May 2024

Apply to this trial

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

for Advanced Solid Tumors

Sites in Boston +9 more locations

Sponsor: Ensem Therapeutics

Sex: All·Age: 18+

Code: NCT06993844·Phase 1, Phase 2·Recruiting·Listed May 2025

Apply to this trial

Study of HLD-0915 in Patients With Metastatic Prostate Cancer

for Metastatic Prostate Cancer

Sites in Boston +10 more locations

Sponsor: Janssen Research & Development, LLC

Sex: Male·Age: 18+

Code: NCT06800313·Phase 1, Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

for Small Cell Lung Cancer (SCLC)

Sites in Boston +14 more locations

Sponsor: Phanes Therapeutics

Sex: All·Age: 18+

Code: NCT05652686·Phase 1, Phase 2·Recruiting·Listed Dec 2022

Apply to this trial

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

for Heart Failure

Sites in Boston +19 more locations

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 29 Days - 17

Code: NCT05714085·Phase 2, Phase 3·Recruiting·Listed Feb 2023

Apply to this trial

A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

for Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations

Sites in Boston +14 more locations

Sponsor: Taiho Oncology, Inc.

Sex: All·Age: 18+

Code: NCT05967689·Phase 2·Recruiting·Listed Aug 2023

Apply to this trial

Investigation of Ubamatamab Combination Therapy in Adult Participants With Platinum-Resistant Ovarian Cancer

for Ovarian Cancer

Sites in Boston +20 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT06787612·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial