Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

for Hormone Receptor Positive HER-2 Negative Breast Cancer

35 locations incl. Birmingham

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06369285·Phase 2·Recruiting

Apply to this trial

Quizartinib or Placebo Plus Chemotherapy in Newly Diagnosed Patients With FLT3-ITD Negative AML

for Leukemia

53 locations incl. Goodyear

Sponsor: Daiichi Sankyo

Sex: All·Age: 18 - 70

Code: NCT06578247·Phase 3·Recruiting

Apply to this trial

Trial of the Impact of Sibeprenlimab on Immunoglobulin A Nephropathy Kidney Tissue

for IgA Nephropathy

4 locations incl. Denver

Sponsor: Otsuka Pharmaceutical Development & Commercialization, Inc.

Sex: All·Age: 16+

Code: NCT06740526·Phase 2·Recruiting

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Virtual Reality to Combat Weight-Based Implicit Bias: BWH Pilot Study

for Implicit Bias

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07283523·Enrolling By Invitation

Application of a Clinical Decision Support System to Reduce Mechanical Ventilation Duration After Cardiac Surgery in Children

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 12

Code: NCT05687292·Recruiting

Apply to this trial

Evaluating Interventions for Intimate Partner Violence Use in Washington State

for Intimate Partner Violence

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18+

Code: NCT06526247·Recruiting

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Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

for Chronic Granulomatous Disease (CGD)

50 locations incl. Montgomery

Sponsor: Ensoma

Sex: All·Age: All ages

Code: NCT06605378·Recruiting

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REcovery From DEXmedetomidine-induced Unconsciousness

for Anesthesia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06003127·Recruiting

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A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

for Migraine

Drug: Rimegepant

27 locations incl. Phoenix

Sponsor: Pfizer

Sex: All·Age: 12 - 17

Code: NCT06616194·Phase 3·Recruiting

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Mind Body Intervention for Chronic Migraine Headaches

for Migraines

2 locations incl. Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06690060·Recruiting

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Avelumab and M1774 in ARID1A-mutated Endometrial Cancer

for Endometrial Cancer

2 locations incl. Boston

Sponsor: Panagiotis Konstantinopoulos, MD, PhD

Sex: Female·Age: 18+

Code: NCT06518564·Phase 2·Recruiting

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A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors

for Solid Tumor

12 locations incl. La Jolla

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06619587·Phase 1·Recruiting

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First-in-Human Trial of DS-2243a in Participants With Advanced Solid Tumors

for Solid Tumors

3 locations incl. Boston

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06644755·Phase 1·Recruiting

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Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B

for HEPATITIS B CHRONIC

1 location in Boston

Sponsor: Precision BioSciences, Inc.

Sex: All·Age: 18 - 70

Code: NCT06680232·Phase 1·Recruiting

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Real-world Effectiveness of HPV Vaccine in Women Living With HIV and Its Impact on Cervical Cancer Screening Accuracies

for Hiv

9 locations incl. Denver

Sponsor: University of California, Los Angeles

Sex: Female·Age: 21 - 40

Code: NCT06144229·Enrolling By Invitation

Adolescent Outcomes of Post-operative Opioid EXposure

for Opioid Use Disorder

5 locations incl. Aurora

Sponsor: Sharon Levy

Sex: All·Age: 12 - 17

Code: NCT06350409·Recruiting

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Acceptability and Safety of MR-C-014 in Persons With Neuromyelitis Optica Spectrum Disorder

for Neuromyelitis Optica Spectrum Disorder

2 locations incl. Atlanta

Sponsor: MedRhythms, Inc.

Sex: All·Age: 18 - 70

Code: NCT06374264·Enrolling By Invitation

Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis

for Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring

12 locations incl. Phoenix

Sponsor: University of Southern California

Sex: All·Age: 60+

Code: NCT06496867·Recruiting

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Multicenter Symphony IL-6 Monitoring Sepsis ICU Validation Study

for Sepsis, Septic Shock

5 locations incl. Gainesville

Sponsor: Bluejay Diagnostics, Inc.

Sex: All·Age: 22+

Code: NCT06654895·Recruiting

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Xeltis Hemodialysis Access Graft (aXess) US Study

for End Stage Renal Disease

7 locations incl. Phoenix

Sponsor: Xeltis

Sex: All·Age: 18+

Code: NCT06494631·Enrolling By Invitation

Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy

for Otoferlin Gene-mediated Hearing Loss

3 locations incl. Iowa City

Sponsor: Akouos, Inc.

Sex: All·Age: All ages

Code: NCT06696456·Enrolling By Invitation

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

for Developmental and Epileptic Encephalopathy

31 locations incl. Little Rock

Sponsor: Longboard Pharmaceuticals

Sex: All·Age: 2 - 65

Code: NCT06719141·Phase 3·Recruiting

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The Effect of PROSE or Scleral Lenses on Mental Health

for Depression - Major Depressive Disorder

1 location in Needham

Sponsor: Boston Sight

Sex: All·Age: All ages

Code: NCT07195721·Recruiting

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Eating to Adjust the Timing System

for Dietary Intervention

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05800990·Recruiting

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Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

for Heart Failure

6 locations incl. Chicago

Sponsor: Northwestern University

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT06517186·Recruiting

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Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU

for Consciousness Disorders

2 locations incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06568536·Recruiting

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Anti-GD2 ADC M3554 in Advanced Solid Tumors

for Advanced Solid Tumor

3 locations incl. Boston

Sponsor: EMD Serono Research & Development Institute, Inc.

Sex: All·Age: 18+

Code: NCT06641908·Phase 1·Recruiting

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A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

for Hereditary Hemorrhagic Telangiectasia

8 locations incl. Birmingham

Sponsor: Alnylam Pharmaceuticals

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06659640·Phase 1, Phase 2·Recruiting

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Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration

for Pacemaker Implantation

2 locations incl. Naples

Sponsor: NCH Healthcare System, Inc. dba Naples Comprehensive Health and dba NCH

Sex: All·Age: 18+

Code: NCT06690333·Recruiting

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A Non-interventional, Post-authorisation Safety Study of Patients Treated With Efgartigimod Alfa

for Myasthenia Gravis

17 locations incl. San Francisco

Sponsor: argenx

Sex: All·Age: 18+

Code: NCT06298565·Recruiting

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PULSED AF Post-Approval Study

for Atrial Fibrillation

18 locations incl. Tampa

Sponsor: Medtronic Cardiac Ablation Solutions

Sex: All·Age: 18+

Code: NCT06578104·Recruiting

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Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty

for Cardiovascular Diseases

2 locations incl. Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06244199·Recruiting

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Chronic Subdural Hematoma Treatment With Embolization Versus Surgery Study

for Chronic Subdural Hematoma

31 locations incl. Phoenix

Sponsor: The University of Texas Medical Branch, Galveston

Sex: All·Age: 40 - 90

Code: NCT06347796·Recruiting

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A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer

for Nasopharyngeal Cancer Recurrent

12 locations incl. Little Rock

Sponsor: Coherus Oncology, Inc.

Sex: All·Age: 12+

Code: NCT06457503·Phase 4·Recruiting

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Elotuzumab + Iberdomide + Dexamethasone Post Ide-Cel in RRMM

for Myeloma

Drug: Iberdomide

3 locations incl. Boston

Sponsor: Omar Nadeem, MD

Sex: All·Age: 18+

Code: NCT06518551·Phase 1, Phase 2·Recruiting

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Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis

for AL Amyloidosis

Drug: Elranatamab

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06569147·Phase 1, Phase 2·Recruiting

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Influences of Long-acting Reversible Contraceptives on Iron Status and Physiological Responses to Extreme Environments in Women

for Contraception

1 location in Natick

Sponsor: United States Army Research Institute of Environmental Medicine

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06909695·Recruiting

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Sotagliflozin to Slow Kidney Function Decline in Persons With Type 1 Diabetes and Diabetic Kidney Disease

for Diabetic Nephropathies

Drug: Sotagliflozin

13 locations incl. Stanford

Sponsor: Alessandro Doria

Sex: All·Age: 18 - 75

Code: NCT06217302·Phase 3·Recruiting

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Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal Thrombosis

for Congenital Heart Disease

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 1 Day - 7 Days

Code: NCT06434207·Recruiting

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Barrigel® PPRT (Post-Prostatectomy Radiation Therapy) Trial

for Prostate Cancer

4 locations incl. Boston

Sponsor: Palette Life Sciences, Inc.

Sex: Male·Age: 18+

Code: NCT06496256·Recruiting

Apply to this trial