Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.

for B-cell Malignancies

10 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06542250·Phase 1, Phase 2·Recruiting

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Emapalumab Prevention of CAR-T Cell Associated Toxicities

for Large B-cell Lymphoma

2 locations incl. Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06550141·Phase 2·Recruiting

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Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients

for Non Small Cell Lung Cancer

Drug: Osimertinib

146 locations incl. Birmingham

Sponsor: PrECOG, LLC.

Sex: All·Age: 18+

Code: NCT06538038·Recruiting

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LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis

for Metabolic Dysfunction Associated Steatohepatitis (MASH)

Drug: Survodutide

165 locations incl. Birmingham

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT06632444·Phase 3·Recruiting

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Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

for Anatomic Stage I Breast Cancer AJCC v8

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 65+

Code: NCT06042569·Phase 2·Recruiting

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A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma

for Monoclonal Gammopathy of Undetermined Significance (MGUS)

Drug: Linvoseltamab

7 locations incl. Baltimore

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06140524·Phase 2·Recruiting

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399692·Phase 3·Recruiting

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A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

for Cystic Fibrosis

4 locations incl. Kansas City

Sponsor: Spirovant Sciences, Inc.

Sex: All·Age: 18 - 65

Code: NCT06526923·Phase 1, Phase 2·Recruiting

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School Inner City Air Study

for Viral Infection

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 6 - 90·Accepts healthy volunteers

Code: NCT05953233·Recruiting

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Cognitive Dysfunction in Chronic and Persistent Immune Thrombocytopenia

for Immune Thrombocytopenia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06817395·Recruiting

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Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

167 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554393·Phase 2·Recruiting

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A Safety, Tolerability, and Preliminary Efficacy of Low-intensity Focused Ultrasound Neuromodulation in Patients With Drug-resistant Epilepsy

for Drug Resistant Epilepsy

3 locations incl. Palo Alto

Sponsor: NaviFUS Corporation

Sex: All·Age: 18+

Code: NCT06388707·Phase 1, Phase 2·Recruiting

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Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery

for Fusion of Spine, Lumbar Region

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06528288·Recruiting

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Initial Resuscitation for Acute Kidney Injury in Cirrhosis

for Cirrhosis, Liver

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06525623·Recruiting

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MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

for Pancreatic Ductal Adenocarcinoma

25 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06586515·Phase 1·Recruiting

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Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

for Metastatic Dedifferentiated Liposarcoma

245 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06422806·Phase 3·Recruiting

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Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

for Treatment Resistant Depression

24 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 22 - 70

Code: NCT06423430·Recruiting

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A Phase II Study of Ensifentrine in Non-Cystic Fibrosis Bronchiectasis

for Non-cystic Fibrosis Bronchiectasis

29 locations incl. Birmingham

Sponsor: Verona Pharma, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA

Sex: All·Age: 18 - 80

Code: NCT06559150·Phase 2·Recruiting

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AVAVA MIRIA General Use

for Acne

1 location in Waltham

Sponsor: AVAVA, Inc.

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06868615·Recruiting

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The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

for Major Depressive Disorder

1 location in Charlestown

Sponsor: Sharmin Ghaznavi

Sex: All·Age: 18 - 55

Code: NCT06247839·Phase 3·Recruiting

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PROSTATE-IQ: Parallel RandOmized STudy of Personalized Apalutamide Treatment and Evaluation to Improve Quality of Life in Post-Operative Radiation With Androgen Axis Suppression. A Phase III Multi-center Study for Men With Detectable PSA After Prostatectomy for Prostate Cancer.

for Androgen Axis Suppression

Drug: Apalutamide

5 locations incl. Chicago

Sponsor: M.D. Anderson Cancer Center

Sex: Male·Age: 18+

Code: NCT06274047·Phase 3·Recruiting

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LIFT: Life Improvement Trial

for ME/CFS

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06366724·Phase 2·Recruiting

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Head-Cancelled Virtual Reality for Ocular Cranial Nerve Palsies

for Internuclear Ophthalmoplegia

2 locations incl. Jacksonville

Sponsor: Kevin Houston

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06417216·Recruiting

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Study of Oral Ubrogepant to Assess Adverse Events and Change in Disease Activity in Adult Participants With Menstrual Migraine

for Migraine

Drug: Ubrogepant

103 locations incl. Birmingham

Sponsor: AbbVie

Sex: Female·Age: 18+

Code: NCT06417775·Phase 3·Recruiting

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Prolonged Overnight Fasting and/or Exercise on Fatigue and Other Patient Reported Outcomes in Women With Hormone Receptor Positive Advanced Breast Cancer

for HER2-positive Breast Cancer

3 locations incl. Phoenix

Sponsor: University of Miami

Sex: Female·Age: 18+

Code: NCT06123988·Recruiting

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Safety and Effectiveness of Mechanical Thrombectomy Using the Anaconda ANA Funnel Catheter

for Acute Ischemic Stroke From Large Vessel Occlusion

11 locations incl. Jacksonville

Sponsor: Anaconda Biomed S.L.

Sex: All·Age: 22 - 85

Code: NCT06370182·Recruiting

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A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)

for Hairy Cell Leukemia

Drug: Rituximab

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06561360·Phase 2·Recruiting

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Safety and Efficacy of Matrix Pro for Eyebrow Lift and Lift of Submental/Neck Laxity

for Laxity

1 location in Marlborough

Sponsor: Candela Corporation

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06640998·Enrolling By Invitation

Long-term Follow-up of Participants Treated With Galapagos Chimeric Antigen Receptor (CAR) T-cell Therapies

for Hematological Malignancies

1 location in Boston

Sponsor: Lakefront Biotherapeutics NV

Sex: All·Age: 18+

Code: NCT06652633·Phase 3·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

for NASH - Nonalcoholic Steatohepatitis

Drug: Efruxifermin

168 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06528314·Phase 3·Recruiting

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

for Crohn's Disease

64 locations incl. Dothan

Sponsor: AbbVie

Sex: All·Age: 18 - 75

Code: NCT06548542·Phase 2·Recruiting

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A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

for Lupus Erythematosus, Systemic

19 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 75

Code: NCT06581198·Phase 2·Recruiting

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A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

for Pulmonary Hypertension

31 locations incl. Phoenix

Sponsor: Tectonic Therapeutic

Sex: All·Age: 18 - 83

Code: NCT06616974·Phase 2·Recruiting

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The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study

for Rheumatoid Arthritis (RA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 35 - 79

Code: NCT07315997·Recruiting

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Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

for Lung Transplant

18 locations incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06399302·Recruiting

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PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm

for Coronary Artery Disease

18 locations incl. Chandler

Sponsor: Kardion Inc

Sex: All·Age: 18 - 90

Code: NCT06445608·Recruiting

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Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease

for Parkinson Disease (PD)

2 locations incl. Allston

Sponsor: Harvard Medical School (HMS and HSDM)

Sex: All·Age: 18 - 90

Code: NCT06602544·Recruiting

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Frequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers

for Huntington Disease

13 locations incl. Birmingham

Sponsor: Hoffmann-La Roche

Sex: All·Age: 25 - 60

Code: NCT06667414·Recruiting

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Cognitive Control to Boost Physical Activity Adherence

for Physical Inactivity

2 locations incl. Iowa City

Sponsor: University of Iowa

Sex: All·Age: 40 - 65·Accepts healthy volunteers

Code: NCT06338774·Recruiting

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The COMPASSION Study

for Breast Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06507930·Recruiting

Apply to this trial