Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

for Specific Advanced Solid Tumors

15 locations incl. Phoenix

Sponsor: Acrivon Therapeutics

Sex: All·Age: 18+

Code: NCT06667141·Phase 1·Recruiting

Apply to this trial

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

for Metastatic Non-small Cell Lung Cancer

Drug: Osimertinib

34 locations incl. Fayetteville

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06417814·Phase 3·Recruiting

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Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

10 locations incl. Los Angeles

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 0 - 21

Code: NCT06690801·Recruiting

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REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities

for Coronary Artery Disease

18 locations incl. Glendale

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT06399705·Phase 3·Recruiting

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Soquelitinib vs Standard of Care in Participants With Relapsed/Refractory Peripheral T-cell Lymphoma Not Otherwise Specified, Follicular Helper T-cell Lymphomas, or Systemic Anaplastic Large-cell Lymphoma

for Peripheral T-Cell Lymphoma, Not Otherwise Specified

Drug: Soquelitinib

21 locations incl. Duarte

Sponsor: Corvus Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06561048·Phase 3·Recruiting

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A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy

for Multiple System Atrophy

19 locations incl. La Jolla

Sponsor: Teva Branded Pharmaceutical Products R&D LLC

Sex: All·Age: 30 - 75

Code: NCT06568237·Phase 2·Recruiting

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Improving Health for Older Adults With Pain Through Engagement

for Chronic Pain

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT06119698·Recruiting

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Behavioral Economics to Implement a Traffic Light Nutrition Ranking System: Study 2

for Food Insecurity

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT06298253·Recruiting

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DISCOVERY of Risk Factors for Type 2 Diabetes in Youth

for Diabetes Mellitus Type 2, Childhood-Onset

20 locations incl. Birmingham

Sponsor: George Washington University

Sex: All·Age: 8 - 15

Code: NCT06525259·Recruiting

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Evaluation of Efficacy and Safety of Suzetrigine for Pain Associated With Diabetic Peripheral Neuropathy

for Diabetic Peripheral Neuropathic Pain

76 locations incl. Anniston

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 80

Code: NCT06628908·Phase 3·Recruiting

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Neural Control of Kidney Blood Flow During Exercise in African American Adults

for Healthy

1 location in Boston

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT03981640·Recruiting

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Preterm Infants Fed a Human Milk Fortifier

for Growth

14 locations incl. Phoenix

Sponsor: Abbott Nutrition

Sex: All·Age: All ages

Code: NCT05551975·Not Yet Recruiting

Prevention of Injury in Skilled Nursing Facilities Through Optimizing Medications

for Accidental Falls/Prevention and Control

2 locations incl. Boston

Sponsor: Duke University

Sex: All·Age: 65+

Code: NCT06304428·Enrolling By Invitation

Phase III Presbyopia Correction Using the VIS Opti-K™ System

for Presbyopia

4 locations incl. Boca Raton

Sponsor: VIS, Inc.

Sex: All·Age: 40+

Code: NCT06487897·Phase 3·Recruiting

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A Study of GSK5764227 in Participants With Advanced Solid Tumors (EMBOLD)

for Neoplasms

15 locations incl. Stanford

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06551142·Phase 1·Recruiting

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Long-term Safety and Efficacy Evaluation of Lunsekimig (SAR443765) in Adult Participants With Asthma

for Asthma

Drug: Lunsekimig

27 locations incl. Chandler

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06609239·Phase 2·Enrolling By Invitation

A Community Health Worker/Pharmacist Team to Improve Blood Sugars in Diabetes Care Using Continuous Glucose Monitoring

for Type 2 Diabetes

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 25 - 75

Code: NCT05911256·Enrolling By Invitation

Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

for Breast Atypical Ductal Hyperplasia

11 locations incl. Tucson

Sponsor: National Cancer Institute (NCI)

Sex: Female·Age: 18 - 55

Code: NCT06184750·Phase 2·Recruiting

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Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

Drug: Venetoclax

221 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06317649·Phase 2·Recruiting

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Evaluation of Multi-Cancer Early Detection Testing in a High-Risk Population: The INFORM Study

for Cancer Predisposition Syndrome

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 22+·Accepts healthy volunteers

Code: NCT06450171·Recruiting

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A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

for Breast Cancer

165 locations incl. Daphne

Sponsor: Stemline Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06492616·Phase 3·Recruiting

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Non-Invasive Monitoring Methods in Patients With Acute Brain Injury

for Brain Injury, Acute

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06504238·Recruiting

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A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4)

for Alzheimer Disease

Drug: KarXT

98 locations incl. Chandler

Sponsor: Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Sex: All·Age: 55 - 90

Code: NCT06585787·Phase 3·Recruiting

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CorEvitas Systemic Lupus Erythematosus (SLE) Drug Safety and Effectiveness Registry

for Systemic Lupus Erythematosus

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 18+

Code: NCT06804057·Recruiting

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Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

for Acute Myeloid Leukemia

211 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 59

Code: NCT05554406·Phase 2·Recruiting

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ALPINE: Maintenance Letrozole/Abemaciclib

for Endometrial Cancer

6 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06366347·Phase 2·Recruiting

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A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)

for Gram-negative Bacterial Infection

11 locations incl. Orange

Sponsor: Pfizer

Sex: All·Age: Up to 39 Weeks

Code: NCT06462235·Phase 2·Recruiting

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Registry Study to Observe Long-term Safety of Vamorolone (AGAMREE®) in Patients With Duchenne Muscular Dystrophy-SUMMIT

for Duchenne Muscular Dystrophy

25 locations incl. Phoenix

Sponsor: Catalyst Pharmaceuticals, Inc.

Sex: Male·Age: 2+

Code: NCT06564974·Recruiting

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Bionic Pancreas in CFRD

for Cystic Fibrosis-related Diabetes

16 locations incl. Aurora

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 14+

Code: NCT06449677·Phase 3·Recruiting

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A Study to Evaluate the Efficacy and Safety of Sotagliflozin in Symptomatic Obstructive and Non-obstructive Hypertrophic Cardiomyopathy

for Obstructive Cardiomyopathy, Hypertrophic

Drug: Sotagliflozin

33 locations incl. Phoenix

Sponsor: Lexicon Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06481891·Phase 3·Recruiting

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Psilocybin in Cancer Pain Study

for Opioid-Related Disorders

1 location in Boston

Sponsor: Yvan Beaussant, MD, MSci

Sex: All·Age: 18+

Code: NCT06001749·Phase 2·Recruiting

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A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib

for Acute Myeloid Leukemia

Drug: Venetoclax

4 locations incl. Baltimore

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 12+

Code: NCT06284486·Phase 1, Phase 2·Recruiting

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Gastroparesis Registry 4

for Gastroparesis

6 locations incl. Scottsdale

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: All·Age: 18 - 85

Code: NCT05846802·Recruiting

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Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

for Bipolar Disorder

2 locations incl. Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 24 - 65

Code: NCT06274567·Recruiting

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Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

for Major Depressive Disorder

50 locations incl. Birmingham

Sponsor: Autobahn Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06633016·Phase 2·Recruiting

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A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

for Metastatic Solid Tumor

17 locations incl. Santa Monica

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06561685·Phase 1·Recruiting

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A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

for Solid Tumor

19 locations incl. Little Rock

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06586957·Phase 1·Recruiting

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A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

for Geographic Atrophy

45 locations incl. Tucson

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 60+

Code: NCT06635148·Phase 2·Recruiting

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Single Participant Study of an Experimental ASO Treatment for TUBB4A-related Leukodystrophy

for Genetic Disease

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 4+

Code: NCT06369974·Phase 1, Phase 2·Enrolling By Invitation

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 locations incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589·Recruiting

Apply to this trial