Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Study Evaluating Dosimetry, Randomized Dose Optimization, Dose Escalation and Efficacy of Ac-225 Rosopatamab Tetraxetan in Participants With PSMA PET-Positive Castration-Resistant Prostate Cancer (CRPC)

for PSMA PET-Positive Castration-Resistant Prostate Cancer

9 locations incl. San Diego

Sponsor: Convergent Therapeutics

Sex: Male·Age: 18+

Code: NCT06549465·Phase 2·Recruiting

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A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

for Chronic Lymphocytic Leukemia

Drug: Venetoclax

32 locations incl. Tucson

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06428019·Phase 3·Recruiting

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Study of ITI-1284 as an Adjunctive Treatment in Patients With Generalized Anxiety Disorder

for Generalized Anxiety Disorder

34 locations incl. Chandler

Sponsor: Intra-Cellular Therapies, Inc.

Sex: All·Age: 18+

Code: NCT06480383·Phase 2·Recruiting

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Targeted Pediatric High-Grade Glioma Therapy

for High Grade Glioma

11 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 12 Months - 39

Code: NCT05839379·Recruiting

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BetterLife FSHD: A Patient-driven Health and Research Platform

for FSH

1 location in Randolph

Sponsor: FSHD Society

Sex: All·Age: 1+

Code: NCT07409142·Recruiting

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Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury

for Traumatic Brain Injury

18 locations incl. San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18 - 65

Code: NCT05826912·Phase 2·Enrolling By Invitation

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

for Head and Neck Squamous Cell Carcinoma

29 locations incl. Duarte

Sponsor: Tempus AI

Sex: All·Age: 18+

Code: NCT06163534·Recruiting

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Connectomic Targeted TMS Target for Refractory Anxiety

for Anxiety Disorders

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 70

Code: NCT06376877·Phase 2·Not Yet Recruiting

Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

for Advanced Breast Cancer

Drug: Camizestrant

54 locations incl. Gilbert

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06380751·Phase 3·Recruiting

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

21 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting

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Yoga Breath Training to Improve Cardiorespiratory Synchrony in Spinal Cord Injury

for Spinal Cord Injuries

1 location in Cambridge

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 60

Code: NCT06514950·Recruiting

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Our Whole Lives Gemini: Virtual Integrative Medical Group Visits for Managing Chronic Pain

for Chronic Pain

1 location in Malden

Sponsor: Cambridge Health Alliance

Sex: All·Age: 18+

Code: NCT06515925·Recruiting

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Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)

for Excessive Sleepiness

Drug: Solriamfetol

38 locations incl. Cullman

Sponsor: Axsome Therapeutics, Inc.

Sex: All·Age: 18 - 65

Code: NCT06568367·Phase 3·Recruiting

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Use of Indocyanine Green (ICG) for the Diagnosis of Biliary Atresia

for Biliary Atresia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 Days - 3 Months

Code: NCT07513038·Phase 1, Phase 2·Recruiting

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BE WELL With Migraine: Brain Education and WELLness With Migraine

for Migraine

3 locations incl. Cambridge

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05987592·Recruiting

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Assessing the Efficacy of an Acceptance-Based Digital Intervention for Veterans With Chronic Pain

for Chronic Pain

3 locations incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT06058624·Recruiting

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Cerebellar Modulation of Cognition in Psychosis

for Schizophrenia

2 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 55

Code: NCT06107764·Recruiting

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A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

for Advanced Solid Tumor

11 locations incl. Irvine

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06147037·Phase 1·Recruiting

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Harness-based Mobility Intervention for Infants With Down Syndrome

for Down Syndrome

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: Up to 2

Code: NCT06219863·Recruiting

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AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention

for Coronary Artery Disease

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40 - 75

Code: NCT06235112·Recruiting

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Long-term Extension of GTX-102 in Angelman Syndrome

for Angelman Syndrome

6 locations incl. Los Angeles

Sponsor: Ultragenyx Pharmaceutical Inc

Sex: All·Age: All ages

Code: NCT06415344·Phase 3·Enrolling By Invitation

Employment Support After Hematopoietic Stem Cell Transplantation

for Hematopoietic Stem Cell Transplantation

1 location in Boston

Sponsor: MGH Institute of Health Professions

Sex: All·Age: 18 - 70

Code: NCT06494423·Recruiting

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A Phase III Study to Investigate Efficacy, Safety and Tolerability of Iptacopan Compared With Placebo in Participants Aged 18 to 85 Years With gMG.

for Generalized Myasthenia Gravis

Drug: Iptacopan

21 locations incl. Scottsdale

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 85

Code: NCT06517758·Phase 3·Recruiting

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Long-term Safety and Tolerability of BHV-7000

for Focal Epilepsy

115 locations incl. Birmingham

Sponsor: Biohaven Therapeutics Ltd.

Sex: All·Age: 18 - 75

Code: NCT06443463·Phase 2·Enrolling By Invitation

A Multicenter Pediatric Deep Brain Stimulation Registry

for Dystonia

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585618·Recruiting

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Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

for Lung Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06252129·Recruiting

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Study of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors

for Advanced Solid Tumors

4 locations incl. Palo Alto

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT06532565·Phase 1·Recruiting

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Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

for Chronic Low-back Pain

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18+

Code: NCT06106191·Recruiting

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PROPEL - A Prospective Observational Patient Registry to Evaluate ENPP1 and ABCC6 Deficiency

for Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Deficiency

5 locations incl. Chicago

Sponsor: Inozyme Pharma

Sex: All·Age: All ages

Code: NCT06302439·Recruiting

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Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

for Depressive Disorder, Major

Drug: Seltorexant

84 locations incl. Birmingham

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18 - 74

Code: NCT06559306·Phase 3·Recruiting

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ASSESS ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06578195·Recruiting

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PREVENT ALL ALS Study

for Amyotrophic Lateral Sclerosis

31 locations incl. Birmingham

Sponsor: St. Joseph's Hospital and Medical Center, Phoenix

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06581861·Recruiting

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Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management

for Inflammatory Bowel Diseases

8 locations incl. San Diego

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 13+

Code: NCT06424769·Enrolling By Invitation

TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)

for Tricuspid Regurgitation

36 locations incl. Phoenix

Sponsor: P+F Products + Features USA Inc.

Sex: All·Age: 18+

Code: NCT06137807·Recruiting

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Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial

for Colorectal Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 50

Code: NCT06202183·Recruiting

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A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)

for Relapsing Multiple Sclerosis

89 locations incl. Birmingham

Sponsor: TG Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06433752·Recruiting

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Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)

for Brainstem Stroke

1 location in Boston

Sponsor: Leigh R. Hochberg, MD, PhD.

Sex: All·Age: 18 - 80

Code: NCT06511934·Recruiting

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Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

for Advanced Lung Non-Small Cell Carcinoma

319 locations incl. Fayetteville

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 70+

Code: NCT06096844·Phase 3·Recruiting

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Efficacy and Safety of Zanidatamab With Standard-of-care Therapy Against Standard-of-care Therapy for Advanced HER2-positive Biliary Tract Cancer

for Biliary Tract Cancer

21 locations incl. Duarte

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06282575·Phase 3·Recruiting

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PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

for High Grade Glioma

13 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 3 - 39

Code: NCT05096481·Phase 2·Recruiting

Apply to this trial