Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

for Locally Advanced Solid Tumor

17 locations incl. Irvine

Sponsor: Nuvalent Inc.

Sex: All·Age: 18+

Code: NCT06521554·Phase 1·Recruiting

Apply to this trial

Letrozole in Uterine Leiomyosarcoma

for Uterine Leiomyosarcoma

25 locations incl. Aurora

Sponsor: GOG Foundation

Sex: Female·Age: 18+

Code: NCT05649956·Phase 2·Recruiting

Apply to this trial

Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline

for Overweight, Childhood

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 4 - 17

Code: NCT06432790·Recruiting

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A Study of Telitacicept for the Treatment of Generalized Myasthenia Gravis (UPSTREAM MG)

for Generalized Myasthenia Gravis

Drug: Telitacicept

26 locations incl. Scottsdale

Sponsor: Vor Biopharma

Sex: All·Age: 18+

Code: NCT06456580·Phase 3·Recruiting

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A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

for Anemia, Sickle Cell

20 locations incl. Birmingham

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06481306·Phase 1, Phase 2·Recruiting

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Blood Pressure Variability and Ischemic Stroke Outcome

for Acute Ischemic Stroke

3 locations incl. New Haven

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT05756257·Recruiting

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A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

for Hepatocellular Carcinoma

Drug: Atezolizumab

60 locations incl. Tucson

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT06096779·Phase 2·Recruiting

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CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for Acute Lymphoblastic Leukemia

3 locations incl. Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06059391·Phase 2·Recruiting

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A Study to Test the Effects and Safety of Riliprubart in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) for Which the Usual Treatments do Not Work

for Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Drug: riliprubart

28 locations incl. Homewood

Sponsor: Sanofi

Sex: All·Age: 18+

Code: NCT06290128·Phase 3·Recruiting

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Exercise Training in Transthyretin Cardiac Amyloidosis

for Amyloid Cardiomyopathy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 60 - 90

Code: NCT05797857·Recruiting

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Modulation of Brain Oscillations Underlying Working Memory

for Working Memory

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT05923606·Recruiting

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Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

for Resectable Intrahepatic Cholangiocarcinoma

Drug: Durvalumab

58 locations incl. Irvine

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06050252·Phase 2·Recruiting

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Lumason® Infusion vs. Bolus Administrations

for Heart Diseases

6 locations incl. West Hills

Sponsor: Bracco Diagnostics, Inc

Sex: All·Age: 18+

Code: NCT06400004·Phase 3·Recruiting

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A Phase 1 Study of CTIM-76 in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

for Platinum-resistant Ovarian Cancer

13 locations incl. Little Rock

Sponsor: Context Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT06515613·Phase 1·Recruiting

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Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

for Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

22 locations incl. Los Angeles

Sponsor: Servier Bio-Innovation LLC

Sex: All·Age: 18+

Code: NCT06127407·Phase 3·Recruiting

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Study to Determine the Clinical Significance of Intravascular OCT-NIRAF

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06374498·Enrolling By Invitation

Virtual Reality Intervention for Fear of Heights

for Acrophobia

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06468878·Recruiting

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Understanding the Acute Pain Phenotype in Patients Undergoing Surgery

for Acute Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06466941·Recruiting

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Continuation Protocol for Obstructive Sleep Apnea (OSA)

for OSA

93 locations incl. Birmingham

Sponsor: Apnimed

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06566820·Phase 3·Enrolling By Invitation

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Participants With Advanced Solid Tumors

for Solid Tumors

18 locations incl. Birmingham

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT06431594·Phase 1·Recruiting

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Neuromodulation for a Novel OCD Biomarker and Treatment

for OCD

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05994053·Recruiting

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Vagus Nerve Stimulation(VNS) As Treatment For Fibromyalgia Patients

for Fibromyalgia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06009159·Recruiting

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Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

for AL Amyloidosis

117 locations incl. Goodyear

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT06022939·Phase 3·Recruiting

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High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

for Melanoma (Skin)

2 locations incl. Boston

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT06298734·Recruiting

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Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

for Amblyopia

73 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 4 - 7

Code: NCT06380517·Phase 3·Recruiting

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Dance and Energy Expenditure Among Adults With Parkinson's

for Parkinson Disease

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT06425731·Recruiting

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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

for Metastatic Solid Tumor

Drug: LY4052031

17 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06465069·Phase 1·Recruiting

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A Retrospective Survey-based Multicenter Study to Delineate the Molecular and Phenotypic Spectrum of Epilepsy-dyskinesia Syndromes

for Epilepsy in Children

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 - 18

Code: NCT06585605·Recruiting

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Trial to Visualize the Ureters With Nizaracianine Triflutate in Adults Undergoing Abdominopelvic Surgery

for Injury of Ureter During Surgery (Disorder)

5 locations incl. Los Angeles

Sponsor: Curadel Surgical Innovations, Inc.

Sex: All·Age: 18+

Code: NCT06101745·Phase 2, Phase 3·Recruiting

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Global Paradise System US Post Approval Study

for Hypertension

39 locations incl. Sacramento

Sponsor: ReCor Medical, Inc.

Sex: All·Age: 18+

Code: NCT06297291·Recruiting

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A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)

for Atrial Fibrillation

43 locations incl. Phoenix

Sponsor: Biosense Webster, Inc.

Sex: All·Age: 18 - 80

Code: NCT06455098·Recruiting

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PAIN: A Project Assessing the Impact of a Novel Cannabinoid Product

for Chronic Pain

1 location in Belmont

Sponsor: Staci Gruber, Ph.D.

Sex: All·Age: 21+

Code: NCT03984565·Phase 2·Recruiting

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Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

for Rectal Cancer

101 locations incl. Phoenix

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT06205485·Phase 3·Recruiting

Apply to this trial

TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

for Cancer

31 locations incl. Birmingham

Sponsor: Tempus AI

Sex: All·Age: 18 - 99

Code: NCT06207032·Recruiting

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A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

76 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting

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ARTEMIS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With a Heart Attack

for Cardiovascular Risk

Drug: Ziltivekimab

208 locations incl. Alexander City

Sponsor: Novo Nordisk A/S

Sex: All·Age: 18+

Code: NCT06118281·Phase 3·Recruiting

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Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

for Transthyretin Amyloidosis

30 locations incl. La Jolla

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06465810·Recruiting

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A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients (LiGeR-HN2)

for Head and Neck Squamous Cell Carcinoma

Drug: Petosemtamab

61 locations incl. Mobile

Sponsor: Merus B.V.

Sex: All·Age: 18+

Code: NCT06496178·Phase 3·Recruiting

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Storytelling for Reducing Gap in Anticoagulation Use in African Americans With Atrial Fibrillation

for Atrial Fibrillation

4 locations incl. Jacksonville

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT05997914·Enrolling By Invitation

Precision Ventilation vs Standard Care for Acute Respiratory Distress Syndrome

for Acute Respiratory Distress Syndrome

33 locations incl. Tucson

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT06066502·Phase 3·Recruiting

Apply to this trial