Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Mixed Methods Pilot Trial of the STEP Home Workshop to Improve Reintegration and Reduce Suicide Risk for Recently Transitioned Veterans

for TBI

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05995678·Recruiting

Apply to this trial

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

for Alpha1-Antitrypsin Deficiency

20 locations incl. Phoenix

Sponsor: Takeda

Sex: All·Age: 18 - 75

Code: NCT06165341·Phase 3·Recruiting

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Comparison of Residual Gastric Volume Between Children Who Drink Different Clear Oral Fluid Volume

for Fasting

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 13 - 17·Accepts healthy volunteers

Code: NCT03741777·Recruiting

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Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors

for Breast Cancer

673 locations incl. Anchorage

Sponsor: NRG Oncology

Sex: All·Age: 18 - 100

Code: NCT05896189·Recruiting

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Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)

for Alzheimer Disease

53 locations incl. Phoenix

Sponsor: Cognito Therapeutics, Inc.

Sex: All·Age: 50 - 92

Code: NCT06245031·Enrolling By Invitation

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

for Early Breast Cancer

Drug: Ribociclib

78 locations incl. Birmingham

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18 - 100

Code: NCT05827081·Phase 3·Recruiting

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Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool

for Liver Transplant

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 80

Code: NCT06088758·Recruiting

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A Study of Raludotatug Deruxtecan (R-DXd) in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

for Solid Cancer

43 locations incl. Anchorage

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06161025·Phase 2, Phase 3·Recruiting

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The Long-term Safety and Effectiveness Evaluation of the QDOT MICRO System Use in Conjunction With VISITAG SURPOINT Module for the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation.

for Paroxysmal Atrial Fibrillation

21 locations incl. Birmingham

Sponsor: Heart Rhythm Clinical and Research Solutions, LLC

Sex: All·Age: 18+

Code: NCT06324201·Recruiting

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Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis

for Endometriosis

1 location in Belmont

Sponsor: Mclean Hospital

Sex: Female·Age: 21+

Code: NCT06477406·Phase 2·Recruiting

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Improving Clinical Efficiency by Reducing Scheduled Follow-ups Using Cochlear America's Population Mean Mapping Strategy

for Deafness

1 location in Boston

Sponsor: Massachusetts Eye and Ear Infirmary

Sex: All·Age: 18 - 85

Code: NCT06960616·Recruiting

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Incremental Hemodialysis: The TwoPlus Trial

for End-Stage Kidney Disease

10 locations incl. Jacksonville

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05828823·Recruiting

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First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer

for Advanced Cancer

13 locations incl. Encinitas

Sponsor: OnKure, Inc.

Sex: All·Age: 18+

Code: NCT06239467·Phase 1·Recruiting

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Phase I/II Study of SKG0106 Intravitreal Injection in Patients With Neovascular Age-related Macular Degeneration (nAMD)

for Neovascular Age-related Macular Degeneration

4 locations incl. St. Petersburg

Sponsor: Skyline Therapeutics (US) Inc.

Sex: All·Age: 50+

Code: NCT05986864·Phase 1, Phase 2·Recruiting

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Efficacy, Effectiveness, and Implementation of Jaspr Health in Emergency Department- Part A

for Suicidal Ideation

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18+

Code: NCT06223867·Recruiting

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Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout

for Gout

7 locations incl. South Birmingham

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 90

Code: NCT04875702·Phase 4·Recruiting

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Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

for AML

38 locations incl. Gilbert

Sponsor: Kura Oncology, Inc.

Sex: All·Age: 18+

Code: NCT06001788·Phase 1·Recruiting

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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

for Cesarean Delivery

34 locations incl. Little Rock

Sponsor: Yale University

Sex: Female·Age: 15 - 55·Accepts healthy volunteers

Code: NCT06030063·Recruiting

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An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for Emphysema, Pulmonary

18 locations incl. Phoenix

Sponsor: Pulmonx Corporation

Sex: All·Age: 40 - 80

Code: NCT06035120·Recruiting

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A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma

for Multiple Myeloma

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06121843·Phase 1·Recruiting

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Maturation of Arteriovenous Fistula With Automated Sonography Assessments Trial

for Diabetes

21 locations incl. Dothan

Sponsor: Sonavex, Inc.

Sex: All·Age: 18 - 84

Code: NCT06190717·Recruiting

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A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease

for COPD (Chronic Obstructive Pulmonary Disease)

234 locations incl. Athens

Sponsor: AstraZeneca

Sex: All·Age: 40 - 80

Code: NCT06283966·Phase 3·Recruiting

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Pulmonary Artery DenerVation Clinical Study Using the Gradient Denervation System in Heart Failure Patients With Pulmonary Hypertension Group 2 (PreVail-PH2 Study)

for Group 2 Pulmonary Hypertension

8 locations incl. Chicago

Sponsor: Gradient Denervation Technologies

Sex: All·Age: 22 - 85

Code: NCT06052072·Enrolling By Invitation

CIML NK Cells With Venetoclax for AML

for Acute Myeloid Leukemia

Drug: Venetoclax

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06152809·Phase 1·Recruiting

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A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)

for Myotonic Dystrophy Type 1 (DM1)

8 locations incl. San Carlos

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 64

Code: NCT06185764·Phase 1, Phase 2·Recruiting

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A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)

for Multiple Myeloma

Drug: Elranatamab

34 locations incl. Coral Gables

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06215118·Phase 1·Recruiting

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Changes in Skeletal Muscle Thickness in Patients With Acute Heart Failure

for Heart Failure

1 location in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 18 - 100

Code: NCT06253104·Recruiting

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Oral Pyridoxal 5'-Phosphate for the Treatment of Patients With PNPO Deficiency

for Pyridox(am)Ine 5'-Phosphate Oxidase Deficiency

6 locations incl. Birmingham

Sponsor: Medicure

Sex: All·Age: All ages

Code: NCT04706013·Phase 3·Recruiting

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

21 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting

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Cognitive Training to Enhance Brain Concordance During Acupuncture

for Fibromyalgia

3 locations incl. Charlestown

Sponsor: Spaulding Rehabilitation Hospital

Sex: All·Age: 18 - 65

Code: NCT06157866·Recruiting

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PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

for Head and Neck Cancer

2 locations incl. Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06239220·Phase 2·Recruiting

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A Study of Valemetostat Tosylate in Combination With DXd ADCs in Subjects With Solid Tumors

for Advanced Solid Tumor

20 locations incl. Irvine

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06244485·Phase 1·Recruiting

Apply to this trial

Low Sodium Oxybate in Patients With Idiopathic Hypersomnia

for Idiopathic Hypersomnia

4 locations incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 65

Code: NCT05837091·Phase 4·Recruiting

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Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio

for Bile Duct Cancer

Drug: Durvalumab

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT05655949·Phase 2·Recruiting

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Tocilizumab in Lung Transplantation

for Lung Transplant

Drug: Tocilizumab

21 locations incl. Phoenix

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 12 - 75

Code: NCT06033196·Phase 2·Recruiting

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A Natural History Study in Participants With Congenital Myasthenic Syndromes (CMS) Due to Mutations in DOK7, MUSK, AGRN, or LRP4

for Congenital Myasthenic Syndrome

6 locations incl. Sacramento

Sponsor: argenx

Sex: All·Age: 2+

Code: NCT06078553·Recruiting

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Behavioral Activation for Independence in Older Veterans

for Functional Independence

1 location in Bedford

Sponsor: VA Office of Research and Development

Sex: All·Age: 65+

Code: NCT05493241·Recruiting

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RecoverPC: Relugolix vs GnRH Agonist in Quality of Life

for Prostate Cancer

Drug: Relugolix

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT05765500·Phase 2·Recruiting

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A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors

for Advanced Solid Tumors With KRAS G12C Mutations

15 locations incl. La Jolla

Sponsor: Frontier Medicines Corporation

Sex: All·Age: 18+

Code: NCT06244771·Phase 1, Phase 2·Recruiting

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A Study of CUSP06 in Patients With Platinum-Refractory/Resistant Ovarian Cancer and Other Advanced Solid Tumors

for Ovarian Cancer

14 locations incl. Denver

Sponsor: OnCusp Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06234423·Phase 1·Recruiting

Apply to this trial