Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

17 locations incl. Birmingham

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting

Apply to this trial

Cognitive Function and Affective Regulation in Meditators

for Cognitive Function and Affective Regulation

1 location in Boston

Sponsor: Balachundhar Subramaniam

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07546786·Recruiting

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A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

30 locations incl. Daphne

Sponsor: Puma Biotechnology, Inc.

Sex: All·Age: 18+

Code: NCT06095505·Phase 2·Recruiting

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MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

for Multiple Myeloma

Drug: Elranatamab

100 locations incl. Mobile

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06152575·Phase 3·Recruiting

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A Study to Evaluate Avacopan in Participants With ANCA-associated Vasculitis

for Antineutrophil Cytoplasmic Antibody-associated Vasculitis

60 locations incl. Anchorage

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT06072482·Phase 4·Recruiting

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Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform

for Shwachman-Diamond Syndrome

1 location in Woburn

Sponsor: Shwachman-Diamond Syndrome Alliance Inc

Sex: All·Age: All ages

Code: NCT06999954·Recruiting

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Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

for Metastatic Dedifferentiated Liposarcoma

Drug: Peposertib

16 locations incl. Los Angeles

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05711615·Phase 1·Recruiting

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Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

for Cystic Fibrosis

18 locations incl. Birmingham

Sponsor: National Jewish Health

Sex: All·Age: 6+

Code: NCT06262282·Enrolling By Invitation

MIRAI-MRI: Comparing Screening MRI for Patients at High Risk for Breast Cancer Identified by Mirai and Tyrer-Cuzick

for Breast Cancer

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 40+

Code: NCT05968157·Recruiting

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Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

for Muscle Invasive Bladder Urothelial Carcinoma

491 locations incl. Phoenix

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05987241·Phase 2, Phase 3·Recruiting

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The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)

for Prostate Cancer

1 location in Boston

Sponsor: VA Office of Research and Development

Sex: Male·Age: 55 - 69·Accepts healthy volunteers

Code: NCT05926102·Recruiting

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Registry of Patients With AQP4+ NMOSD Treated With Alexion C5 Inhibitor Therapies

for Neuromyelitis Optica Spectrum Disorder

6 locations incl. Washington D.C.

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT05966467·Recruiting

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Preliminary Efficacy of Different Exercise Training During Immunotherapy in Patients With Lung Cancer: The ENHANCE Trial

for Lung Cancer

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06026111·Recruiting

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Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

for Advanced Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06062745·Phase 1·Recruiting

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Enhanced Coordinated Specialty Care for Early Psychosis

for Psychosis

5 locations incl. Belmont

Sponsor: Mclean Hospital

Sex: All·Age: All ages

Code: NCT06071858·Recruiting

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A Study of Pembrolizumab With Trastuzumab and Chemotherapy in People With Esophagogastric Cancer

for Esophageal Cancer

10 locations incl. Boston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT06123338·Phase 2·Recruiting

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A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF

for Cystic Fibrosis

13 locations incl. Birmingham

Sponsor: ReCode Therapeutics

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06237335·Phase 2·Recruiting

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Safety and Efficacy of Empagliflozin in Hemodialysis

for End Stage Renal Disease

Drug: Empagliflozin

2 locations incl. Boston

Sponsor: NYU Langone Health

Sex: All·Age: 18+

Code: NCT05786443·Phase 2·Recruiting

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Acetazolamide as a Means to Mitigate Falling Ventilatory Drive and Drive-dependent OSA

for OSA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT06091085·Phase 1, Phase 2·Recruiting

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Transmaculine One-on-One and Group Empowerment for Targeted HIV Reduction

for HIV Infections

1 location in Boston

Sponsor: Fenway Community Health

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06182280·Not Yet Recruiting

Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

for Bipolar Disorder

3 locations incl. Belmont

Sponsor: Stony Brook University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06373016·Recruiting

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Ti-Mesh Frame Comparison for Alveolar Bone Augmentation

for Tooth Loss

1 location in Boston

Sponsor: Boston University

Sex: All·Age: 18 - 80

Code: NCT06077513·Enrolling By Invitation

STIMIT Activator 1 IDE Study

for Diaphragm Issues

3 locations incl. New Haven

Sponsor: Stimit AG

Sex: All·Age: 21+

Code: NCT05883163·Recruiting

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Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

for Acute Myeloid Leukemia

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06138587·Phase 1·Recruiting

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AZD3470 as Monotherapy or in Combination With Anticancer Agent(s) in Participants With Haematologic Malignancies.

for Lymphoma

7 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 12+

Code: NCT06137144·Phase 1, Phase 2·Recruiting

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A Study to Assess BMS-986453 in Participants With Relapsed and/or Refractory Multiple Myeloma

for Relapsed and/or Refractory Multiple Myeloma

13 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT06153251·Phase 1·Recruiting

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Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

for Chronic Lymphocytic Leukemia

Drug: Polatuzumab Vedotin

5 locations incl. Atlanta

Sponsor: Christine Ryan

Sex: All·Age: 18+

Code: NCT06043674·Phase 2·Recruiting

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A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2

for Metastatic Malignant Neoplasm

6 locations incl. Baltimore

Sponsor: NextPoint Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06240728·Phase 1·Recruiting

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A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

for Anal Fistula

9 locations incl. Los Angeles

Sponsor: RedDress Ltd.

Sex: All·Age: 18+

Code: NCT05641844·Recruiting

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A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)

for Phenylketonuria (PKU)

11 locations incl. Aurora

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: All ages

Code: NCT06305234·Recruiting

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Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors

for Advanced Solid Tumor

4 locations incl. Bethesda

Sponsor: Ankyra Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06171750·Phase 1·Recruiting

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Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

for Non-Small Cell Lung Cancer, NSCLC

26 locations incl. Gilbert

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06162221·Phase 1, Phase 2·Recruiting

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CV CARE: CardioVascular Care in PC Patients

for Prostate Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Male·Age: 18+

Code: NCT06202820·Recruiting

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A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

for Heart Failure

Drug: Finerenone

77 locations incl. Birmingham

Sponsor: Colorado Prevention Center

Sex: All·Age: 18+

Code: NCT06008197·Phase 3·Recruiting

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A Study of NST-6179 in Subjects With Intestinal Failure-Associated Liver Disease (IFALD).

for Intestinal Failure Associated Liver Disease

13 locations incl. Scottsdale

Sponsor: NorthSea Therapeutics B.V.

Sex: All·Age: 16+

Code: NCT05919680·Phase 2·Recruiting

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Multisite Implementation of COMPRENDO

for Pediatric Cancer

4 locations incl. Birmingham

Sponsor: University of California, San Diego

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06055296·Recruiting

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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

for Metastatic Head-and-neck Squamous-cell Carcinoma

28 locations incl. Gilbert

Sponsor: AVEO Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06064877·Phase 3·Recruiting

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LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

for Pulmonary Hypertension

41 locations incl. Tucson

Sponsor: Tenax Therapeutics, Inc.

Sex: All·Age: 18 - 85

Code: NCT05983250·Phase 3·Recruiting

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ShotBlocker During Intramuscular Injection Randomized Control Trial

for Neonatal Pain

1 location in Worcester

Sponsor: Lauren Fortier

Sex: All·Age: 37 Weeks - 42 Weeks·Accepts healthy volunteers

Code: NCT06624176·Recruiting

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Hyperbaric Oxygen Therapy for Ulcerative Colitis (HBOT-UC)

for Ulcerative Colitis

13 locations incl. Birmingham

Sponsor: Northwestern University

Sex: All·Age: 18 - 85

Code: NCT05987852·Recruiting

Apply to this trial