Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

for Non-muscle-invasive Bladder Cancer

9 locations incl. West Haven

Sponsor: White River Junction Veterans Affairs Medical Center

Sex: All·Age: 18+

Code: NCT05796375·Phase 2·Recruiting

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Pilot Testing a Novel Remotely Delivered Intensive Outpatient Program for Individuals With OUD

for Opioid Use Disorder

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05817825·Recruiting

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uTRACT Jelmyto Registry: A Registry of Patients With Upper Tract Urothelial Cancer (UTUC) Treated With Jelmyto

for Urothelial Carcinoma

22 locations incl. Santa Monica

Sponsor: UroGen Pharma Ltd.

Sex: All·Age: 18+

Code: NCT05874921·Recruiting

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A Randomized Clinical Trial of a Novel Drug Education and Diversion Program (iDECIDE) for Middle and High School Students

for Substance Use

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 9 - 22

Code: NCT06115746·Recruiting

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A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

for Obesity

49 locations incl. Chandler

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 75

Code: NCT06143956·Phase 2·Recruiting

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Treatment With Endovascular Intervention for STroke Patients With Existing Disability

for Stroke

25 locations incl. Phoenix

Sponsor: University of Cincinnati

Sex: All·Age: 18+

Code: NCT05911568·Recruiting

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A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

for Non-Small Cell Lung Cancer (NSCLC)

Drug: Sotorasib

21 locations incl. Santa Barbara

Sponsor: Amgen

Sex: All·Age: 18 - 100

Code: NCT05920356·Phase 3·Recruiting

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OP-1250 (Palazestrant) vs. Standard of Care for the Treatment of ER+/HER2- Advanced Breast Cancer

for Breast Cancer

Drug: Palazestrant

47 locations incl. Tucson

Sponsor: Olema Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06016738·Phase 3·Recruiting

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Pembro Plus CAR T-cell Therapy in R/R in PMBCL

for Primary Mediastinal Large B-cell Lymphoma (PMBCL)

2 locations incl. Boston

Sponsor: Jennifer Crombie, MD

Sex: All·Age: 18+

Code: NCT05934448·Phase 2·Recruiting

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Phase 3 Study of Toripalimab Alone or in Combination With Tifcemalimab as Consolidation Therapy in Patients With Limited-stage Small Cell Lung Cancer (LS-SCLC)

for Limited-stage Small Cell Lung Cancer (LS-SCLC)

29 locations incl. Goodyear

Sponsor: Shanghai Junshi Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06095583·Phase 3·Recruiting

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GEnetic Testing in Elective Single Embryo Transfer (GETSET): A Randomized Clinical Trial

for Infertility, Female

1 location in Waltham

Sponsor: Genomic Prediction Inc.

Sex: Female·Age: 35 - 40

Code: NCT06141135·Recruiting

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A Study of Nasal Foralumab in Non-Active Secondary Progressive Multiple Sclerosis Patients

for Secondary Progressive Multiple Sclerosis

Drug: Foralumab

7 locations incl. North Haven

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 18 - 75

Code: NCT06292923·Phase 2·Recruiting

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Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

for Non-Small Cell Lung Cancer (NSCLC)

Drug: daraxonrasib

21 locations incl. Duarte

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06128551·Phase 1, Phase 2·Recruiting

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A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)

for X-Linked Retinitis Pigmentosa

7 locations incl. Jacksonville

Sponsor: Beacon Therapeutics

Sex: Male·Age: 12+

Code: NCT06275620·Phase 2·Enrolling By Invitation

Trial to Reduce Antimicrobial Use in Nursing Home Residents With Alzheimer's Disease and Other Dementias 2.0

for Dementia

1 location in Boston

Sponsor: Hebrew SeniorLife

Sex: All·Age: 60 - 106

Code: NCT05950607·Recruiting

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Comprehensive HHT Outcomes Registry of the United States (CHORUS)

for Hereditary Hemorrhagic Telangiectasia

16 locations incl. Birmingham

Sponsor: Cure HHT

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06259292·Recruiting

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Home OCT-Guided Treatment Versus Treat and Extend for the Management of Neovascular AMD

for Neovascular Age-related Macular Degeneration

63 locations incl. Glendale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 50+

Code: NCT05904028·Phase 3·Recruiting

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Mind Body Intervention for Long COVID-19

for Long COVID

1 location in Boston

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18 - 65

Code: NCT06045338·Recruiting

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Preventing Childbirth-Related PTSD With Expressive Writing

for PTSD (Childbirth-Related)

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT05662423·Recruiting

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NeuroPathways Intervention for Brain Tumor Patients

for Malignant Brain Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05976490·Recruiting

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Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy

for Open tíbia Fracture

29 locations incl. Chandler

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18+

Code: NCT05615844·Phase 3·Recruiting

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Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition

for Memory

2 locations incl. College Park

Sponsor: University of Maryland, College Park

Sex: All·Age: 36 Months - 60 Months·Accepts healthy volunteers

Code: NCT06351098·Recruiting

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Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

for Carcinoma, Hepatocellular

34 locations incl. Birmingham

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 75

Code: NCT05486572·Recruiting

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Performance and Safety of a Digital Tool for Unsupervised Self-assessment of NMOSD

for Neuromyelitis Optica

10 locations incl. Los Angeles

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT05566769·Recruiting

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Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors

for Advanced Solid Tumor

7 locations incl. Tucson

Sponsor: Vaxiion Therapeutics

Sex: All·Age: 18+

Code: NCT05901285·Phase 1·Recruiting

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Open-Label Extension of EDG-5506 in Participants With Becker Muscular Dystrophy

for Becker Muscular Dystrophy

24 locations incl. Little Rock

Sponsor: Edgewise Therapeutics, Inc.

Sex: Male·Age: All ages

Code: NCT06066580·Phase 2·Enrolling By Invitation

Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

for Major Depressive Episode

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 65

Code: NCT04130958·Recruiting

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Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

for Salivary Gland Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05553782·EARLY_Phase 1·Recruiting

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Bowel

for Bowel

33 locations incl. Scottsdale

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561127·Phase 3·Recruiting

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Alcohol and "Heat of the Moment" Sexual Decision Making

for Alcohol Drinking

1 location in Boston

Sponsor: Boston University Charles River Campus

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT05729256·Recruiting

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Study of ISB 2001 in Relapsed/Refractory Multiple Myeloma (TRIgnite-1)

for Relapsed/Refractory Multiple Myeloma

10 locations incl. Palo Alto

Sponsor: Ichnos Sciences SA

Sex: All·Age: 18+

Code: NCT05862012·Phase 1·Recruiting

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Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

for Overweight and Obesity

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06069622·Recruiting

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Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

for Metastatic Breast Cancer

36 locations incl. Scottsdale

Sponsor: LeonaBio

Sex: All·Age: 18+

Code: NCT05696626·Phase 3·Recruiting

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Fontan Udenafil Exercise Longitudinal Assessment Trial - 2

for Single Ventricle Heart Disease

37 locations incl. Phoenix

Sponsor: Mezzion Pharma Co. Ltd

Sex: All·Age: 12 - 18

Code: NCT05918211·Phase 3·Recruiting

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Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)

for Progressive Pulmonary Fibrosis

71 locations incl. Birmingham

Sponsor: United Therapeutics

Sex: All·Age: 18+

Code: NCT05943535·Phase 3·Recruiting

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Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Pain Following Thoracic Trauma

for Rib Fracture

5 locations incl. La Jolla

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT06069154·Enrolling By Invitation

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

for Non-Small Cell Lung Cancer

Drug: Ivonescimab

76 locations incl. Phoenix

Sponsor: Summit Therapeutics

Sex: All·Age: 18+

Code: NCT05899608·Phase 3·Recruiting

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CD79b-19 CAR T Cells in Non-Hodgkin Lymphoma

for Non-hodgkin Lymphoma

1 location in Boston

Sponsor: Marcela V. Maus, M.D.,Ph.D.

Sex: All·Age: 18+

Code: NCT06026319·Phase 1·Recruiting

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Chronic Non-Specific Neck Pain Treated With Tai Chi and Chiropractic Care

for Neck Pain

1 location in Chestnut Hill

Sponsor: Harvard University Faculty of Medicine

Sex: All·Age: 18 - 65

Code: NCT05726331·Recruiting

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Nectero EAST System Clinical Study

for Abdominal Aortic Aneurysm

37 locations incl. Scottsdale

Sponsor: Nectero Medical, Inc.

Sex: All·Age: 21 - 85

Code: NCT06001918·Phase 2, Phase 3·Recruiting

Apply to this trial