Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy

for Locally Advanced Head and Neck Squamous Cell Carcinoma

70 locations incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06129864·Phase 3·Recruiting

Apply to this trial

Efficacy and Safety of Magnesium Vitamin B6 in First Episode Bipolar Disorder

for Bipolar I Disorder

1 location in Belmont

Sponsor: Mclean Hospital

Sex: All·Age: 18 - 50

Code: NCT05837104·Phase 2·Recruiting

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A Study to Compare How Well Odronextamab Combined With Chemotherapy Works and How Safe it is Against Rituximab Combined With Chemotherapy, in Adult Patients With Previously Untreated Diffuse Large B-cell Lymphoma

for Diffuse Large B-cell Lymphoma (DLBCL)

Drug: Odronextamab

20 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091865·Phase 3·Recruiting

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MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)

for Transthyretin Amyloidosis (ATTR) With Cardiomyopathy

38 locations incl. Tucson

Sponsor: Intellia Therapeutics

Sex: All·Age: 18 - 90

Code: NCT06128629·Phase 3·Recruiting

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Detoxification of the Liver In PSC (Dolphin)

for Primary Sclerosing Cholangitis

1 location in Chestnut Hill

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 75

Code: NCT05835505·Phase 2·Recruiting

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A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma

for Follicular Lymphoma (FL)

Drug: Odronextamab

20 locations incl. Tucson

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06091254·Phase 3·Recruiting

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Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU

for Pulmonary Edema

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06538376·Recruiting

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A Study to Assess Adverse Events, Change in Disease Activity, and How Intravenous and Subcutaneous Risankizumab Moves Through the Body of Pediatric Participants With Moderately to Severely Active Crohn's Disease

for Crohn's Disease

Drug: Risankizumab

11 locations incl. Phoenix

Sponsor: AbbVie

Sex: All·Age: 2 - 17

Code: NCT05995353·Phase 3·Recruiting

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A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

for Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer

Drug: Giredestrant

61 locations incl. Daphne

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT06065748·Phase 3·Recruiting

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FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)

for Type 1 Diabetes Mellitus

Drug: Frexalimab

14 locations incl. San Francisco

Sponsor: Sanofi

Sex: All·Age: 12 - 35

Code: NCT06111586·Phase 2·Recruiting

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Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis

for Liver Cirrhosis

1 location in Charlestown

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 99

Code: NCT06265272·Recruiting

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Zenith® Fenestrated+ Clinical Study

for Aortic Aneurysm, Abdominal

32 locations incl. Birmingham

Sponsor: Cook Research Incorporated

Sex: All·Age: 18+

Code: NCT04875429·Recruiting

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Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

for Kidney Transplant

15 locations incl. Birmingham

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18 - 70

Code: NCT05917522·Phase 2·Recruiting

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Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

for Chronic Graft Versus Host Disease

5 locations incl. Duarte

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT05996627·Phase 2·Recruiting

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A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

for Choroidal Melanoma

36 locations incl. Birmingham

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06007690·Phase 3·Recruiting

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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myeloma

for Multiple Myeloma

9 locations incl. Duarte

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06106945·Phase 1, Phase 2·Recruiting

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Middle Meningeal Artery Embolization (MMAE) Outcomes for Chronic Subdural Hematoma (cSDH)

for Chronic Subdural Hematoma

15 locations incl. Coral Gables

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06181994·Recruiting

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Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

16 locations incl. Davis

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting

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High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumors: A Pilot Feasibility Study

for Pediatric Brain Tumor

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05740839·Recruiting

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A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

for Myeloproliferative Neoplasms

Drug: Ruxolitinib

13 locations incl. Duarte

Sponsor: Incyte Corporation

Sex: All·Age: 18+

Code: NCT06034002·Phase 1·Recruiting

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CorEvitas International Adolescent Atopic Dermatitis (AD) Drug Safety and Effectiveness Registry

for Atopic Dermatitis

1 location in Waltham

Sponsor: CorEvitas

Sex: All·Age: 12 - 15·Accepts healthy volunteers

Code: NCT06238765·Recruiting

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Paclitaxel Coated Balloon for the Treatment of Chronic bEnigN sTricture- Esophagus

for Esophageal Stricture

34 locations incl. Birmingham

Sponsor: GIE Medical

Sex: All·Age: 22+

Code: NCT05561114·Phase 3·Recruiting

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Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms

for Normal Physiology

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05829044·Recruiting

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ED90 of Bupivacaine After Lidocaine Test Dose with DPE and EPL

for Labor Pain

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: Female·Age: All ages·Accepts healthy volunteers

Code: NCT06146842·Phase 4·Recruiting

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A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

for NASH With Fibrosis

Drug: Efruxifermin

205 locations incl. Birmingham

Sponsor: Akero Therapeutics, Inc

Sex: All·Age: 18 - 80

Code: NCT06215716·Phase 3·Recruiting

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GWICTIC: NAC Mechanistic Study in Gulf War Veterans

for Gulf War Syndrome

7 locations incl. Palo Alto

Sponsor: Nova Southeastern University

Sex: All·Age: 47 - 70

Code: NCT04987775·EARLY_Phase 1·Recruiting

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The Fourth Left Atrial Appendage Occlusion Study

for Atrial Fibrillation

51 locations incl. Birmingham

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 18+

Code: NCT05963698·Recruiting

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Study of ADI-PEG 20 or Placebo Plus Gem and Doc in Previously Treated Subjects With Leiomyosarcoma (ARGSARC)

for Soft Tissue Sarcoma

26 locations incl. Phoenix

Sponsor: Polaris Group

Sex: All·Age: 18 - 99

Code: NCT05712694·Phase 3·Recruiting

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PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

for Heart Failure NYHA Class II

47 locations incl. Phoenix

Sponsor: Endotronix, Inc.

Sex: All·Age: 18+

Code: NCT05934487·Recruiting

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Evaluation of the GORE® Ascending Stent Graft

for Aortic Aneurysm, Thoracic

41 locations incl. Birmingham

Sponsor: W.L.Gore & Associates

Sex: All·Age: 18+

Code: NCT05800743·Enrolling By Invitation

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

for Lung Cancer Diagnosis

36 locations incl. Los Angeles

Sponsor: Freenome Holdings Inc.

Sex: All·Age: 50+

Code: NCT06122077·Recruiting

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Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

for Spinal Muscular Atrophy

15 locations incl. Phoenix

Sponsor: Alcyone Therapeutics, Inc

Sex: All·Age: 3+

Code: NCT05866419·Recruiting

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Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for Anatomic Stage II Breast Cancer AJCC v8

Drug: Durvalumab

539 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06058377·Phase 3·Recruiting

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A Multicenter Multinational Observational Study of Children With Hypochondroplasia

for Hypochondroplasia

16 locations incl. Phoenix

Sponsor: BioMarin Pharmaceutical

Sex: All·Age: Up to 15

Code: NCT06212947·Recruiting

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Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

for Lymphatic Malformations

16 locations incl. Oakland

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 0 - 100

Code: NCT05948943·Phase 2, Phase 3·Recruiting

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A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer

for Breast Cancer

Drug: Durvalumab

64 locations incl. Daphne

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06103864·Phase 3·Recruiting

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ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves

for Aortic Valve Insufficiency

32 locations incl. Newport Beach

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT05172973·Recruiting

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Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations

for Locally Advanced Cholangiocarcinoma

4 locations incl. San Francisco

Sponsor: Tyra Biosciences, Inc

Sex: All·Age: 18+

Code: NCT06160752·Phase 1·Recruiting

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Prospective Screening for Pancreatic Ductal Adenocarcinoma in High-Risk Individuals

for Pancreatic Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06122896·EARLY_Phase 1·Recruiting

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A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors

for Colorectal Neoplasms

21 locations incl. Phoenix

Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All·Age: 18+

Code: NCT06131840·Phase 1·Recruiting

Apply to this trial