Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 23, 2026.

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3,605 clinical trials

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Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)

for Chronic Lymphocytic Leukemia (CLL)

Drug: Venetoclax

8 locations incl. Evanston

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT03824483·Phase 2·Recruiting

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CenteringParenting Clinical Intervention on Kindergarten Readiness in Early Childhood

for Parent-Child Relations

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: Up to 3 Months·Accepts healthy volunteers

Code: NCT03641092·Recruiting

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Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support

for Drug Effect

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 0 Days - 17

Code: NCT03593408·Recruiting

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Low Intensity Focused Ultrasound Epilepsy: A Pilot Trial

for Drug Resistant Epilepsy

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03868293·Recruiting

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Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

for Previously Treated Non-Small Cell Lung Cancer

1229 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03851445·Phase 2, Phase 3·Recruiting

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EVOC - EVs in Obesity and Cardiometabolic Disease

for Cardiovascular Diseases

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT06408961·Recruiting

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Computerized Decision Support for Prevention of VTE in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)

for Venous Thromboembolism

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 40+

Code: NCT03728166·Recruiting

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Cardiac Sarcoidosis Randomized Trial

for Cardiac Sarcoidosis

9 locations incl. New Haven

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18+

Code: NCT03593759·Phase 3·Recruiting

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Natural History Study of Patients With Succinic Semialdehyde Dehydrogenase (SSADH) Deficiency

for Succinic Semialdehyde Dehydrogenase Deficiency

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT03758521·Recruiting

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Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting

for Barrett Esophagus

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04561791·Enrolling By Invitation

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

37 locations incl. Birmingham

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting

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RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer

for Endometrial Cancer

3 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT03675893·Phase 2·Recruiting

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The T1D Exchange Registry

for Diabetes Mellitus, Type 1

1 location in Boston

Sponsor: T1D Exchange, United States

Sex: All·Age: All ages

Code: NCT04629586·Recruiting

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Pulmonary Hemodynamics During Exercise - Research Network

for Pulmonary Circulation Diseases

8 locations incl. Phoenix

Sponsor: Medical University of Graz

Sex: All·Age: 18+

Code: NCT03954574·Recruiting

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IVTCC 2.0: A Prospective Multicenter Ventricular Tachycardia Catheter Ablation Registry

for Ventricular Arrhythmia

34 locations incl. Phoenix

Sponsor: University of California, Los Angeles

Sex: All·Age: All ages

Code: NCT04520347·Enrolling By Invitation

Vagal Nerve Stimulation for Functional Dyspepsia and Gastroparesis

for Dyspepsia

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT03603730·Recruiting

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

73 locations incl. Tucson

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting

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A 90 Day, Phase 3,Open Labeled Exploratory Study of RELiZORB

for Short Bowel Syndrome

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 2 - 18

Code: NCT03530852·Recruiting

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Medtronic Terminate AF Study

for Persistent Atrial Fibrillation

15 locations incl. Palo Alto

Sponsor: Medtronic Cardiac Surgery

Sex: All·Age: 18+

Code: NCT03546374·Recruiting

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Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

for Mesothelioma

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT03683680·Recruiting

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Predicting Progression of Developing Myeloma in a High-Risk Screened Population (PROMISE)

for Multiple Myeloma

1 location in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 30+·Accepts healthy volunteers

Code: NCT03689595·Recruiting

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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

for Pulmonary Invasive Fungal Infections

32 locations incl. Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days - 21

Code: NCT03827694·Recruiting

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Endovascular Treatment of Thoracic Aortic Disease

for Thoracic Aortic Aneurysms

2 locations incl. Boston

Sponsor: Matthew Eagleton

Sex: All·Age: 18+

Code: NCT00583817·Enrolling By Invitation

Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

for Breast Cancer

451 locations incl. Fairbanks

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 35+

Code: NCT03488693·Phase 3·Recruiting

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Nutrition in Patient With Critical Limb Ischemia

for Critical Limb Ischemia

1 location in Boston

Sponsor: Boston Medical Center

Sex: All·Age: 18 - 99

Code: NCT03529019·EARLY_Phase 1·Recruiting

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Alvimopan Versus Placebo in Patients Undergoing Radical Cystectomy on an Enhanced Recovery Protocol

for Bladder Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 85

Code: NCT03216525·Phase 3·Recruiting

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Confocal Laser Endomicroscopy as an Imaging Biomarker for the Diagnosis of Pancreatic Cystic Lesions

for Pancreatic Cyst

10 locations incl. Scottsdale

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT03492151·Recruiting

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Developing Viability Index for Machine Perfused Livers

for Liver Cirrhoses

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT03694691·Recruiting

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Local Control, Quality of Life and Toxicities in Adults With Benign or Indolent Brain Tumors Undergoing Proton Radiation Therapy

for Brain Tumor

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT03286335·Recruiting

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Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

334 locations incl. Gilbert

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting

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Extension Study for the Port Delivery System With Ranibizumab (Portal)

for Neovascular Age-Related Macular Degeneration

Drug: Ranibizumab

81 locations incl. Phoenix

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50+

Code: NCT03683251·Phase 3·Recruiting

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

709 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting

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Image Guided VATS vs. VATS Resection

for Lung Cancer

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT03623958·Recruiting

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Imaging Histone Deacetylase in the Heart

for Heart Failure With Normal Ejection Fraction

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT03549559·Recruiting

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Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance

for Ascending Aortic Aneurysm Enlargement

15 locations incl. San Francisco

Sponsor: Ottawa Heart Institute Research Corporation

Sex: All·Age: 18 - 79

Code: NCT03536312·Recruiting

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Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study

for Atherosclerosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT04496947·Recruiting

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The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL

for B-cell Acute Lymphoblastic Leukemia

24 locations incl. Birmingham

Sponsor: Pediatric Transplantation & Cellular Therapy Consortium

Sex: All·Age: 1 - 25

Code: NCT03509961·Phase 2·Recruiting

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North American Prodromal Synucleinopathy Consortium

for REM Sleep Behavior Disorder

9 locations incl. Sun City

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT03623672·Enrolling By Invitation

Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

65 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting

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NLP to Aid in the Evaluation and Diagnosis of FGIDs

for Functional Gastrointestinal Disorders

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05501028·Enrolling By Invitation